Recent progress in nutrition最新文献

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Nutritional Health and Bioflavonoids 营养健康与生物类黄酮
Recent progress in nutrition Pub Date : 2022-03-23 DOI: 10.21926/rpn.2203017
H. Hoensch, B. Weigmann
{"title":"Nutritional Health and Bioflavonoids","authors":"H. Hoensch, B. Weigmann","doi":"10.21926/rpn.2203017","DOIUrl":"https://doi.org/10.21926/rpn.2203017","url":null,"abstract":"Flavonoids are phytochemicals (polyphenols) of plant origin. They can trap free oxygen radicals generated by mitochondria and other electronic transport chains, thereby inhibiting inflammatory and carcinogenic changes in vivo and in vitro. Why the body requires these compounds for the well-being of the organism and the maintenance of human health remains unclear. However, a deficit of flavonoids could lead to molecular malfunctions in cells, organelles, and macromolecules. This manuscript describes the occurrence and prevalence of flavonoid exposure in some chronic inflammatory diseases and their relationship with each other.","PeriodicalId":74647,"journal":{"name":"Recent progress in nutrition","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44718446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Translating Evidence into Practice: A Case Study of Extended Use of a Very Low Energy Diet for Treatment of Co-Morbid Obesity and Chronic Disease 将证据转化为实践:长期使用极低能量饮食治疗合并肥胖和慢性病的案例研究
Recent progress in nutrition Pub Date : 2022-02-21 DOI: 10.21926/rpn.2202015
Claudia Harper, R. Seimon, B. Yee, A. Sainsbury, E. Cayanan
{"title":"Translating Evidence into Practice: A Case Study of Extended Use of a Very Low Energy Diet for Treatment of Co-Morbid Obesity and Chronic Disease","authors":"Claudia Harper, R. Seimon, B. Yee, A. Sainsbury, E. Cayanan","doi":"10.21926/rpn.2202015","DOIUrl":"https://doi.org/10.21926/rpn.2202015","url":null,"abstract":"We report the case of a 30-year-old male with significant obesity (body mass index 47 kg/m2) with co-existing moderate obstructive sleep apnoea, hypertension, hypercholesteremia and hypogonadotropic hypogonadism, who was treated with a very-low-energy diet (VLED) and lifestyle modification programme for 12 months. The patient lost weight throughout the entire treatment period (average weight loss was 2.1 kg/week, for a total of 42.7 kg), and showed marked improvement in co-morbidities and no adverse effects. This case demonstrates that prolonged (5-month) use of a VLED, under close medical supervision, is safe and effective in certain patients with obesity.","PeriodicalId":74647,"journal":{"name":"Recent progress in nutrition","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48917751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Microwave-Assisted Extraction of Phenolic Compounds from Broccoli (Brassica oleracea) Stems, Leaves, and Florets: Optimization, Characterization, and Comparison with Maceration Extraction 微波辅助提取花椰菜茎、叶和小花中酚类化合物的工艺优化、表征及与微波萃取的比较
Recent progress in nutrition Pub Date : 2022-02-17 DOI: 10.21926/rpn.2202011
Sheila Lucía Rodríguez García, V. Raghavan
{"title":"Microwave-Assisted Extraction of Phenolic Compounds from Broccoli (Brassica oleracea) Stems, Leaves, and Florets: Optimization, Characterization, and Comparison with Maceration Extraction","authors":"Sheila Lucía Rodríguez García, V. Raghavan","doi":"10.21926/rpn.2202011","DOIUrl":"https://doi.org/10.21926/rpn.2202011","url":null,"abstract":"Microwave-assisted extraction (MAE) to obtain phenolics from vegetable wastes has been of recent interest. Broccoli is one of the most globally produced vegetables, and around 43% of the harvest is considered waste. Thus, given the significant quantity of broccoli waste generated, the objective of this work was to optimize the MAE, to maximize the total phenolic content (TPC) from broccoli by-products (leaves and stems) and broccoli florets. The Response Surface Analysis was used in the optimization model to evaluate the impacts of methanol concentration, time, and temperature, and their interactions on the TPC of the broccoli extracts. The optimal MAE conditions were found to be 74.54% (methanol), 15.9 min, and 74.45 °C for broccoli stems; 80% (methanol), 10 min, and 73.27 °C for broccoli leaves; and 80% (methanol), 18.9 min, and 75 °C for broccoli florets. Under these conditions, the broccoli leaves exhibited the highest TPC (1940.35 ± 0.794 µg GAE/g DW), followed by the florets (657.062 ± 0.771 µg GAE/g DW) and stems (225.273 ± 0.897 µg GAE/g DW). The antioxidant activity of the broccoli extracts was evaluated under the optimal conditions by DPPH and ABTS assays, and the same behavior was observed in both studies, the broccoli leaves exhibited the highest antioxidant activity, among florets and stems. In addition, vanillic, sinapic, caffeic, chlorogenic, ferulic, gallic, neochlorogenic, and p-coumaric acids in the broccoli extracts were identified and quantified using HPLC. Furthermore, MAE was found to increase the phenolic yield up to 45.70% for broccoli leaves, 133.57% for broccoli florets, and 65.30% for broccoli stems, in less time compared with maceration extraction. MAE proved to be an efficient and sustainable technique to obtain phenolics from broccoli by-products, which can constitute a viable solution for valorizing broccoli wastes.","PeriodicalId":74647,"journal":{"name":"Recent progress in nutrition","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47427421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
