Schizophrenia (Heidelberg, Germany)最新文献

{"title":"Risperidone reduces individualized morphometric similarity deviation in schizophrenia and associates with cortical transcriptomic patterns.","authors":"Liju Liu, Mi Yang, Jinxing Chen, Chunchen Yi, Di Kong, Guocheng Zhao, Huafu Chen, Xiangyang Zhang","doi":"10.1038/s41537-025-00724-9","DOIUrl":"10.1038/s41537-025-00724-9","url":null,"abstract":"<p><p>Schizophrenia has been linked to reduced cortical thickness and abnormal gene expression. While antipsychotic treatment has been found to affect cortical morphology and gene expression, its impact on subject-specific deviations in cortical morphometric similarity and the underlying genetic mechanisms remain unclear. To quantify risperidone-related changes in morphometric similarity at the individual level and test their spatial alignment with cortical transcriptomic patterns. Twenty-four drug-naive first-episode schizophrenia patients and 30 healthy controls underwent T1-weighted imaging scans. Patients were scanned before and after 12 weeks of treatment with risperidone; symptoms and cognitive function were assessed with PANSS and MCCB scale. For each scan, cortical morphometric similarity matrices were built from regional cortical thickness distributions using the Wasserstein distance. We defined Morphometric Similarity Deviation (MSD) as a subject-level, normative-referenced departure from the healthy morphometric similarity pattern, derived from node-wise fingerprint correlations with the healthy template. Partial least squares regression related treatment-induced MSD changes to cortical transcriptomic data obtained from the Allen Human Brain Atlas. Patients exhibited high MSD in the frontal, temporal, and temporoparietal regions. Greater baseline MSD across the whole brain and multiple networks were associated with more severe positive symptoms. After treatment, MSD decreased, and reductions within the salience/ventral attention network associated with improved Emotional Intelligence. Moreover, risperidone-induced changes in MSD were spatially correlated with the expression of specific genes enriched in neurotransmission, cell adhesion, immune function, and schizophrenia. Specific expression analyses revealed that these genes were specifically expressed in astrocytes and oligodendrocytes, and spanned almost all developmental stages. Risperidone reduces MSD, reflecting convergence toward a normative cortical morphometric similarity pattern. These changes were spatially aligned with gene expression patterns involved in neurotransmission and immune processes, suggesting a molecular basis for treatment-linked structural normalization and its cognitive benefits.</p>","PeriodicalId":74758,"journal":{"name":"Schizophrenia (Heidelberg, Germany)","volume":" ","pages":"19"},"PeriodicalIF":4.1,"publicationDate":"2026-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12881435/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145947177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Post-mortem brain analysis reveals altered monoaminergic system in the dorsolateral prefrontal cortex and hippocampus in chronic schizophrenia.","authors":"Anna Di Maio, Valentina Bassareo, Giuseppe De Simone, Amber Hassan, Alessandro Bertolino, Francesco Errico, Antonio Rampino, Andrea de Bartolomeis, Alessandro Usiello","doi":"10.1038/s41537-025-00722-x","DOIUrl":"10.1038/s41537-025-00722-x","url":null,"abstract":"<p><p>Schizophrenia is a multifactorial psychiatric disorder in which monoaminergic neurotransmission, particularly dopamine (DA), serotonin (5-HT), and norepinephrine (NE), is implicated in both pathophysiology and response to treatments. However, the regional composition and functional interaction among these neurotransmitters and their catabolites remain unclear. In this study, using high-performance liquid chromatography (HPLC), we quantified DA, 5-HT, NE and their metabolites, HVA, DOPAC, and 5-HIAA, along with protein levels of key monoamine-metabolizing enzymes (MAO-A, MAO-B, and COMT isoforms) in post-mortem dorsolateral prefrontal cortex (DLPFC) and hippocampus from chronic schizophrenia patients and matched healthy controls. Although absolute monoamine and enzyme levels did not differ between cases and controls, partial correlation analyses revealed remarkable schizophrenia-specific interactions. In particular, patients exhibited distinct 5-HT-DOPAC correlations in both regions, suggesting an abnormal coupling between serotonergic and dopaminergic metabolism. In the DLPFC, the DA-NE correlation was markedly attenuated in schizophrenia, potentially reflecting disrupted catecholaminergic integration relevant to cognitive function and salience processing. Furthermore, an increased 5-HIAA-5-HT correlation emerged in the hippocampus of schizophrenia patients, indicative of abnormal serotonin turnover. In conclusion, our observations indicate that while the cerebral concentrations of monoamines and their catabolites remain relatively stable in patients with schizophrenia, their interactions are significantly dysregulated compared to those reported in healthy controls. These postmortem findings provide new insights into the monoaminergic neurotransmission crosstalk in the schizophrenia brain.