Recent advances in food, nutrition & agriculture最新文献

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Enhancing Nutrient Composition and Bioavailability in Common Beans Using Combined Zinc and Iron Fertilizers. 锌铁复合肥料提高普通豆营养成分和生物利用度。
Recent advances in food, nutrition & agriculture Pub Date : 2025-07-07 DOI: 10.2174/012772574X380973250624115024
Fitsum Merkeb, Tarekegn Yoseph, Berhanu Amsalu
{"title":"Enhancing Nutrient Composition and Bioavailability in Common Beans Using Combined Zinc and Iron Fertilizers.","authors":"Fitsum Merkeb, Tarekegn Yoseph, Berhanu Amsalu","doi":"10.2174/012772574X380973250624115024","DOIUrl":"https://doi.org/10.2174/012772574X380973250624115024","url":null,"abstract":"<p><strong>Objective: </strong>This investigation aims to elucidate the potential of nutraceuticals as a therapeutic modality for depression by enhancing the solubility and bioavailability of Withania somnifera (Ashwagandha) using specific solid dispersion techniques.</p><p><strong>Methods: </strong>Solid Withania somnifera and Valeriana officinalis dispersions were prepared via hot melt extrusion and solvent evaporation. These processes increased the aqueous solubility of Ashwagandha by 3.2-fold (from 44.2 μg/mL to 142 μg/mL). An optimal 1:2 drugto- hydrotropic agent ratio was selected based on comprehensive DSC, PXRD, and FTIR characterisation, indicating partial amorphisation and effective molecular interactions with β-cyclodextrin. The resulting solid dispersion was incorporated into nutraceutical gummies, formulated using type B gelatin, high-methoxyl pectin, and food-grade guar gum via a standardized molding process. The antidepressant efficacy of these gummies was assessed in murine models using the Forced Swim Test, with quantitative evaluation of changes in immobility time and climbing behavior.</p><p><strong>Results: </strong>The solid dispersion methodology significantly enhanced Ashwagandha's solubility (3.2-fold increase). In the Forced Swim Test, animals treated with the gummy formulation exhibited a 40% reduction in immobility time and a 35% increase in climbing activity compared to controls, indicating a robust antidepressant effect.</p><p><strong>Conclusion: </strong>This study presents a novel nutraceutical approach to managing depression. By optimizing the solubility and bioavailability of key herbal constituents through advanced solid dispersion techniques, the gummy formulation offers a promising alternative or adjunctive treatment for depressive disorders.</p>","PeriodicalId":74644,"journal":{"name":"Recent advances in food, nutrition & agriculture","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144585831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Probiotification of a Tropical Juice Blend using Lactobacillus bulgaricus and Lactobacillus plantarum: A Preliminary Study. 保加利亚乳杆菌和植物乳杆菌对热带混合果汁的益生作用初步研究。
Recent advances in food, nutrition & agriculture Pub Date : 2025-06-19 DOI: 10.2174/012772574X394951250611073352
Carmencita Duberry, Rohanie Maharaj, Dimple Singh-Ackbarali, Vishal Ganessingh
{"title":"Probiotification of a Tropical Juice Blend using Lactobacillus bulgaricus and Lactobacillus plantarum: A Preliminary Study.","authors":"Carmencita Duberry, Rohanie Maharaj, Dimple Singh-Ackbarali, Vishal Ganessingh","doi":"10.2174/012772574X394951250611073352","DOIUrl":"https://doi.org/10.2174/012772574X394951250611073352","url":null,"abstract":"<p><strong>Background: </strong>Probiotics are beneficial microorganisms that support host health when consumed in adequate amounts. While fruit juices are promising non-dairy carriers for probiotics, consumer acceptance remains a challenge.</p><p><strong>Objective: </strong>This study aimed to develop a viable, palatable probiotic beverage using a blend of fresh fruits and a vegetable, providing an easy-to-consume source of nutrients.</p><p><strong>Methods: </strong>Probiotification of pasteurized and untreated tropical juice blends (carrot, orange, pineapple, and passion fruit juices) was achieved through fermentation using two strains of Lactic Acid Bacteria (LAB) (Lactobacillus bulgaricus and Lactobacillus plantarum). Fermentation was carried out at 37℃ for 48 h in a microaerophilic environment. Shelf-life studies were conducted at 35℃, 23°C, and 4°C, over 10, 10, and 21 days for untreated and pasteurized juices, respectively. Parameters assessed included the probiotic viability, presence of spoilage coliforms, pH, titratable acidity, ascorbic acid, total soluble solids content, and colour.