Daniélle Bernardi Silveira, Rodrigo da Silva Batisti, Liana Vitória Marchezi, Beatriz Felipe da Rocha, Ernani Bohrer da Rosa, Jamile Dutra Correia, Leonardo Leiria de Moura da Silva, Rafael Fabiano Machado Rosa, Paulo Ricardo Gazzola Zen
{"title":"Patients' prognosis with congenital heart disease followed by ten years: survival and associated factors.","authors":"Daniélle Bernardi Silveira, Rodrigo da Silva Batisti, Liana Vitória Marchezi, Beatriz Felipe da Rocha, Ernani Bohrer da Rosa, Jamile Dutra Correia, Leonardo Leiria de Moura da Silva, Rafael Fabiano Machado Rosa, Paulo Ricardo Gazzola Zen","doi":"10.1590/1984-0462/2024/42/2023134","DOIUrl":"10.1590/1984-0462/2024/42/2023134","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the prognosis and influence of associated factors in patients with congenital heart disease admitted for the first time to the Intensive Care Unit of the Hospital da Criança Santo Antônio/Irmandade da Santa Casa de Misericórdia de Porto Alegre, especially those factors associated with death.</p><p><strong>Methods: </strong>Patients were prospectively and consecutively allocated over a period of one year (August 2005 to July 2006). Now, 15 years after the initial selection, we collected data from these patients in the database of the Cytogenetics Laboratory of the Universidade Federal de Ciências da Saúde de Porto Alegre and in the medical records of the hospital.</p><p><strong>Results: </strong>Of the 96 patients, 11 died and 85 were alive until 20 years old. Four patients died in the Intensive Care Unit. The survival probability up to 365 days of life was 95.8%. The survival assessment identified that the deaths occurred mainly before the patients completed one thousand days of life. We found that complex heart disease was independently associated with an odds ratio of 5.19 (95% confidence interval - CI:1.09-24.71; p=0.038) for death.</p><p><strong>Conclusions: </strong>Knowledge about the factors that interfere with the prognosis can be crucial in care practice planning, especially considering that congenital heart disease is an important cause of mortality in the first year of life.</p>","PeriodicalId":74721,"journal":{"name":"Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo","volume":"42 ","pages":"e2023134"},"PeriodicalIF":0.0,"publicationDate":"2024-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10868512/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139742879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Luisa Pinheiro Neiva, Luiza Correia Lopez, Rafaela Orsi Pasiani, Mayco José Reinaldi Serra, Vera Esteves Vagnozzi Rullo
{"title":"Use of probiotics and similar in pediatric patients with Type 1 Diabetes Mellitus: a systematic review.","authors":"Luisa Pinheiro Neiva, Luiza Correia Lopez, Rafaela Orsi Pasiani, Mayco José Reinaldi Serra, Vera Esteves Vagnozzi Rullo","doi":"10.1590/1984-0462/2024/42/2023097","DOIUrl":"10.1590/1984-0462/2024/42/2023097","url":null,"abstract":"<p><strong>Objective: </strong>To perform a systematic review of randomized controlled trials, evaluating the effect of probiotics, prebiotics or symbiotics supplementation on glycemic and inflammatory control in children with Type 1 Diabetes Mellitus (T1DM).</p><p><strong>Data source: </strong>The Medical Literature Analysis and Retrieval System Online (MEDLINE/PubMed), Clinical Trials, Literatura Latino-Americana e do Caribe em Ciências da Saúde (LILACS) and Scientific Electronic Library Online (SciELO) databases were searched. Randomized clinical trials of pediatric patients with DM1 using probiotics, prebiotics or symbiotics were included, regardless of year or language of publication. Studies that did not evaluate glycated hemoglobin (HbA1c) were excluded. Metabolic results (HbA1c, total insulin dose and C-peptide) and inflammatory control [interleukin-10 (IL-10), tumor necrosis factor-alpha (TNF-α) and interferon-gamma (IFN-γ)] during probiotic supplementation or similar, related to modification of the intestinal microbiota, were analyzed. PROSPERO ID: CRD42022384485.</p><p><strong>Data synthesis: </strong>Five studies were selected for a systematic review. Regarding metabolic markers, only one of the articles that analyzed HbA1c showed a significant decrease (p=0.03) in the intervention group. One study identified a reduction in the total dose of insulin and increased C-peptide levels. Regarding the evaluation of inflammatory parameters (IL-10, TNF-α, INF-γ), there were no statistical relevant modifications.</p><p><strong>Conclusions: </strong>Current data from the literature were not conclusive in identifying an improvement in glycemic control and did not observe changes in inflammatory parameters with the use of probiotics, prebiotics or symbiotics in pediatric patients with T1DM.