</p>","PeriodicalId":74758,"journal":{"name":"Schizophrenia (Heidelberg, Germany)","volume":" ","pages":"17"},"PeriodicalIF":4.1,"publicationDate":"2026-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12877066/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145949289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Altered neural processing in middle frontal gyrus and cerebellum during temporal recalibration of action-outcome predictions in schizophrenia spectrum disorders.","authors":"Christina V Schmitter, Benjamin Straube","doi":"10.1038/s41537-025-00721-y","DOIUrl":"10.1038/s41537-025-00721-y","url":null,"abstract":"<p><p>A key function of the perceptual system is to predict the (multi)sensory outcomes of actions and recalibrate these predictions in response to changing conditions. In schizophrenia spectrum disorders (SSD), impairments in this ability have been linked to difficulties in self-other distinction. This study investigated the neural correlates of the recalibration of action-outcome predictions to delays, the transfer of this process across sensory modalities, and whether participants with SSD exhibit alterations in the underlying neural processes. SSD participants and healthy controls (HC) underwent fMRI while exposed to delays between active or passive button presses and auditory outcomes. A delay detection task assessed recalibration effects on auditory perception (unimodal trials) and its transfer to visual perception (cross-modal trials). In unimodal trials, HC exhibited reduced activation in left middle frontal gyrus (MFG) after recalibration, particularly for active movements, whereas this effect was reversed in SSD. In cross-modal trials, recalibration was linked to increased activation in bilateral cerebellum in HC, especially for active movements, a pattern significantly reduced in SSD. These findings suggest that unimodal temporal recalibration of action-outcome predictions in HC is reflected in reduced prediction error-related MFG activity, which is significantly reduced in SSD revealing potentially disrupted recalibration processes. Additionally, cerebellar engagement appears crucial for cross-modal transfer of recalibrated action-outcome timings, a process that may be impaired in SSD, leading to severe perceptual disturbances like hallucinations.</p>","PeriodicalId":74758,"journal":{"name":"Schizophrenia (Heidelberg, Germany)","volume":" ","pages":"10"},"PeriodicalIF":4.1,"publicationDate":"2026-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12858854/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145949322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Whole-brain functional connectivity predicts ultra-high risk for psychosis status and level of functioning.","authors":"Karen S Ambrosen, Tina D Kristensen, Louise B Glenthøj, Merete Nordentoft, Birte Y Glenthøj, Anita D Barber, Bjørn H Ebdrup","doi":"10.1038/s41537-025-00685-z","DOIUrl":"10.1038/s41537-025-00685-z","url":null,"abstract":"<p><p>Resting-state functional magnetic resonance imaging (rs-fMRI) has offered insights into the neural mechanisms underlying psychosis, particularly when associated with clinically relevant features. 102 individuals at ultra-high risk for psychosis (UHR) and 105 matched healthy controls (HC) aged 18-40 underwent clinical and cognitive assessments and rs-fMRI at baseline. Using a recently developed prediction-based extension of the network-based statistics (NBS-predict), incorporating nested cross-validation, we tested the predictive power of functional connectivity estimated from rs-fMRI data, investigating diagnostic classification and prediction of level of functioning, estimated IQ, and UHR-symptoms. Hyper-connectivity predicted group with a classification accuracy of 0.58, p = 0.043, and hypo-connectivity predicted group with a classification accuracy of 0.59, p = 0.018. Hyper-connectivity in UHR-individuals was observed primarily in interhemispheric and cortico-thalamic connections, within networks that predicted poorer levels of functioning across groups. Hypo-connectivity in UHR-individuals was observed mainly in thalamic connections with posterior cingulate