Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo最新文献

{"title":"Evaluating the prevalence and adequate treatment for congenital syphilis in a Brazilian reference maternity hospital.","authors":"Alan Oliveira Duarte, Mariellen Santos de Jesus Souza, Ricardo Sampaio Hein da Silva, Géssica Almeida Vasconcelos, Lorena Cunha Martins, Maria Aline Silva Alves, Ciro Gomes Machado, Soraia Machado Cordeiro, Carina Carvalho Dos Santos, Junia Raquel Dutra Ferreira, Patrícia Santos de Oliveira, Juan Ignacio Calcagno, Isadora Cristina de Siqueira","doi":"10.1590/1984-0462/2025/43/2024285","DOIUrl":"https://doi.org/10.1590/1984-0462/2025/43/2024285","url":null,"abstract":"<p><strong>Objective: </strong>To delineate characteristics associated with congenital syphilis in newborns from a capital city of Brazil, as well as to report prevalence rates, diagnostic approaches, and treatment data through document analysis.</p><p><strong>Methods: </strong>A cross-sectional, retrospective, and documentary observational study was conducted at a maternity hospital based on congenital syphilis cases reported through notification forms produced between 2016-2019. Statistical analysis involved absolute and relative frequency evaluations.</p><p><strong>Results: </strong>A total of 879 cases were included, with 2018 being the year with the most cases. Analysis revealed a high proportion of mothers with secondary education (289; 33.0%), and most selfidentifying as mixed-race (400; 45.6%). Infection diagnosis occurred at the time of or following delivery in a large percentage of the women (337; 38.4%). Among newborns, 249 cases (28.3%) exhibited symptoms, with jaundice being the most prevalent (235; 26.9%). While most newborns were discharged following treatment, four cases (0.4%) resulted in syphilis-related fatalities, including one abortion and one stillbirth.</p><p><strong>Conclusions: </strong>This study highlights deficiencies in the diagnosis and treatment of mothers affected by syphilis, emphasizing the importance of access to early diagnostic testing in pregnant women, as well as newborn screening. We further call attention to the critical need for expanded health education initiatives targeting congenital syphilis awareness among pregnant women and their partners.</p>","PeriodicalId":74721,"journal":{"name":"Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo","volume":"43 ","pages":"e2024285"},"PeriodicalIF":2.0,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12360696/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144981898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Asthma risk in young people who attended chlorinated swimming pools in early childhood.","authors":"Cristiano de Lima Silvestre, Ricardo Freitas-Dias, Emília Chagas Costa, Marcos André Moura Dos Santos, Jânio Luiz Correia Júnior, Décio Medeiros Peixoto, Edil de Albuquerque Rodrigues Filho, Marco Aurélio de Valois Correia Júnior","doi":"10.1590/1984-0462/2025/43/2024251","DOIUrl":"https://doi.org/10.1590/1984-0462/2025/43/2024251","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this study was to evaluate the association between exposure to volatile chlorination by-products from swimming during early childhood and the subsequent development of asthma.</p><p><strong>Data source: </strong>This systematic review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The review protocol was registered in the International Prospective Register of Systematic Reviews (PROSPERO) under CRD42021291850. Searches were carried out in the following electronic databases: PubMed, Cochrane Library, Google Scholar, and ScienceDirect, using the terms \"children in early childhood,\" \"swimming in a chlorinated pool,\" \"exposed and unexposed,\" and \"asthma risk,\" covering studies published between 2003 and 2020. The review included cohort and cross-sectional studies of individuals who swam in chlorinated pools during early childhood. The methodological quality of the studies was evaluated for risk of bias.</p><p><strong>Data synthesis: </strong>Out of 6865 studies screened, six met the inclusion criteria, involving 4058 subjects and 310 asthma events (2365 in the exposure group and 1693 in the control group). The combined effect, expressed as an odds ratio for asthma risk in all included studies, was 1.09 (95%CI 0.67-1.77; p=0.740).</p><p><strong>Conclusions: </strong>This is the first systematic review to comprehensively evaluate the association between swimming in chlorinated pools and the risk of developing asthma. No association was found between childhood swimming in chlorinated pools and the risk of asthma development.