Recent advances in anti-infective drug discovery最新文献

{"title":"Synthesis, Molecular docking and In-Vitro Antimycobacterial Studies on N'-arylidene-4-nitrobenzohydrazides.","authors":"D. Bhosale, Suraj N. Mali, B. Thorat, Swati S Wavhal, D. Bhagat, R. M. Borade","doi":"10.2174/1570193X19666220531154544","DOIUrl":"https://doi.org/10.2174/1570193X19666220531154544","url":null,"abstract":"BACKGROUND\u0000Mycobacterium tuberculosis (Mtb) is the organism that causes tuberculosis to develop (TB). In 2019, 10 million individuals worldwide contracted tuberculosis, with 1.4 million people dying from the disease each year (World Health Organization, 2021). Hydrazones-hydrazide-based drugs have been shown to be bactericidal against M. tuberculosis replication.\u0000\u0000\u0000OBJECTIVES\u0000We herein intended to synthesize a series of acid hydrazones (3a-3l) by condensing 4-nitrobenzohydrazine with substituted aromatic acids in ethanol at room temperature.\u0000\u0000\u0000MATERIALS AND METHODS\u0000All newly synthesized compounds were characterized by standard spectroscopic techniques. Synthesized compounds were then tested for anti-mycobacterial analysis, H37Rv strains. Molecular docking analysis was performed for three crystal structures of 1ENY, 1TED and 2FUM Mycobacterium tuberculosis receptors.\u0000\u0000\u0000RESULTS\u0000Among all tested molecules, 3i (MIC: 50 μg/mL) and 3b (MIC: 50 μg/mL) were found to best ligands for further development of new anti-TB drug. We noticed that our proposed molecules were having higher docking scores that corresponding standard anti-TB agents such as Ciprofloxacin and Isoniazid. Synthesized compounds were found to have Drug-Likeness properties when tested with Lipinski's filter for drug-likeness.\u0000\u0000\u0000CONCLUSION\u0000From our current study, we wish to propose N'-arylidene-4-nitrobenzohydrazides as anti-TB agents. Agents with such system can be developed in future for developments into active lead molecules.","PeriodicalId":74643,"journal":{"name":"Recent advances in anti-infective drug discovery","volume":"55 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82837193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mapping of new pharmacological alternatives in the face of the emergence of antibiotic resistance in COVID-19 patents treated for opportunistic respiratory bacterial pathogens.","authors":"A. M. Santos, Mariana Mendonça Santos, José Adão Carvalho Nascimento Júnior, João Rafael Lisboa Rêgo Brito, Tatianny de Araújo Andrade, L. Frank, M. Serafini","doi":"10.2174/1574891X16666220518142347","DOIUrl":"https://doi.org/10.2174/1574891X16666220518142347","url":null,"abstract":"BACKGROUND\u0000The worldwide pandemic fought by COVID-19 could emerge another type of pandemic, the increase in bacterial resistance against antibiotics. Emergency treatment based on antibioticsis a major influence in increasing this resistance. Bacteria, such as Klebsiella pneumoniae, are most affected by the indiscriminate use of antibiotics since they are resistant to most antibiotics currently available on the market.\u0000\u0000\u0000OBJECTIVE\u0000This review aimed to evaluate patents of new drugs and formulations, for the treatment of infections caused by Klebsiella pneumoniae.\u0000\u0000\u0000METHODS\u0000The present patent review was carried out through a specialized search database Espacenet. The selection was based on the criteria of patents published from 2010 to May 2021, in any language, and containing the keywords in title or abstract. Also, a research was performed on the PubMed database, using the inclusion criteria.\u0000\u0000\u0000RESULTS\u0000Twenty-two patents were selected for the analysis according to the aim of the study. The advance of new patents has been mostly seen in World Intellectual Property Organization, China, and United States. The results showed that the main approach was the drug association, followed by drug carriers, new isolated products, and vaccines.\u0000\u0000\u0000CONCLUSION\u0000It has been observed that few studies use new drug alternatives for the treatment, probably due to the higher cost of the development and lack of investments. The effectiveness and safety of these therapies depend on the acceptance, the correct prescription, and rational use of medicines. Therefore, this review can further develop new treatments as alternatives against Klebsiella pneumoniae and pneumonia caused by it.","PeriodicalId":74643,"journal":{"name":"Recent advances in anti-infective drug discovery","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79598936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New Frontier in Drugs for Antivirals in Disorders of The Respiratory System.","authors":"Hai-long Zhang, Yongxia Li, Ai-Feng Zhou, Yiqian Li","doi":"10.2174/1574891X16666220416164740","DOIUrl":"https://doi.org/10.2174/1574891X16666220416164740","url":null,"abstract":"BACKGROUND\u0000COVID-19 is still soaring around the world, and the new delta COVID-19 variant is on the rise and spreading around the world.