Recent advances in food, nutrition & agriculture最新文献

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Unravelling Phyto-Compound Therapeutics Against Colorectal Cancer: Targeting SRC proto-oncogene via Fibroblast Growth Factor Signalling Pathway -A Comprehensive Approach Integrating Omics Data Analysis, Network Pharmacology, Virtual Screening, and Molecular Dynamics. 通过 FGF 通路靶向揭示针对 SRC 蛋白的植物化合物疗法--一种整合 Omics 数据分析、网络药理学、虚拟筛选和分子动力学的综合方法。
Recent advances in food, nutrition & agriculture Pub Date : 2025-01-01 DOI: 10.2174/012772574X294492240527081926
Pankaj Kumar Tripathi, Chakresh Kumar Jain
{"title":"Unravelling Phyto-Compound Therapeutics Against Colorectal Cancer: Targeting SRC proto-oncogene via Fibroblast Growth Factor Signalling Pathway -A Comprehensive Approach Integrating Omics Data Analysis, Network Pharmacology, Virtual Screening, and Molecular Dynamics.","authors":"Pankaj Kumar Tripathi, Chakresh Kumar Jain","doi":"10.2174/012772574X294492240527081926","DOIUrl":"10.2174/012772574X294492240527081926","url":null,"abstract":"<p><strong>Introduction: </strong>Colorectal cancer is a complex condition influenced by genetic mutations and environmental factors. Due to its intricate nature, the diagnosis and treatment of this condition require a comprehensive approach that considers individual circumstances. The study aimed to identify genes linked with colorectal cancer and their therapeutic agents from natural bioactive compounds.</p><p><strong>Methods: </strong>The significantly prognostic differentially expressed genes (DEGs) were screened out from NCBI Gene Expression Omnibus (GEO) datasets. A protein-protein interaction network was constructed using STRING Database, and key genes were identified using Network Analyzer and CytoNCA plugins within Cytoscape. Further analysis involved functional annotations, and biological pathways analysis, SRC mechanism to uncover the role of SRC in CRC. Additionally, we performed virtual screening and molecular docking, Physiochemical property analysis along with MD simulation study to propose suitable natural compounds for promising therapeutic targets.</p><p><strong>Results: </strong>The study conducted differential gene expression analysis, identifying 3621 statistically significant genes, with 1467 upregulated and 2154 downregulated. The top ten genes with the highest degree, betweenness centrality, and closeness centrality in the PPI network were selected as key genes. The SRC gene was found to have the highest degree and closeness centrality. Functional annotation and pathway analysis of key genes with a specific focus on the SRC mechanism revealed that the SRC's role in activating the RAS-RAF-MEK-ERK and Wnt/β-catenin pathways in CRC cells, promoting proliferation and invasion. Molecular modelling of SRC led to the screening of phytocompounds from tropical fruits, with Rutin exhibiting a higher docking score compared to FDAapproved anticancer drugs. MD simulations over 100 ns and the post-MD analysis i.e. RMSD, SASA, RMSF, FEL, RG, Hydrogen bond, PCA, and MMPBSA, comprehended the stable and robust interactions of a protein-ligand complex. These findings suggest Rutin's potential as a potent natural molecule for treating CRC.</p><p><strong>Conclusion: </strong>The study concludes that SRC plays a pivotal role in CRC, influencing cellular processes critical to cancer development and Rutin has been found to be a promising SRC inhibitor, suggesting a potential alternative therapeutic strategy for CRC. The consistent molecular interactions of Rutin necessitate further validation through wet lab experiments, offering hope for individuals affected by CRC.</p>","PeriodicalId":74644,"journal":{"name":"Recent advances in food, nutrition & agriculture","volume":" ","pages":"185-205"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141452370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Jivamrit as a Sustainable Approach: A Review of Natural Farming and Future Agriculture. 作为可持续方法的 Jivamrit:自然农耕与未来农业述评》。
Recent advances in food, nutrition & agriculture Pub Date : 2025-01-01 DOI: 10.2174/012772574X332918240911033507
Ashish Warghane, Vaibhav Bhatt, B A Chopade, Jigisha Thakkar, Ritu Sharma, Arijit Sankar Mondal, Priyanka Sabhadiya, Ankit Singh, Gayatary Bhardwaj
