{"title":"Integrated Network Pharmacology, In Silico Analysis, and Experimental Validation to Reveal Antidiarrheal Activity of Psidium guajava L. Leaf Extract.","authors":"Dipika Rani Sahu, Shrikrishna Mohanta, Abhijit Sahu, Biswajit Samantaray, Pradeep Kumar Naik, Ashirbad Nanda, Satish Kanhar, Biswa Mohan Sahoo","doi":"10.2174/012772574X476738260909075618","DOIUrl":"https://doi.org/10.2174/012772574X476738260909075618","url":null,"abstract":"<p><strong>Introduction: </strong>Psidium guajava L. (guava) is a well-known equatorial plant exploited for food and medicinal purposes. The present study is based on the antidiarrheal activity of the hydroalcoholic extract of its leaves in castor oil-induced diarrhea.</p><p><strong>Methods: </strong>The extract was analysed by GC-MS, and secondary metabolites were identified. The pharmacokinetic analysis and toxicity profiling of the identified components were performed. The network pharmacological analysis was performed to find compound-key target interaction pathways. In silico docking analysis was performed against epidermal growth factor receptor (EGFR) and prostaglandin E receptor 3 (EP3), and ligand binding efficiency was calculated. The diarrheal model was developed by administering castor oil and evaluated antidiarrheal activities using loperamide as a standard drug.</p><p><strong>Results: </strong>GC-MS identified major compounds that were screened for physicochemical properties and toxicity profiling, and network pharmacological pathways were established. GC-MS identified compounds such as α-cubebene, caryophyllene, and ipriflavone, which were computationally docked with key proteins EGFR and ER3.</p><p><strong>Discussion: </strong>The docking study exhibited good binding energy and ligand efficiency. The animals were administered different doses of extracts, and their antidiarrheal effect was appraised via castor oil-induced diarrhea, charcoal meal assay, and the in vivo antidiarrheal index was calculated.</p><p><strong>Conclusion: </strong>Further, histopathological analysis of the ileal tissue of the small intestine was conducted to support its diarrheal protection effect.</p>","PeriodicalId":74644,"journal":{"name":"Recent advances in food, nutrition & agriculture","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149186541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Medication-induced Micronutrient Deficiencies in Early-stage Chronic Kidney Disease.","authors":"Mounika Gunasekaran, Chamundeeswari Duraipandian, Supriya Velraja, Pavithra Krishnamoorthy Baskaran, Jayasurya Ramesh","doi":"10.2174/012772574X431273251217105628","DOIUrl":"https://doi.org/10.2174/012772574X431273251217105628","url":null,"abstract":"<p><strong>Background: </strong>Chronic Kidney Disease (CKD) is a growing global health burden, with early-stage patients often managed through long-term pharmacotherapy. However, prolonged use of common medications may unintentionally disrupt micronutrient balance, compounding the metabolic and cardiovascular risks already present in CKD.</p><p><strong>Objective: </strong>This narrative review aims to explore the associations between frequently prescribed medications and the development of micronutrient deficiencies in early-stage, non-dialysis CKD patients, highlighting underlying mechanisms, clinical implications, and potential management strategies.</p><p><strong>Methods: </strong>Relevant literature published between 2020 and 2025 was identified through structured searches of PubMed, MEDLINE, and the Cochrane Library. Eligible studies included randomized controlled trials, observational cohorts, and prior reviews evaluating the effects of medications on micronutrient status in CKD stages 1-3. Evidence was narratively synthesized according to medication class, nutrient affected, and reported clinical outcomes.</p><p><strong>Results: </strong>Approximately 30-35 key studies were included. Phosphate binders, diuretics, antihypertensives, proton pump inhibitors, and immunosuppressants were most commonly associated with disruptions in vitamin D, iron, vitamin B12, calcium, and magnesium metabolism. These imbalances may contribute to anemia, mineral bone disorder, cardiovascular complications, and immune dysfunction in early CKD.</p><p><strong>Discussion: </strong>These findings suggest that medication-induced micronutrient disturbances may act as modifiable contributors to anemia, mineral-bone disorder, cardiovascular risk, and immune dysfunction in early-stage CKD. Routine nutritional monitoring alongside pharmacotherapy may therefore represent an important preventive strategy.