Schizophrenia (Heidelberg, Germany)最新文献_第7页

Reduced speech coherence in psychosis-related social media forum posts. 与精神病有关的社交媒体论坛帖子中的语音连贯性降低。

IF 3

Schizophrenia (Heidelberg, Germany) Pub Date : 2024-07-04 DOI: 10.1038/s41537-024-00481-1

Laurin Plank, Armin Zlomuzica

{"title":"Reduced speech coherence in psychosis-related social media forum posts.","authors":"Laurin Plank, Armin Zlomuzica","doi":"10.1038/s41537-024-00481-1","DOIUrl":"10.1038/s41537-024-00481-1","url":null,"abstract":"The extraction of linguistic markers from social media posts, which are indicative of the onset and course of mental disorders, offers great potential for mental healthcare. In the present study, we extracted over one million posts from the popular social media platform Reddit to analyze speech coherence, which reflects formal thought disorder and is a characteristic feature of schizophrenia and associated psychotic disorders. Natural language processing (NLP) models were used to perform an automated quantification of speech coherence. We could demonstrate that users who are active on forums geared towards disorders with a higher degree of psychotic symptoms tend to show a lower level of coherence. The lowest coherence scores were found in users of forums on dissociative identity disorder, schizophrenia, and bipolar disorder. In contrast, a relatively high level of coherence was detected in users of forums related to obsessive-compulsive disorder, anxiety, and depression. Users of forums on posttraumatic stress disorder, autism, and attention-deficit hyperactivity disorder exhibited medium-level coherence. Our findings provide promising first evidence for the possible utility of NLP-based coherence analyses for the early detection and prevention of psychosis on the basis of posts gathered from publicly available social media data. This opens new avenues for large-scale prevention programs aimed at high-risk populations.","PeriodicalId":74758,"journal":{"name":"Schizophrenia (Heidelberg, Germany)","volume":"10 1","pages":"60"},"PeriodicalIF":3.0,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11224262/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141536162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Functional phenotypes in schizophrenia spectrum disorders: defining the constructs and identifying biopsychosocial correlates using data-driven methods. 精神分裂症谱系障碍的功能表型：使用数据驱动方法定义结构并确定生物-心理-社会相关性。

IF 3

Schizophrenia (Heidelberg, Germany) Pub Date : 2024-06-24 DOI: 10.1038/s41537-024-00479-9

Sunny X Tang, Katrin Hänsel, Lindsay D Oliver, Erin W Dickie, Colin Hawco, Majnu John, Aristotle Voineskos, James M Gold, Robert W Buchanan, Anil K Malhotra

{"title":"Functional phenotypes in schizophrenia spectrum disorders: defining the constructs and identifying biopsychosocial correlates using data-driven methods.","authors":"Sunny X Tang, Katrin Hänsel, Lindsay D Oliver, Erin W Dickie, Colin Hawco, Majnu John, Aristotle Voineskos, James M Gold, Robert W Buchanan, Anil K Malhotra","doi":"10.1038/s41537-024-00479-9","DOIUrl":"10.1038/s41537-024-00479-9","url":null,"abstract":"Functional impairments contribute to poor quality of life in schizophrenia spectrum disorders (SSD). We sought to (Objective I) define the main functional phenotypes in SSD, then (Objective II) identify key biopsychosocial correlates, emphasizing interpretable data-driven methods. Objective I was tested on independent samples: Dataset I (N = 282) and Dataset II (N = 317), with SSD participants who underwent assessment of multiple functioning areas. Participants were clustered based on functioning. Objective II was evaluated in Dataset I by identifying key features for classifying functional phenotype clusters from among 65 sociodemographic, psychological, clinical, cognitive, and brain volume measures. Findings were replicated across latent discriminant analyses (LDA) and one-vs.-rest binomial regularized regressions to identify key predictors. We identified three clusters of participants in each dataset, demonstrating replicable functional phenotypes: Cluster 1-poor functioning across domains; Cluster 2-impaired Role Functioning, but partially preserved Independent and Social Functioning; Cluster 3-good functioning across domains. Key correlates were Avolition, anhedonia, left hippocampal volume, and measures of emotional intelligence and subjective social experience. Avolition appeared more closely tied to role functioning, and anhedonia to independent and social functioning. Thus, we found three replicable functional phenotypes with evidence that recovery may not be uniform across domains. Avolition and anhedonia were both critical but played different roles for different functional domains. It may be important to identify critical functional areas for individual patients and target interventions accordingly.","PeriodicalId":74758,"journal":{"name":"Schizophrenia (Heidelberg, Germany)","volume":"10 1","pages":"58"},"PeriodicalIF":3.0,"publicationDate":"2024-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11196713/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141447737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Topological abnormalities of the morphometric similarity network of the cerebral cortex in schizophrenia. 精神分裂症患者大脑皮层形态计量相似性网络的拓扑异常。

