Rheumatology and immunology research最新文献

{"title":"A survey of artificial intelligence in rheumatoid arthritis.","authors":"Jiaqi Wang,&nbsp;Yu Tian,&nbsp;Tianshu Zhou,&nbsp;Danyang Tong,&nbsp;Jing Ma,&nbsp;Jingsong Li","doi":"10.2478/rir-2023-0011","DOIUrl":"https://doi.org/10.2478/rir-2023-0011","url":null,"abstract":"<p><p>The article offers a survey of currently notable artificial intelligence methods (released between 2019-2023), with a particular emphasis on the latest advancements in detecting rheumatoid arthritis (RA) at an early stage, providing early treatment, and managing the disease. We discussed challenges in these areas followed by specific artificial intelligence (AI) techniques and summarized advances, relevant strengths, and obstacles. Overall, the application of AI in the fields of RA has the potential to enable healthcare professionals to detect RA at an earlier stage, thereby facilitating timely intervention and better disease management. However, more research is required to confirm the precision and dependability of AI in RA, and several problems such as technological and ethical concerns related to these approaches must be resolved before their widespread adoption.</p>","PeriodicalId":74736,"journal":{"name":"Rheumatology and immunology research","volume":"4 2","pages":"69-77"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10362600/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10475410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lupus with initial mesenteric vasculitis.","authors":"Jing-Jing Xie,&nbsp;Gui-Chen Ling,&nbsp;Yu-Bao Jiang,&nbsp;Jian-Yong Zhang","doi":"10.2478/rir-2023-0015","DOIUrl":"https://doi.org/10.2478/rir-2023-0015","url":null,"abstract":"A 39-year-old woman was admitted because of abdominal pain, nausea, and vomiting after meals for 2 days. She also had fecal incontinence, urination frequency, and urgency for 4 days. She had no specific past medical history. Physical examination revealed diffuse abdominal distension, tender - ness below the sternum, and rebound pain without rigidity. Laboratory tests showed mild anemia, positive homogeneous pattern antinuclear antibody (ANA) with a titer of 1:320, she was also positive for anti-U1-RNP antibodies, anti-double-stranded DNA antibodies, anti-nucleosome antibodies, anti-SSA antibodies, anti-RO-52 antibodies, and anti-histone antibodies, with decreased complements levels. Her D-dimer was 2745 μ g/L. Enhanced computed tomography of the abdomen revealed diffuse circumferential wall thickening with submucosal edema of the entire small bowel, accompanied by ascites. “Fence-like” changes of mesenteric vessels with dilatation of bowel loops, thickened bowel walls, and the “double-halo” sign or “target” sign were observed","PeriodicalId":74736,"journal":{"name":"Rheumatology and immunology research","volume":"4 2","pages":"102-103"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10362800/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9865677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum to \"Social media for research discourse, dissemination, and collaboration in rheumatology\".","authors":"Ariella Coler-Reilly,&nbsp;Elizabeth R Graef,&nbsp;Alfred H J Kim,&nbsp;Jean W Liew,&nbsp;Michael S Putman,&nbsp;Sebastian E Sattui,&nbsp;Kristen J Young,&nbsp;Jeffrey A Sparks","doi":"10.2478/rir-2023-0017","DOIUrl":"https://doi.org/10.2478/rir-2023-0017","url":null,"abstract":"","PeriodicalId":74736,"journal":{"name":"Rheumatology and immunology research","volume":"4 2","pages":"107-108"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10457546/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10139750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Animal models for large vessel vasculitis - The unmet need.","authors":"Cong-Qiu Chu","doi":"10.2478/rir-2023-0002","DOIUrl":"10.2478/rir-2023-0002","url":null,"abstract":"<p><p>Our understanding of the pathogenesis of large vessel vasculitis (LVV) are mainly achieved by studying the arteries taken from temporal artery biopsy in giant cell arteries (GCA) or surgical or autopsy specimens in Takayasu arteritis (TAK). These artery specimens provide invaluable information about pathological changes in these conditions that GCA and TAK are similar but are distinctly different in immune cell infiltrate and distribution of inflammatory cells in anatomical locations. However, these specimens of established arteritis do not provide information of the arteritis initiation and early events which are impossible to obtain in human artery specimens. Animal models for LVV are needed but not available. Here, several approaches are proposed for experimentation to generate animal models to aid in delineating the interaction of immune reaction with arterial wall components.</p>","PeriodicalId":74736,"journal":{"name":"Rheumatology and immunology research","volume":"4 1","pages":"4-10"},"PeriodicalIF":0.0,"publicationDate":"2023-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/39/53/rir-4-1-rir-2023-0002.PMC10150876.