</p>","PeriodicalId":74721,"journal":{"name":"Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo","volume":"42 ","pages":"e2023097"},"PeriodicalIF":0.0,"publicationDate":"2024-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10868513/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139742880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Effect of treatment with growth hormone on body composition and metabolic profile of short children born small for gestational age.","authors":"Adriana Masiero Kühl, Márcia Regina Messaggi Gomes Dias, Rosana Marques Pereira","doi":"10.1590/1984-0462/2024/42/2023073","DOIUrl":"10.1590/1984-0462/2024/42/2023073","url":null,"abstract":"<p><strong>Objective: </strong>To assess the effect of recombinant growth hormone (rGH) on body composition and metabolic profile of prepubertal short children born small for gestational age (SGA) before and after 18 months of treatment.</p><p><strong>Methods: </strong>It is a clinical, non-randomized, and paired study. Children born SGA, with birth weight and/or length <-2 standard deviations (SD) for gestational age and sex, prepubertal, born at full term, of both genders, with the indication for treatment with rGH were included. The intervention was performed with biosynthetic rGH at doses ranging from 0.03 to 0.05 mg/kg/day, administered subcutaneously, once a day at bedtime. Total lean mass (LM) and total fat mass (FM) were carried out using dual-energy X-ray absorptiometry (DXA), and the metabolic profile was assessed for insulin, glycemia, IGF-1 levels and lipid profile.</p><p><strong>Results: </strong>Twelve patients (nine girls, 8.17±2.39 y) were evaluated; three patients dropped out of the study. There was an increase of LM adjusted for length (LMI) (p=0.008), LMI standard deviation score (SDS) adjusted for age and sex (p=0.007), and total LM (p<0.001). The percentage of body fat (BF%) and abdominal fat (AF) remained unaltered in relation to the beginning of treatment. Among the metabolic variables, blood glucose remained within normal levels, and there was a reduction in the number of participants with altered cholesterol (p=0.023).</p><p><strong>Conclusions: </strong>The effect of rGH treatment was higher on LM than in FM, with increased LM adjusted for length and standardized for age and sex. Glycemia remained within the normal limits, and there was a decreased number of children with total cholesterol above the recommended levels.</p>","PeriodicalId":74721,"journal":{"name":"Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo","volume":"42 ","pages":"e2023073"},"PeriodicalIF":0.0,"publicationDate":"2024-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10868514/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139742812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Maria Luíza de Faria Alves, Deisiane Oliveira Souto, Angélica Cristina Sousa Fonseca Romeros, Elton Duarte Dantas Magalhães, Larissa Gabrielle Mendes, Kênnea Martins Almeida Ayupe, Paula Silva de Carvalho Chagas, Ana Carolina de Campos, Rafaela Silva Moreira, Aline Martins de Toledo, Ana Cristina Resende Camargos, Egmar Longo, Hércules Ribeiro Leite, Rosane Luzia de Souza Morais
{"title":"Characterization of environmental factors in children and adolescents with cerebral palsy in Minas Gerais: Participa Minas.","authors":"Maria Luíza de Faria Alves, Deisiane Oliveira Souto, Angélica Cristina Sousa Fonseca Romeros, Elton Duarte Dantas Magalhães, Larissa Gabrielle Mendes, Kênnea Martins Almeida Ayupe, Paula Silva de Carvalho Chagas, Ana Carolina de Campos, Rafaela Silva Moreira, Aline Martins de Toledo, Ana Cristina Resende Camargos, Egmar Longo, Hércules Ribeiro Leite, Rosane Luzia de Souza Morais","doi":"10.1590/1984-0462/2024/42/2023043","DOIUrl":"10.1590/1984-0462/2024/42/2023043","url":null,"abstract":"<p><strong>Objective: </strong>To characterize the environmental factors of children and adolescents with Cerebral Palsy (CP) in the state of Minas Gerais (MG), Brazil.</p><p><strong>Methods: </strong>This is a cross-sectional study involving 164 caregivers of children/adolescents with CP, aged 1-14 years. The Gross Motor Function Classification System (GMFCS) and the Manual Ability Classification System (MACS) were used to classify the participants' functioning, and environmental factors were evaluated by an on-line questionnaire that examined products and technologies, physical environment, services, and systems. A descriptive analysis was performed using percentage and frequency.