Recent advances in anti-infective drug discovery最新文献

{"title":"Revolutionising Wound Healing: Exploring A Novel Herbal Hydrogel Formulation of Amorphophallus paeoniifolius and Colocasia esculenta.","authors":"Aishwaraya, Saumya Das, Smriti Ojha, Swarupanjali Padhi, Chandana Majee, Manas Das","doi":"10.2174/0127724344428364251223074220","DOIUrl":"https://doi.org/10.2174/0127724344428364251223074220","url":null,"abstract":"<p><strong>Background: </strong>Wound healing is a complex biological process involving tissue regeneration and repair. Ethnomedicinal plants have long been used in traditional medicine for wound care due to their natural healing and antimicrobial properties. Colocasia esculenta and Amorphophallus paeoniifolius are two such plants traditionally known for their therapeutic value.</p><p><strong>Objective: </strong>To evaluate the wound healing potential of ethanolic extracts and hydrogel formulations prepared from the roots of C. esculenta and A. paeoniifolius using in vitro and in vivo models.</p><p><strong>Methods: </strong>The antibacterial activity of the ethanolic extracts was assessed via the agar well diffusion method. Wound healing efficacy was tested on Wistar albino rats using incision and excision wound models. Histological analysis was performed to observe cellular regeneration and tissue morphology at the wound site.</p><p><strong>Results: </strong>Both C. esculenta and A. paeoniifolius extracts demonstrated significant antibacterial activity. In vivo studies revealed that the ethanolic extracts and hydrogel formulations enhanced wound contraction, reduced inflammatory cell infiltration, increased vascularization, and accelerated tissue regeneration compared to standard and control groups. Histological findings supported the enhanced healing activity of the test formulations.</p><p><strong>Discussion: </strong>The enhanced wound healing activity may be attributed to the synergistic antimicrobial, anti-inflammatory, and tissue-regenerative properties of phytoconstituents present in the extracts. These findings suggest that such hydrogel formulations can potentially reduce reliance on synthetic agents in wound management.</p><p><strong>Conclusion: </strong>The ethanolic extracts and hydrogels of A. paeoniifolius and C. esculenta roots exhibit promising wound healing potential and could serve as effective alternative therapies for promoting skin regeneration. These findings support the integration of traditional medicinal knowledge with modern wound care approaches.</p>","PeriodicalId":74643,"journal":{"name":"Recent advances in anti-infective drug discovery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147847337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antibiotics and Resistance: Why We Need New Medicines?","authors":"Darpan Sood, Sakshi Attri, Rajwinder Kaur, Rohit Bhatia","doi":"10.2174/0127724344440177260409110006","DOIUrl":"https://doi.org/10.2174/0127724344440177260409110006","url":null,"abstract":"","PeriodicalId":74643,"journal":{"name":"Recent advances in anti-infective drug discovery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147724855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pharmacological Potential of Ginger: Bioactive Constituents, Anti-Inflammatory Mechanisms, and Rheumatoid Arthritis.","authors":"Shikha Kamboj, Ritu Dahiya, Sweta Kamboj, Rohit Kamboj, Khushi, Drishti Sharma, Pooja Mathur","doi":"10.2174/0127724344434483260325231354","DOIUrl":"https://doi.org/10.2174/0127724344434483260325231354","url":null,"abstract":"<p><p>One of the most popular natural cures, ginger (Zingiber officinale), has long been valued in ancient medical systems, including Ayurveda, ancient Chinese Medicine, and Unani. The bioactive components of this multipurpose plant, such as paradols, shogaols, and gingerols, are largely responsible for its wide range of pharmacological qualities. These compounds are responsible for ginger's strong antibacterial, anti-inflammatory, antiemetic, and antioxidant qualities. Ginger is therefore useful in treating a variety of illnesses, from nausea and gastrointestinal distress to metabolic problems, cardiovascular diseases, arthritis, and several respiratory infections. Ginger has therapeutic potential for both preventative and supplemental health care, according to recent scientific