Rheumatology and immunology research最新文献_第8页

Bilateral Ureterohydronephrosis after Intestinal Pseudo-obstruction in a Patient with Systemic Lupus Erythematosus. 系统性红斑狼疮患者假性肠梗阻后双侧输尿管积水1例。

Rheumatology and immunology research Pub Date : 2022-12-01 DOI: 10.2478/rir-2022-0037

Wanting Qi, Yangzhong Zhou, Jiuliang Zhao

引用次数: 0

Social Media and the Patient - on Education and Empowerment. 社会媒体与患者——教育与赋权。

Rheumatology and immunology research Pub Date : 2022-12-01 DOI: 10.2478/rir-2022-0028

Geraldine T Zamora

引用次数: 2

Social Media for Research Discourse, Dissemination, and Collaboration in Rheumatology. 风湿病学研究话语、传播和合作的社会媒体。

Rheumatology and immunology research Pub Date : 2022-12-01 DOI: 10.2478/rir-2022-0031

Ariella Coler-Reilly, Elizabeth R Graef, Alfred H J Kim, Jean W Liew, Michael S Putman, Sebastian E Sattui, Kristen J Young, Jeffrey A Sparks

{"title":"Social Media for Research Discourse, Dissemination, and Collaboration in Rheumatology.","authors":"Ariella Coler-Reilly, Elizabeth R Graef, Alfred H J Kim, Jean W Liew, Michael S Putman, Sebastian E Sattui, Kristen J Young, Jeffrey A Sparks","doi":"10.2478/rir-2022-0031","DOIUrl":"https://doi.org/10.2478/rir-2022-0031","url":null,"abstract":"Social media has become an important venue for rheumatologists, patients, organizations, and other stakeholders to discuss recent research advances in diagnosis and management of rheumatic disorders. In this article, we describe the current state of how social media may enhance dissemination, discourse, and collaboration in rheumatology research. Social media may refer to social platforms like Twitter and Instagram or digital media like podcasts and other websites that are operated for providing as free, open-access medical education (FOAM). Twitter has been one of the most active social media venues and continues to host a vibrant rheumatology community. Examples of research discussions on Twitter include organic user tweets, educational threads (\"tweetorials\"), live-tweeting academic conferences, and journals posting recently-accepted articles. Some research collaborations have been initiated through social media interactions. Social media may also directly contribute to research by facilitating the recruitment of study participants and the collection of survey-based data. Thus, social media is an evolving and important tool to enhance research discourse, dissemination, and collaboration in rheumatology.","PeriodicalId":74736,"journal":{"name":"Rheumatology and immunology research","volume":"3 4","pages":"169-179"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/21/3f/rir-03-169.PMC9984924.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9118086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

RheumCloud App: A Novel Mobile Application for the Management of Rheumatic Diseases Patients in China. 风湿云App:中国风湿病患者管理的新型移动应用。

Rheumatology and immunology research Pub Date : 2022-12-01 DOI: 10.2478/rir-2022-0033

Can Huang, Jiuliang Zhao, Xinping Tian, Qian Wang, Dong Xu, Mengtao Li, Xiaofeng Zeng

引用次数: 1

Editorial for "Social Media in Rheumatology". “风湿病学的社交媒体”社论。

Rheumatology and immunology research Pub Date : 2022-12-01 DOI: 10.2478/rir-2022-0025