The Role of Vitamin D for Children with Inflammatory Bowel Disease 维生素D在儿童炎症性肠病中的作用
Recent progress in nutrition Pub Date : 2022-01-23 DOI: 10.21926/rpn.2202013
A. Vernon-Roberts, A. Day
{"title":"The Role of Vitamin D for Children with Inflammatory Bowel Disease","authors":"A. Vernon-Roberts, A. Day","doi":"10.21926/rpn.2202013","DOIUrl":"https://doi.org/10.21926/rpn.2202013","url":null,"abstract":"Children with inflammatory bowel disease (IBD) have a high prevalence of vitamin D insufficiency secondary to factors such as malabsorption and decreased intake. In recent years the benefits of optimal vitamin D status have been highlighted for their potential to improve the disease course and long-term outcomes in this population. Clinical benefits have been seen to bone health, the immune system, and gut health, with further improvements to disease and treatment outcomes. Recommendations for vitamin D treatment parameters to optimize these benefits have been developed, as well as the identification of risk factors for insufficiency specific to children with IBD. While various supplementation regimens are available reports of efficacy are inconsistent, as are guidelines for frequency of testing. Further research is required to elucidate whether hypovitaminosis D is a cause or consequence of IBD, and the role of vitamin D supplementation in treatment warrants significant attention.","PeriodicalId":74647,"journal":{"name":"Recent progress in nutrition","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42339833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of the COVID-19 Pandemic Measures on the Number of Meals and the Types of Physical Activity of Adolescents: Cross-Sectional Study in Delhi, India 2019冠状病毒病大流行措施对青少年膳食数量和身体活动类型的影响:印度德里的横断面研究
Recent progress in nutrition Pub Date : 2022-01-10 DOI: 10.21926/rpn.2201010
Tina Rawal, J. Muris, V. Mishra, M. Arora, N. Tandon, O. V. Schayck
{"title":"Impact of the COVID-19 Pandemic Measures on the Number of Meals and the Types of Physical Activity of Adolescents: Cross-Sectional Study in Delhi, India","authors":"Tina Rawal, J. Muris, V. Mishra, M. Arora, N. Tandon, O. V. Schayck","doi":"10.21926/rpn.2201010","DOIUrl":"https://doi.org/10.21926/rpn.2201010","url":null,"abstract":"COVID-19 greatly affected the lives of adolescents through restrictions such as less playtime, more screen time, and limited interaction with peers. In this study, we assessed the impact of the COVID-19 pandemic on the dietary and physical activity-related behavior of school students aged 10–16 years. This cross-sectional study was conducted with adolescents recruited from seven randomly selected private schools in Delhi, India, during 2021. A self-administered web-based survey was conducted to evaluate the behavior of the participants before and during the pandemic. Of the 512 students (53% males) who participated in the survey, 39% gained weight during the COVID-19 pandemic. There was a significant increase in the number of meals per day (p = 0.005) and a reduction in physical activity (p = 0.00) compared to the situation before the pandemic. The percentage of students who played indoor board and computer games increased from 13% to 46%. Students’s gender (p = 0.007) and parents’ education (mother: p = 0.003; father: p = 0.025) were significantly associated with physical activity during the pandemic. Higher socioeconomic status was significantly associated with consumption of more than two meals per day. The students who had working fathers with advanced/professional degrees were three times more likely [AOR 3.24, 95% CI (0.91–11.53)] to be physically active and eat a minimum of three major meals per day [AOR 3.21, 95% CI (1.77–5.81)] during the pandemic compared to those whose fathers were unemployed. This study highlighted the need for innovative strategies for adolescents and parents to adopt and practice a healthy lifestyle, especially during public health crises, such as the COVID-19 pandemic.","PeriodicalId":74647,"journal":{"name":"Recent progress in nutrition","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43380085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Sulforaphane: The Principal Broccoli Phytochemical as a Cancer Challenger 硫福拉芬:作为癌症挑战者的主要西兰花植物化学物质
Recent progress in nutrition Pub Date : 2022-01-10 DOI: 10.21926/rpn.2201008
M. Djaldetti