studies. It works particularly well to lessen nausea related to chemotherapy, pregnancy, and the healing process after surgery. Additionally, studies have shown that ginger can enhance lipid profiles, boost immunity, and reduce blood sugar levels. It helps reduce arthritic symptoms, menstrual pain, and muscular soreness because of its analgesic and antiinflammatory qualities. Further supporting ginger's all-encompassing health advantages is its function in improving digestion and lowering oxidative stress. This abstract emphasizes ginger's increasing significance as a readily available, reasonably priced, and natural health-promoting substance. More thorough research is required to ascertain uniform doses, long-term safety, and possible interactions with prescription medications, even while clinical evidence is growing. Ginger's medicinal benefits and adaptability, however, make it an intriguing topic for further study and an essential part of integrative medicine. A wide spectrum of acute and chronic medical disorders may be addressed if their full therapeutic potential is realized.</p>","PeriodicalId":74643,"journal":{"name":"Recent advances in anti-infective drug discovery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147679376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring Antileptospiral Agents of Phytochemicals from Cardiospermum Halicacabum Through In Silico Docking Approach.","authors":"S Vinoth Kumar, R Mahavidhya, A Shobana, S Mohamed Akram Ali, R Varshini, G Swathi","doi":"10.2174/0127724344431025260212190455","DOIUrl":"https://doi.org/10.2174/0127724344431025260212190455","url":null,"abstract":"<p><strong>Introduction: </strong>The objective of this study was to identify potential natural inhibitors of peptide deformylase (PDF), an essential bacterial enzyme involved in leptospiral survival. By targeting PDF, the study aims to explore alternative therapeutic options for leptospirosis using phytochemicals derived from Cardiospermum halicacabum.</p><p><strong>Methods: </strong>A total of 22 phytochemicals reported from C. halicacabum were selected for this in silico study. Drug-likeness, pharmacokinetic properties, and toxicity profiles were evaluated using SwissADME and ProTox-II. Based on Lipinski's rule of five, 19 compounds were shortlisted and subjected to molecular docking using PyRx software to examine their binding interactions with peptide deformylase. ; Results: Docking results showed that stigmasterol (-9.3 kcal/mol), β-sitosterol (-8.7 kcal/mol), and chrysoeriol (-8.5 kcal/mol) had stronger binding affinities toward PDF than the reference drug penicillin (-7.3 kcal/mol). Interaction analysis revealed that these compounds formed stable hydrogen bonds and hydrophobic interactions with key active-site residues of the enzyme.</p><p><strong>Discussion: </strong>The observed binding patterns suggest that the selected phytochemicals may effectively interfere with PDF activity. The stronger binding affinity compared to the standard drug highlights their potential as natural anti-leptospiral agents. This study also demonstrates the value of computational approaches in identifying promising lead compounds at an early stage of drug discovery.</p><p><strong>Conclusion: </strong>Overall, the findings indicate that phytochemicals from Cardiospermum halicacabum, particularly stigmasterol, β-sitosterol, and chrysoeriol, show promising inhibitory potential against peptide deformylase. Further experimental studies are needed to confirm these results and assess their potential application in the treatment of leptospirosis.</p>","PeriodicalId":74643,"journal":{"name":"Recent advances in anti-infective drug discovery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147701049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antimicrobial Resistance: Global Challenges, Resistance Mechanisms and Mitigation Strategies.","authors":"Arvind Kumar Patel, Neha Singh, Vidhan Chand Bala, Pragyandip Parthasarathi Dash, Pawan Kumar Goswami, Sandip Chatterjee","doi":"10.2174/0127724344421494251207174255","DOIUrl":"https://doi.org/10.2174/0127724344421494251207174255","url":null,"abstract":"<p><p>Antimicrobial resistance (AMR) poses a significant threat to global public health and economic stability, driven by the overuse and misuse of antibiotics in human