</p><p><strong>Results: </strong>Both LAB strains reduced the juice pH within 48 hours of fermentation. The viability of probiotic cells was maintained at 4.08 × 1010 CFU mL-1 with no spoilage coliforms detected during refrigerated storage. No significant differences were observed in physicochemical properties (pH, TSS, TA, or colour) between the pasteurized and unpasteurized probiotic juice blends after 48 hours at 37°C. Sensory analysis indicated higher consumer acceptance of the fermented juice blends over a commercial probiotic beverage in terms of appearance, fruity flavour, sweetness, and mouthfeel.</p><p><strong>Conclusion: </strong>Probiotic juice blends could offer a potential option for lactose-intolerant and vegan consumers, providing a nutritious, palatable, and viable alternative to commercial dairy probiotic beverages.</p>","PeriodicalId":74644,"journal":{"name":"Recent advances in food, nutrition & agriculture","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144478179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Antidepressant Efficacy of Nutraceutical Gummies: Formulation of With-ania Somnifera and Valeriana officinalis Evaluated in Force Swim Test Model. 营养药用胶的抗抑郁作用:用强力游泳试验模型评价含冬草和缬草的配方。
Recent advances in food, nutrition & agriculture Pub Date : 2025-06-11 DOI: 10.2174/012772574X375447250528171314
Parvinder Mann, Uddeshya Sharma, Gurvirender Singh, Geeta Jangra
{"title":"Antidepressant Efficacy of Nutraceutical Gummies: Formulation of With-ania Somnifera and Valeriana officinalis Evaluated in Force Swim Test Model.","authors":"Parvinder Mann, Uddeshya Sharma, Gurvirender Singh, Geeta Jangra","doi":"10.2174/012772574X375447250528171314","DOIUrl":"https://doi.org/10.2174/012772574X375447250528171314","url":null,"abstract":"<p><strong>Objective: </strong>This investigation aims to elucidate the potential of nutraceuticals as a therapeutic modality for depression by enhancing the solubility and bioavailability of Withania somnifera (Ashwagandha) using specific solid dispersion techniques.</p><p><strong>Methodology: </strong>Solid Withania somnifera and Valeriana officinalis dispersions were prepared via hot melt extrusion and solvent evaporation. These processes increased the aqueous solubility of Ashwagandha by 3.2-fold (from 44.2 μg/mL to 142 μg/mL). An optimal 1:2 drug-to-hydrotropic agent ratio was selected based on comprehensive DSC, PXRD, and FTIR characterisation, indicating partial amorphisation and effective molecular interactions with β-cyclodextrin. The resulting solid dispersion was incorporated into nutraceutical gummies, formulated using type B gelatin, high-methoxyl pectin, and food-grade guar gum via a standardized molding process. The antidepressant efficacy of these gummies was assessed in murine models using the Forced Swim Test, with quantitative evaluation of changes in immobility time and climbing behavior.</p><p><strong>Results: </strong>The solid dispersion methodology significantly enhanced Ashwagandha's solubility (3.2-fold increase). In the Forced Swim Test, animals treated with the gummy formulation exhibited a 40% reduction in immobility time and a 35% increase in climbing activity compared to controls, indicating a robust antidepressant effect.</p><p><strong>Conclusions: </strong>This study presents a novel nutraceutical approach to managing depression. By optimizing the solubility and bioavailability of key herbal constituents through advanced solid dispersion techniques, the gummy formulation offers a promising alternative or adjunctive treatment for depressive disorders.</p>","PeriodicalId":74644,"journal":{"name":"Recent advances in food, nutrition & agriculture","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144287514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unraveling the Nutritional Perspectives of Probiotics and Prebiotics in Female Healthcare. 揭示益生菌和益生元在女性保健中的营养观点。
Recent advances in food, nutrition & agriculture Pub Date : 2025-05-08 DOI: 10.2174/012772574X374047250325183211