{"title":"Jivamrit as a Sustainable Approach: A Review of Natural Farming and Future Agriculture.","authors":"Ashish Warghane, Vaibhav Bhatt, B A Chopade, Jigisha Thakkar, Ritu Sharma, Arijit Sankar Mondal, Priyanka Sabhadiya, Ankit Singh, Gayatary Bhardwaj","doi":"10.2174/012772574X332918240911033507","DOIUrl":"10.2174/012772574X332918240911033507","url":null,"abstract":"<p><p>Green Revolution aims to boost food production and feed millions of Indians, but it also has negative effects on agriculture and society's health. Natural manures like cow dung and cow urine can counteract the adverse effects of inorganic fertilizer on soil along with improving physicochemical qualities, maintaining the soil quality, and increasing crop output. Zero Budget Natural Farming (ZBNF) formulations like Jivamrit promote soil health and microbial activities and are an excellent source of macronutrients, other micronutrients needed for plant growth, plus adds beneficial microbes, nitrogen (N2), phosphorus (P), potassium (K), and natural carbon (C). Further, conventional agricultural methods, like monocropping and heavy tillage, can damage soil bacteria which contributes to sustainable agriculture through nitrogen fixation, siderophore synthesis and nutrient absorption. A sustainable agricultural system is resource-efficient, socially and commercially competitive, ecologically sound, and supportive of society. Jivamrit, a natural organic manure, is gaining interest due to concerns about the sustainability of input-intensive agriculture systems. It promotes crop growth, quality, and yield, enhances soil pH, population, and activity of beneficial microorganisms, and helps with nitrogen fixation, phosphate solubilization, and easy decomposition. Long-term use of Jivamrit, may disrupt soil microbial balance, may leading to overpopulation of certain species. The current review on the Jivamrit emphasizes on the biological and chemical characterization and its significance to the agriculture.</p>","PeriodicalId":74644,"journal":{"name":"Recent advances in food, nutrition & agriculture","volume":" ","pages":"241-249"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142514344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cocos nucifera Husk Biomass as an Effective Adsorbent for Industrial Wastewater Removal: Harnessing the Power of Nature. 将椰子壳生物质作为去除工业废水的有效吸附剂:利用大自然的力量。
Recent advances in food, nutrition & agriculture Pub Date : 2025-01-01 DOI: 10.2174/012772574X288759240305065156
Rishav Sharma, Rajendra Awasthi, Rishabha Malviya
{"title":"<i>Cocos nucifera</i> Husk Biomass as an Effective Adsorbent for Industrial Wastewater Removal: Harnessing the Power of Nature.","authors":"Rishav Sharma, Rajendra Awasthi, Rishabha Malviya","doi":"10.2174/012772574X288759240305065156","DOIUrl":"10.2174/012772574X288759240305065156","url":null,"abstract":"<p><strong>Background: </strong>Rapid industrialization has polluted waterways, threatened aquatic ecosystems and endangered human health. To solve this problem, sustainable industrial practices and innovative water treatment technology must be implemented to ensure clean and safe water for future generations.</p><p><strong>Methods: </strong>This study aimed to investigate the adsorbent capacity of <i>Cocos nucifera</i> husk for ineffective removal of methylene blue (MB), a cationic dye abundantly found in industrial effluent. Adsorption capacity is measured using parameters such as dye elimination percentage and polymer dosage. The Langmuir and Freundlich isotherms, adsorption kinetics (pseudo-first, pseudo-second, and second order), and intraparticle diffusion were determined to better understand the adsorption process.</p><p><strong>Results: </strong>The increased dosage of cellulose fiber results in the availability of a greater number of adsorption sites and an increased surface area. However, the dye removal efficacy decreased after reaching a specific dosage of 0.6 g/L. A concentration of 0.05 g/L was most effective in eliminating Methylene blue (MB). The value of the separation factor (0.99) suggested a favorable adsorption isotherm. The reciprocal of the heterogeneity factor (-1.469) demonstrated the concentration-independent adsorption behavior of Fiber. Freundlich and Langmuir's isotherm model showed that the pseudo-second-order kinetic model demonstrated the highest level of correlation with the experimental data about the mechanism of adsorption. The Methylene blue (MB) adsorption is not limited by the intraparticle diffusion and adsorption is influenced by surface area and concentration variation of fiber as well as solvent concentration, as evidenced by low R2 value and the fact that the intraparticle diffusion plot does not intersect with the origin.</p><p><strong>Conclusion: </strong>The study concludes that Cocos nucifera husk can be effectively used for the treatment of wastewater.</p>","PeriodicalId":74644,"journal":{"name":"Recent advances in food, nutrition & agriculture","volume":" ","pages":"79-85"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140133467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Physical, Chemical and Enzymatic Changes in Amla (Emblica officinalis) Fruit during Growth and Maturation. 阿木拉(Emblica officinalis)果实在生长和成熟过程中的物理、化学和酶变化。