cortex, frontal medial, and precuneus, within networks that predicted higher level of functioning across groups. Post hoc analyses identified a significant groupwise interaction effect on the association between functional connectivity and level of functioning (ρ = 0.34, p < 0.001), with main nodes in the frontal medial regions connected across hemispheres. Within-group, no connections predicted level of functioning or UHR-symptoms. Whole-brain functional connectivity predicted UHR-status in hyper- and hypo-connected networks, with thalamus as a central integrative hub across networks. Connections that predicted level of functioning across groups were equivalent to the connections predicting UHR-status, hence capturing a neural correlate to a key clinical component of the UHR-status.</p>","PeriodicalId":74758,"journal":{"name":"Schizophrenia (Heidelberg, Germany)","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2026-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12923647/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145914102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peripheral inflammation mediates cognitive deficits in drug-naive schizophrenia through hippocampal-thalamo-visual circuitry dysfunction.","authors":"Ningzhi Gou, Qingyan Ma, Min Jia, Zhiyang Qi, Yuan Gao, Wei Wang, Xiancang Ma, Yajuan Fan","doi":"10.1038/s41537-025-00719-6","DOIUrl":"10.1038/s41537-025-00719-6","url":null,"abstract":"<p><p>Converging evidence indicates that dysregulated cortico-subcortical connectivity underpins core cognitive impairment in schizophrenia (SCZ). However, the mechanistic basis linking this disrupted brain function to cognitive deficits remains elusive. We hypothesized that dysfunction within the hippocampal-thalamocortical circuitry mediates the impact of peripheral inflammation on cognitive deficits in SCZ. We recruited 62 drug-native patients with SCZ and 44 age and sex-matched healthy controls (HCs), assessing: serum levels of cytokines, cognition using the MATRICS Consensus Cognitive Battery, and resting-state functional connectivity (FC) and functional connectivity network (FCN) features. Correlation and mediation analyses were employed to examine relationships among peripheral inflammation, brain functional alterations, and cognitive deficits. The findings revealed reduced FC in SCZ between the right subiculum of the hippocampus and the anterior division of the right parahippocampal gyrus (aPaHC), as well as the entorhinal cortex and the left lingual gyrus/precuneus. Conversely, the thalamus exhibited aberrant hyperconnectivity with widespread areas, including the Cornu Ammonis of the hippocampus, right lateral occipital cortex, intraparietal sulcus (IPS), and sensorimotor areas. Conjunction analysis identified distinct disruptions within hippocampal-thalamo-visual circuitry, suggesting that an imbalance in thalamo-visual and intra-hippocampal connectivity may mediate the relationship between peripheral inflammation (e.g., IL-4, CCL-2) and working memory dysfunction. This study advances our understanding of the role of peripheral inflammation in SCZ, revealing complex cross-domain interactions between pathophysiological changes (e.g., dysregulated peripheral immunity and circuit-specific dysfunction) and behavioral features. Our findings highlight a novel combinatorial therapeutic strategy-integrating cytokine-specific agents (e.g., for CCL-2 and IL-4) with circuit-directed neuromodulation of the dysfunctional hippocampal-thalamic-visual circuitry, thereby ameliorating cognitive deficits in SCZ.</p>","PeriodicalId":74758,"journal":{"name":"Schizophrenia (Heidelberg, Germany)","volume":" ","pages":"15"},"PeriodicalIF":4.1,"publicationDate":"2026-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12867995/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145896149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between second-generation antipsychotics and metabolic outcomes in patients with schizophrenia and metabolic abnormalities.","authors":"Zhengluan Liao, Yaguan Zhou, Junjie Lin, Suhong Ye, Haihang Yu, Xilong Jin, Lixiu Wei, Guidong Zhu, Zhiyong Lan, Kedeng Fu, Tiantian Zu, Li Ni, Yingying Dong, Heqiu Wang, Yong Zhou, Wei Lv, Juan Huang, Hongfei Wang, Xueming Xu, Xiao Qian, Wanzhen Wu, Liying Liu, Huabin Liu, HuanPing Zhan, Yanbo Chen, Zhilian Pi, Minghua Xie, Xiaolin Xu, Enyan Yu","doi":"10.1038/s41537-025-00718-7","DOIUrl":"10.1038/s41537-025-00718-7","url":null,"abstract":"<p><p>Second-generation antipsychotics (SGAs) were found to have varying metabolic side-effects for patients with schizophrenia, while no studies have examined the associations between adding or switching low-risk SGAs and