Priscilla C Wong, Yew Kuang Cheng

{"title":"Editorial for \"Social Media in Rheumatology\".","authors":"Priscilla C Wong, Yew Kuang Cheng","doi":"10.2478/rir-2022-0025","DOIUrl":"https://doi.org/10.2478/rir-2022-0025","url":null,"abstract":"The Asia Pacific League of Associations for Rheumatology (APLAR) Young Rheumatologists (AYR) group is a network of young rheumatologists in the Asia Pacific region united to move forward in education, collaboration, and research in the Asia Pacific and beyond. AYR is an integrated part of the APLAR community, representing the full spectrum of rheumatology. The AYR Board first organized a “Social Media in Rheumatology” symposium at the annual APLAR Congress in 2021. This pioneering educational activity connected aspiring young clinicians from different countries and regions (China, Hong Kong [special administrative region {SAR} of China], India, Pakistan, the Philippines, Sri Lanka, the United Arab Emirates, and the United Kingdom [UK]) to share their knowledge and experience on social media via focused presentations and live dialogue. The feedback was exemplary and has opened the gateway for future collaboration among different societies of rheumatology. In this special edition covering “Social Media in Rheumatology”, AYR proudly further presents this impactful theme for our rheumatology community. We are honored and very excited to collaborate with several impassioned young academics from the Emerging European League Against Rheumatism (EULAR) NETwork (EMEUNET) and the American College of Rheumatology (ACR) in this particular issue. As citizens of the","PeriodicalId":74736,"journal":{"name":"Rheumatology and immunology research","volume":"3 4","pages":"149-150"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/e8/72/rir-03-149.PMC9984935.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10850211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An Overview of Social Media within APLAR Rheumatology Societies. 美国风湿病学会的社交媒体概述。

Rheumatology and immunology research Pub Date : 2022-12-01 DOI: 10.2478/rir-2022-0029

Himantha Atukorale

引用次数: 1

Successful Treatment with Bortezomib for Refractory Thrombotic Thrombocytopenic Purpura Associated with Systemic Lupus Erythematosus. 硼替佐米成功治疗难治性血栓性血小板减少性紫癜伴系统性红斑狼疮。

Rheumatology and immunology research Pub Date : 2022-12-01 DOI: 10.2478/rir-2022-0036

Ruyu Yan, Shuang Zhou, Jinuo Wang, Huaxia Yang

引用次数: 0

Olfactory Ecto-mesenchymal Stem Cell-derived Exosomes Ameliorate Murine Sjögren's Syndrome via Suppressing Tfh Cell Response. 嗅觉外充质干细胞衍生的外泌体通过抑制Tfh细胞反应改善小鼠Sjögren综合征。

Rheumatology and immunology research Pub Date : 2022-12-01 DOI: 10.2478/rir-2022-0035

Ke Rui, Ziwei Shen, Na Peng, Futao Zhao, Yuan Tang, Shiyi Liu, Xinyi Xu, Chang Liu, Ling Wu, Jie Tian, Liwei Lu

{"title":"Olfactory Ecto-mesenchymal Stem Cell-derived Exosomes Ameliorate Murine Sjögren's Syndrome via Suppressing Tfh Cell Response.","authors":"Ke Rui, Ziwei Shen, Na Peng, Futao Zhao, Yuan Tang, Shiyi Liu, Xinyi Xu, Chang Liu, Ling Wu, Jie Tian, Liwei Lu","doi":"10.2478/rir-2022-0035","DOIUrl":"https://doi.org/10.2478/rir-2022-0035","url":null,"abstract":"Objectives: To investigate the effect of olfactory ecto-mesenchymal stem cell-derived exosomes (OE-MSC-Exos) on T follicular helper (Tfh) cell response and their implication in treating experimental Sjögrens syndrome (ESS).Methods: C57BL/6 mice were immunized with salivary glands (SG) proteins to induce ESS mouse model. OE-MSC-Exos were added to the Tfh cell polarization condition, and the proportion of Tfh cells was detected by FCM. The PD-L1 of OE-MSCs was silenced with small interfering RNA to extract siPD-L1-OE-MSC-Exos.Results: We found that transfer of OE-MSC-Exos markedly attenuated disease progression and reduced Tfh cell response in mice with ESS. In culture, OE-MSC-Exos potently inhibited the differentiation of Tfh cells from naïve T cells. Moreover, OE-MSC-Exos expressed high level of the ligand for the programmed cell death protein 1 (PD-L1), knocking down PD-L1 expression in OE-MSC-Exos significantly decreased their capacity to suppress Tfh cell differentiation in vitro. Consistently, transfer of OE-MSC-Exos with PD-L1 knockdown exhibited profoundly diminished therapeutic effect in ESS mice, accompanied with sustained Tfh cell response and high levels of autoantibody production.Conclusion: Our results suggest that OE-MSC-Exos may exert their therapeutic effect in ameliorating ESS progression via suppressing Tfh cell response in a PD-L1-dependent manner.","PeriodicalId":74736,"journal":{"name":"Rheumatology and immunology research","volume":"3 4","pages":"198-207"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/48/da/rir-03-198.PMC9984929.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9424479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Corona Virus Disease-19 Vaccine-associated Autoimmune Disorders. 科罗娜病毒病-19 疫苗相关自身免疫性疾病。