\u0000\u0000\u0000OBJECTIVE\u0000to show development of therapeutic strategy of antiviruses in drugs for antivirals in disorders of the respiratory system, we conduct patent analysis surrounding drugs for antivirals in disorders of the respiratory system.\u0000\u0000\u0000MATERIALS AND METHOD\u0000European granted patents filed from January 2002 to June 2021 were analyzed. We use a combination of International patent classification (IPC) \"A61p31/12\" (antivirals) and \"A61p11/00\" (drugs for disorders of the respiratory system) to identify relevant European patent documents.\u0000\u0000\u0000RESULTS\u0000Our study showed that R&D of drugs for antivirals in disorders of the respiratory systems was decreasing over past 20 years. Chemical drugs show more variety in structures and no a common feature for this drug development. The chemical drugs or herbal medicines were much earlier appeared than biological products in research and development. In addition, large global companies play a leading role in developing kinase inhibitors as chemical drugs.\u0000\u0000\u0000CONCLUSION\u0000There are three strategies for developing drugs for antivirals in disorders of the respiratory system, including chemical drugs, herbal medicines or natural products, and biological products. Herbal medicines may provide a new insight and approach for developing drugs for antivirals in disorders of the respiratory system. A combination of chemical drugs and natural products may be a therapeutic method for treating patients with COVID-19.","PeriodicalId":74643,"journal":{"name":"Recent advances in anti-infective drug discovery","volume":"55 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78328659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Meet the Editorial Board Member","authors":"S. Ghafourian","doi":"10.2174/277243441701220830144428","DOIUrl":"https://doi.org/10.2174/277243441701220830144428","url":null,"abstract":"<jats:sec>\u0000<jats:title />\u0000<jats:p />\u0000</jats:sec>","PeriodicalId":74643,"journal":{"name":"Recent advances in anti-infective drug discovery","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81474987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Herbal Phytomedicine 'Irisolidone' in chronic diseases: Biological Efficacy and pharmacological activity.","authors":"D. Patel","doi":"10.2174/1574891x16666220304231934","DOIUrl":"https://doi.org/10.2174/1574891x16666220304231934","url":null,"abstract":"BACKGROUND\u0000Plant derived products have been used in the medicine as a source of bioactive molecules due to its therapeutic potential. Nowadays plants derived products have been used for the development of novel drug leads. Polyphenols are an important class of secondary metabolites found to be present in plant material and their derived products. Polyphenols are having an important role in the nutrition for human beings. It also has a significant role in plant resistance against pests and diseases. Scientific studies have proven the biological importance of flavonoids in medicine and other allied health sectors. Anti-oxidant, analgesic, anti-microbial, anti-inflammatory, anti-viral, anti-tumor and anti-allergic activities are the important pharmacological features of flavonoids. Irisolidone is an important isoflavone found to be present in Pueraria lobata flowers.\u0000\u0000\u0000METHODS\u0000In order to know the medicinal importance and therapeutic benefit of irisolidone, numerous scientific research data have been collected from Google, Google Scholar, PubMed, Science Direct and Scopus. Pharmacological activities scientific data of irisolidone has been collected and analyzed in the present works to know the health beneficial aspects of irisolidone. Detailed pharmacological activities of irisolidone have been investigated through scientific data analysis of scientific research works.\u0000\u0000\u0000RESULTS\u0000Scientific research data analysis of irisolidone revealed the anti-inflammatory, anti-angiogenic, anti-cancer, anti-platelet, anti-oxidant, anti-hyperlipidemic, immunomodulating, hepatoprotective and estrogenic activities. However biological effect of irisolidone on gastric system, aldose reductase enzymes, malignant gliomas and JC virus has been also investigated. Scientific data analysis revealed the significance of analytical tools for separation and identification of irisolidone.