Recent advances in food, nutrition & agriculture Pub Date : 2025-01-01 DOI: 10.2174/012772574X290070240306092255
Neelam Sachan, Vivek Kumar
{"title":"Physical, Chemical and Enzymatic Changes in Amla (<i>Emblica officinalis</i>) Fruit during Growth and Maturation.","authors":"Neelam Sachan, Vivek Kumar","doi":"10.2174/012772574X290070240306092255","DOIUrl":"10.2174/012772574X290070240306092255","url":null,"abstract":"<p><strong>Background: </strong>Amla (<i>Emblica officinalis</i>) is one of the most prominent fruits in terms of nutritional and medicinal properties and is utilized for the preparation of many traditional processed foods and in Ayurvedic formulations.</p><p><strong>Objective: </strong>This study aims to investigate the enzyme activity and physical and chemical quality parameters during the growth and development stages of amla fruit for the determination of proper harvesting time to get optimum nutrient contents of fruit.</p><p><strong>Methods: </strong>The amla fruits of the chakaiya variety were harvested at 135 to 270 days after fruit set (DAFS) in 2021 and 2022 to study the various physical, chemical and enzymatic changes during growth and maturation.</p><p><strong>Results: </strong>The geometrical and gravimetric attributes of the fruit, viz. diameter, height, weight, volume, surface area, sphericity, aspect ratio, and radius of curvature increased. However, density decreased with the growth and maturation of the fruit. Furthermore, the rolling resistance, yellowness index and firmness of the fruit increased during the entire harvesting period of 135 to 270 DAFS. Total soluble solids and titratable acidity of the fruits increased only up to 195 DAFS and after that, continuously decreased. In contrast, ascorbic acid concentration grew in the entire growth and development period. Tannin, phenolic compounds and naringin content of the fruit steadily dropped until the final stage of harvest. Pectin Methyl Esterase (PME) activity was detected very low, 0.009 unit/ml at 135 DAFS, but as the fruit grew and matured, activity increased to 0.307 unit/ml at 270 DAFS. Polygalactouronase (PG) activity was not detected until 210 DAFS and, therefore significantly increased with maturity.</p><p><strong>Conclusion: </strong>Considering the optimal value of all studied physical, chemical and enzymatic attributes of the fruit during the entire harvesting period of 135 to 270 DAFS, the optimal harvesting time of the fruit was 210 DAFS.</p>","PeriodicalId":74644,"journal":{"name":"Recent advances in food, nutrition & agriculture","volume":" ","pages":"86-98"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140144795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dandelion (Taraxacum officinale): A Promising Source of Nutritional and Therapeutic Compounds. 蒲公英(Taraxacum officinale):一种有前景的营养和治疗化合物来源。
Recent advances in food, nutrition & agriculture Pub Date : 2025-01-01 DOI: 10.2174/012772574X293072240217185616
Umi Laila, Jaspreet Kaur, Kartik Sharma, Jyoti Singh, Prasad Rasane, Sawinder Kaur, Vishesh Bhadariya
{"title":"Dandelion (<i>Taraxacum officinale</i>): A Promising Source of Nutritional and Therapeutic Compounds.","authors":"Umi Laila, Jaspreet Kaur, Kartik Sharma, Jyoti Singh, Prasad Rasane, Sawinder Kaur, Vishesh Bhadariya","doi":"10.2174/012772574X293072240217185616","DOIUrl":"10.2174/012772574X293072240217185616","url":null,"abstract":"<p><strong>Background: </strong>Taraxacum officinale, commonly referred to as dandelion, is a selfgrowing plant/ weed in various parts of India and the rest of the world (particularly the northern hemisphere). The plant's chemical composition, including sesquiterpene lactones, saponins, flavonoids, phenols, and many other compounds, contributes positively to the human body, promoting overall health.