</p>","PeriodicalId":74721,"journal":{"name":"Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo","volume":"43 ","pages":"e2024251"},"PeriodicalIF":2.0,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12360697/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144981848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The use of choline supplementation in premature newborns: a systematic review.","authors":"Ligia Modelli Rodrigues, Allan Chiaratti de Oliveira, Tulio Konstantyner","doi":"10.1590/1984-0462/2025/43/2024214","DOIUrl":"10.1590/1984-0462/2025/43/2024214","url":null,"abstract":"<p><strong>Objective: </strong>To identify the routes and doses of choline supplementation required to meet the metabolic demands of preterm infants.</p><p><strong>Data source: </strong>The information was searched in three databases: US National Library of Medicine National Institute of Health (PubMed), Scientific Electronic Library Online (SciELO) and Web of Science. The search for articles was updated in August 2024, with no restrictions on publication year or language. This review was registered in the International Prospective Register of Systematic Reviews - PROSPERO (ID: 549568).</p><p><strong>Data synthesis: </strong>The final selection of studies yielded eight original articles, which were subsequently evaluated for their methodological quality. The recommended dosage of parenteral choline remains uncertain. However, studies have demonstrated a reduction in serum choline level inversely proportional to the quantity administered via parenteral nutrition, particularly in preterm infants with slow progression to enteral nutrition. The dose of 40-50 mg/kg/day of enteral choline appears to be sufficient to maintain plasmatic levels at a concentration comparable to that observed in the umbilical cord of preterm infants.</p><p><strong>Conclusions: </strong>The need for daily choline supplementation from the first day of life is still controversial. The results of the selected studies do not allow for the determination of the optimal choline dosage for parenteral nutrition in these infants. Nevertheless, there is some scientific evidence suggesting that providing 40-50 mg/kg/day enterally is sufficient to meet the metabolic needs of preterm infants.</p>","PeriodicalId":74721,"journal":{"name":"Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo","volume":"43 ","pages":"e2024214"},"PeriodicalIF":2.0,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12334154/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144839314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antiretroviral medications for pediatric use in the context of the Unified Health System: are there therapeutic gaps in Brazil?","authors":"Suelen Martins da Costa, Patricia Melo Aguiar","doi":"10.1590/1984-0462/2025/43/2024141","DOIUrl":"10.1590/1984-0462/2025/43/2024141","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the incorporation and adequacy of antiretrovirals for the treatment of HIV in children within the context of the Unified Health System in Brazil.</p><p><strong>Methods: </strong>Data were collected from the 2022 edition of the Brazilian National List of Essential Medicines and compared with the World Health Organization's 2023 Essential Medicines List for Children. Furthermore, records from the Brazilian Health Regulatory Agency were reviewed for new medications and pediatric formulations with the potential to fill identified gaps.</p><p><strong>Results: </strong>Twenty-one antiretrovirals are listed in the latest edition of the National List of Essential Medicines, of which 16 are suitable for pediatric use. These formulations are available predominantly in tablets (44.4%), oral solutions (22.2%), and capsules (14.8%). Compared to the World Health Organization list, the Brazilian list offers more pediatric options, including, for example, efavirenz (removed from the international list) and tipranavir. The only medication included on the international list that is registered in Brazil but not listed on the national list is the 25 mg chewable tablet of raltegravir. Recently, the Brazilian Health Regulatory Agency registered six new antiretroviral medications, with only one being child-friendly (dolutegravir) and it was incorporated into the Unified Health System.</p><p><strong>Conclusions: </strong>The comparison between the national and international essential medicines lists highlights the greater variety of pediatric antiretrovirals in Brazil but underscores the need for more child-friendly formulations. The implementation of protocols for the manipulation and fractionation of solid pharmaceutical forms is urgent in order to improve treatment adherence and therapeutic efficacy.