Rheumatology and immunology research最新文献_第8页

Seronegative enthesoarthritis as the first presentation of the atrial myxoma. 血清阴性的房端关节炎是心房粘液瘤的首次表现。

Rheumatology and immunology research Pub Date : 2023-09-27 eCollection Date: 2023-09-01 DOI: 10.2478/rir-2023-0024

Bonomi Francesco, Orlandi Martina, Conforti Maria Letizia, Guiducci Serena, Matucci Cerinic Marco

{"title":"Seronegative enthesoarthritis as the first presentation of the atrial myxoma.","authors":"Bonomi Francesco, Orlandi Martina, Conforti Maria Letizia, Guiducci Serena, Matucci Cerinic Marco","doi":"10.2478/rir-2023-0024","DOIUrl":"https://doi.org/10.2478/rir-2023-0024","url":null,"abstract":"Atrial myxoma (AM) is the most common primary cardiac tumor. Its clinical presentation can be highly heterogeneous and can be characterized by many constitutional manifestations and development of rheumatologic symptoms.We report the case of a patient presenting with a seronegative arthritis characterized by articular and enthesis involvement and purpuric cutaneous lesions that was refractory to conventional treatments and that was later diag- nosed with an AM as first cause of the manifestations. AM can present with different symptoms; among them, it is able to cause some rheumatological manifestation as it is able to secrete proinflammatory cytokines, as interleukin 6 (IL-6), tumor necrosis factor α (TNF-α), and interferon γ (IFN-γ). The present case is of particular interest as it presents an AM as the cause of an inflammatory arthropathy with articular and enthesis involvement. A paraneoplastic screening is always relevant in rheumatology, especially when encountering a refractory disease.","PeriodicalId":74736,"journal":{"name":"Rheumatology and immunology research","volume":"4 3","pages":"167-170"},"PeriodicalIF":0.0,"publicationDate":"2023-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10538594/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41159639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

2022 Chinese guideline for the management of pregnancy and reproduction in systemic lupus erythematosus. 2022中国系统性红斑狼疮妊娠和生殖管理指南。

Rheumatology and immunology research Pub Date : 2023-09-27 eCollection Date: 2023-09-01 DOI: 10.2478/rir-2023-0019

Xinping Tian, Jiuliang Zhao, Yijun Song, Qian Wang, Mengtao Li, Juntao Liu, Xiaofeng Zeng

{"title":"2022 Chinese guideline for the management of pregnancy and reproduction in systemic lupus erythematosus.","authors":"Xinping Tian, Jiuliang Zhao, Yijun Song, Qian Wang, Mengtao Li, Juntao Liu, Xiaofeng Zeng","doi":"10.2478/rir-2023-0019","DOIUrl":"10.2478/rir-2023-0019","url":null,"abstract":"Systemic lupus erythematosus (SLE), a prevalent autoimmune disease predominantly affecting women of childbearing age, presents ongoing challenges despite notable advances in diagnosis and treatment. Although survival rates for SLE patients have significantly improved, pregnancy continues to pose a considerable obstacle. Addressing this critical need for enhanced reproductive and prenatal care, there is a pressing imperative to establish standardized protocols for peri-gestational monitoring and treatment in SLE patients. This guideline is jointly sponsored by the National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), the Chinese Systemic Lupus Erythematosus Treatment and Research Group (CSTAR), and the Chinese Research Committee of Pregnancy and Reproduction in Autoimmune Rheumatic Diseases (CHOPARD). Thirteen pertinent clinical questions have been generated through several rounds of rigorous clinical and methodological expert discussions and selections for a comprehensive understanding of key aspects in this domain. Guided by thorough examination of research evidence and expert perspectives, the formulated recommendations aim to optimize pregnancy success rates, reduce maternal and infant mortality rates, and ultimately enhance the overall well-being of SLE patients.","PeriodicalId":74736,"journal":{"name":"Rheumatology and immunology research","volume":"4 3","pages":"115-138"},"PeriodicalIF":0.0,"publicationDate":"2023-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10538620/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41176127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Peptide-based immunotherapy in lupus: Where are we now? 基于肽的狼疮免疫疗法：我们现在在哪里？