</p><p><strong>Aim: </strong>This review aims to shed light on the therapeutic potential of dandelion by summarizing its nutritional benefits, phytochemical constituents, and effectiveness in addressing health conditions like diabetes, inflammation, and cancer. It also provides insights into the applications of this plant beyond the food industry to gain researchers' attention to unravel the unexplored aspects of this therapeutic plant. It will further help in laying specific considerations, which are required to be taken into account before the development of functional foods incorporated with dandelion. Scope and approach: Being rich in essential vitamins, minerals, and other phytoconstituents, dandelion is a natural remedy for various ailments. Whether consumed raw or cooked, the plant's inclusion in the diet poses potential therapeutic effects on conditions such as diabetes, inflammation, liver disease, and tumors. It also aids in immune system modulation and fights infections by targeting microbes at their root. Researchers have developed various value-added food products by incorporating different parts of dandelion.</p><p><strong>Conclusion: </strong>This review highlights the therapeutic potential of dandelion, emphasizing its effectiveness against various health conditions. Insights into dosage, toxicity, and diverse applications further underscore its role as a versatile and promising natural remedy.</p>","PeriodicalId":74644,"journal":{"name":"Recent advances in food, nutrition & agriculture","volume":" ","pages":"41-56"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139998473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cost-effective Phytohormone Extraction of Sargassum swartzii from the Persian Gulf. 利用磁性离子液体从波斯湾马尾藻中提取具有成本效益的植物激素
Recent advances in food, nutrition & agriculture Pub Date : 2025-01-01 DOI: 10.2174/012772574X315517240626065435
Ali Rajabiyan, Amanollah Zarei-Ahmady, Mohammad Izadi, Fatemeh Kardani
{"title":"Cost-effective Phytohormone Extraction of <i>Sargassum swartzii</i> from the Persian Gulf.","authors":"Ali Rajabiyan, Amanollah Zarei-Ahmady, Mohammad Izadi, Fatemeh Kardani","doi":"10.2174/012772574X315517240626065435","DOIUrl":"10.2174/012772574X315517240626065435","url":null,"abstract":"<p><strong>Introduction: </strong>Algae extracts are utilized as biofertilizers instead of chemical fertilizers in agriculture. Further, algae are known to possess a high content of plant hormones, such as gibberellin, salicylic acid, abscisic acid, and brassinosteroids.</p><p><strong>Objective: </strong>The main objective of this study was to increase the extraction yield and simultaneously extract hormones required for plant growth from Sargassum swartzii using Magnetic recoverable ionic liquid (IL).</p><p><strong>Methods: </strong>In this study, extraction was performed by acidic digestion with acetic acid and then alkaline digestion with potassium hydroxide.</p><p><strong>Results: </strong>The results showed the ionic liquid effect in extraction yield by 266 percent. The extracted phytohormones were analyzed using high-performance liquid chromatography (HPLC) methods. High levels of gibberellin, salicylic acid, abscisic acid, and brassinosteroids in improved algae extraction showed that seaweed extract could be used as environmentally friendly liquid bio-fertilizers to replace chemical fertilizers and could play a crucial role in organic farming for sustainable agriculture. Additionally, the recoverability of ionic liquid eight times with negligible leaching proved the introduced procedure to be cost-effective.</p><p><strong>Conclusion: </strong>The reported procedure for algae extraction improved by using an acidic/primary ionic liquid environment. This procedure is economical because of the simple reusability of ionic liquid due to its magnetic features.</p>","PeriodicalId":74644,"journal":{"name":"Recent advances in food, nutrition & agriculture","volume":" ","pages":"233-240"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141790231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of Diet and Dietary Patterns on the Progression of Multiple Sclerosis: A Review. 饮食和饮食模式对多发性硬化症进展的影响:综述。
Recent advances in food, nutrition & agriculture Pub Date : 2025-01-01 DOI: 10.2174/012772574X325602240910075218
Rabie Khattab, Arafat Goja, Welayah AlAmmar