Nilu Kumari, Yogendra Pal, Chandra Shekhar Tailor, Deepti Negi, Jasmeen Syan, Anubi Badhani, Rashmi Saxena Pal
{"title":"Unraveling the Nutritional Perspectives of Probiotics and Prebiotics in Female Healthcare.","authors":"Nilu Kumari, Yogendra Pal, Chandra Shekhar Tailor, Deepti Negi, Jasmeen Syan, Anubi Badhani, Rashmi Saxena Pal","doi":"10.2174/012772574X374047250325183211","DOIUrl":"https://doi.org/10.2174/012772574X374047250325183211","url":null,"abstract":"<p><p>Prebiotics are the indigestible components of meals that promote the formation of probiotics, that contain living bacteria that have positive effects. Synbiotics combine the two. These components may be found in foods such as fresh fruits and vegetables, fermented foods like yogurt and pickles, or pharmaceutical preparations and functional meals made specifically to improve gut health. Consolidating current knowledge and study findings, this paper examines the body of literature on the impact of probiotics, prebiotics, and synbiotics on women's health. Thus, these components' advantageous modes of action are examined, offering insight into how they support the general well-being of the GIT and, consequently, the host. Probiotics, for instance, are crucial for restoring the gut flora. Conversely, prebiot-ics are thought to be a dietary source that promotes the development and activity of good bacteria. This promotes the synthesis of fatty acids, which are essential for a healthy gut and have anti-inflammatory properties, and increases microbial diversity. By combining the ad-vantages of pre and probiotics, the synergistic impact of synbiotics makes them a more po-tent strategy for boosting gut flora and promoting health outcomes. These include probiotics, which have been shown to alleviate the symptoms of GIT disorders such as inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS). Additionally, it is known to help prebiotics improve gut health by boosting beneficial bacteria that improve immunity and digestion. Synbiotics stimulate immunity, enhance nutrient absorption, and encourage good digestion by encouraging a varied and balanced gut microbiota. This in turn aids in the treat-ment of particular medical conditions including menopause, challenging high-risk pregnan-cies, and hormonal changes. Including probiotics and prebiotics in the diet can control insu-lin resistance, assist in managing pain and oxidative stress, and encourage a normal gut mi-crobiome all of which are advantageous in the treatment of female health-related issues such as PCOS, Osteoporosis, PMS, etc.</p>","PeriodicalId":74644,"journal":{"name":"Recent advances in food, nutrition & agriculture","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144058379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nutraceuticals in Depression Management: Current Evidence and Perspectives. 营养药品在抑郁症管理:目前的证据和观点。
Recent advances in food, nutrition & agriculture Pub Date : 2025-05-07 DOI: 10.2174/012772574X361750250323111150
Parvinder Mann, Geeta Jangra, Komal Saini, Smita Narwal, Ashwani K Dhingra, Gurvirender Singh
{"title":"Nutraceuticals in Depression Management: Current Evidence and Perspectives.","authors":"Parvinder Mann, Geeta Jangra, Komal Saini, Smita Narwal, Ashwani K Dhingra, Gurvirender Singh","doi":"10.2174/012772574X361750250323111150","DOIUrl":"https://doi.org/10.2174/012772574X361750250323111150","url":null,"abstract":"<p><strong>Background: </strong>Depression is a common psychiatric disorder characterized by feel-ings of sadness, diminished interest in activities, and disruptions in sleep patterns. Pharmaco-therapy, which often involves the use of antidepressant medicines, are method for managing depression. There are potential negative effects linked to the utilization of these medicines, even though many people have found them to be beneficial.</p><p><strong>Objective: </strong>Traditional pharmacological therapies for depression can have a variety of ad-verse effects or drawbacks. To overcome these constraints, nutraceuticals have come into the picture of interest. Nutraceuticals, which are naturally derived compounds with potential therapeutic benefits, have attracted interest as an innovative approach to treating depression. In this review, the efficacy of nutraceuticals in depression will be discussed.