medicine, veterinary practice, and agriculture. The spread of resistance mechanisms, such as enzymatic degradation, efflux pumps, and horizontal gene transfer, further exacerbates this issue, particularly in low-resource settings. This review aims to summarize the current understanding of antimicrobial resistance, including its molecular mechanisms, global challenges, economic burden, and innovative mitigation strategies such as antimicrobial stewardship, phage therapy, antimicrobial peptides, and CRISPR-based approaches. A comprehensive literature review was conducted using scientific databases such as PubMed, Scopus, and Web of Science to gather recent studies, reviews, and guidelines related to AMR. Relevant data on resistance mechanisms, global trends, clinical implications, and mitigation strategies were synthesized to provide an integrated overview of current challenges and solutions. The review highlights how AMR contributes to increased mortality, prolonged illness, and healthcare costs, while barriers such as limited antibiotic research and diagnostic capacity hinder progress. Integrated approaches, including antimicrobial stewardship, vaccination, phage therapy, and CRISPR-based therapies, are essential to reduce resistance. Additionally, global initiatives like surveillance systems and public awareness campaigns play a vital role in controlling the spread of resistant infections. Addressing AMR requires coordinated global efforts involving stewardship programs, novel therapeutics, education, and surveillance systems. Sustainable action can reduce antibiotic misuse and delay resistance development, securing effective treatments for future generations.</p>","PeriodicalId":74643,"journal":{"name":"Recent advances in anti-infective drug discovery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147679450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Third-Generation Cephalosporins for Spontaneous Bacterial Peritonitis: Clinical Characteristics for Treatment Response in Cirrhotic Patients: A Cohort Study.","authors":"Fathia Elsayed Assal, Mohamed Elsayed Elhendawy, Enas Mohamed Abo Eta, Wesam Hatem Amer, Dina Abdelhai, Ferial Salah Eldein El-Kalla, Mohamed Elsayed Enar, Sherif Abdelbaky, Nehad Ibrahim Hawash","doi":"10.2174/0127724344429679260220073151","DOIUrl":"https://doi.org/10.2174/0127724344429679260220073151","url":null,"abstract":"<p><strong>Introduction: </strong>For a long time, third-generation cephalosporins (TGCs) have been the first-line therapy for spontaneous bacterial peritonitis (SBP) in cirrhotic patients. However, their efficacy has been questioned in recent years. This study aimed to assess the clinical characteristics, bacterial spectrum, initial treatment response, and in-hospital mortality rate among a cohort of Egyptian cirrhotic patients diagnosed with SBP and treated with TGCs.</p><p><strong>Methods: </strong>A total of 107 cirrhotic patients with SBP were included in this prospective cohort study. All included patients received TGCs as first-line therapy. Baseline characteristics (both clinical and laboratory), initial treatment response, and the rate of in-hospital mortality were documented and compared between treatment responders and nonresponders.</p><p><strong>Results: </strong>Antibiotic response rate was as follows: 20 patients (18.7%) showed a primary response to TGCs treatment, while 63 (58.9%) showed a response only after switching to more appropriate antibiotics elevatingthe final response to 77.6%. History of repeated attacks of SBP, presence of refractory ascites and elevated alkalinephosphatase levels were significantly more frequent among patients who did not achieve primary response(P= 0.002, 0.048, and 0.029, respectively), with no significant difference concerning the rate of in-hospital mortality among the studied groups (P= 0.276). Regarding ascitic fluid culture, Escherichia coli was the most commonly isolated organism (23%), while no bacterial growth was found among 49 (56.3%) of the non-responders.</p><p><strong>Discussion: </strong>Increased resistance to TGCs necessitates evaluation of patients' history and clinical assessment to re-escalate antibiotics.</p><p><strong>Conclusion: </strong>A history of recurrent SBP or the presence of refractory ascites should preclude the use of TGC as first-line therapy in cirrhotic patients with SBP.