</p><p><strong>Conclusion: </strong>Medication-induced micronutrient deficiencies represent a clinically relevant yet underrecognized challenge in CKD management. The findings of this review are hypothesisgenerating and underscore the need for systematic, longitudinal research to establish causal pathways and inform evidence-based supplementation guidelines. Integrating nutritional monitoring into pharmacologic care may improve outcomes in early-stage CKD.</p>","PeriodicalId":74644,"journal":{"name":"Recent advances in food, nutrition & agriculture","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149168637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Unveiling the Phytoconstituents and Health Benefits of Carica papaya L.: From Traditional Medicine to Modern Therapeutics.","authors":"Pawan Kumar Goswami, Saloni Kumari, Qumar Negar, Arvind Kumar Patel, Neha Singh, Dharmendra Kumar","doi":"10.2174/012772574X457422260907105614","DOIUrl":"https://doi.org/10.2174/012772574X457422260907105614","url":null,"abstract":"<p><strong>Introduction: </strong>The tropical plant Carica papaya L., which is a member of the Caricaceae family, is well known for its medicinal and nutritional qualities. The plant's leaves, fruits, seeds, and latex have all historically been used to treat inflammatory diseases, cancer, metabolic abnormalities, and infections. The objective of this review is to provide a thorough overview of the phytochemical composition, pharmacological activity, mechanisms of action, and clinical evidence that support its potential for therapeutic use.</p><p><strong>Methods: </strong>Based on a thorough evaluation of the literature, this work is a narrative review. Electronic databases such as PubMed, Scopus, ScienceDirect, Web of Science, and Google Scholar were used to conduct a thorough search. Based on predetermined inclusion and exclusion criteria, pertinent peer-reviewed publications, including experimental research, clinical trials, and ethnomedical reports, were selected. The following keywords were used: phytochemistry, pharmacological activity, mechanisms of action, and Carica papaya. An integrative assessment of its therapeutic potential was produced by rigorously analysing and synthesizing the extracted data.</p><p><strong>Results: </strong>Alkaloids (carpaine), flavonoids (quercetin, kaempferol), phenolic acids, and enzymes (papain, chymopapain) are among the many bioactive substances found in Carica papaya. These substances have a variety of pharmacological actions, such as immunomodulatory, antiinflammatory, antioxidant, anticancer, antibacterial, and antidiabetic properties. Mechanistically, they reduce oxidative stress and inflammation by modulating important molecular pathways such as NF-κB, MAPK, and COX-2. Clinical research indicates that leaf extracts may have positive effects, especially in dengue-associated thrombocytopenia. High-dose seed extracts, however, could be harmful.</p><p><strong>Discussion: </strong>Carica papaya's extensive phytochemical profile and capacity to control important molecular pathways involved in oxidative stress and inflammation are responsible for the vast range of pharmacological activity seen in this plant. Its promise as a therapeutic agent is highlighted by the merging of ancient knowledge with contemporary pharmacological research, particularly in infectious and inflammatory illnesses.</p><p><strong>Conclusion: </strong>Carica papaya shows great promise as a nutraceutical and phytotherapeutic agent. Even though there is encouraging experimental and clinical evidence, more carefully planned research is needed to determine uniform dosages, long-term safety, and clinical efficacy for its wider therapeutic application.</p>","PeriodicalId":74644,"journal":{"name":"Recent advances in food, nutrition & agriculture","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149083277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Akshita Giri, Soubhik Bhattacharyya, Dhrubajyoti Sarkar, Ashim Kumar Sen, Vinod Kumar Gauttam, Swarupananda Mukherjee, Bhaskar Das
