COVID-19 Infection After Vaccination Among Healthcare Workers at a Tertiary Level Health Care Center in Northern India: A Cross-Sectional Study.

Recent advances in anti-infective drug discovery Pub Date : 2022-01-01 DOI:10.2174/2772434417666221011095128

Nandita Sharma, Mahendra Singh, Pradeep Aggarwal, Yogesh Bahurupi, P K Panda, Gaurika Saxena

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Abstract

Background and aims: COVID-19 vaccines are now accessible to all Indian citizens. Infection with COVID-19, on the other hand, continues to spread constantly. Our study aimed to determine the number of persons who had COVID-19 infections despite receiving the recommended number of doses of the COVID-19 vaccination at AIIMS Rishikesh, a tertiary care facility in Uttarakhand, India.

Methods: We analysed meticulously preserved data regarding COVID-19 vaccination, COVID-19 infection, clinical symptoms, and RT-PCR testing among all HCWs in our healthcare institution from 16 January 2021 to 30th June 2021.

Results: During this period, 5273 (90.3%) HCWs received two doses of the COVID-19 vaccine, while 566 (9.7%) received only one dose. 628 HCWs (10.8%) were BBV152 recipients and 5211 (89.2%) were AZD1222 (ChAdOx1-S) recipients. 423 HCWs (7.2%, confidence interval of 95% - 13.8, 22.0) reported COVID-19 infections. 274 (5.19% of total vaccinated HCWs) breakthrough infections and 149 non-breakthrough COVID-19 infections were reported in HCWs who had previously received a single dose of the COVID-19 vaccination.

Conclusion: Viral infections, especially breakthrough infections, following adequate vaccination, are a cause for concern, but there is a lack of data on these infections in the actual world. Therefore, the primary focus of research should be on the emergence of illness in India following the completion of a full vaccine course.

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印度北部三级卫生保健中心医护人员接种疫苗后COVID-19感染:一项横断面研究

背景和目的:所有印度公民现在都可以获得COVID-19疫苗。另一方面，COVID-19感染继续不断蔓延。我们的研究旨在确定在印度北阿坎德邦的三级医疗机构AIIMS Rishikesh接种了推荐剂量的COVID-19疫苗后仍感染COVID-19的人数。方法:我们仔细分析了2021年1月16日至2021年6月30日在我们医疗机构所有医护人员中保存的COVID-19疫苗接种、COVID-19感染、临床症状和RT-PCR检测数据。结果:5273名(90.3%)卫生保健工作者接种了两剂新冠肺炎疫苗，566名(9.7%)卫生保健工作者只接种了一剂新冠肺炎疫苗。628例患者为BBV152受体(10.8%)，5211例患者为AZD1222 (ChAdOx1-S)受体(89.2%)。423家卫生保健中心(7.2%，可信区间为95% - 13.8,22.0)报告了COVID-19感染。此前接种过单剂COVID-19疫苗的卫生保健工作者报告了274例突破感染(占接种过疫苗的卫生保健工作者总数的5.19%)和149例非突破感染。结论:充分接种疫苗后的病毒感染，特别是突破性感染，是一个令人担忧的问题，但在现实世界中缺乏有关这些感染的数据。因此，研究的主要重点应放在完成整个疫苗疗程后印度出现的疾病上。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Recent advances in anti-infective drug discovery

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1.80

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0.00%

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