</p><p><strong>Results: </strong>Most participants had bilateral CP (66.9%) and 45% of them were spastic. Levels II and V of the GMFCS and MACS were the most frequent. About half (49.4%) used anticonvulsants, 27.4% underwent botulinum toxin application, and 29% went through orthopedic surgery in the lower limbs. Among the participants, 71.3% used orthoses in the lower limbs, and 51.8% used the public health care system. Most had access to physiotherapy (91.5%), but found difficulties to access interventions with other professionals, such as psychologists (28%) and nutritionists (37.8%). The school was the most frequently adapted environment (78%), and had the highest level of structural adaptation (42.7%).</p><p><strong>Conclusions: </strong>The results of this study suggest that the barriers to access health services and barriers to the physical environment may impact participation and social inclusion.</p>","PeriodicalId":74721,"journal":{"name":"Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo","volume":"42 ","pages":"e2023043"},"PeriodicalIF":0.0,"publicationDate":"2024-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10877669/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139742811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"ERRATUM.","authors":"","doi":"10.1590/1984-0462/2024/42/2022241erratum","DOIUrl":"10.1590/1984-0462/2024/42/2022241erratum","url":null,"abstract":"<p><p>[This corrects the article doi: 10.1590/1984-0462/2024/42/2022241].</p>","PeriodicalId":74721,"journal":{"name":"Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo","volume":"42 ","pages":"e2022241erratum"},"PeriodicalIF":0.0,"publicationDate":"2024-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10841101/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139704427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jaiana Xavier Santos, Pedro Ykaro Fialho Silva, Maria Clara Lima da Cruz, Bianca Fernandes Vasconcelos E Silva, Ingrid Guerra Azevedo, Silvana Alves Pereira
{"title":"Real-time changes in rib cage expansion and use of abdominal mechanical stimulation in newborns: a quasi-experimental study.","authors":"Jaiana Xavier Santos, Pedro Ykaro Fialho Silva, Maria Clara Lima da Cruz, Bianca Fernandes Vasconcelos E Silva, Ingrid Guerra Azevedo, Silvana Alves Pereira","doi":"10.1590/1984-0462/2024/42/2023032","DOIUrl":"10.1590/1984-0462/2024/42/2023032","url":null,"abstract":"<p><strong>Objective: </strong>To assess the rib cage expansion and respiratory rate in newborns using an abdominal stabilization band.</p><p><strong>Methods: </strong>The study included 32 newborns of both genders, with gestational age between 35 and 41 weeks. The abdominal stabilization band was used for 15 minutes between the xiphoid process and the anterosuperior iliac crest, with an abdominal contention 0.5cm smaller than the abdominal circumference. The rib cage expansion was evaluated by a breathing transducer (Pneumotrace II™) three minutes before using the band, during the use (15 minutes), and ten minutes after removing the band. The Shapiro-Wilk test verified data normality, and the Wilcoxon test compared the variables considering rib cage expansion and respiratory rate. Significance was set to p<0.05.</p><p><strong>Results: </strong>There was an increase in respiratory rate when comparing before and ten minutes after removing (p=0.008) the abdominal stabilization band, as well as when comparing during its use and ten minutes after its removal (p=0.001). There was also an increase in rib cage expansion when comparing before and during the use of the abdominal stabilization band (p=0.005).</p><p><strong>Conclusions: </strong>The use of the abdominal stabilization band promoted an increase in the rib cage expansion and respiratory rate in the assessed newborns and may be a viable option to improve the respiratory kinematics of this population.</p>","PeriodicalId":74721,"journal":{"name":"Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo","volume":"42 ","pages":"e2023032"},"PeriodicalIF":0.0,"publicationDate":"2023-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10742371/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138833423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Vera Bain, Marcelo Luiz Abramczyk, Ricardo Luiz Soares Costa, Milena Ribeiro Paixão, José Leão de Souza Junior