{"title":"Ethnobotanical, Phyto-pharmacological, and Bio-economic Prospects of Phyllostachys edulis (Carrière) J.Houz.: Review of Recent Advances.","authors":"Akshita Giri, Soubhik Bhattacharyya, Dhrubajyoti Sarkar, Ashim Kumar Sen, Vinod Kumar Gauttam, Swarupananda Mukherjee, Bhaskar Das","doi":"10.2174/012772574X495894260902101643","DOIUrl":"https://doi.org/10.2174/012772574X495894260902101643","url":null,"abstract":"<p><strong>Background: </strong>Phyllostachys edulis (Carrière) J.Houz. (Moso bamboo) has historically been recognised as a structural timber resource (\"Green Gold\"), overshadowing its significant potential as a reservoir of therapeutic bioactive compounds. This review aims to thoroughly integrate current knowledge on phytochemistry, pharmacological mechanisms of action, safety issues, and agricultural and industrial aspects to identify future research areas.</p><p><strong>Methods: </strong>The literature search was conducted across five major databases (PubMed, ScienceDirect, Google Scholar, ResearchGate, and Semantic Scholar) covering the period from January 2019 to December 2025. Following rigorous screening of 630 initial records, 101 primary studies that met strict inclusion criteria for phytochemical characterisation and molecular pharmacology were synthesised. Important articles published before 2019 were included to provide essential background and context.</p><p><strong>Results: </strong>Phytochemical analysis reveals a unique radial metabolite gradient, dominated by stable flavone C-glycosides (isoorientin, vitexin) and immunomodulatory polysaccharides (BSDF-1). Mechanistic evidence supports their efficacy in regulating metabolic syndrome via the PI3K/Akt signalling axis and in mitigating chronic inflammation by suppressing the NLRP3 inflammasome. Additionally, novel sterol derivatives isolated from shoot residues exhibit significant cytotoxicity against the MCF-7 breast cancer cell line.</p><p><strong>Discussion: </strong>Clinical translation is currently impeded by the poor oral bioavailability of Cglycosides and the species' capacity for heavy metal bioaccumulation (Pb, Cd) in polluted soils.</p><p><strong>Conclusion: </strong>P. edulis represents a validated therapeutic bioresource with distinct advantages in metabolic and neuroprotective interventions. Future utilisation must prioritise the development of nano-delivery systems to overcome bioavailability barriers, the implementation of rigorous heavy metal monitoring to ensure safety within a circular bioeconomy, and well-designed clinical studies, pharmacokinetic optimisation, standardisation of bioactive constituents, and advanced drugdelivery strategies to facilitate clinical translation.</p>","PeriodicalId":74644,"journal":{"name":"Recent advances in food, nutrition & agriculture","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149013337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Phytochemical-Integrated Nanoparticles and AI-Enabled Delivery Systems for Biomedical, Agricultural, and Environmental Applications: Current Advances and Future Perspectives.","authors":"Sourav Kole, Hindol Chakraborty, Suman Sahu, Rituparna Saha, Kuntal Manna, Soumitra Sahana, Siddheswar Maiti, Sonjit Das","doi":"10.2174/012772574X481602260829082630","DOIUrl":"https://doi.org/10.2174/012772574X481602260829082630","url":null,"abstract":"<p><p>The combination of phytochemicals, nanotechnology, and data-centric engineering is changing sustainable innovation in healthcare, agriculture, and ecological consciousness. This review combines progress in phyto-nanotechnology, emphasising bioprocessing techniques such as hairy root and plant cell cultures for the scalable development of plant-derived nanomaterials. The green synthesis of nanoparticles (NPs) using plant extracts delivers sustainable and environmentally friendly alternative methods to the conventional procedures and enhances the biological efficacy of NPs. The applications of phyto-engineered nanomaterials are critically reviewed here. These include oncology, where they act as targeted drug-delivery systems with theranostic potential; agriculture, for crop yield enhancement through nutrient delivery and nanopesticides; and environmental management, for remediation of contamination. This review also highlights the importance of multidisciplinary collaboration and artificial intelligence (AI) for the design and evaluation of different plant-derived NPs. Predictive modelling and digital twins are the most important technologies for efficiency and safety. Subsequently, community involvement and ethical considerations are still needed to promote sustainable innovation and regulatory compliance, which are currently lacking in this field.</p>","PeriodicalId":74644,"journal":{"name":"Recent advances in food, nutrition & agriculture","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148946095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Raúl Gonzalez Belo, Maria Paula Laserna, Daniel Latorre Marrero, Natalia Gabriela Izquierdo
