Psoriasis (Auckland, N.Z.)最新文献_第10页

Psoriasis and inflammatory bowel disease: links and risks. 牛皮癣和炎症性肠病:联系和风险。

Psoriasis (Auckland, N.Z.) Pub Date : 2016-07-20 eCollection Date: 2016-01-01 DOI: 10.2147/PTT.S85194

Christoforos Vlachos, Georgios Gaitanis, Konstantinos H Katsanos, Dimitrios K Christodoulou, Epameinondas Tsianos, Ioannis D Bassukas

{"title":"Psoriasis and inflammatory bowel disease: links and risks.","authors":"Christoforos Vlachos, Georgios Gaitanis, Konstantinos H Katsanos, Dimitrios K Christodoulou, Epameinondas Tsianos, Ioannis D Bassukas","doi":"10.2147/PTT.S85194","DOIUrl":"https://doi.org/10.2147/PTT.S85194","url":null,"abstract":"Psoriasis and the spectrum of inflammatory bowel diseases (IBD) are chronic, inflammatory, organotropic conditions. The epidemiologic coexistence of these diseases is corroborated by findings at the level of disease, biogeography, and intrafamilial and intrapatient coincidence. The identification of shared susceptibility loci and DNA polymorphisms has confirmed this correlation at a genetic level. The pathogenesis of both diseases implicates the innate and adaptive segments of the immune system. Increased permeability of the epidermal barrier in skin and intestine underlies the augmented interaction of allergens and pathogens with inflammatory receptors of immune cells. The immune response between psoriasis and IBD is similar and comprises phagocytic, dendritic, and natural killer cell, along with a milieu of cytokines and antimicrobial peptides that stimulate T-cells. The interplay between dendritic cells and Th17 cells appears to be the core dysregulated immune pathway in all these conditions. The distinct similarities in the pathogenesis are also reflected in the wide overlapping of their therapeutic approaches. Small-molecule pharmacologic immunomodulators have been applied, and more recently, biologic treatments that target proinflammatory interleukins have been introduced or are currently being evaluated. However, the fact that some treatments are quite selective for either skin or gut conditions also highlights their crucial pathophysiologic differences. In the present review, a comprehensive comparison of risk factors, pathogenesis links, and therapeutic strategies for psoriasis and IBD is presented. Specific emphasis is placed on the role of the immune cell species and inflammatory mediators participating in the pathogenesis of these diseases.","PeriodicalId":74589,"journal":{"name":"Psoriasis (Auckland, N.Z.)","volume":"6 ","pages":"73-92"},"PeriodicalIF":0.0,"publicationDate":"2016-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2147/PTT.S85194","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35783444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 50

Psoriasis and smoking: links and risks. 牛皮癣和吸烟:联系和风险。

Psoriasis (Auckland, N.Z.) Pub Date : 2016-05-27 eCollection Date: 2016-01-01 DOI: 10.2147/PTT.S85189

Luigi Naldi

{"title":"Psoriasis and smoking: links and risks.","authors":"Luigi Naldi","doi":"10.2147/PTT.S85189","DOIUrl":"10.2147/PTT.S85189","url":null,"abstract":"Smoking is a complex environmental exposure influenced by genetic, environmental, and social factors. Nicotine is the principal alkaloid in tobacco that mediates the addicting effects of tobacco products. Tobacco is a mixture of more than 7,000 chemicals, and smoking is recognized as a risk factor for many diseases in humans, including cardiovascular and pulmonary disease and several cancers, and is the single most preventable cause of mortality worldwide. A number of inflammatory immune-related conditions have been associated with smoking, including psoriasis. Smoking affects the onset of psoriasis. In a pooled analysis of 25 case-control studies, the odds ratio of psoriasis among smokers was 1.78 (95% confidence interval [CI]: 1.53-2.06). A dose-effect relationship is also documented. In a pooled analysis of three cohort studies, the risk of incident psoriasis was 1.81 (95% CI: 1.38-2.36) in those who smoked 1-14 cigarettes per day, and 2.29 (95% CI: 1.74-3.01) in those who smoked ≥25 cigarettes per day. Smoking also impacts on the clinical severity of psoriasis, its response to treatment, and explains some of the associated comorbidities, eg, cardiovascular disease, inflammatory bowel disease, and several cancers (especially those of the respiratory tract). Data on the role of smoking in psoriatic arthritis are less consistent compared with those concerning psoriasis. Several pathophysiological mechanisms may explain the association of psoriasis with smoking, including oxidative stress, interaction with signaling pathways active in psoriasis, and vascular influences. In conclusion, psoriasis is just one of the many diseases associated with smoking, but it is visible and disabling. Dermatologists could play a major role in reducing the health burden of smoking by influencing the patients to change their behavior.","PeriodicalId":74589,"journal":{"name":"Psoriasis (Auckland, N.Z.)","volume":"6 ","pages":"65-71"},"PeriodicalIF":0.0,"publicationDate":"2016-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2147/PTT.S85189","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35783441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 61