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9411900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unusual presentation of a mass and \"cobble-stone like\" changes in the bronchus of a patient with granulomatosis with polyangitis.","authors":"Ping Fan,&nbsp;Zhiming Hao,&nbsp;Peilong Cao,&nbsp;Lan He","doi":"10.2478/rir-2023-0007","DOIUrl":"https://doi.org/10.2478/rir-2023-0007","url":null,"abstract":"A 44-year-old male was diagnosed with granulomatosis with polyangiitis (GPA) 1 year ago because of intermittent cough, short of breath, epistaxis, hearing loss and a positive protein-ase-3 anti-neutrophilic cytoplasmatic antibody (PR3-ANCA) test. After being treated with oral prednisone, cyclophospha-mide for a year, he was hospitalized due to reappearance of cough and epistaxis. The nasopharyngoscopy showed extensive necrosis of the left nasal cavity. The biopsy of nasal cavity mucosa revealed fibrinoid necrotizing vasculitis","PeriodicalId":74736,"journal":{"name":"Rheumatology and immunology research","volume":"4 1","pages":"44-45"},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/99/d1/rir-4-1-rir-2023-0007.PMC10150860.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9411901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COVID-19 vaccine-associated autoimmune disorders: Comments.","authors":"Amnuay Kleebayoon,&nbsp;Viroj Wiwanitkit","doi":"10.2478/rir-2023-0008","DOIUrl":"https://doi.org/10.2478/rir-2023-0008","url":null,"abstract":"We would like to comment on the article “Corona Virus Disease-19 Vaccine-associated Autoimmune Disorders”.[1] Awan et al. attempt to summarize the various autoimmune phenomena reported after corona virus disease 2019 (COVID-19) vaccination in order to sensitize the medical community so that they can better manage these diseases when confronted with them.[1] According to Awan et al., this review in no way negates the potential benefit of COVID-19 vaccination, which has cemented its place in preventing infections and significantly reducing severity and mortality.[1]","PeriodicalId":74736,"journal":{"name":"Rheumatology and immunology research","volume":"4 1","pages":"46"},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/4e/9a/rir-4-1-rir-2023-0008.PMC10150862.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9411899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and vascular features of stroke in Takayasu's arteritis: A 24-year retrospective study.","authors":"Guizhi Zhang,&nbsp;Jun Ni,&nbsp;Yunjiao Yang,&nbsp;Jing Li,&nbsp;Xinping Tian,&nbsp;Xiaofeng Zeng","doi":"10.2478/rir-2023-0004","DOIUrl":"https://doi.org/10.2478/rir-2023-0004","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the clinical characteristics, vascular imaging features, and prognosis of Takayasu's arteritis (TA) patients with stroke in China.</p><p><strong>Methods: </strong>Medical charts of 411 in-patients who fulfilled the classification criteria of modified 1990 American College of Rheumatology (ACR) criteria for TA and with complete data from 1990 to 2014 were reviewed retrospectively. The demographic data, symptoms and signs, laboratory test results, radiological features, treatment, and interventional or surgical procedures were collected and analyzed. Patients with radiological confirmed stroke were identified. Chi-square test or Fisher exact test was used to compare the differences between patients with and without stroke.</p><p><strong>Results: </strong>Twenty-two patients with ischemic stroke (IS) and 4 patients with hemorrhagic stroke were identified. The incidence of stroke in TA patients was 6.3% (26/411), of which 11 patients were considered to be the initial manifestation. Stroke patients had more visual acuity loss (15.4% vs. 4.7%, <i>P</i> = 0.042). Systemic inflammatory symptoms and inflammatory markers were less common in patients with stroke than in those without stroke [fever <i>P</i> = 0.007; erythrocyte sedimentation rate (ESR) or C-reactive protein (CRP), <i>P</i> < 0.001]. Cranial angiography showed that common carotid artery (CCA) (73.0%, 19/26) and subclavian artery (SCA) (73.0%, 19/26) were the most involved, followed by internal carotid artery (ICA) (57.7%, 15/26) in stroke patients. The intracranial vascular involvement rate of stroke patients was 38.5% (10/26); the middle cerebral artery (MCA) was the most common artery involved. The most common site of stroke was the basal ganglia region. The occurrence of intracranial vascular involvement was much higher in patients with stroke when compared to patients without stroke (38.5% vs. 5.5%, <i>P <</i> 0.001). Among all patients with intracranial vascular involvement, patients without stroke received more aggressive treatment than patients with stroke (90.4% vs. 20.0%, <i>P <</i> 0.001). There was no significant increase in in-hospital mortality in patients with stroke compared with patients without stroke (3.8% vs. 2.3%, <i>P</i> = 0.629).</p><p><strong>Conclusion: </strong>Stroke is the initial presentation in 50% of TA patients with stroke. The intracranial vascular involvement rate is significantly increased in stroke patients than in patients without stroke. The artery invloved in patients with stroke are cervical artery and intracranial involvement. Systemic inflammation is less in patients with stroke. Aggressive treatment for TA with glucosteroid (GC) and immunosuppressive agents combined with anti-stroke therapy is needed to improve the prognosis of TA complicated stroke.</p>","PeriodicalId":74736,"journal":{"name":"Rheumatology and immunology research","volume":"4 1","pages":"22-29"},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/c6/8a/rir-4-1-rir-2023-0004.PMC10150874.