Rheumatology and immunology research Pub Date : 2023-09-27 eCollection Date: 2023-09-01 DOI: 10.2478/rir-2023-0020

Ram P Singh, David S Bischoff, Satendra S Singh, Bevra H Hahn

引用次数: 0

mRNA vaccine against fibroblast activation protein ameliorates murine models of inflammatory arthritis. 针对成纤维细胞活化蛋白的信使核糖核酸疫苗可改善炎症性关节炎小鼠模型。

Rheumatology and immunology research Pub Date : 2023-07-22 eCollection Date: 2023-06-01 DOI: 10.2478/rir-2023-0013

Xiaowei Zhang, Antony Jozic, Pingfang Song, Qiang Xu, Xiaofei Shi, Hong Wang, Lindsey Bishop, Hillary M Struthers, John Rutledge, Shuang Chen, Fei Xu, Meaghan H Hancock, Daocheng Zhu, Gaurav Sahay, Cong-Qiu Chu

{"title":"mRNA vaccine against fibroblast activation protein ameliorates murine models of inflammatory arthritis.","authors":"Xiaowei Zhang, Antony Jozic, Pingfang Song, Qiang Xu, Xiaofei Shi, Hong Wang, Lindsey Bishop, Hillary M Struthers, John Rutledge, Shuang Chen, Fei Xu, Meaghan H Hancock, Daocheng Zhu, Gaurav Sahay, Cong-Qiu Chu","doi":"10.2478/rir-2023-0013","DOIUrl":"10.2478/rir-2023-0013","url":null,"abstract":"Objective: Synovial fibroblasts in patients with rheumatoid arthritis (RA) contribute substantially to the perpetuation of synovitis and invasion to cartilage and bone, and are potential therapeutic targets. Fibroblast activation protein (FAP) is highly expressed by RA synovial fibroblasts and the expression is relatively specific. We tested whether FAP can serve as a molecular target to modulate synovial fibroblasts for therapy in experimental arthritis.Methods: mRNA encoding consensus FAP (cFAP) was encapsulated in lipid nanoparticles (LNP) and was injected intramuscularly as vaccine prior to induction of collagen-induced arthritis (CIA) and collagen antibody induced arthritis (CAIA) in mice. Development of CIA and CAIA was assessed clinically and by histology.Results: cFAP mRNA-LNP vaccine provoked immune response to cFAP and mouse FAP (mFAP); prevented onset of CIA in 40% of mice and significantly reduced the severity of arthritis. In CAIA, cFAP mRNA-LNP did not prevent onset of arthritis but significantly reduced the severity of arthritis.Conclusion: cFAP mRNA-LNP vaccine was able to provoke immune response to mFAP and suppress inflammatory arthritis.","PeriodicalId":74736,"journal":{"name":"Rheumatology and immunology research","volume":"4 2","pages":"90-97"},"PeriodicalIF":0.0,"publicationDate":"2023-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10561064/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41223011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Depression in Sjögren's syndrome mediates the relationship between pain, fatigue, sleepiness, and overall quality of life. 干燥综合征的抑郁症介导了疼痛、疲劳、嗜睡和整体生活质量之间的关系。

Rheumatology and immunology research Pub Date : 2023-07-22 eCollection Date: 2023-06-01 DOI: 10.2478/rir-2023-0012

