Radiochemistry最新文献_第10页

Radiosynthesis and Preclinical Evaluation of [89Zr]Zr-3,4,3-LI(1,2-HOPO)-Durvalumab for Immuno-PET [89Zr] zr -3,4,3- li (1,2- hopo)-Durvalumab用于免疫pet的放射合成及临床前评价

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Radiochemistry Pub Date : 2025-12-14 DOI: 10.1134/S1066362225050133

S. Q. Shah, D. Ilem-Ozdemir, S. Shirin

{"title":"Radiosynthesis and Preclinical Evaluation of [89Zr]Zr-3,4,3-LI(1,2-HOPO)-Durvalumab for Immuno-PET","authors":"S. Q. Shah, D. Ilem-Ozdemir, S. Shirin","doi":"10.1134/S1066362225050133","DOIUrl":"10.1134/S1066362225050133","url":null,"abstract":"This study describes the radiosynthesis and preclinical testing of 89Zr-labeled conjugated durvalumab, a new immuno-PET probe aimed at improving in vivo stability and facilitating sensitive imaging of PD-L1 dynamics. Durvalumab was conjugated site-specifically to the bifunctional chelator 3,4,3-LI(1,2-HOPO) (LI-HOPO) and radiolabeled using 89Zr under mild conditions. MALDI-TOF-MS and SDS-PAGE characterization validated successful conjugation with the chelator : antibody ratio of ~5 : 1 and the antibody integrity maintained. The radiolabeling efficiency reached 70.45 ± 1.8, with radiochemical purity >98.5%. The immunoreactivity, determined by Lindmo assay against PD-L1-positive CT26 cells, was 85.4 ± 1.2%. The radiotracer was highly serum stable in vitro (>96% intact at 120 h). PET/CT imaging in CT26 tumor-bearing mice revealed progressively higher tumor uptake, with the highest value at 120 h post injection. The tumor uptake correlated with the PD-L1 expression and immune modulation, particularly in mice receiving combination therapy with durvalumab and the epigenetic modulator I-BET762. Ex vivo biodistribution established the increased PD-L1 expression in tumors with high radiotracer accumulation. [89Zr]Zr-3,4,3-LI(1,2-HOPO)-durvalumab is a promising immuno-PET tracer with high radiochemical stability, high specificity, and efficient tumor targeting. It permits quantitative noninvasive evaluation of PD-L1 expression and immune modulation, exhibiting significant potential as a new radiotracer for the guidance and monitoring of cancer immunotherapy.","PeriodicalId":747,"journal":{"name":"Radiochemistry","volume":"67 5","pages":"680 - 689"},"PeriodicalIF":1.0,"publicationDate":"2025-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145750412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Complexation of the [99Tc(CO)3(H2O)3]+ Ion with Phosphoric Acid Anions in Aqueous Solution: A 99Тс NMR Study [99Tc(CO)3(H2O)3]+离子与磷酸阴离子在水溶液中的络合：99Тс核磁共振研究

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Radiochemistry Pub Date : 2025-12-14 DOI: 10.1134/S1066362225050029

G. V. Sidorenko, A. E. Miroslavov, L. S. Chisty, A. P. Sakhonenkova, M. Yu. Tyupina, T. S. Ulidova

引用次数: 0

Sorption Equilibria of U(VI) Ions with Oxide–Graphene Composite TiO2||C and with TiO2 in the Region of the Henry Law U（VI）离子在氧化物-石墨烯复合材料TiO2||C和TiO2在Henry定律区域的吸附平衡

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Radiochemistry Pub Date : 2025-12-14 DOI: 10.1134/S106636222505008X