Schizophrenia (Heidelberg, Germany) Pub Date : 2024-06-17 DOI: 10.1038/s41537-024-00477-x

Sung Woo Joo, Young Tak Jo, Woohyeok Choi, Sun Min Kim, So Young Yoo, Soohyun Joe, Jungsun Lee

{"title":"Topological abnormalities of the morphometric similarity network of the cerebral cortex in schizophrenia.","authors":"Sung Woo Joo, Young Tak Jo, Woohyeok Choi, Sun Min Kim, So Young Yoo, Soohyun Joe, Jungsun Lee","doi":"10.1038/s41537-024-00477-x","DOIUrl":"10.1038/s41537-024-00477-x","url":null,"abstract":"A morphometric similarity (MS) network can be constructed using multiple magnetic resonance imaging parameters of each cortical region. An MS network can be used to assess the similarity between cortical regions. Although MS networks can detect microstructural alterations and capture connections between histologically similar cortical areas, the influence of schizophrenia on the topological characteristics of MS networks remains unclear. We obtained T1- and diffusion-weighted images of 239 healthy controls and 190 individuals with schizophrenia to construct the MS network. Group comparisons of the mean MS of the cortical regions and subnetworks were performed. The strengths of the connections between the cortical regions and the global and nodal network indices were compared between the groups. Clinical associations with the network indices were tested using Spearman's rho. Compared with healthy controls, individuals with schizophrenia had significant group differences in the mean MS of several cortical regions and subnetworks. Individuals with schizophrenia had both superior and inferior strengths of connections between cortical regions compared with those of healthy controls. We observed regional abnormalities of the MS network in individuals with schizophrenia regarding lower centrality values of the pars opercularis, superior frontal, and superior temporal areas. Specific nodal network measures of the right pars opercularis and left superior temporal areas were associated with illness duration in individuals with schizophrenia. We identified regional abnormalities of the MS network in schizophrenia with the left superior temporal area possibly being a key region in topological organization and cortical connections.","PeriodicalId":74758,"journal":{"name":"Schizophrenia (Heidelberg, Germany)","volume":"10 1","pages":"57"},"PeriodicalIF":0.0,"publicationDate":"2024-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11183129/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141422177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Excitation/inhibition imbalance in schizophrenia: a meta-analysis of inhibitory and excitatory TMS-EMG paradigms. 精神分裂症的兴奋/抑制失衡：抑制性和兴奋性 TMS-EMG 范例的荟萃分析。

Schizophrenia (Heidelberg, Germany) Pub Date : 2024-06-15 DOI: 10.1038/s41537-024-00476-y

Orsolya Lányi, Boróka Koleszár, Alexander Schulze Wenning, David Balogh, Marie Anne Engh, András Attila Horváth, Péter Fehérvari, Péter Hegyi, Zsolt Molnár, Zsolt Unoka, Gábor Csukly

{"title":"Excitation/inhibition imbalance in schizophrenia: a meta-analysis of inhibitory and excitatory TMS-EMG paradigms.","authors":"Orsolya Lányi, Boróka Koleszár, Alexander Schulze Wenning, David Balogh, Marie Anne Engh, András Attila Horváth, Péter Fehérvari, Péter Hegyi, Zsolt Molnár, Zsolt Unoka, Gábor Csukly","doi":"10.1038/s41537-024-00476-y","DOIUrl":"10.1038/s41537-024-00476-y","url":null,"abstract":"Cortical excitation-inhibition (E/I) imbalance is a potential model for the pathophysiology of schizophrenia. Previous research using transcranial magnetic stimulation (TMS) and electromyography (EMG) has suggested inhibitory deficits in schizophrenia. In this meta-analysis we assessed the reliability and clinical potential of TMS-EMG paradigms in schizophrenia following the methodological recommendations of the PRISMA guideline and the Cochrane Handbook. The search was conducted in three databases in November 2022. Included articles reported Short-Interval Intracortical Inhibition (SICI), Intracortical Facilitation (ICF), Long-Interval Intracortical Inhibition (LICI) and Cortical Silent Period (CSP) in patients with schizophrenia and healthy controls. Meta-analyses were conducted using a random-effects model. Subgroup analysis and meta-regressions were used to assess heterogeneity. Results of 36 studies revealed a robust inhibitory deficit in schizophrenia with a significant decrease in SICI (Cohen's d: 0.62). A trend-level association was found between SICI and antipsychotic medication. Our findings support the E/I imbalance hypothesis in schizophrenia and suggest that SICI may be a potential pathophysiological characteristic of the disorder.","PeriodicalId":74758,"journal":{"name":"Schizophrenia (Heidelberg, Germany)","volume":"10 1","pages":"56"},"PeriodicalIF":0.0,"publicationDate":"2024-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11180212/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141328204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Copy number deletion of PLA2G4A affects the susceptibility and clinical phenotypes of schizophrenia. PLA2G4A 的拷贝数缺失会影响精神分裂症的易感性和临床表型。