{"title":"Sulforaphane: The Principal Broccoli Phytochemical as a Cancer Challenger","authors":"M. Djaldetti","doi":"10.21926/rpn.2201008","DOIUrl":"https://doi.org/10.21926/rpn.2201008","url":null,"abstract":"Broccoli has long been reported to exert a positive impact on human health. It contains high levels of isocyanates, the most important of which is sulforaphane (SFN). Numerous studies have demonstrated that SFN can be used as an effective supplement for treating a variety of diseases. In addition, it is known to possess anti-cancer properties such as chemopreventive properties against gastrointestinal, breast, lung, bladder, prostate, and other cancers. The reported data indicates that broccoli could be a potent inhibitor of cancer development and progression and can be used alone or in combination with other isocyanates or conventional anti-cancer medications. Because in vivo studies of SFN’s effects are scarce, this review provides an overview of the beneficial effects of SFN on different malignant tumor cells performed mostly in vitro with an expectation that the results will incite research in humans.","PeriodicalId":74647,"journal":{"name":"Recent progress in nutrition","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49233649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Emerging Nutrition Approaches to Support the Mind and Muscle for Healthy Aging. 支持心智和肌肉健康老龄化的新兴营养方法。
Recent progress in nutrition Pub Date : 2022-01-01 Epub Date: 2022-11-16 DOI: 10.21926/rpn.2204022
Gabrielle M Mey, Jacob T Mey
{"title":"Emerging Nutrition Approaches to Support the Mind and Muscle for Healthy Aging.","authors":"Gabrielle M Mey, Jacob T Mey","doi":"10.21926/rpn.2204022","DOIUrl":"10.21926/rpn.2204022","url":null,"abstract":"<p><p>This narrative review highlights recent advances and ongoing trials using nutrition approaches for healthy aging. Focus will be placed on nutrition therapies that target cognition (\"the mind\") and mobility (\"the muscle\"), both critical components to maintaining a high quality of life for older adults. For \"the mind,\" two seemingly incongruent therapies are being investigated to improve cognition-the MIND diet (high in carbohydrates and anti-oxidant fruits and vegetables) and the ketogenic diet (low in carbohydrates, high in fats). For \"the muscle,\" a focus on protein and energy intake has dominated the literature, yet a recent clinical trial supports the use of whole-grains as a tool to improve whole-body protein turnover-a primary regulator of lean body mass and muscle. Finally, emerging data and clinical trials on caloric restriction have solidified this strategy as the only nutritional approach to slow intrinsic factors of whole-body aging, which may positively impact both \"the mind\" and \"the muscle.\"</p>","PeriodicalId":74647,"journal":{"name":"Recent progress in nutrition","volume":"2 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9850802/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10611227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficacy of a Plant-based Diet (Semi-lacto-ovo-vegetarian Diet) for Treating Constipation 植物性饮食(半乳蛋素食)治疗便秘的疗效
Recent progress in nutrition Pub Date : 2021-12-23 DOI: 10.21926/rpn.2202012
M. Chiba, Satoko Tsuda, Haruhiko Tozawa
{"title":"Efficacy of a Plant-based Diet (Semi-lacto-ovo-vegetarian Diet) for Treating Constipation","authors":"M. Chiba, Satoko Tsuda, Haruhiko Tozawa","doi":"10.21926/rpn.2202012","DOIUrl":"https://doi.org/10.21926/rpn.2202012","url":null,"abstract":"A modern lifestyle, including dietary westernization, has increased the prevalence of constipation. The authors developed a plant-based diet for inflammatory bowel disease. This study investigated whether a diet containing a high amount of dietary fiber is also effective for constipation. Consecutive patients with constipation were recruited in this study from April 2003 to March 2004. Their constipation was unresponsive to a conventional laxative. The patients were provided a plant-based diet during hospitalization for around two weeks. The plant-based diet was a semi-lacto-ovo-vegetarian diet: unrefined whole brown rice, fish once a week, and meat once every two weeks. The diet contained 29.9±1.9 g of dietary fiber/1,700 kcal. The plant-based diet score, where a higher score indicates greater adherence to the plant-based diet, was 35. A diet of 30 kcal/kg of standard body weight was provided. Defecation within two days with the diet alone or in combination with laxatives was regarded as highly effective and effective, respectively. Eleven patients (three men and eight women, 16 to 92 years old; median age: 70 years) were included; seven patients had no complications of constipation, but the remaining four patients had complications that included fecal impaction, megabowel, colonic pseudo-obstruction, and abdominal distention. Among the seven patients with uncomplicated constipation, the diet was highly effective in six patients and ineffective in one patient. It was effective in all four patients with complicated constipation. There were no adverse effects of the diet. The mean plant-based diet score before hospitalization in nine cases was 18.0. A clinical path of 13 days of hospitalization for the management of uncomplicated constipation was designed. The plant-based diet was safe and highly effective for uncomplicated constipation and effective for complicated constipation. A plant-based diet can be introduced as a special meal in a hospital setting for patients suffering from serious constipation.","PeriodicalId":74647,"journal":{"name":"Recent progress in nutrition","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46770165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Metabolic, Anthropometric and Blood Pressure Effects of Adding Two Kiwifruit or Bottled Water into the Diets of People with Pre-Diabetes: A Randomised, Parallel Group, Intervention Study 糖尿病前期患者饮食中添加两种猕猴桃或瓶装水对代谢、人体测量和血压的影响:一项随机平行组干预研究