Tiago Costa, Stephen P Rushton, Stuart Watson, Wan-Fai Ng

{"title":"Depression in Sjögren's syndrome mediates the relationship between pain, fatigue, sleepiness, and overall quality of life.","authors":"Tiago Costa, Stephen P Rushton, Stuart Watson, Wan-Fai Ng","doi":"10.2478/rir-2023-0012","DOIUrl":"10.2478/rir-2023-0012","url":null,"abstract":"Objectives: Sjögren's syndrome (SS) includes many extra-glandular symptoms such as fatigue, pain, sleepiness and depression, which impact on quality of life (QoL). These symptoms also influence each other and could be linked by autonomic nervous system (ANS) dysregulation. Our aim was to model the role of putative predictive variables, including depression in the relationships between ANS function, fatigue, and QoL in SS.Methods: Cross-sectional analysis of self-reported data from the multicentre UK primary SS registry. The Composite Autonomic Symptom Scale (COMPASS) was used to assess autonomic function, the Hospital Anxiety and Depression Scale (HADS) to assess anxiety and depression and the EuroQol-5 Dimension (EQ-5D) to assess QoL. Validated scales were used for other clinical variables. Using multiple regression analysis and structural equation modelling (SEM), we investigated how the QoL of people with SS is impacted by the direct and indirect effects of fatigue, sleepiness, depression, symptom burden and ANS function, and their interactions.Results: Data was obtained for 1046 people with SS, 56% COMPASS completers. Symptoms of ANS dysregulation were common. Participants with ANS dysregulation had more severe depression, anxiety, dryness, fatigue, pain, sleepiness and QoL (P < 0.01 for all). Depression, anxiety, dryness, and pain were independent predictors of ANS function in the multiple regression model (P < 0.05 for all). ANS function could not be included in the SEM. The SEM model had good fit to the data (comparative fit index = 0.998) and showed that, in people with SS, depression mediates the effects of pain, fatigue and sleepiness on QoL.Conclusion: Our results show that diagnosing and treating depression in people with SS could have direct positive impact on QoL, and significantly ameliorate the impact of fatigue and pain.","PeriodicalId":74736,"journal":{"name":"Rheumatology and immunology research","volume":"4 2","pages":"78-89"},"PeriodicalIF":0.0,"publicationDate":"2023-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10561071/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41223010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Consensus on targeted drug therapy for spondyloarthritis. 脊椎关节炎靶向药物治疗的共识。

Rheumatology and immunology research Pub Date : 2023-06-01 DOI: 10.2478/rir-2023-0009

Xinping Tian, Mengtao Li, Shengyun Liu, Xiaomei Leng, Qian Wang, Jiuliang Zhao, Yi Liu, Yan Zhao, Yizhi Zhang, Huji Xu, Jieruo Gu, Xiaofeng Zeng

{"title":"Consensus on targeted drug therapy for spondyloarthritis.","authors":"Xinping Tian, Mengtao Li, Shengyun Liu, Xiaomei Leng, Qian Wang, Jiuliang Zhao, Yi Liu, Yan Zhao, Yizhi Zhang, Huji Xu, Jieruo Gu, Xiaofeng Zeng","doi":"10.2478/rir-2023-0009","DOIUrl":"https://doi.org/10.2478/rir-2023-0009","url":null,"abstract":"Spondyloarthritis (SpA) is a group of chronic inflammatory diseases that predominantly involve the spine and/or peripheral joints. The clinical manifestations of SpA are highly heterogenous and complicated with various comorbidities. SpA is a disabling disease and adversely affects the quality of life of patients. Many new medications that target cytokines or pathways specific for the pathogenesis of SpA have been developed and they are becoming increasingly important in the treatment of SpA. However, identifying the target patient population and standardizing the usage of these drugs are critical issues in the clinical application of these \"targeted therapeutic drugs\". Under the leadership of National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), managed by Peking Union Medical College Hospital, the \"Consensus on targeted drug therapy for spondyloarthritis\" has been developed in collaboration with the Rheumatology and Immunology Physicians Committee, Chinese Medical Doctors Association, Rheumatology and Immunology Professional Committee, Chinese Association of Rehabilitation Medicine, and Chinese Research Hospital Association Rheumatology and Immunology Professional Committee. This consensus has been developed with evidence-based methodology and has followed the international standard for consensus development.","PeriodicalId":74736,"journal":{"name":"Rheumatology and immunology research","volume":"4 2","pages":"47-59"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10362604/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10456589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A new bed side test for inflammatory arthritis. 炎症性关节炎的新床侧试验。

Rheumatology and immunology research Pub Date : 2023-06-01 DOI: 10.2478/rir-2023-0016