Schizophrenia (Heidelberg, Germany) Pub Date : 2024-05-30 DOI: 10.1038/s41537-024-00474-0

Zibo Gao, Xinru Guo, Zhouyang Sun, Songyu Wu, Qianyi Wang, Qianlong Huang, Wei Bai, Changgui Kou

{"title":"Copy number deletion of PLA2G4A affects the susceptibility and clinical phenotypes of schizophrenia.","authors":"Zibo Gao, Xinru Guo, Zhouyang Sun, Songyu Wu, Qianyi Wang, Qianlong Huang, Wei Bai, Changgui Kou","doi":"10.1038/s41537-024-00474-0","DOIUrl":"10.1038/s41537-024-00474-0","url":null,"abstract":"Phospholipase A2(PLA2) superfamily is recognized as being involved in the pathogenesis of schizophrenia by affecting lipid homeostasis in cell membranes. We hypothesized that PLA2 gene copy number variation (CNV) may affect PLA2 enzyme expression and be associated with schizophrenia risk. This study indicated that in the discovery stage, an increased copy number of PLA2G6 and the deletion of PLA2G3, PLA2G4A, PLA2G4F and PLA2G12F was associated with increased risk of schizophrenia. CNV segments involving six PLA2 genes were detected in publicly available datasets, including two deletion segments specific to the PLA2G4A gene. The relationship between the deletion of PLA2G4A and susceptibility to schizophrenia was then reaffirmed in the validation group of 806 individuals. There was a significant correlation between PLA2G4A deletion and the symptoms of poverty of thought in male patients and erotomanic delusion in females. Furthermore, ELISA results demonstrate a significant decrease in peripheral blood cytosolic PLA2(cPLA2) levels in patients with the PLA2G4A deletion genotype compared to those with normal and copy number duplicate genotypes. These data suggest that the functional copy number deletion in the PLA2G4A gene is associated with the risk of schizophrenia and clinical phenotypes by reducing the expression of cPLA2, which may be an indicator of susceptibility to schizophrenia.","PeriodicalId":74758,"journal":{"name":"Schizophrenia (Heidelberg, Germany)","volume":"10 1","pages":"55"},"PeriodicalIF":0.0,"publicationDate":"2024-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11139948/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141181323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multimodal fusion of brain signals for robust prediction of psychosis transition. 多模态融合大脑信号，稳健预测精神病转变。

Schizophrenia (Heidelberg, Germany) Pub Date : 2024-05-21 DOI: 10.1038/s41537-024-00464-2

Jenna M Reinen, Pablo Polosecki, Eduardo Castro, Cheryl M Corcoran, Guillermo A Cecchi, Tiziano Colibazzi

{"title":"Multimodal fusion of brain signals for robust prediction of psychosis transition.","authors":"Jenna M Reinen, Pablo Polosecki, Eduardo Castro, Cheryl M Corcoran, Guillermo A Cecchi, Tiziano Colibazzi","doi":"10.1038/s41537-024-00464-2","DOIUrl":"10.1038/s41537-024-00464-2","url":null,"abstract":"The prospective study of youths at clinical high risk (CHR) for psychosis, including neuroimaging, can identify neural signatures predictive of psychosis outcomes using algorithms that integrate complex information. Here, to identify risk and psychosis conversion, we implemented multiple kernel learning (MKL), a multimodal machine learning approach allowing patterns from each modality to inform each other. Baseline multimodal scans (n = 74, 11 converters) included structural, resting-state functional imaging, and diffusion-weighted data. Multimodal MKL outperformed unimodal models (AUC = 0.73 vs. 0.66 in predicting conversion). Moreover, patterns learned by MKL were robust to training set variations, suggesting it can identify cross-modality redundancies and synergies to stabilize the predictive pattern. We identified many predictors consistent with the literature, including frontal cortices, cingulate, thalamus, and striatum. This highlights the advantage of methods that leverage the complex pathophysiology of psychosis.","PeriodicalId":74758,"journal":{"name":"Schizophrenia (Heidelberg, Germany)","volume":"10 1","pages":"54"},"PeriodicalIF":0.0,"publicationDate":"2024-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11109212/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141077461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The contribution of prosody to machine classification of schizophrenia. 前奏对精神分裂症机器分类的贡献。