{"title":"Effect of Diet and Dietary Patterns on the Progression of Multiple Sclerosis: A Review.","authors":"Rabie Khattab, Arafat Goja, Welayah AlAmmar","doi":"10.2174/012772574X325602240910075218","DOIUrl":"10.2174/012772574X325602240910075218","url":null,"abstract":"<p><p>The link between diet and the progression of Multiple Sclerosis (MS) is a topic of growing interest and investigation within the medical community. This review explored the mechanisms through which dietary interventions can impact the course of MS and shape the clinical outcomes and quality of life of individuals with the disease. By synthesizing current knowledge from clinical studies and observational research, the review aimed to provide insights into the role of diet in managing MS. A comprehensive literature search was conducted, focusing on the effect of diet and dietary patterns on the progression of MS. Key findings indicated that individuals with higher diet quality exhibit reduced disability levels and lower symptom severity, emphasizing the importance of maintaining a healthy diet and adopting a holistic, healthy lifestyle in managing MS. The review also delved into the potential impact of macronutrients, vitamins, and minerals on the progression of MS, highlighting the importance of adequate nutrient intake for optimal health outcomes. Additionally, the study explored the association between dietary intake variations and the severity of MS, suggesting that further investigation is needed to understand the potential implications of nutrient deficiencies in MS patients. Overall, the review serves as a valuable resource for healthcare professionals and individuals living with MS, providing evidence-based dietary approaches that may help optimize health outcomes and mitigate the burden of the disease. It also calls for future research directions in the critical area of dietary management of MS to enhance our understanding and improve patient care.</p>","PeriodicalId":74644,"journal":{"name":"Recent advances in food, nutrition & agriculture","volume":" ","pages":"282-298"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142514343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chitosan and Chitosan-Essential Oil Composites as Edible Coatings for Meat and Meat Products: A Review. 壳聚糖和壳聚糖-精油复合材料作为肉类和肉制品的食用涂层:综述。
Recent advances in food, nutrition & agriculture Pub Date : 2025-01-01 DOI: 10.2174/012772574X301555240503070126
Mohamed Abd Elgadir, Mohamed E S Mirghani, Abdalbasit Mariod
{"title":"Chitosan and Chitosan-Essential Oil Composites as Edible Coatings for Meat and Meat Products: A Review.","authors":"Mohamed Abd Elgadir, Mohamed E S Mirghani, Abdalbasit Mariod","doi":"10.2174/012772574X301555240503070126","DOIUrl":"10.2174/012772574X301555240503070126","url":null,"abstract":"<p><p>The massive and uncontrolled use of petroleum-based plastic food packaging has resulted in serious environmental problems. As a result, the food packaging industry should improve packaging materials based on biodegradable polymers, such as chitosan. Edible food coating maintains and improves the shelf life and condition of packaged foods. Researchers have widely investigated the potential applications of biodegradable natural polymers, such as chitosan, cellulose, starch, whey protein, and gelatin in the food packaging industry. Among the natural biodegradable materials available, chitosan and its derivatives have attracted great interest because they have antimicrobial, antifungal, and metal-chelating properties. They are biodegradable polysaccharides and are non-toxic; therefore, they are considered perfect materials for food coating. Adding other active materials, such as fruit extracts, phenolic compounds, and essential oils, can significantly enhance the antimicrobial and antioxidant capacity of chitosan-based packaging materials. Thus, this article investigates the recent updates in food packaging applications based on chitosan essential oil composites.</p>","PeriodicalId":74644,"journal":{"name":"Recent advances in food, nutrition & agriculture","volume":" ","pages":"109-120"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141066501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Current State of Scientific Knowledge on Curcumin Encapsulation and Applications. 姜黄素封装和应用的科学现状。
Recent advances in food, nutrition & agriculture Pub Date : 2025-01-01 DOI: 10.2174/012772574X330008240827052241
Wissam Zam, Mohamed Reda Zahi, Mohamed El Hattab