\u0000\u0000\u0000CONCLUSION\u0000Present work signified the biological importance and therapeutic potential of irisolidone in the medicine.","PeriodicalId":74643,"journal":{"name":"Recent advances in anti-infective drug discovery","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89670912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Structural Insights and Pharmaceutical Relevance of Plumbagin in Parasitic Disorders: A Comprehensive Review.","authors":"Amrat Pal Singh,&nbsp;Alok Sharma","doi":"10.2174/2772434417666220905121531","DOIUrl":"https://doi.org/10.2174/2772434417666220905121531","url":null,"abstract":"<p><p>Recently, natural products have been became the center of attraction for the scientific society and exploration of their biologically abilities is proceeding continuously. In search for novel antiparasitic agents with an objective of protecting humans from parasitic infections, the present work was focused on naphthoquinones possessing antiparasitic activity. Among naphthoquinones, plumbagin is one of the secondary metabolites exhibiting diverse biological properties such as antibacterial, antimalarial, antiinflammatory, insecticidal and antiparasitic. Plumbagin is reported to have antischistosomiasis, anti-haemonchosis, anti-fascioliasis, antiotoacariasis, anti-leishmaniasis, antimalaria, antiallergic and anthelmintic activities. Besides, various methods of extraction of plumbagin from different methods, their effectiveness against different parasites, and the structure-activity relationship reported by different researchers. This work highlight on recent advancements in the phytochemistry of plumbagin, studies associated with various biological activities. The structure-activity relationship studies have also been summarized. To conclude, present review could be beneficial for the scientific community to get better insight into medicinal research of plumbagin and may provide a new horizon for the rational design of plumbagin based compounds.</p>","PeriodicalId":74643,"journal":{"name":"Recent advances in anti-infective drug discovery","volume":"17 3","pages":"187-198"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10394754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Medicinal Importance, Pharmacological Activities, and Analytical Aspects of Strictinin: A Mini-Review.","authors":"Dinesh Kumar Patel","doi":"10.2174/2772434417666220628153913","DOIUrl":"https://doi.org/10.2174/2772434417666220628153913","url":null,"abstract":"<p><strong>Background: </strong>Plants and their derived products have been used in history as food and medicine. Plant materials are rich sources of fiber, minerals, vitamins, and bioactive phytochemicals, which are useful for human beings. Strictinin is an important phytoconstituent of green tea.</p><p><strong>Methods: </strong>Present work mainly focuses on the biological importance, therapeutic potential, and pharmacological activities of strictinin in medicine. Numerous scientific data have been collected from various literature databases such as Google Scholar, Science Direct, PubMed, and Scopus database in order to realize the health beneficial potential of strictinin. Pharmacological data has been collected and analyzed in the present work to find the effectiveness of strictinin against human disorders and complications. Analytical data of strictinin has been also collected and analyzed in the present work.</p><p><strong>Results: </strong>Scientific data analysis revealed the biological importance of strictinin in medicine. Scientific data analysis signified the therapeutic benefit of strictinin mainly due to its anticancer, antimicrobial, antibacterial, antiviral, and antioxidant activity. However, enzymatic activities, cytotoxicity, effectiveness on skin disorders, and osteogenic potential of strictinin have also been discussed. Analytical data revealed the importance of modern analytical techniques in medicine for the separation, identification, and isolation of strictinin.</p><p><strong>Conclusion: </strong>Present work signified the biological importance and therapeutic benefits of strictinin in medicine and other allied health sectors.</p>","PeriodicalId":74643,"journal":{"name":"Recent advances in anti-infective drug discovery","volume":" ","pages":"86-94"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40406437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COVID-19: An Update.","authors":"Prasan Kumar Panda","doi":"10.2174/277243441703221110102821","DOIUrl":"https://doi.org/10.2174/277243441703221110102821","url":null,"abstract":"<jats:sec>\u0000<jats:title />\u0000<jats:p />\u0000</jats:sec>","PeriodicalId":74643,"journal":{"name":"Recent advances in anti-infective drug discovery","volume":"17 3","pages":"158"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10403843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparing India's Second COVID Wave with the First Wave-A Single-Center Experience.","authors":"Mayank Kapoor,&nbsp;Budha O Singh,&nbsp;Prasan Kumar Panda,&nbsp;Pathik Dhanger,&nbsp;Anant Kataria","doi":"10.2174/2772434417666220628153110","DOIUrl":"https://doi.org/10.2174/2772434417666220628153110","url":null,"abstract":"<p><strong>Background: </strong>The COVID-19 pandemic has resurfaced in India as a hardhitting second wave. This study aims to compare the clinical profile of the first wave (April-June 2020) and the second wave (March-May 2021) of the severe acute respiratory syndrome coronavirus-2 pandemic (SARS-CoV-2) in a single tertiary care center in India.