metabolic outcomes. This real-world observational study aimed to examine the association of adding or switching to low-risk SGAs with metabolic syndrome and metabolic abnormalities for patients with schizophrenia from 25 healthcare organizations across Zhejiang Province, China. Participants were dichotomized into the low-risk SGAs group and the high/intermediate SGAs group according to whether adding or switching to low-risk SGAs. A 1:1 propensity score matching (PSM) using a nearest-neighbor method was conducted to balance the baseline characteristics between groups. The mean [standard deviation (SD)] age of included patients was 50.0 (12.4) years, and 288 (37.7%) were women. The PSM yielded 223 matched pairs, with no between-group differences in baseline characteristics. Compared to the high/intermediate SGAs group, the low-risk SGAs group showed consistent decreases in the proportion of participants with metabolic syndrome [e.g., at 6 months: risk differences = 19.28%, 95% confidence interval (CI) = -28.19% to -10.38%; odds ratio = 0.47, 95% CI = 0.30 to 0.72] and the number of metabolic abnormalities [e.g., at 6 months: mean difference (MD) = -0.52, 95% CI = -0.75 to -0.29; relative risk = 0.79, 95% CI = 0.71 to 0.87]. The low-risk SGAs group presented significant improvement in metabolic parameters, including lower levels of weight, glucose and triglyceride (e.g., for triglycerise, (MD = -0.41 mmol/L, 95% CI = -0.61 to -0.21 mmol/L at 6 months), compared to the high/intermediate risk SGAs group. These assocaitions were more pronounced in those with no comorbid physical conditions, lower BMI, shorter duration and reporting smoking or drinking. Adding or switching to low-risk antipsychotics was associated with a decrease in metabolic outcomes, which can be considered as an appropriate secondary prevention strategy for patients with both schizophrenia and metabolic abnormalities.</p>","PeriodicalId":74758,"journal":{"name":"Schizophrenia (Heidelberg, Germany)","volume":" ","pages":"14"},"PeriodicalIF":4.1,"publicationDate":"2026-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12868826/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145897186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neurobiological illness models of schizophrenia and stigma reduction: has that ship sailed?","authors":"Philipp Sterzer, Nicolai Rohner, Christian Huber","doi":"10.1038/s41537-025-00717-8","DOIUrl":"10.1038/s41537-025-00717-8","url":null,"abstract":"<p><p>Stigma substantially contributes to the burden of psychotic disorders such as schizophrenia. Previous attempts to reduce stigma based on neurobiological illness models were unsuccessful. In this Perspective article, we argue that these models may have failed to reduce stigma in schizophrenia because of their lack of explanatory power and their connotations of biological otherness and determinism. We suggest that recent developments in the realm of computational psychiatry may help to remedy this situation. In particular, we discuss the potential of predictive processing, a highly influential computational framework of brain function, to reduce the stigma associated with schizophrenia. We argue that predictive processing accounts may do so by bridging the explanatory gap between biology and psychotic experiences within a normative theory of brain function, thus offering a normalizing perspective on the neural underpinnings of schizophrenia. This may facilitate not only a better understanding of psychotic experiences but also counteract connotations of biological determinism and foster belief in change. Viewing schizophrenia through the lens of predictive processing may thus pave the way for the integration of neurobiologically grounded models into the communication with patients, their relatives, and the public, which have the potential to reduce stigma.</p>","PeriodicalId":74758,"journal":{"name":"Schizophrenia (Heidelberg, Germany)","volume":" ","pages":"13"},"PeriodicalIF":4.1,"publicationDate":"2025-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12868759/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145879581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polygenic risk for schizophrenia is associated with white matter microstructure, cognitive and mental health.","authors":"Qian Qian, Guoshu Zhao, Nannan Zhang, Shaoying Wang, Jinghan Sun, Feng Liu, Jiayuan Xu, Chunshui Yu","doi":"10.1038/s41537-025-00714-x","DOIUrl":"10.1038/s41537-025-00714-x","url":null,"abstract":"<p><p>Schizophrenia is highly heritable, and polygenic risk score for schizophrenia (PRS_SCZ) has been associated with brain and behavior in healthy populations. However, the full associations of PRS_SCZ with