{"title":"Current State of Scientific Knowledge on Curcumin Encapsulation and Applications.","authors":"Wissam Zam, Mohamed Reda Zahi, Mohamed El Hattab","doi":"10.2174/012772574X330008240827052241","DOIUrl":"10.2174/012772574X330008240827052241","url":null,"abstract":"<p><p>The yellow pigment curcumin has long been used in traditional medicine for its anti-inflammatory, antibacterial and antioxidant activities. Over the past half-century, scientific investigations have shown that curcumin is endowed with additional health benefits because it can modify key molecular targets associated with a number of pathologies, such as diabetes, cancer, and arthritis, in addition to cardiovascular, multiple sclerosis, Alzheimer's, and Crohn's diseases. However, this molecule has several disadvantages, such as low bioavailability and solubility, severe oxidative destruction, light sensitivity, fast systemic clearance and breakdown at alkaline pH levels. To address these drawbacks, several methods of microencapsulation employing a variety of shell materials have been investigated. These techniques contributed toward the increase of curcumin's solubility and stability against heat, light, oxygen, and an alkaline pH. The various shell materials and methods used to microencapsulate this chemical are the main topics of this review. The use of microencapsulated curcumin in food, medicine, and cosmetics is also discussed in more detail. Recent relevant research from the last few years has been given in this area, along with future difficulties.</p>","PeriodicalId":74644,"journal":{"name":"Recent advances in food, nutrition & agriculture","volume":" ","pages":"315-333"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142395800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cholesterol Absorption Inhibition by Some Nutraceuticals. 某些保健食品对胆固醇吸收的抑制作用
Recent advances in food, nutrition & agriculture Pub Date : 2025-01-01 DOI: 10.2174/012772574X285280240220065812
Shivendra Kumar, Sunam Saha, Devender Pathak, Talever Singh, Atul Kumar, Kuldeep Singh, Avinash Kumar Mishra, Sakshi Singh, Shubham Singh
{"title":"Cholesterol Absorption Inhibition by Some Nutraceuticals.","authors":"Shivendra Kumar, Sunam Saha, Devender Pathak, Talever Singh, Atul Kumar, Kuldeep Singh, Avinash Kumar Mishra, Sakshi Singh, Shubham Singh","doi":"10.2174/012772574X285280240220065812","DOIUrl":"10.2174/012772574X285280240220065812","url":null,"abstract":"<p><p>Hyperlipidemia, characterized by elevated levels of lipids in the blood, represents a major risk factor for cardiovascular diseases, a leading cause of morbidity and mortality worldwide. Conventional pharmacological interventions have been effective in managing hyperlipidemia, but concerns about side effects and long-term use have prompted interest in alternative approaches, particularly the use of nutraceuticals. This comprehensive review aims to summarize and critically evaluate the current body of knowledge surrounding the role of nutraceuticals in the management of hyperlipidemia. We provide an overview of the different classes of nutraceuticals, including plant sterols, omega-3 fatty acids, soluble fiber, antioxidants, and various herbal extracts, which have been investigated for their lipid-lowering properties. The mechanisms of action of these nutraceuticals are discussed, highlighting their ability to modulate lipid metabolism, reduce oxidative stress, and promote cardiovascular health. Furthermore, we review the results of clinical trials and epidemiological studies that have assessed the efficacy of nutraceutical interventions in lowering cholesterol levels, improving lipid profiles, and reducing the risk of cardiovascular events. In addition to their lipid-lowering effects, we examine the safety profile, dosage recommendations, and potential interactions of nutraceuticals with conventional lipid-lowering medications. We also address the importance of patient adherence to dietary and lifestyle modifications in conjunction with nutraceutical supplementation. While nutraceuticals offer a promising avenue for managing hyperlipidemia, we emphasize the need for further research to establish evidence-based guidelines for their use in clinical practice. Challenges related to standardization, quality control, and regulatory considerations are also discussed. In conclusion, this comprehensive review provides valuable insights into the potential of nutraceuticals as adjunctive or alternative therapies for managing hyperlipidemia. While further research is needed, the accumulating evidence suggests that nutraceuticals can play a valuable role in promoting cardiovascular health and reducing the burden of hyperlipidemia-related diseases.</p>","PeriodicalId":74644,"journal":{"name":"Recent advances in food, nutrition & agriculture","volume":" ","pages":"2-11"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140029755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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