</p><p><strong>Methods: </strong>In this retrospective observational study, we examined the demographic profile, symptoms at presentation, severity of illness, baseline investigations, treatments received, underlying comorbidities, and outcomes of the COVID-19 patients belonging to the first (W1) and the second wave (W2) of the pandemic in India.</p><p><strong>Results: </strong>The age group affected most in the W2 is 50.5 (17.7) versus 37·1 (16·9) years for W1. The baseline oxygen saturation is lower in W2, being 84·0 (13·4) % compared with 91·9 (7·4) % in W1 [SpO2 < 90% OR 14.3 (6.1-33), P < 0.0001]. 70.2 % of the cases belonged to the severe category in W2 compared to 37.5% in W1. W2 has worse outcomes. Incidence of acute respiratory distress syndrome (ARDS) [48.7% v/s 6.45%; OR 15.4 (6.5-35.7), P<0.0001], Acute Kidney Injury (AKI) [18% v/s 2.4%; OR 6 (1.7- 22.2), P = 0.005], Acute Liver Injury (transaminitis) [12.8% v/s 6.4%, OR 7.3 (3.7- 14.3), P < 0.0001], and deaths (29% v/s 9.6%, standardized mortality ratio 3.5) is higher in W2. Similarly, the CT severity score for W2 [29.5 (6.7)] was higher than W1 [23·2 (11·5), P < 0.05]. The proportion of patients requiring oxygen [81.8% v/s 11.2%; OR 125 (40-333.3), P < 0.0001], high flow nasal cannula (HFNC) (11.4% v/s 5.6%), Non- Invasive Ventilation (NIV) (41.2% v/s 1.5%), invasive ventilation [24.5% v/s 0.9%; OR 22.72 (2.94-166.6), P = 0.003], as well as ICU/HDU admissions [56.4% v/s 12.0%; OR 10.5 (5.3-21.2), P < 0.0001] was higher for W2 as compared with W1. Cough, invasive ventilation, inotrope requirement, and ARDS are significantly related to higher mortality in the W2 than W1.</p><p><strong>Conclusion: </strong>Higher age, oxygen requirement, ventilator requirement, ICU admission, and organ failure are more prevalent in the admitted COVID-19 cases during the second wave that hit India than in the first wave and are associated with more fatalities. Strategy for another wave should be planned accordingly.</p>","PeriodicalId":74643,"journal":{"name":"Recent advances in anti-infective drug discovery","volume":"17 3","pages":"178-186"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10369651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COVID-19 Infection After Vaccination Among Healthcare Workers at a Tertiary Level Health Care Center in Northern India: A Cross-Sectional Study.","authors":"Nandita Sharma,&nbsp;Mahendra Singh,&nbsp;Pradeep Aggarwal,&nbsp;Yogesh Bahurupi,&nbsp;P K Panda,&nbsp;Gaurika Saxena","doi":"10.2174/2772434417666221011095128","DOIUrl":"https://doi.org/10.2174/2772434417666221011095128","url":null,"abstract":"<p><strong>Background and aims: </strong>COVID-19 vaccines are now accessible to all Indian citizens. Infection with COVID-19, on the other hand, continues to spread constantly. Our study aimed to determine the number of persons who had COVID-19 infections despite receiving the recommended number of doses of the COVID-19 vaccination at AIIMS Rishikesh, a tertiary care facility in Uttarakhand, India.</p><p><strong>Methods: </strong>We analysed meticulously preserved data regarding COVID-19 vaccination, COVID-19 infection, clinical symptoms, and RT-PCR testing among all HCWs in our healthcare institution from 16 January 2021 to 30th June 2021.</p><p><strong>Results: </strong>During this period, 5273 (90.3%) HCWs received two doses of the COVID-19 vaccine, while 566 (9.7%) received only one dose. 628 HCWs (10.8%) were BBV152 recipients and 5211 (89.2%) were AZD1222 (ChAdOx1-S) recipients. 423 HCWs (7.2%, confidence interval of 95% - 13.8, 22.0) reported COVID-19 infections. 274 (5.19% of total vaccinated HCWs) breakthrough infections and 149 non-breakthrough COVID-19 infections were reported in HCWs who had previously received a single dose of the COVID-19 vaccination.</p><p><strong>Conclusion: </strong>Viral infections, especially breakthrough infections, following adequate vaccination, are a cause for concern, but there is a lack of data on these infections in the actual world. Therefore, the primary focus of research should be on the emergence of illness in India following the completion of a full vaccine course.</p>","PeriodicalId":74643,"journal":{"name":"Recent advances in anti-infective drug discovery","volume":"17 3","pages":"223-231"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10385892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}