brain white matter microstructure and cognitive and mental health outcomes, the potential effects of sex and areal deprivation on these associations, and the mediation of white matter microstructure for the associations between PRS_SCZ and behavioral outcomes remain largely unknown. In up to 300,000 participants from the UK Biobank, we investigated the associations of PRS_SCZ with eight white matter microstructure metrics of 48 tracts and 14 cognitive and mental health phenotypes, and we further tested the moderation of sex and index of multiple deprivation (IMD) on these associations and the mediation of brain white matter phenotypes for the associations between PRS_SCZ and behavioral outcomes. We found that higher PRS_SCZ was associated with decreased white matter integrity in 26 tracts, such as cingulum, corona radiata, and fornix. We also found that higher PRS_SCZ was associated with poorer mental health and worse cognitive performance. These associations were not significantly moderated by sex and IMD. Causal mediation analyses revealed that these adverse effects of PRS_SCZ on cognitive and mental health outcomes were partially mediated by brain white matter phenotypes. These results indicate that genetic risk for schizophrenia affects the integrity of white matter tracts, which may account for its adverse effects on cognitive and mental health outcomes.</p>","PeriodicalId":74758,"journal":{"name":"Schizophrenia (Heidelberg, Germany)","volume":" ","pages":"12"},"PeriodicalIF":4.1,"publicationDate":"2025-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12858994/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145866190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disrupted rest-task shift of multi-band electroencephalography complexity in patients with schizophrenia.","authors":"Shunsuke Tamura, Tsuyoshi Iwasaki, Osamu Ichikawa, Kantaro Nishigori, Yoshihiro Iwamura, Takako Fujimoto, Tatsuhiro Tamada, Hidetaka Nagata, Yoji Hirano","doi":"10.1038/s41537-025-00713-y","DOIUrl":"10.1038/s41537-025-00713-y","url":null,"abstract":"<p><p>Brain activity undergoes intrinsic fluctuations with complexities specific to both the resting state and the task state. However, in patients with schizophrenia (SZ), where the boundary between internal and external realms is blurred, optimal modulation of these complexities between rest and stimulus phases is likely disrupted. Here, we present a frequency-dependent rest-task shift in electroencephalography (EEG) complexity in normal controls (NCs) and the associated abnormal patterns in patients with SZ. Specifically, we examined EEG complexity in different frequency bands, quantified by multiscale entropy (MSE), during the resting state and a 40 Hz auditory steady-state response (ASSR) task in 77 normal controls (NCs) and 103 patients with SZ. We compared the ASSR/resting MSE ratio between the NC and SZ groups. In the NC group, transitioning from the resting state to the ASSR state caused increased alpha-band entropy and decreased gamma-band entropy, whereas no such shifts were observed in patients with SZ. This study suggests that in NCs, alpha-band oscillatory complexity, which influences cortical response properties, increases during the transition from intrinsic to extrinsic information processing, while gamma-band oscillatory complexity decreases, likely due to concentration on auditory processing of a temporal enriching stimulation with high salience. Patients with SZ, which are marked by impaired neural synchrony, lacked the NCs' pronounced changes in neural complexity across frequency bands. This indicates that in patients with SZ, disruptions in the spontaneous activity that shapes the internal mental state may alter the properties of cortical responses and entrainment to external stimuli.</p>","PeriodicalId":74758,"journal":{"name":"Schizophrenia (Heidelberg, Germany)","volume":" ","pages":"156"},"PeriodicalIF":4.1,"publicationDate":"2025-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12749793/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145812248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Empowering clinicians and patients in antipsychotic dose reduction for schizophrenia: the role of online tools.","authors":"Stefan Leucht, Alessandro Rodolico","doi":"10.1038/s41537-025-00699-7","DOIUrl":"10.1038/s41537-025-00699-7","url":null,"abstract":"","PeriodicalId":74758,"journal":{"name":"Schizophrenia (Heidelberg, Germany)","volume":"11 1","pages":"153"},"PeriodicalIF":4.1,"publicationDate":"2025-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12712091/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145776747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}