Saba Samreen, Babur Salim, Haris Gul, Shahida Parveen

{"title":"A new bed side test for inflammatory arthritis.","authors":"Saba Samreen, Babur Salim, Haris Gul, Shahida Parveen","doi":"10.2478/rir-2023-0016","DOIUrl":"https://doi.org/10.2478/rir-2023-0016","url":null,"abstract":"E-mail: sabasamreen@hotmail.com. https://orcid.org/0000-0002-7320-4739 Inflammatory arthritis is characterized by pain, swelling and early morning stiffness in the affected joints. This group of arthritis have the propensity to lead to erosions and joint damage.[1] The resulting joint damage and functional disability not only leads to morbidity but adds to the burden on health care infrastructure. This is an area of particular concern especially in developing countries where the health care facilities and budget is scarce.[2] There are several tools to detect synovitis. Out of these magnetic resonance imaging (MRI) has a fair sensitivity and specificity but cost hampers it is regular use in daily practice especially in developing countries. Similarly musculoskeletal ultrasound also picks up synovitis early in the disease with acceptable sensitivity and specificity[3] but it is not yet commonly available in all setups. Therefore, we need to maximally rely on examination skills especially in developing countries. Timely diagnosis of synovitis and prompt initiation of treatment[4] is the key to better patient related outcomes.","PeriodicalId":74736,"journal":{"name":"Rheumatology and immunology research","volume":"4 2","pages":"104-106"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10362586/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10456590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Posterior reversible encephalopathy syndrome: A rare complication of rituximab therapy in rheumatoid arthritis. 后部可逆性脑病综合征:美罗华治疗类风湿性关节炎的罕见并发症。

Rheumatology and immunology research Pub Date : 2023-06-01 DOI: 10.2478/rir-2023-0014

Marriam Hussain Awan, Saba Samreen, Shahida Perveen, Babur Salim, Haris Gul, Anum Khan

引用次数: 0

Hypermobility spectrum disorders: A review. 多动谱系障碍:综述。

Rheumatology and immunology research Pub Date : 2023-06-01 DOI: 10.2478/rir-2023-0010

Matthew B Carroll

{"title":"Hypermobility spectrum disorders: A review.","authors":"Matthew B Carroll","doi":"10.2478/rir-2023-0010","DOIUrl":"https://doi.org/10.2478/rir-2023-0010","url":null,"abstract":"It remains a clinical challenge identifying when joint hypermobility (JH) is responsible for pain. Previous nomenclature utilized terms such as (benign) joint hypermobility syndrome (JHS) but this was updated in 2017 as advances in genetics provide a basis for nearly all variants of Ehlers-Danlos syndrome (EDS) with the exception of hypermobile EDS (hEDS). New terminology describes hypermobility spectrum disorders (HSDs) as the updated term for JHS. Diagnosis of a subtype of HSDs should be considered in patients who have JH coupled with the presence of secondary musculo-skeletal manifestations (trauma, chronic pain, disturbed proprioception, and other manifestations) and at the exclusion of hEDS. Extra-articular manifestations are common. Treatment relies on management strategies for other chronic pain syndromes with a multidisciplinary approach likely optimal. Lifestyle modifications focus on weight loss and exercise. Physical therapy helps strengthen periarticular muscles, improving mobility. Pharmacologic therapies focus on judicious use of non-steroidal anti-inflammatory drugs and acetaminophen. Serotonin and norepinephrine reuptake inhibitor may help widespread pain. Avoidance of opioids remains prudent. The purpose of this review is to provide clinicians the rationale for the update in nomenclature, understand the musculoskeletal and extra-articular manifestations of the subtypes of HSDs, considerations when making the diagnosis, and treatment.","PeriodicalId":74736,"journal":{"name":"Rheumatology and immunology research","volume":"4 2","pages":"60-68"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10457547/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10482873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A survey of artificial intelligence in rheumatoid arthritis. 人工智能在类风湿关节炎中的研究进展。

Rheumatology and immunology research Pub Date : 2023-06-01 DOI: 10.2478/rir-2023-0011

Jiaqi Wang, Yu Tian, Tianshu Zhou, Danyang Tong, Jing Ma, Jingsong Li

引用次数: 3