</p>","PeriodicalId":74643,"journal":{"name":"Recent advances in anti-infective drug discovery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147616755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Monkeypox Virus: A Brief Overview of Epidemiology, Pathophysiology, and Emerging Treatment Strategies.","authors":"Sonia Singh, Ashima Ahuja, Yachna Vats, Kirti Baghel","doi":"10.2174/0127724344437471260219061028","DOIUrl":"https://doi.org/10.2174/0127724344437471260219061028","url":null,"abstract":"<p><strong>Introduction: </strong>Monkeypox (Mpox) is a pandemic disease and is recognised as a global threat in the European and American regions. Mpox has increased the global health burden on various health policymakers due to an increase in mortality rates. Furthermore, the widespread transmission of Mpox presents a challenge for health researchers and other scientists. The World Health Organization (WHO) considers Mpox a pandemic condition that affects nearly a million people across the globe. Mpox is regarded as a global health emergency worldwide that requires strategic implementation from different sectors like pharma, health care, and herbal industries for effective management.</p><p><strong>Methodology: </strong>The Mpox-related research and its impact on health were screened in the databases like PubMed, Scopus, Web of Science, Google Scholar, and ScienceDirect.</p><p><strong>Results: </strong>Advances in therapeutic approaches require the development of novel anti-M pox drugs and vaccines, which provide valuable insights for scientists and researchers in successful pharmaceutical intervention. It helps provide new research and clinical translation into animal studies for future therapeutic directions, reducing the health burden.</p><p><strong>Discussion: </strong>Mpox becomes a global threat and further requires pharmaceutical intervention due to the presence of multivariant virus mutant strains. Furthermore, the resistance to existing therapeutics requires screening for other alternative and targeted therapies for patients experiencing health impacts. This paper provides insights into the therapeutic intervention of Mpox, epidemiology, and pathogenesis of the virus. Further, it helps to improve patient compliance and reduce the global health burden. Additionally, it aims to provide better therapeutic approaches that can manage an Mpox infection.</p><p><strong>Conclusion: </strong>Mpox has certain drawbacks of toxicity, drug resistance, dose dumping, and poor patient outcomes. It presents a challenge for researchers and health scientists. There is a constant surge to search for novel antiviral drugs that are capable of addressing drug resistance, toxicity, poor patient compliance, and other toxic side effects. It will further help to mitigate the global Mpox threat through in-depth analysis of complex pathological and physiological mechanisms.</p>","PeriodicalId":74643,"journal":{"name":"Recent advances in anti-infective drug discovery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147616757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Progress and Innovation in Japanese Encephalitis Vaccines: Toward Global Immunization.","authors":"Mohd Sayeed Shaikh, Thamir M AlShammari, Dinesh Kumar, Md Faiyazuddin","doi":"10.2174/0127724344413950251212043612","DOIUrl":"https://doi.org/10.2174/0127724344413950251212043612","url":null,"abstract":"<p><p>Japanese encephalitis (JE) remains a major public health concern, especially in Asia and the Western Pacific, where more than 3 billion people are at risk. Despite advances in vaccine development, challenges such as viral strain diversity, limited crossprotection, and access barriers persist. JE directly impacts economic development because disease patterns are influenced by factors such as healthcare infrastructure, surveillance, vaccine availability, and agricultural trends across low-, middle-, upper-, and high-income countries. Current vaccines primarily target genotype III strains, but genotype I has become dominant in many endemic areas, raising concerns about vaccine efficacy. Furthermore, the need for booster doses, cold chain storage requirements, and high production costs all contribute to limited immunization coverage. Recent innovations, including thermostable formulations, multivalent vaccines, and mRNA-based candidates, offer promising solutions for JE prevention. Global initiatives by organizations such as WHO, GAVI, and PATH have played a critical role in increasing vaccine accessibility, yet gaps remain in achieving universal coverage. This review addresses the progress, challenges, and emerging strategies in JE vaccine development, emphasizing the importance of innovative approaches to ensure global protection against this life-threatening disease.