</p><p><strong>Methods: </strong>To find pertinent research on nutraceuticals in the treatment of depression, a thor-ough literature analysis was enacted. Studies investigating the significance of nutraceuticals on depression signs, patent perspectives, and clinical studies were included.</p><p><strong>Results: </strong>The findings suggest that several nutraceuticals, including omega-3 fatty acids, di-etary fibers, and phytochemicals, including Ashwagandha and valerian, exhibit antidepres-sant effects. These compounds have shown promising results in improving depressive symp-toms, enhancing neuroplasticity and neurogenesis, and regulating neurotransmitter imbal-ances.</p><p><strong>Conclusion: </strong>Nutraceuticals offer a novel approach to depression, providing potential bene-fits in alleviating depressive symptoms. Correlative review suggests that increasing intake of these substances could be an alternate method for delaying the early symptoms and course of depression. Supplementation with dietary fibers, Omega-3 fatty acids, and phytochemi-cals can be utilized as a complementary strategy for anti-depressant therapy.</p>","PeriodicalId":74644,"journal":{"name":"Recent advances in food, nutrition & agriculture","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144063184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Harnessing Artificial Intelligence for Sustainable Agriculture: A Comprehensive Scientometric Review. 利用人工智能促进可持续农业:科学计量学综述。
Recent advances in food, nutrition & agriculture Pub Date : 2025-03-24 DOI: 10.2174/012772574X355955250212112211
Hardeep Kaur, Bhanu Priya, Kuldeep Singh
{"title":"Harnessing Artificial Intelligence for Sustainable Agriculture: A Comprehensive Scientometric Review.","authors":"Hardeep Kaur, Bhanu Priya, Kuldeep Singh","doi":"10.2174/012772574X355955250212112211","DOIUrl":"https://doi.org/10.2174/012772574X355955250212112211","url":null,"abstract":"<p><p>Agriculture empowers the economies of most developing countries as it contributes to the GDP and provides employment to half of the population. To augment the functionalities of agriculture, Artificial Intelligence (AI) has emerged as a significant solution. Consequently, substantial research endeavours have been carried out in this direction lately. However, a com-prehensive study and scientometric analysis highlighting the potential of AI in agriculture has not been reported in the literature. Therefore, the presented scientometric study depicts the evolution of the pattern of research related to Artificial Intelligence technologies in agricultural practices based on the bibliographic data obtained from Scopus from 2015 to 2024. The data was analyzed and visualized using VOSviewer and Bibliometrix software by examining the publication growth trends, keyword co-occurrence networks, co-authorship networks, co-cita-tion networks, institutional coupling networks, and journal coupling networks. The presented research concluded that India excels in the field, contributing 874 research documents, a sub-stantial portion of the global total of 1,938. As per the link strength, China has secured the top position with 56 links and a total link strength of 1,080, while India follows closely in second place with 56 links and a total link strength of 871. The leading institution funding researchers with the highest number of publications is ICAR, while Science of the Total Environment stands out as the most relevant journal for disseminating their findings. The research topics explored involve using AI for disease detection, addressing nutrient deficiencies, analyzing soil content, and optimizing irrigation schedules. A notable emerging research topic highlights the effectiveness of AI in terms of increasing yield in agriculture. The future of AI in agricul-ture includes supply chain optimization, task automation, and climate adaptability, boosting food security and sustainability.</p>","PeriodicalId":74644,"journal":{"name":"Recent advances in food, nutrition & agriculture","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143702276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pharmacognostic, GC-MS, and In Silico Molecular Docking Studies of Phytoconstituents from Urtica dioica and Zanthoxylum armatum for Male Antifertility Potential. 雄蕊花和花椒植物成分对雄性抗生育作用的生药学、气相色谱-质谱及硅分子对接研究。