Recent progress in nutrition Pub Date : 2021-12-22 DOI: 10.21926/rpn.2201006
Suman Mishra, Kerry L. Bentley-Hewitt, Alexandra C Lubransky, B. Venn, D. Hedderley, Hannah Dinnan, Sheridan Martell, J. Haszard, J. Monro
{"title":"Metabolic, Anthropometric and Blood Pressure Effects of Adding Two Kiwifruit or Bottled Water into the Diets of People with Pre-Diabetes: A Randomised, Parallel Group, Intervention Study","authors":"Suman Mishra, Kerry L. Bentley-Hewitt, Alexandra C Lubransky, B. Venn, D. Hedderley, Hannah Dinnan, Sheridan Martell, J. Haszard, J. Monro","doi":"10.21926/rpn.2201006","DOIUrl":"https://doi.org/10.21926/rpn.2201006","url":null,"abstract":"People with pre-diabetes may be reluctant to add fruit to their diets due to concerns around sugars. Our objective was to measure outcomes associated with potential adverse effects of ingesting fruit sugars while assessing metabolic benefits from eating nutrient-rich kiwifruit. Thirty-four people with pre-diabetes were randomized to receive two kiwifruit or 250 mL bottled water per day for 12-weeks; two people withdrew. The primary outcomes were between-group differences for glycated haemoglobin (HbA1c) and plasma vitamin C concentration. Secondary outcomes included anthropometry, blood pressure, lipids, uric acid, glycaemic-, inflammatory- and oxidative-markers. Mean (95% confidence interval) vitamin C intake and plasma concentration increased by 170 (141, 200) mg/d (P<0.001) and 11 (5, 17) µM (P = 0.001), respectively, in the kiwifruit compared with the control group. There was no between-group difference for HbA1c or for anthropometric, blood pressure or metabolic markers except for Trolox equivalent antioxidant capacity (TEAC) assay, for which there was a mean decrease of 27 (3, 51) mM (P = 0.027) in the plasma of the kiwifruit compared with the control group. The inclusion of two kiwifruit per day into the diets of people with pre-diabetes raised vitamin C intake and status without causing metabolic disturbance due to the sugars contained in the fruit. The reason behind a reduction in TEAC in the kiwifruit group despite an increase in plasma vitamin C is unclear. For any beneficial effect on HbA1c to become evident, it may require a larger sample and a longer intervention.","PeriodicalId":74647,"journal":{"name":"Recent progress in nutrition","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41381349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
The Potential Role of Commensal Microbes in Optimizing Nutrition Care Delivery and Nutrient Metabolism 共生微生物在优化营养护理和营养代谢中的潜在作用
Recent progress in nutrition Pub Date : 2021-12-20 DOI: 10.21926/rpn.2202014
Anikka Swaby, L. Agellon
{"title":"The Potential Role of Commensal Microbes in Optimizing Nutrition Care Delivery and Nutrient Metabolism","authors":"Anikka Swaby, L. Agellon","doi":"10.21926/rpn.2202014","DOIUrl":"https://doi.org/10.21926/rpn.2202014","url":null,"abstract":"Microbes have been part of the diet throughout human history. In the evolution of food preservation practices, some techniques inadvertently leveraged microbial activity not only to extend the storage life but also to enhance the properties and nutritive value of foods. In the last century, a variety of bacterial species (referred to as probiotics) were found to confer health benefits to the host. The advent of high-throughput sequencing methods facilitated improved surveillance of conventional probiotics within gut microbial communities as well as fueled the deep exploration of the human gut microbiota. Metagenomic analyses along with improvements in microbial culture techniques and comprehensive functional characterization of specific microbes both in vitro and in vivo have shed new insights into the intimate relationship of the gut microbiota and its host. Recent findings suggest the potential of conventional and newly identified bacterial species in enhancing nutrient processing and holds promise in improving the efficacy of conventional nutrition intervention strategies in managing diseases as well as in the delivery of personalized nutrition therapy support.","PeriodicalId":74647,"journal":{"name":"Recent progress in nutrition","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47889413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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