</p>","PeriodicalId":74721,"journal":{"name":"Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo","volume":"43 ","pages":"e2024141"},"PeriodicalIF":2.0,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12324735/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144791002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aerobic fitness, phase angle, and bioelectrical impedance vector analysis in adolescents living with HIV: a cross-sectional study.","authors":"Marcos Cezar Pitombo da Silva Junior, Diego Augusto Santos Silva, Priscila Custódio Martins, Nassib Bezerra Bueno, Fabiana Andréa Moura, Luiz Rodrigo Augustemak de Lima","doi":"10.1590/1984-0462/2025/43/2024277","DOIUrl":"10.1590/1984-0462/2025/43/2024277","url":null,"abstract":"<p><strong>Objective: </strong>To analyze the association between phase angle (PhA) and bioelectrical impedance vector analysis (BIVA) with aerobic fitness in HIV+ adolescents.</p><p><strong>Methods: </strong>Aerobic fitness was assessed using the modified Canadian Aerobic Fitness Test, PhA, and BIVA by bioelectrical impedance analysis. Multivariable linear regression was performed to test the association between peak oxygen consumption (peak VO2) and PhA. BIVA ellipses were evaluated considering a reference population of Spanish adolescents.</p><p><strong>Results: </strong>Forty-seven HIV-infected adolescents (10-18 years old) were included; 25 (53%) were females. Mean peak VO2 and PhA were 48.9 standard deviation (±) 7.0 ml.kg-1.min-1 and 4.6±1.4 degrees, respectively. Multivariable analysis revealed a significant positive association between peak VO2 and PhA (βstd=0.349; p=0.025). Peak VO2 adjusted for covariates explained 49% of PhA variation. BIVA ellipses indicated lower classifications for body cell mass (BCM) and fatfree mass (FFM) in HIV+ adolescents (vs reference population) (p<0.001). HIV+ females (vs HIV+ males) showed a higher classification for dehydration and a lower classification for BCM (p=0.007). No relevant differences were found between the subgroups based on aerobic fitness (p=0.735).</p><p><strong>Conclusions: </strong>A significant association exists between peak VO2 and PhA in HIV+ adolescents. Alterations in hydration and lower classifications for BCM and FFM were observed in this population.</p>","PeriodicalId":74721,"journal":{"name":"Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo","volume":"43 ","pages":"e2024277"},"PeriodicalIF":2.0,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12313315/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144746425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is there a relationship between parental concern and suspicion of developmental delay?","authors":"Mitali Lopes Melo, Daniela Akemi Tezuka Yamazaki, Luziani Leão Dos Santos, Janaina Medeiros de Souza, Rafaela Silva Moreira","doi":"10.1590/1984-0462/2025/43/2024187","DOIUrl":"10.1590/1984-0462/2025/43/2024187","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the existence of an association between parents' concerns about their child's development and alterations in the child's development, risk factors, and family socioeconomic status.</p><p><strong>Methods: </strong>A cross-sectional study was performed, using data collected at child care centers in municipalities in the south of Santa Catarina, Brazil, from parents of children aged between four and 65 months. Information about parental concerns, child development, and family risk factors was collected using the \"Survey of Wellbeing of Young Children (SWYC-BR)\" instrument. The \"Classification of the Brazilian Association of Research Companies\" was applied to classify socioeconomic status. The data were then subjected to a multivariate analysis using the R Studio software. A significance level of 0.05 was adopted.</p><p><strong>Results: </strong>A total of 498 children participated in the study, with an average age of 41 months. The multivariate analysis revealed that parents who expressed concern about their children's current development are approximately three times more likely to have children with suspected developmental delay (prevalence ratio - PR 2,97; 95% confidence interval - 95%CI 1.85-4.33). Furthermore, abuse of illicit substances increases the risk of children with suspected delay by almost two times (p=0.034). However, the other environmental variables were not associated with developmental delay.</p><p><strong>Conclusions: </strong>The study demonstrated that parents' concern about their child's development is a significant predictor of suspected developmental delay. This finding highlights the importance of considering parental concern as a factor in developmental monitoring and family-centered intervention programs.