E. V. Polyakov, I. V. Volkov, A. A. Ioshin, V. N. Krasil’nikov

{"title":"Sorption Equilibria of U(VI) Ions with Oxide–Graphene Composite TiO2||C and with TiO2 in the Region of the Henry Law","authors":"E. V. Polyakov, I. V. Volkov, A. A. Ioshin, V. N. Krasil’nikov","doi":"10.1134/S106636222505008X","DOIUrl":"10.1134/S106636222505008X","url":null,"abstract":"The results of studying the sorption equilibria of U(VI) ions with TiO2||C oxide–graphene composite and with the oxide TiO2 prepared from it were analyzed within the framework of the surface complexation theory. According to the established equilibrium mechanism, the following species participate in the sorption in the region of the Henry law at pH 2–11: UO22+, UO2(OH)+, UO2(OH)20, UO2(OH)3–, and UO2(CO3)0; they react with the surface {≡Ti–OH} groups. Anionic carbonate complexes are not adsorbed onto titanium oxide. Oligomeric titanium complexes do not affect the resultant sorption because of a sharp decrease in the equilibrium analytical concentration of uranium due to the extremely high distribution coefficient Kd (mL/g) of the sorbent, exceeding 6 log units at рН 6.5. The linear correlation between the Henry constants of the sorption of uranium species onto titanium oxide and their stability constants in the electrolyte solution confirms the similarity of energy processes in the formation of U(VI) species in the contacting phases.","PeriodicalId":747,"journal":{"name":"Radiochemistry","volume":"67 5","pages":"648 - 657"},"PeriodicalIF":1.0,"publicationDate":"2025-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145750393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Soft Zoobenthos of Special Industrial Reservoirs of the Mayak Production Association 玛雅克生产协会特殊工业水库的软底栖动物

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Radiochemistry Pub Date : 2025-12-14 DOI: 10.1134/S1066362225050194

A. A. Peretykin, N. I. Atamanyuk, E. A. Pryakhin

引用次数: 0

Justification of Explosion Safety Conditions in Evaporation of Nitric Acid Solutions Containing Various Reductants 含各种还原剂的硝酸溶液蒸发爆炸安全条件的论证

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Radiochemistry Pub Date : 2025-12-14 DOI: 10.1134/S1066362225050078

E. V. Belova, E. R. Nazin, A. S. Obedkov, B. F. Myasoedov

引用次数: 0

Estimation of the Contribution of Chernobyl 137Cs to the Caspian Sea Pollution by 137Cs from Global Fallout 用全球沉降物中的137Cs估算切尔诺贝利137Cs对里海污染的贡献

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Radiochemistry Pub Date : 2025-12-14 DOI: 10.1134/S1066362225050170

N. A. Bakunov, V. I. Polyakov

{"title":"Estimation of the Contribution of Chernobyl 137Cs to the Caspian Sea Pollution by 137Cs from Global Fallout","authors":"N. A. Bakunov, V. I. Polyakov","doi":"10.1134/S1066362225050170","DOIUrl":"10.1134/S1066362225050170","url":null,"abstract":"The concentration of 137Cs originating from the Chernobyl accident in the Caspian water was estimated by subtracting the concentration of global 137Cs from the total concentration of 137Cs radionuclides in water at the monitoring date (1996). Late monitoring of the Caspian waters in 1996 made it impossible to determine the “Chernobyl” 137Cs from the 134Cs/137Cs ratio because of the decay of the short-lived radionuclide. The concentration of global 137Cs in the seawater was calculated using the sorption–diffusion model of the 137Cs absorption by bottom sediments with sorption coefficients (Kd) and diffusion coefficients (D) equal to 2700 L/kg and 1.0 × 10–7 cm2/s, respectively. By the monitoring date (1995–1996), the inventories of global and “Chernobyl” 137Cs in the seawater were determined to be 312.6 and 93.8 TBq, respectively, with “Chernobyl” 137Cs accounting for 23% of the total amount. With low fallout of “Chernobyl” 137Cs on the Caspian Sea, 137Cs of global fallout dominated in the marine pollution. During the 56-year exposure (1964–2020), the concentration of global 137Cs in the Caspian water decreased from 23.7 to 1.8 Bq/m3, which is typical of the current level of 137Cs in waters of the world ocean.","PeriodicalId":747,"journal":{"name":"Radiochemistry","volume":"67 5","pages":"721 - 726"},"PeriodicalIF":1.0,"publicationDate":"2025-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145750400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluating the Parameters of the Source of Water Aerosol Generation from the V-2 Reservoir Water Area V-2水库水区气溶胶源参数评价

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Radiochemistry Pub Date : 2025-12-14 DOI: 10.1134/S1066362225050212