Improving access to home phototherapy for patients with psoriasis: current challenges and future prospects. 改善牛皮癣患者家庭光疗的可及性:当前挑战和未来前景

Psoriasis (Auckland, N.Z.) Pub Date : 2016-05-18 eCollection Date: 2016-01-01 DOI: 10.2147/PTT.S81958

Sylvie M Franken, Carlijn L Vierstra, Thomas Rustemeyer

{"title":"Improving access to home phototherapy for patients with psoriasis: current challenges and future prospects.","authors":"Sylvie M Franken, Carlijn L Vierstra, Thomas Rustemeyer","doi":"10.2147/PTT.S81958","DOIUrl":"https://doi.org/10.2147/PTT.S81958","url":null,"abstract":"Introduction: Although the treatment burden for phototherapy in the outpatient setting is considerable, prescription of home-based phototherapy has not been instigated. Home-based phototherapy seems more patient friendly in terms of avoiding the thrice-weekly hospital visits. So why are most treatments still given in a hospital setting? Is home-based treatment less effective? Are there financial barriers? Is the treatment not available? To answer these questions, a literature search was done.Methods: A literature search of PubMed, Embase, and Cochrane Library databases was performed, using the search terms \"psoriasis\" and \"phototherapy\". Selection was based on two rounds; the first round involved screening the title and abstract of all records and second involved evaluating the full text of the remaining articles for eligibility according to inclusion and exclusion criteria.Results: In total, 23 publications were included with consensus of both researchers. Overall, the patients reported being very satisfied with home-based phototherapy. Results regarding effectivity in terms of improvement from disease severity and in quality of life were variable but generally positive. Reasons for reluctance varied from medicolegal and social aspects to lack of reimbursement and unfamiliarity on the side of the prescriber.Conclusion: In the treatment for psoriasis, home-based phototherapy is as effective and safe as phototherapy in an outpatient setting. Patients were more satisfied with home-based phototherapy. Factors that negatively influence the prescription of or choice for home-based phototherapy can be summarized in terms of lack of control, lack of knowledge, and lack of a good reimbursement system.","PeriodicalId":74589,"journal":{"name":"Psoriasis (Auckland, N.Z.)","volume":"6 ","pages":"55-64"},"PeriodicalIF":0.0,"publicationDate":"2016-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2147/PTT.S81958","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35783439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Assessment and monitoring of biologic drug adverse events in patients with psoriasis. 银屑病患者生物药物不良事件的评估与监测。

Psoriasis (Auckland, N.Z.) Pub Date : 2016-04-01 eCollection Date: 2016-01-01 DOI: 10.2147/PTT.S68869

Tessa Hanley, Marc Handford, Dawn Lavery, Zenas Zn Yiu

{"title":"Assessment and monitoring of biologic drug adverse events in patients with psoriasis.","authors":"Tessa Hanley, Marc Handford, Dawn Lavery, Zenas Zn Yiu","doi":"10.2147/PTT.S68869","DOIUrl":"https://doi.org/10.2147/PTT.S68869","url":null,"abstract":"Background: Current treatment guidelines for biologic therapies in psoriasis differ in their recommendation for the monitoring of adverse events.Objective: The aim of this paper was to draw together evidence from the currently available guidelines as a summary of how biologics licensed for the treatment of psoriasis should be monitored for adverse events.Methods: The MEDLINE database was searched to identity the current literature on the safety and screening guidance associated with infliximab, etanercept, adalimumab, ustekinumab, and secukinumab.Limitations: This study was limited by the lack of data evaluating monitoring in patients with psoriasis undergoing treatment with a biologic therapy.Results: This review of the current literature highlights that there are areas of routine screening, which are recommended in current practice, which require further evidence to investigate its true utility.Conclusion: Most screening and monitoring tests performed routinely in clinical practice are supported by minimal clinical evidence, highlighting the need for more studies to evaluate the role and value of the different modalities of screening and monitoring for adverse events in those with psoriasis receiving treatment with biologic therapies.","PeriodicalId":74589,"journal":{"name":"Psoriasis (Auckland, N.Z.)","volume":"6 ","pages":"41-54"},"PeriodicalIF":0.0,"publicationDate":"2016-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2147/PTT.S68869","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35783529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Management of scalp psoriasis: current perspectives. 头皮牛皮癣的管理:目前的观点。