</p>","PeriodicalId":74643,"journal":{"name":"Recent advances in anti-infective drug discovery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147494712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inhibition of Biofilm Formation and Gene Expression by Silicon Dioxide Nanoparticles and Zinc Oxide/Zeolite Nanocomposites on Streptococcus mutans.","authors":"Zahra Hosseinali, Farhad Jeddi, Ali Niapour, Mohsen Arzanlou, Safura Mirzaei, Hadi Peeri Dogaheh, Alireza Jafari","doi":"10.2174/0127724344367073251106200403","DOIUrl":"https://doi.org/10.2174/0127724344367073251106200403","url":null,"abstract":"<p><strong>Background: </strong>Streptococcus mutans (S. mutans) is recognized as the primary oral pathogen responsible for dental caries. The formation of biofilms on tooth surfaces is a crucial virulence factor for S. mutans. This study aimed to investigate the antimicrobial and anti-biofilm effects of silicon dioxide nanoparticles (SiO2 NPs) and zinc oxide/zeolite nanocomposites (ZnO/Zeolite NCs) on S. mutans gene expression and biofilm formation.</p><p><strong>Methods: </strong>Minimum inhibitory concentrations (MICs), minimum bactericidal concentrations (MBCs), sub-MIC, safranin staining, growth curve analysis, and MTT assays were performed to evaluate the anti-biofilm properties of the nanoparticles. The expression levels of the ftf, gtfB, vicR, and gbpB genes were evaluated by real-time PCR. Cytotoxic effects of the nanoparticles were measured by the MTT assay with human gingival fibroblast (HGF2PI2) cells.</p><p><strong>Results: </strong>Both SiO2 NPs and ZnO/Zeolite NCs effectively inhibited S. mutans biofilm formation, with MTT assay results showing a 79% inhibition by SiO2 NPs and 95% by ZnO/Zeolite NCs. Additionally, both nanoparticles reduced the transcription levels of the ftf, gtfB, vicR, and gbpB genes, with no toxic effects observed on HGF2PI2 cells at a concentration of 32 mg/ml.</p><p><strong>Discussion: </strong>These findings suggest that SiO2 NPs and ZnO/Zeolite NCs are promising agents against S. mutans biofilms, with potential applications in oral care products.</p><p><strong>Conclusion: </strong>SiO2 NPs and ZnO/Zeolite NCs show significant potential for preventing biofilm formation by S. mutans, representing effective and cost-efficient antibacterial options for oral health.</p>","PeriodicalId":74643,"journal":{"name":"Recent advances in anti-infective drug discovery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146055350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Patent Review on the Use of Thymosin Peptides Against Viruses.","authors":"Nishad Deshpande, Shabib Ahmed Shaikh, Alok Khode","doi":"10.2174/0127724344411797251205091136","DOIUrl":"https://doi.org/10.2174/0127724344411797251205091136","url":null,"abstract":"<p><p>Thymosins are a group of immunomodulatory peptides secreted by the thymus. They play an important role in immune function by inducing T-cell expression and inhibiting viral replication. In light of the COVID-19 pandemic caused by coronavirus, there has been renewed interest in their activity, resulting in a revival of patents claiming the use of thymosin to combat coronavirus. This article reviews patents on the therapeutic application of thymosin peptides against viruses. Conventionally, thymosin is administered via injection or infusion; however, recent research has explored alternative routes, including oral formulations. Thymosin administration is used to complement antiviral drug treatments. Similarly, recent antiviral regimens against SARS-CoV-2 may be supplemented with thymosin based on its proven immunopotentiating activity.</p>","PeriodicalId":74643,"journal":{"name":"Recent advances in anti-infective drug discovery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146055337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}