K. Yu. Mokrov

{"title":"Evaluating the Parameters of the Source of Water Aerosol Generation from the V-2 Reservoir Water Area","authors":"K. Yu. Mokrov","doi":"10.1134/S1066362225050212","DOIUrl":"10.1134/S1066362225050212","url":null,"abstract":"The concentration ratio of chemical elements in a water aerosol may differ significantly from the concentration ratio of the same elements in bulk water from which this water aerosol was generated. Fractionation of chemical elements in water aerosols occurs in the surface microlayer of water and is observed only for water-soluble trace elements. For radionuclides (trace elements), the relative fractionation factor F(X/Cs) is defined as the degree of accumulation of the activity of radionuclide X in the water aerosol relative to that of another (reference) radionuclide (137Cs). The paper suggests a technique for field evaluation of relative fractionation factors for various trace elements in water aerosols that are generated by interaction of a stream of hot wastewater and cold lake water. During this interaction, air dissolved in the cold water passes into the gas phase in the form of bubbles. The technique was tested under natural conditions in the V-2 reservoir (Lake Kyzyl-Tash), in which the 90Sr activity concentration in water was 1.4 kBq/L and concentration of basic trace chemical elements was less than ~10 mg/L. The relative fractionation factors F(Y/Sr) for various trace elements in the water aerosol were estimated at ~15 for aluminum, ~13 for iron, >15 for lead, >46 for zinc, ~1.1 for calcium, ~0.3 for magnesium, and ~30 for nickel. The absolute fractionation factors F(Y) for these elements were 5.5 times higher than the relative fractionation factors. The 90Sr activity concentration in air in the vicinity of the V-2 reservoir for the period from March 21 till March 26, 2025 was estimated at ~0.2 mBq/m3 due to all sources of contamination, with the water aerosol generation contributing no more than 3%.","PeriodicalId":747,"journal":{"name":"Radiochemistry","volume":"67 5","pages":"763 - 769"},"PeriodicalIF":1.0,"publicationDate":"2025-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145750404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sorbents Based on Clinoptilolite and Bentonite for the Immobilization of 137Cs, 90Sr, Uranium, and 241Am at Radioactive Waste Repositories 基于斜沸石和膨润土的吸附剂固定化放射性废物储存库中的137Cs、90Sr、铀和241Am

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Radiochemistry Pub Date : 2025-12-14 DOI: 10.1134/S1066362225050157

A. V. Voronina, M. A. Averianov, V. A. Rogozhnikov, A. K. Suetina

引用次数: 0

32P Carriers Based on Hydroxyapatite-Modified Alginate Beads 羟基磷灰石修饰藻酸盐微球的32P载体

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Radiochemistry Pub Date : 2025-12-14 DOI: 10.1134/S1066362225050121

I. N. Chernykh, A. V. Gopin, A. N. Kharlanov, B. I. Kharisov, A. L. Nikolaev

引用次数: 0

A New Method for Studying the Extraction Kinetics with Monitoring of the Organic Phase Properties by Attenuated Total Reflection IR Spectroscopy 用衰减全反射红外光谱监测有机相性质研究萃取动力学的新方法

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Radiochemistry Pub Date : 2025-12-14 DOI: 10.1134/S1066362225050054

T. S. Aleksandrov, M. D. Karavan, E. S. Babitova, A. A. Brechalov, I. V. Smirnov

{"title":"A New Method for Studying the Extraction Kinetics with Monitoring of the Organic Phase Properties by Attenuated Total Reflection IR Spectroscopy","authors":"T. S. Aleksandrov, M. D. Karavan, E. S. Babitova, A. A. Brechalov, I. V. Smirnov","doi":"10.1134/S1066362225050054","DOIUrl":"10.1134/S1066362225050054","url":null,"abstract":"The kinetics of europium and yttrium extraction with mono- and polyfunctional ligands in organic diluents was studied by attenuated total reflection IR spectroscopy and a method using a diffusion cell. The extraction rate is influenced by the kind of the ligand, solvate formation mechanism, and specific features of diffusion. The extraction rate constants in the systems studied were calculated. In the extraction of europium with organophosphorus ligands, the extraction rate constants range from 3.3 × 10–4 to 1.1 × 10–3 cm s–1. A stepwise complexation mechanism with polyfunctional ligands containing P=O and C=O groups was revealed. In the case of yttrium extraction, the extraction rate constant with a mixed extractant, 2,3-dihydroxynaphthalene + methyltrioctylammonium carbonate, is 1.5 × 10–3 cm s–1, which is higher by an order of magnitude than the rate constant obtained with 8-hydroxyquinoline (k = 4.3 × 10–4 cm s–1), owing to a synergistic effect.","PeriodicalId":747,"journal":{"name":"Radiochemistry","volume":"67 5","pages":"616 - 629"},"PeriodicalIF":1.0,"publicationDate":"2025-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145750405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0