{"title":"Integrating Protein and Residual Dynamics: Understanding Low Oil Concentration at Elevated Source/Sink Ratios in Sunflower.","authors":"Raúl Gonzalez Belo, Maria Paula Laserna, Daniel Latorre Marrero, Natalia Gabriela Izquierdo","doi":"10.2174/012772574X482327260828111935","DOIUrl":"https://doi.org/10.2174/012772574X482327260828111935","url":null,"abstract":"<p><strong>Introduction/objective: </strong>To evaluate the effect of the source/sink (S/S) ratio on oil and protein accumulation dynamics in sunflower and its impact on final grain composition.</p><p><strong>Methods: </strong>Field experiments (2012-2014) in Balcarce used three hybrids with S/S ratios modified through defoliation and grain thinning. Oil (NMR) and protein (NIR) contents were measured. Accumulation rates and durations were analyzed using linear-plateau models based on thermal time.</p><p><strong>Results: </strong>High S/S ratios increased protein concentration (from 12.6% to 20.4%) but reduced oil concentration. While oil accumulation ceased around 500°Cd, protein accumulation continued until 800°Cd. Protein accumulation rates were significantly higher with increased assimilate availability than in the control and defoliated treatments.</p><p><strong>Discussion: </strong>Protein synthesis was less sensitive to defoliation than oil, suggesting independent regulatory mechanisms. The protein increases at high S/S ratios, resulting from both higher accumulation rates and extended periods, likely influenced by sucrose signaling. The data refute a simple 1:1 trade-off between oil and protein.</p><p><strong>Conclusion: </strong>Sunflower grain composition involves variations in \"residual\" components like fiber and carbohydrates. Breeding to reduce this residual fraction could simultaneously enhance oil and protein content, optimizing the industrial quality of both oil and protein meals.</p>","PeriodicalId":74644,"journal":{"name":"Recent advances in food, nutrition & agriculture","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148945990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Anwarbaig C Mirza, Shital S Panchal, Milan Satia, Sanjay N Mandhane, Mohammad Abuzar, Ziyaul Haque
{"title":"Recent Comparative Advances in the Mechanistic Actions and Translational Relevance of Syringic Acid and Vanillic Acid for Oxidative Stress-Associated Disorders.","authors":"Anwarbaig C Mirza, Shital S Panchal, Milan Satia, Sanjay N Mandhane, Mohammad Abuzar, Ziyaul Haque","doi":"10.2174/012772574X469463260728053407","DOIUrl":"https://doi.org/10.2174/012772574X469463260728053407","url":null,"abstract":"<p><strong>Introduction: </strong>Vanillic acid and syringic acid are structurally similar phenolic acids reported to possess significant anti-inflammatory and antioxidant activities. Despite their therapeutic evidence, comparative evaluations of these agents based on molecular mechanisms, pharmacokinetic profiles, and translational potential remain unexplored.</p><p><strong>Method: </strong>A comprehensive literature search was conducted to discover in vitro, in vivo, and in silico studies on syringic acid and vanillic acid by using various search engines such as Pub- Med, Scopus, Web of Science, Google Scholar, and ScienceDirect. Peer-reviewed literature claiming dietary or botanical sources, molecular mechanisms, pharmacokinetics, and structureactivity relationships was included, whereas research not specifically focusing on these compounds was excluded. Scientifically valid data were analyzed and qualitatively examined to compare both their biological function and therapeutic potential.</p><p><strong>Results: </strong>Syringic acid and vanillic acid exhibit diverse pharmacological actions, preclinical safety, and regulatory acceptability. Available evidence suggests that syringic acid may possess a desirable bioavailability profile with metabolic, vascular, and antioxidant effects, whereas vanillic acid has been reported to exhibit significant anti-inflammatory and antidiabetic effects. Further, syringic acid may be more appropriate for metabolic abnormalities and acute inflammatory conditions, while vanillic acid will be a promising therapeutic agent in hepatic, renal, neurological, and cardiometabolic disorders.