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9411897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pathogenesis of anti-neutrophil cytoplasmic antibody-associated vasculitis.","authors":"Xiao-Jing Sun,&nbsp;Zhi-Ying Li,&nbsp;Min Chen","doi":"10.2478/rir-2023-0003","DOIUrl":"https://doi.org/10.2478/rir-2023-0003","url":null,"abstract":"<p><p>Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) encompasses a group of potentially life-threatening disorders characterized by necrotizing small vessel vasculitis with positive serum ANCA. To date, the pathogenesis of AAV has not been fully elucidated, but remarkable progress has been achieved in the past few decades. In this review, we summarize the mechanism of AAV. The pathogenesis of AAV involves various factors. ANCA, neutrophils, and the complement system play key roles in disease initiation and progression, forming a feedback amplification loop leading to vasculitic injury. Neutrophils activated by ANCA undergo respiratory burst and degranulation, as well as releasing neutrophils extracellular traps (NETs), thus causing damage to vascular endothelial cells. Activated neutrophils could further activate the alternative complement pathway, leading to the generation of complement 5a (C5a), which amplifies the inflammatory response by priming neutrophils for ANCA-mediated overactivation. Neutrophils stimulated with C5a and ANCA could also activate the coagulation system, generate thrombin, and subsequently cause platelet activation. These events in turn augment complement alternative pathway activation. Moreover, disturbed B-cell and T-cell immune homeostasis is also involved in disease development. In-depth investigation in pathogenesis of AAV might help to offer more effective targeted therapies.</p>","PeriodicalId":74736,"journal":{"name":"Rheumatology and immunology research","volume":"4 1","pages":"11-21"},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/61/7e/rir-4-1-rir-2023-0003.PMC10150877.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9411896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The challenge of ocular inflammation in systemic vasculitis: How to address inequalities of care?","authors":"Nima Ghadiri,&nbsp;Jagdish Nair,&nbsp;Robert J Moots","doi":"10.2478/rir-2023-0001","DOIUrl":"https://doi.org/10.2478/rir-2023-0001","url":null,"abstract":"The systemic vasculitides cause considerable morbidity, not least by their potential to affect so many organs. In major referral centres, they are managed optimally, by multidisciplinary teams comprising specialists in the individual organ systems involved, working together to provide a holistic approach and the optimal environment to assess disease activity and deliver optimal therapy. For example, the National Centre for Behçet’s syndrome (BS) in Liverpool UK[1] brings together clinicians from disparate disciplines to provide patient-centred state-of-the-art care for this form of vasculitis. Unfortunately, in many countries, access to diagnostic techniques and appropriately experienced specialists in systemic vasculitis can be difficult. In this article, we will highlight the challenges of detecting and managing systemic vasculitis in the eye and consider how advances in “oculomics” and artificial intelligence (AI) may enhance the management of this major complication and help address the current inequalities of care. We will focus on ocular disease in BS, where early diagnosis and prompt treatment can be sight-preserving.","PeriodicalId":74736,"journal":{"name":"Rheumatology and immunology research","volume":"4 1","pages":"1-3"},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/a0/b2/rir-4-1-rir-2023-0001.PMC10150873.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9465782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intermittent fever and cough in a 56-year-old patient: Relapsing polychondritis and extranodal NK/T-cell lymphoma.","authors":"Qin Huang,&nbsp;Danyu Cui,&nbsp;Jianhui Chen,&nbsp;Hao Ren,&nbsp;Min Yang","doi":"10.2478/rir-2023-0006","DOIUrl":"https://doi.org/10.2478/rir-2023-0006","url":null,"abstract":"<p><p>Relapsing polychondritis (RP) is a rare autoimmune disease in which recurrent and progressive chondritis occurs throughout the body. We report a case of a 56-year-old female subject presented as intermittent fever and cough, who was found obvious luminal stenosis and intense ¹⁸F-fluorodeoxyglucose (FDG) uptake in her larynx and trachea <i>via</i> bronchoscopy and FDG positron emission tomography/computed tomography (PET/CT). The auricular cartilage biopsy demonstrated chondritis. At first she was diagnosed as RP and treated by glucocorticoid and methotrexate, leading to completely response. Fever and cough recurred after 18 months, and FDG PET/CT were performed again and targeted a newfound nasopharyngeal lesion, where the biopsy proved to be an extranodal natural killer (NK)/T-cell lymphoma, nasal type.</p>","PeriodicalId":74736,"journal":{"name":"Rheumatology and immunology research","volume":"4 1","pages":"40-43"},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/15/13/rir-4-1-rir-2023-0006.PMC10150861.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9411895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}