</p>","PeriodicalId":74721,"journal":{"name":"Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo","volume":"43 ","pages":"e2024187"},"PeriodicalIF":2.0,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12313316/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144746426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic factors of neuroblastoma in limited-resource settings.","authors":"Roberta Gomes Ribeiro Gonçalves Pinto, Mecneide Mendes Lins, Kaline Maria Maciel de Oliveira Pereira, Ticiana Ester Mattos Pascoal Meira, Eduarda Coutinho Albuquerque Neiva Coêlho, Alice Rodrigues Barbosa de Moraes, Marina Lundgren de Melo Batista, Leticia Ribeiro Maciel Pereira, Maria Júlia Gonçalves de Mello","doi":"10.1590/1984-0462/2025/43/2024200","DOIUrl":"10.1590/1984-0462/2025/43/2024200","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to analyze survival and risk factors for death in children with neuroblastoma that may contribute to a viable risk classification for low-income countries.</p><p><strong>Methods: </strong>A historic cohort involving patients under 19 years of age with neuroblastoma was followed at a reference center in Northeast Brazil between July 2005 and July 2020. Data on sociodemographic, were collected. The outcomes studied were recurrence, disease progression, and five-year mortality. Multivariate analysis of Cox proportional hazards for death was performed. Overall and eventfree survivals were evaluated using the Kaplan-Meier method and the comparison between the groups studied, by the log-rank test.</p><p><strong>Results: </strong>Patients (n=126) were predominantly female with a median age of 26.5 months. Most presented primary adrenal, tumor stage 4 according to the International Neuroblastoma Staging System, unfavorable histology, and median serum lactate dehydrogenase (LDH) levels of 640.5 U/L. LDH≥640.5 U/L (hazard ratio [HRa] 2.49; 95% confidence interval [CI] 1.57-3.95; p<0.001) and stage 4 (HRa 1.67; 95%CI 1.00-2.78; p=0.047) were identified as risk factors for death. The overall survival was 32.4%, showing distinct curves regarding LDH serum levels and staging (log-rank p<0.05); the event-free survival was 26.3%.</p><p><strong>Conclusions: </strong>Elevated LDH serum levels were a risk factor for five-year mortality, and can be utilized as a prognostic marker in resource-limited settings.</p>","PeriodicalId":74721,"journal":{"name":"Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo","volume":"43 ","pages":"e2024200"},"PeriodicalIF":2.0,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12313317/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144746438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Undescended testis: an epidemiological study from a single institution.","authors":"Marcela Almeida Bazaga, Márcia Emília Francisco Shida, Mila Torii Corrêa Leite","doi":"10.1590/1984-0462/2025/43/2024186","DOIUrl":"10.1590/1984-0462/2025/43/2024186","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this study was to assess the referral and treatment timelines for patients with undescended testis treated in the Pediatric Surgery Division at Escola Paulista de Medicina/UNIFESP.</p><p><strong>Methods: </strong>Retrospective review of patients treated for undescended testis at a tertiary care institution from 1992 to 2021. Ethical approval was granted by the institutional ethics committee. Data collected included patients' demographics and clinical characteristics, referral age, age at orchidopexy, testis laterality and position prior to surgery, and duration of postoperative follow-up. A descriptive analysis was performed for each variable, excluding patients with incomplete medical records.</p><p><strong>Results: </strong>In the cohort of 350 patients with undescended testis, 72.6% had unilateral and 27.4% bilateral presentations; and 8% of the patients had differences in sex development. Ultrasound was requested in 19.5% of cases. The average age at referral was 47.3 standard deviation (±) 41.6 months, with 72.5% referred after 18 months. Among 131 orchidopexy procedures, 12.8% were performed before 12 months of age, 15.9% until 18 months, and the majority after 60 months. Of the 120 patients who underwent surgery, only 78.3% had postoperative follow-up data, and 52.1% lost follow-up. The average follow-up period was 23.1±26.20 months.</p><p><strong>Conclusions: </strong>The average age at diagnosis and treatment of undescended testis was higher than recommended by international guidelines, indicating the need for enhanced medical and non-medical community referral practices.