Recent advances in food, nutrition & agriculture Pub Date : 2025-02-25 DOI: 10.2174/012772574X356434250128112359
Swati Wadhawan, Anurag Chaudhary, Sameksha Koul
{"title":"Pharmacognostic, GC-MS, and In Silico Molecular Docking Studies of Phytoconstituents from Urtica dioica and Zanthoxylum armatum for Male Antifertility Potential.","authors":"Swati Wadhawan, Anurag Chaudhary, Sameksha Koul","doi":"10.2174/012772574X356434250128112359","DOIUrl":"https://doi.org/10.2174/012772574X356434250128112359","url":null,"abstract":"<p><strong>Background: </strong>Research on non-hormonal alternatives to traditional methods of male contraception has been prompted by the growing world population as well as the need for effective and reversible treatments. This study aimed to examine the possible antifertility potential of two medicinal herbs, i.e., Urtica dioica and Zanthoxylum armatum, that have been utilized for centuries in different cultures.</p><p><strong>Methodology: </strong>A thorough pharmacognostical analysis was carried out to identify the ingre-dients of these plants. The phytoconstituents from Urtica dioica aqueous 96% methanolic leaf extract and Zanthoxylum armatum fruit essential oil were subjected to in silico molec-ular docking screening. The phytoconstituents were profiled using GC-MS analysis. To in-vestigate how these phytoconstituents interact with important proteins involved in male fer-tility and identify potential candidates for the development of a plant-based oral contracep-tive for men, further in silico molecular docking (receptor protein ID of 7FIH (3.20 Å), 7BPR (1.95 Å), and 2Q7J (1.90 Å) ) experiments were carried out.</p><p><strong>Results: </strong>The GC-MS analysis revealed a wide variety of bioactive chemicals. Promising interactions between the discovered phytoconstituents and specific protein targets were found by the in silico molecular docking investigation, indicating the possibility of antifertil-ity effects.</p><p><strong>Conclusion: </strong>The results of this study demonstrate the medicinal use of these plants and provide the basis for the development of novel male contraceptive medicines and their fur-ther experimental validation.</p>","PeriodicalId":74644,"journal":{"name":"Recent advances in food, nutrition & agriculture","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143517362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
α-Phellandrene: A Promising Natural Remedy for Rotenone-Induced Parkinson's Disease. α-黄檀烯:一种治疗鱼藤酮诱导帕金森病的有前途的天然药物。
Recent advances in food, nutrition & agriculture Pub Date : 2025-01-29 DOI: 10.2174/012772574X341801241218051720
Ravi Kumar, Swamita Arora, Sanjar Alam, Mohammad Rashid, Shivendra Kumar
{"title":"α-Phellandrene: A Promising Natural Remedy for Rotenone-Induced Parkinson's Disease.","authors":"Ravi Kumar, Swamita Arora, Sanjar Alam, Mohammad Rashid, Shivendra Kumar","doi":"10.2174/012772574X341801241218051720","DOIUrl":"https://doi.org/10.2174/012772574X341801241218051720","url":null,"abstract":"<p><p>Parkinson's Disease (PD) is a neurodegenerative disorder characterized by the pro-gressive loss of dopaminergic neurons in the substantia nigra, leading to motor dysfunction and non-motor symptoms. Current treatments primarily offer symptomatic relief without halt-ing disease progression. This has driven the exploration of natural compounds with neuropro-tective properties. In previous studies, α-phellandrene, a monoterpene present in essential oils of various aromatic plants, has shown promise in mitigating neurodegenerative processes. This study focuses on alpha-phellandrene's therapeutic potential in a rotenone-induced Parkinson's Disease model. Rotenone, a mitochondrial complex I inhibitor, is commonly used to induce PD-like symptoms in experimental models due to its ability to mimic the neurodegenerative processes observed in human PD. Our review explores the neuroprotective effects of alpha-phellandrene, focusing on its antioxidant, anti-inflammatory, and anti-apoptotic properties. Experimental groups of rodents received rotenone to induce PD-like symptoms, followed by alpha-phellandrene