{"title":"Pediatric COVID-19: clinical and epidemiological data of 1303 cases in a general hospital in Brazil.","authors":"Vera Bain, Marcelo Luiz Abramczyk, Ricardo Luiz Soares Costa, Milena Ribeiro Paixão, José Leão de Souza Junior","doi":"10.1590/1984-0462/2024/42/2023031","DOIUrl":"10.1590/1984-0462/2024/42/2023031","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to describe the clinical characteristics of the pediatric population with COVID-19 in an Emergency Department (ED) of a Brazilian general hospital.</p><p><strong>Methods: </strong>Epidemiological and clinical data of patients younger than 20 years old were collected from patients' medical records from February 2020 to July 2021. Most of the epidemiological data described pertains to hospitalized patients. We also reviewed coinfections, treatment, and outcomes and compared the first and second waves of COVID-19.</p><p><strong>Results: </strong>We identified a total of 1303 episodes of SARS-CoV-2 infection. The median time from symptom onset to diagnosis was three days. Symptoms were present in 92.3% of the patients. The most common symptoms were fever (45.2%), nasal congestion/discharge (44.2%), and cough (39.4%). Chest radiography and tomography were performed in 7.7 and 3.3% of cases, with abnormal findings in 29.7 and 53.4%, respectively. Hospital admissions occurred in 3.5% of patients, mainly in the presence of comorbidities, in children under five years old and in those who presented to the ED during the first wave of COVID-19. Coinfection with a viral agent was identified in 20% of the 71 cases tested in this study, and a positive rapid test for Streptococcus pyogenes was found in 8% of the 174 cases tested, with no impact of these coinfections on hospitalization.</p><p><strong>Conclusions: </strong>We found that COVID-19 was a mild disease in most children in our study population, with most hospitalizations and readmissions occurring during the first wave of COVID-19.</p>","PeriodicalId":74721,"journal":{"name":"Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo","volume":"42 ","pages":"e2023031"},"PeriodicalIF":0.0,"publicationDate":"2023-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10742344/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138833422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Priscilla Márcia Bezerra de Oliveira, Márcia de Oliveira Lima, Patrícia de Menezes Marinho, Jonas Augusto Cardoso da Silveira, Risia Cristina Egito de Menezes, Giovana Longo-Silva
{"title":"Association between sleep duration and latency, nocturnal awakenings, and body mass index among infants.","authors":"Priscilla Márcia Bezerra de Oliveira, Márcia de Oliveira Lima, Patrícia de Menezes Marinho, Jonas Augusto Cardoso da Silveira, Risia Cristina Egito de Menezes, Giovana Longo-Silva","doi":"10.1590/1984-0462/2024/42/2023058","DOIUrl":"10.1590/1984-0462/2024/42/2023058","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the association between sleep duration, nocturnal awakenings, and sleep latency with body mass index (BMI) at six and 12 months of age.</p><p><strong>Methods: </strong>179 children from a birth cohort were enrolled. At six and 12 months of age, anthropometric data were obtained using standardized techniques and infants' mothers answered the Brief Infant Sleep Questionnaire for sleep data. The association of BMI with the independent variables (sleep duration, latency, and nocturnal awakenings) was assessed by linear regression models. Analyses were adjusted for potential confounders and a p-value<0.05 was adopted to define statistical significance.</p><p><strong>Results: </strong>For each additional hour of sleep duration, BMI was reduced by 0.15 kg/m² (95% confidence interval [CI] -0.28; -0.01; p=0.03) and each additional minute of sleep latency increased BMI by 0.01 kg/m² (95%CI -0.00; 0.03; p=0.02). These associations were independent of gestational age, child sex, birth weight, duration of exclusive breastfeeding, smoking during pregnancy, and mother's BMI, education, and marital status. Nocturnal awakenings showed no association with the outcome.</p><p><strong>Conclusions: </strong>Our findings suggest that sleep duration and sleep latency time are associated with BMI in the first year of life. Insights into the influence of sleep early in life on weight status may be helpful to complement future nutritional recommendations and prevent and treat obesity.</p>","PeriodicalId":74721,"journal":{"name":"Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo","volume":"42 ","pages":"e2023058"},"PeriodicalIF":0.0,"publicationDate":"2023-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10742347/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138833414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Angelica Godoi Romagnoli Blum, Tais Daiene Hortencio Russo, Roberto José Negrão Nogueira