</p><p><strong>Conclusion: </strong>Syringic acid and vanillic acid exhibit significant therapeutic potential owing to diverse pharmacological activities. However, their clinical translation remains limited due to challenges in formulation design, poor bioavailability, and incomplete mechanistic understanding. Future research must focus on advanced drug delivery systems, detailed molecular mechanisms, and well-designed clinical trials to establish them as effective, evidence-based therapeutic agents for human disorders.</p>","PeriodicalId":74644,"journal":{"name":"Recent advances in food, nutrition & agriculture","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148809594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jerry Junior Rama, Devina David, Ahmad Asnawi Bin Mus, Nor Azizun Binti Rusdi, Jualang Azlan Gansau, Syahriel Abdullah, Chong Khim Phin, Lucky Goh Poh Wah
{"title":"Trichoderma as a Sustainable Plant Growth Promoter: Mechanisms of IAA Production, Phosphate Solubilization, and Siderophore Activity.","authors":"Jerry Junior Rama, Devina David, Ahmad Asnawi Bin Mus, Nor Azizun Binti Rusdi, Jualang Azlan Gansau, Syahriel Abdullah, Chong Khim Phin, Lucky Goh Poh Wah","doi":"10.2174/012772574X404768251205142703","DOIUrl":"https://doi.org/10.2174/012772574X404768251205142703","url":null,"abstract":"<p><p>The growing global population and rising food demand have intensified reliance on chemical fertilizers, leading to soil degradation, environmental pollution, and heavy metal accumulation. As a sustainable alternative, Trichoderma spp. have gained prominence as bioinoculants due to their diverse plant growth-promoting abilities. However, emerging evidence highlights strain-specific variability and regulatory complexity in their beneficial traits, aspects that remain insufficiently addressed in current literature. This review explores the molecular basis of three key mechanisms: (i) indole-3-acetic acid (IAA) biosynthesis through indole-3-pyruvic acid (IPA), indole-3-acetamide (IAM), and tryptophan-independent pathways; (ii) phosphate solubilization mediated by phytase, phosphatase, and organic acid production; and (iii) iron (Fe) acquisition through siderophore production, primarily synthesized by nonribosomal peptide synthetases (NRPSs). Not all Trichoderma species exhibit the full spectrum of plant growth-promoting traits; while some are efficient in phosphate solubilization, others may primarily contribute through IAA production or siderophore production. Genomic and bioinformatic studies have revealed that T. atroviride, T. asperellum, T. virens, T. harzianum, T. citrinoviride, T. reesei, T. longibrachiatum, and T. koningiopsis harbor putative genes encoding proteins homologous to enzymes associated with IAA production, such as flavin monooxygenase and indoleamine-2,3-dioxygenase, as well as genes involved in siderophore production, including sidA, sidF, sidL, sidC, sidD, and sidG. However, the genetic and regulatory mechanisms underlying IAA production and phosphate solubilization in Trichoderma remain poorly characterized, with limited genomic information available on genes encoding auxin-related enzymes, phytases, acid phosphatases, and those involved in organic acid biosynthesis. These findings highlight the importance of targeted molecular research to support the development of strain-specific bioformulations that enhance nutrient use efficiency, reduce chemical inputs, and advance sustainable agricultural practices.</p>","PeriodicalId":74644,"journal":{"name":"Recent advances in food, nutrition & agriculture","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148400114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"From Plate to Platform: Food Waste Valorization into Biodegradable Delivery Systems for Sustainable Health and Nutrition.","authors":"Ayush Mor, Shikha Baghel Chauhan","doi":"10.2174/012772574X483729260606202426","DOIUrl":"https://doi.org/10.2174/012772574X483729260606202426","url":null,"abstract":"<p><strong>Objective: </strong>The rapidly growing phenomenon of food waste worldwide is a major cause of environmental concern; however, it represents a sustainable source of useful biomolecules. This review highlights the possibility of using agro-food waste products as a renewable source of environmentally friendly, biocompatible, and biodegradable materials for the production of delivery systems.