treatment. Biochemical analyses were performed to measure oxidative stress markers, inflammatory cytokines, and apoptotic signals in brain tissues. Results indi-cated that alpha-phellandrene administration significantly improved motor function and re-duced rotenone-induced oxidative stress, inflammation, and apoptosis in dopaminergic neu-rons. Histopathological examinations revealed a notable preservation of neuronal integrity in alpha-phellandrene-treated groups compared to controls. In conclusion, alpha-phellandrene demonstrates considerable neuroprotective effects in a rotenone-induced Parkinson's dmodel. These findings suggest that alpha-phellandrene could be a promising natural therapeutic agent for PD, warranting further investigation into its mechanisms of action and potential clinical applications. Specifically, our review indicates that alpha-phellandrene may exert neuropro-tective effects by various mechanisms, such as reducing oxidative stress, modulating neuro-transmitter levels, or inhibiting neuroinflammation. These mechanisms highlight its potential to alleviate PD symptoms and slow disease progression, underscoring the need for in-depth studies to validate these therapeutic effects in clinical settings.</p>","PeriodicalId":74644,"journal":{"name":"Recent advances in food, nutrition & agriculture","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143070282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Therapeutic Potential of Plant Phenolic Acids Combating Cancer Drug Resistance. 植物酚酸对抗癌症耐药的治疗潜力。
Recent advances in food, nutrition & agriculture Pub Date : 2025-01-22 DOI: 10.2174/012772574X350275241230053727
Prerana Kapil, Arpan Kumar Tripathi, Rashmi Saxena Pal, Sachin Kumar Singh, Kuldeep Singh, Divya Jain, Mvnl Chaitanya
{"title":"Therapeutic Potential of Plant Phenolic Acids Combating Cancer Drug Resistance.","authors":"Prerana Kapil, Arpan Kumar Tripathi, Rashmi Saxena Pal, Sachin Kumar Singh, Kuldeep Singh, Divya Jain, Mvnl Chaitanya","doi":"10.2174/012772574X350275241230053727","DOIUrl":"https://doi.org/10.2174/012772574X350275241230053727","url":null,"abstract":"<p><p>Despite notable progress in treatment modalities, cancer continues to be a prom-inent cause of death globally. Chemotherapy is the main method used to treat cancer, and chemotherapeutic medications are categorized according to how they work. Nevertheless, the issue of multidrug resistance (MDR) is a significant obstacle, impacting almost 90% of cancer patients who receive chemotherapy or innovative targeted medicines. MDR pro-cesses involve the quick metabolism of foreign substances, the accelerated removal of drugs from cells, the stimulation of growth hormones, the enhancement of DNA repair ability, and the influence of genetic variables. Recent studies have mostly concentrated on studying the anticancer effects of dietary phytoconstituents as a possible remedy for overcoming multidrug resistance (MDR). Various bioactive compounds, such as phenolic acids, phe-nylpropanoids, flavonoids, stilbenes, terpenoids, and organo-sulfur compounds, have shown potential in fighting cancer. It is worth mentioning that a number of phenylpro-panoids are now being tested in clinical trials to evaluate their effectiveness in fighting cancer. This review presents a comprehensive summary of the existing knowledge regard-ing dietary phytoconstituents as possible agents for treating cancer, particularly their ability to overcome MDR. This discussion will focus on the mechanisms by which these com-pounds work, as well as the data from both preclinical and clinical studies. Additionally, we have explored the potential future applications of these compounds in the development of cancer therapeutics.</p>","PeriodicalId":74644,"journal":{"name":"Recent advances in food, nutrition & agriculture","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143026098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biochar Amendment Alleviates the Risk of High-Salinity Saltwater Intrusion for the Growth and Yield of Rice (Oryza sativa L.). 生物炭改良缓解高盐度海水入侵对水稻生长和产量的影响。
Recent advances in food, nutrition & agriculture Pub Date : 2025-01-08 DOI: 10.2174/012772574X351256241129102136
Bualuang Faiyue
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