</p>","PeriodicalId":74721,"journal":{"name":"Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo","volume":"43 ","pages":"e2024186"},"PeriodicalIF":0.0,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12208631/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144562248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Air pollution and respiratory diseases in conurbated cities in the state of São Paulo.","authors":"Luiz Fernando Costa Nascimento, Ana Clara Silva Raposo de Almeida, Julia Ferreira Gomes Pereira, Mariana Telles de Castro, Adriana Oliveira Ribeiro Dos Santos","doi":"10.1590/1984-0462/2025/43/2024178","DOIUrl":"10.1590/1984-0462/2025/43/2024178","url":null,"abstract":"<p><strong>Objective: </strong>To estimate the association between exposure to particulate matter with less than 10u of aerodynamic diameter (PM10) and hospital admissions due to acute respiratory diseases in children.</p><p><strong>Methods: </strong>This is an ecological time series study with data on hospitalizations for respiratory diseases in children living in the conurbated cities of Taubaté, Tremembé, and Pindamonhangaba located in the Vale do Paraíba in São Paulo. Hospital admission data refer to the period between January 1, 2016 and December 31, 2019. Information on hospital admissions was obtained from the DATASUS database, and concentration values (μg/m3) of the pollutant PM10, temperature, and humidity relative air were obtained from the Environmental Company of the State of São Paulo. Negative binomial regression was used. Population attributable fraction and hospitalization costs were estimated.</p><p><strong>Results: </strong>A total of 1,291 hospitalizations were identified in the conurbated municipalities with a daily average of 0.88 standard deviation (±) 1.06, varying between 0-7 hospitalizations. Significant exposures to PM10 can be observed at all lags, except the four-day lag (Lag 4). The total cost of hospitalizations was around US$ 800,000.00 and the excess number of hospitalizations (135) represented an expense of around US$ 80,000.00.</p><p><strong>Conclusions: </strong>Studies with conurbated cities are easily applicable, extending the study area. The results reinforce the harmful role of exposure to air pollutants in children's health.</p>","PeriodicalId":74721,"journal":{"name":"Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo","volume":"43 ","pages":"e2024178"},"PeriodicalIF":0.0,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12208630/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144562319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Postural control in early stages of Duchenne muscular dystrophy.","authors":"Cristhina Bonilha Huster Siegle, Flaviana Kelly de Lima Maciel, Pedro Claudio Gonsales de Castro, Daniel Seiei Uehara Tamashiro, Cristina Dos Santos Cardoso de Sá","doi":"10.1590/1984-0462/2025/43/2024243","DOIUrl":"10.1590/1984-0462/2025/43/2024243","url":null,"abstract":"<p><strong>Objective: </strong>To verify whether there is an increase in the center of pressure (COP) displacement velocity and area in individuals with Duchenne muscular dystrophy (DMD) in Vignos stages 2 and 3, assessed under different sensory conditions; to verify whether COP displacement velocity and area increase within the same Vignos stage with changes in sensory conditions during postural control assessment.</p><p><strong>Methods: </strong>A cross-sectional study was conducted with individuals with DMD in Vignos stages 2 and 3, aged between 7 and 19 years old (mean 9.58, SD±3.22). Postural control was assessed using the Wii Balance Board and a modified sensory organization test. COP displacement velocity and area were recorded. Independent samples t-tests were performed to compare the average values of these variables between Vignos 2 and 3 under each sensory condition and within the same Vignos stage across different sensory conditions.</p><p><strong>Results: </strong>No significant difference were found in any analyzed variable between Vignos 2 and 3. However. A significant difference was observed when comparing sensory condition 1 with condition 4, within the same disease stage.</p><p><strong>Conclusions: </strong>Despite the decrease in muscle strength from Vignos 2 to 3, participants were able to employ motor strategies to maintain postural control. However, postural control performance significantly worsens with changes in sensory conditions within the same Vignos stage.</p>","PeriodicalId":74721,"journal":{"name":"Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo","volume":"43 ","pages":"e2024243"},"PeriodicalIF":0.0,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12208632/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144562320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}