Schizophrenia (Heidelberg, Germany) Pub Date : 2024-05-18 DOI: 10.1038/s41537-024-00463-3

Tomer Ben Moshe, Ido Ziv, Nachum Dershowitz, Kfir Bar

引用次数: 0

Combination of UGT1A1 polymorphism and baseline plasma bilirubin levels in predicting the risk of antipsychotic-induced dyslipidemia in schizophrenia patients. 结合 UGT1A1 多态性和血浆胆红素基线水平预测精神分裂症患者因抗精神病药引起血脂异常的风险。

Schizophrenia (Heidelberg, Germany) Pub Date : 2024-05-17 DOI: 10.1038/s41537-024-00473-1

Chenquan Lin, Shuangyang Zhang, Ping Yang, Bikui Zhang, Wenbin Guo, Renrong Wu, Yong Liu, Jianjian Wang, Haishan Wu, Hualin Cai

{"title":"Combination of UGT1A1 polymorphism and baseline plasma bilirubin levels in predicting the risk of antipsychotic-induced dyslipidemia in schizophrenia patients.","authors":"Chenquan Lin, Shuangyang Zhang, Ping Yang, Bikui Zhang, Wenbin Guo, Renrong Wu, Yong Liu, Jianjian Wang, Haishan Wu, Hualin Cai","doi":"10.1038/s41537-024-00473-1","DOIUrl":"10.1038/s41537-024-00473-1","url":null,"abstract":"The prolonged usage of atypical antipsychotic drugs (AAPD) among individuals with schizophrenia often leads to metabolic side effects such as dyslipidemia. These effects not only limit one's selection of AAPD but also significantly reduce compliance and quality of life of patients. Recent studies suggest that bilirubin plays a crucial role in maintaining lipid homeostasis and may be a potential pre-treatment biomarker for individuals with dyslipidemia. The present study included 644 schizophrenia patients from two centers. Demographic and clinical characteristics were collected at baseline and 4 weeks after admission to investigate the correlation between metabolites, episodes, usage of AAPDs, and occurrence of dyslipidemia. Besides, we explored the combined predictive value of genotypes and baseline bilirubin for dyslipidemia by employing multiple PCR targeted capture techniques to sequence two pathways: bilirubin metabolism-related genes and lipid metabolism-related genes. Our results indicated that there existed a negative correlation between the changes in bilirubin levels and triglyceride (TG) levels in patients with schizophrenia. Among three types of bilirubin, direct bilirubin in the baseline (DBIL-bl) proved to be the most effective in predicting dyslipidemia in the ROC analysis (AUC = 0.627, p < 0.001). Furthermore, the odds ratio from multinomial logistic regression analysis showed that UGT1A1*6 was a protective factor for dyslipidemia (ß = -12.868, p < 0.001). The combination of baseline DBIL and UGT1A1*6 significantly improved the performance in predicting dyslipidemia (AUC = 0.939, p < 0.001). Schizophrenia patients with UGT1A1*6 mutation and a certain level of baseline bilirubin may be more resistant to dyslipidemia and have more selections for AAPD than other patients.","PeriodicalId":74758,"journal":{"name":"Schizophrenia (Heidelberg, Germany)","volume":"10 1","pages":"52"},"PeriodicalIF":0.0,"publicationDate":"2024-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11101411/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140961109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bridging cholinergic signalling and inflammation in schizophrenia. 连接精神分裂症中的胆碱能信号和炎症

Schizophrenia (Heidelberg, Germany) Pub Date : 2024-05-11 DOI: 10.1038/s41537-024-00472-2

Christine N Metz, Michael Brines, Valentin A Pavlov

引用次数: 0

Author Correction: The network characteristics in schizophrenia with prominent negative symptoms: a multimodal fusion study. 作者更正：具有突出阴性症状的精神分裂症患者的网络特征：一项多模态融合研究。

Schizophrenia (Heidelberg, Germany) Pub Date : 2024-04-08 DOI: 10.1038/s41537-024-00467-z

Li Kong, Yao Zhang, Xu-Ming Wu, Xiao-Xiao Wang, Hai-Su Wu, Shuai-Biao Li, Min-Yi Chu, Yi Wang, Simon S Y Lui, Qin-Yu Lv, Zheng-Hui Yi, Raymond C K Chan

引用次数: 0