Rheumatology and immunology research Pub Date : 2022-10-20 eCollection Date: 2022-10-01 DOI: 10.2478/rir-2022-0019

Marriam Hussain Awan, Saba Samreen, Babur Salim, Haris Gul, Shahida Perveen, Amjad Nasim

{"title":"Corona Virus Disease-19 Vaccine-associated Autoimmune Disorders.","authors":"Marriam Hussain Awan, Saba Samreen, Babur Salim, Haris Gul, Shahida Perveen, Amjad Nasim","doi":"10.2478/rir-2022-0019","DOIUrl":"10.2478/rir-2022-0019","url":null,"abstract":"Coronavirus disease is a highly infectious viral disease caused by severe acute respiratory syndrome virus (SARS nCoV2). It was declared a pandemic within a few months of identification of its index case. The spread of COVID-19 across the globe was rampant, overwhelming healthcare systems and crippling global economies. Since the world was caught off guard by the pandemic, vaccine programs had to be rolled out in emergency to curb its spread. Ten vaccines have been granted Emergency Use Authorization thus far. Much of the side effects we know today are post-marketing adverse effects. Most of them are mild like myalgia and injection-site reactions, but a few of them such as post-vaccination autoimmune diseases have alerted the medical community. These include vaccine-induced thrombotic thrombocytopenia, autoimmune hepatitis, myocarditis, and Graves' disease. We attempt to summarize the diverse autoimmune phenomena reported after COVID-19 vaccination, with an aim to sensitize the medical community so that they can be better equipped in management when confronted with these diseases. This review by no means refutes the potential benefit of COVID-19 vaccination which has consolidated its place in preventing infections and substantially reducing severity and mortality.","PeriodicalId":74736,"journal":{"name":"Rheumatology and immunology research","volume":"3 3","pages":"111-119"},"PeriodicalIF":0.0,"publicationDate":"2022-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9895874/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10726530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Designing Studies for Epigenetic Biomarker Development in Autoimmune Rheumatic Diseases. 为自身免疫性风湿病的表观遗传生物标记开发设计研究。

Rheumatology and immunology research Pub Date : 2022-10-20 eCollection Date: 2022-10-01 DOI: 10.2478/rir-2022-0018

Carlos de la Calle-Fabregat, Javier Rodríguez-Ubreva, Juan D Cañete, Esteban Ballestar

{"title":"Designing Studies for Epigenetic Biomarker Development in Autoimmune Rheumatic Diseases.","authors":"Carlos de la Calle-Fabregat, Javier Rodríguez-Ubreva, Juan D Cañete, Esteban Ballestar","doi":"10.2478/rir-2022-0018","DOIUrl":"10.2478/rir-2022-0018","url":null,"abstract":"In just a few years, the number of epigenetic studies in autoimmune rheumatic and inflammatory diseases has greatly increased. This is in part due to the need of identifying additional determinants to genetics to explain the pathogenesis and development of these disorders. In this regard, epigenetics provides potential mechanisms that determine gene function, are linked to environmental factors, and could explain a wide range of phenotypic variability among patients with these diseases. Despite the high interest and number of studies describing epigenetic alterations under these conditions and exploring their relationship to various clinical aspects, few of the proposed biomarkers have yet reached clinical practice. The potential of epigenetic markers is high, as these alterations link measurable features with a number of biological traits. In the present article, we present published studies in the field, discuss some frequent limitations in the existing research, and propose a number of considerations that should be taken into account by those starting new projects in the field, with an aim to generate biomarkers that could make it into the clinics.","PeriodicalId":74736,"journal":{"name":"Rheumatology and immunology research","volume":"3 3","pages":"103-110"},"PeriodicalIF":0.0,"publicationDate":"2022-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9895872/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10735010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0