{"title":"Dual x-ray absorptiometry monitoring in pediatric short bowel syndrome: an integrative review.","authors":"Angelica Godoi Romagnoli Blum, Tais Daiene Hortencio Russo, Roberto José Negrão Nogueira","doi":"10.1590/1984-0462/2024/42/2023064","DOIUrl":"10.1590/1984-0462/2024/42/2023064","url":null,"abstract":"<p><strong>Objective: </strong>To analyze the bone health of pediatric patients with short bowel syndrome intestinal failure (SBS-IF).</p><p><strong>Data source: </strong>An integrative literature review was performed using the data published in the MEDLINE-PubMed and Scientific Electronic Library Online (SciELO) databases between January 2010 and April 2021, and through a manual search of the reference lists of relevant studies. Studies were included if they assessed bone mineral density by the Dual X-Ray Absorptiometry (DXA) technique, incorporated pediatric patients (up to 20 years of age) with SBS under parenteral nutrition (PN) and were written in English. Eleven primary sources met the inclusion criteria for this study.</p><p><strong>Data synthesis: </strong>Pediatric patients with SBS-IF under long-term parenteral nutrition experienced frequent changes in bone metabolism, leading to osteoporotic fractures and growth failure. These patients have deficiencies in multiple nutrients, such as calcium, magnesium, phosphorus, and vitamin D. Consequently, there are variations in the secretion and regulation of the parathyroid hormone. In addition, the pharmacotechnical limitations related to calcium and phosphorus in the PN solution, use of glucocorticoids, and difficulty performing physical activity are risk factors for the development of metabolic bone disease in pediatric patients with SBS-IF.</p><p><strong>Conclusions: </strong>Low bone mineral density was associated with a high risk of developing osteoporosis, fractures, and growth deficiency in pediatric patients with SBS-IF on PN therapy in the long term.</p>","PeriodicalId":74721,"journal":{"name":"Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo","volume":"42 ","pages":"e2023064"},"PeriodicalIF":0.0,"publicationDate":"2023-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10742346/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138833415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Justo Santiago, Gabriela Karl, Claudia Florez, Yudisay Molina, Javier Castro, Alexandra Hurtado, Valeria García
{"title":"Infectious endarteritis in aortic coarctation: two spectra of an infrequent disease.","authors":"Justo Santiago, Gabriela Karl, Claudia Florez, Yudisay Molina, Javier Castro, Alexandra Hurtado, Valeria García","doi":"10.1590/1984-0462/2024/42/2023084","DOIUrl":"10.1590/1984-0462/2024/42/2023084","url":null,"abstract":"<p><strong>Objective: </strong>To describe two different degrees of clinical commitment and results in the evolution of infectious endarteritis in patients without a previous diagnosis of aortic coarctation.</p><p><strong>Case description: </strong>Two male patients aged 13 and 9 years old were admitted. The first due to a fever for 2 months, which started after dental cleaning, and the second due to high blood pressure, both patients with asthenia and weight loss. In the first case, the transthoracic echocardiogram showed aortic coarctation, and the transesophageal echocardiogram showed the presence of vegetations in the post-coarctation area, without pseudoaneurysms, with blood culture positive for Streptococcus mitis. This patient was treated for six weeks with crystalline penicillin, resolving the infection without complications. The second case was assessed for high blood pressure with a history of fever, and was treated with antibiotics. When performing a transthoracic echocardiogram, aortic coarctation was observed with a saccular image classified as a pseudoaneurysm by angiography and tomography. Blood culture was negative, and the patient developed an episode of hematemesis whose initial etiology could not be determined. Before surgical repair, he had a second episode of copious hematemesis with hypovolemic shock and death.</p><p><strong>Comments: </strong>We need to have a high index of clinical suspicion to establish the diagnosis of aortic coarctation complicated by endarteritis and start the appropriate antibiotic treatment, always maintaining surveillance for the early detection of pseudoaneurysms.</p>","PeriodicalId":74721,"journal":{"name":"Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo","volume":"42 ","pages":"e2023084"},"PeriodicalIF":0.0,"publicationDate":"2023-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10742369/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138833418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}