</p><p><strong>Methods: </strong>A review of the latest developments in the fabrication of delivery systems from food waste was performed. Particular attention was paid to sustainable processing methods, namely enzyme-assisted extraction, supercritical CO₂ extraction, and deep eutectic solvents extraction. Moreover, different types of delivery systems, such as nanoparticles, hydrogels, 3D printing technology, capsules, and microneedles, have been considered.</p><p><strong>Results: </strong>The food waste-based polymer materials exhibited high encapsulation efficiencies (70- 95%) and increased bioavailability (1.8-3.5 fold) with a controlled drug release rate for 24-72 hours. The nanocarriers and hydrogels increased the gut retention and wound healing rates by 30-45%, retained the probiotics at 10⁸ CFU/g, and extended shelf-life through active packaging. Furthermore, they provided 40-70% reductions in carbon footprint and biodegradability of 90% within several months.</p><p><strong>Discussion: </strong>The study results reveal that food waste conversion into value-added polymers has potential for creating both economic and ecological benefits.</p><p><strong>Conclusion: </strong>The developed polymers from food waste materials are promising and ecofriendly alternatives compared to traditional polymer materials. Standardization, regulation compliance, and development of environmentally friendly production processes will play key roles in promoting these polymers.</p>","PeriodicalId":74644,"journal":{"name":"Recent advances in food, nutrition & agriculture","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148304264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Impact of Natural Antioxidants on the Chemical Stability of Corn Oil During Deep Frying.","authors":"Tamany Alanezi, Namariq Dhahir, Amer AbuGhazaleh","doi":"10.2174/012772574X449791260605095629","DOIUrl":"https://doi.org/10.2174/012772574X449791260605095629","url":null,"abstract":"<p><strong>Introduction/objective: </strong>Reusing frying oils increases the level of oxidation products while decreasing the healthiness and quality of the frying oils. One way to improve the oxidative stability of frying oils is to use them in combination with oils rich in natural antioxidants. The aim of this study was to evaluate how enriching refined corn oil with antioxidant-rich oils affected the corn oil's behavior during deep frying over an extended period.</p><p><strong>Methods: </strong>Refined Corn Oil (COO) was blended with Black Seed Oil (BSO), Blackberry Oil (BBO), Sesame Oil (SSO), Extra Virgin Olive Oil (EVOO), and Pomegranate Oil (PMO) in a proportion of 85:15 (v/v) to obtain five blends (COO/BSO, COO/BBO, COO/SSO, COO/EVOO, COO/PMO). Each oil was used to deep-fry falafel (frying temperature: 175 ± 5 °C for 20 minutes per cycle, 36 cycles) over 12 hours. Acid Value (AV), Peroxide Value (PV), p-Anisidine Value (p-AV), total oxidation value (TOTOX), Free Fatty Acids (FFA), Fatty Acid Profile (FAP), Total Polar Compounds (TPC), and viscosity were determined. The samples were collected after the last frying cycle and stored at -20 °C until analysis.</p><p><strong>Results: </strong>All oil blends had significantly lower values of oxidation indicators (PV, p-AV, TOTOX), FFA, and TPC than corn oil. The most significant reductions in oxidation values, TPC, and FFA were observed in the olive, pomegranate, and sesame oil blends. Based on TOTOX values, oliveand pomegranate-based blends showed the highest oxidative resistance. Deep frying reduced C18:2 and C18:3 and increased trans-C18:1 in all studied samples. The least degradation of FAP was found in the olive and pomegranate blends.</p><p><strong>Discussion: </strong>Enrichment of corn oil with naturally antioxidant-rich oils may slow oxidative processes during deep frying and reduce the degradation of polyunsaturated fatty acids. The highest protective effect was observed for the pomegranate and extra virgin olive oil blends.</p><p><strong>Conclusion: </strong>Enrichment of corn oil with pomegranate or extra virgin olive oil significantly improved its oxidative stability during deep frying.</p>","PeriodicalId":74644,"journal":{"name":"Recent advances in food, nutrition & agriculture","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148229220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}