Psoriasis (Auckland, N.Z.) Pub Date : 2016-03-29 eCollection Date: 2016-01-01 DOI: 10.2147/PTT.S85330

Kim Blakely, Melinda Gooderham

引用次数: 21

Current knowledge on psoriasis and autoimmune diseases. 关于牛皮癣和自身免疫性疾病的最新知识。

Psoriasis (Auckland, N.Z.) Pub Date : 2016-02-22 eCollection Date: 2016-01-01 DOI: 10.2147/PTT.S64950

Nilmarie Ayala-Fontánez, David C Soler, Thomas S McCormick

{"title":"Current knowledge on psoriasis and autoimmune diseases.","authors":"Nilmarie Ayala-Fontánez, David C Soler, Thomas S McCormick","doi":"10.2147/PTT.S64950","DOIUrl":"https://doi.org/10.2147/PTT.S64950","url":null,"abstract":"Psoriasis is a prevalent, chronic inflammatory disease of the skin, mediated by crosstalk between epidermal keratinocytes, dermal vascular cells, and immunocytes such as antigen presenting cells (APCs) and T cells. Exclusive cellular \"responsibility\" for the induction and maintenance of psoriatic plaques has not been clearly defined. Increased proliferation of keratinocytes and endothelial cells in conjunction with APC/T cell/monocyte/macrophage inflammation leads to the distinct epidermal and vascular hyperplasia that is characteristic of lesional psoriatic skin. Despite the identification of numerous susceptibility loci, no single genetic determinant has been identified as responsible for the induction of psoriasis. Thus, numerous other triggers of disease, such as environmental, microbial and complex cellular interactions must also be considered as participants in the development of this multifactorial disease. Recent advances in therapeutics, especially systemic so-called \"biologics\" have provided new hope for identifying the critical cellular targets that drive psoriasis pathogenesis. Recent recognition of the numerous co-morbidities and other autoimmune disorders associated with psoriasis, including inflammatory bowel disease, multiple sclerosis, rheumatoid arthritis, and systemic lupus erythematosus suggest common signaling elements and cellular mediators may direct disease pathogenesis. In this review, we discuss common cellular pathways and participants that mediate psoriasis and other autoimmune disorders that share these cellular signaling pathways.","PeriodicalId":74589,"journal":{"name":"Psoriasis (Auckland, N.Z.)","volume":"6 ","pages":"7-32"},"PeriodicalIF":0.0,"publicationDate":"2016-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2147/PTT.S64950","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35783440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 143

Integrating lifestyle-focused approaches into psoriasis care: improving patient outcomes? 将以生活方式为重点的方法纳入牛皮癣护理:改善患者预后?

Psoriasis (Auckland, N.Z.) Pub Date : 2016-01-19 eCollection Date: 2016-01-01 DOI: 10.2147/PTT.S81957

Angelo Landriscina, Adam J Friedman

引用次数: 5

Erythrodermic psoriasis: pathophysiology and current treatment perspectives. 红皮病型银屑病：病理生理学与当前治疗前景。

Psoriasis (Auckland, N.Z.) Pub Date : 2016-01-01 Epub Date: 2016-07-20 DOI: 10.2147/PTT.S101232

Rasnik K Singh, Kristina M Lee, Derya Ucmak, Merrick Brodsky, Zaza Atanelov, Benjamin Farahnik, Michael Abrouk, Mio Nakamura, Tian Hao Zhu, Wilson Liao

{"title":"Erythrodermic psoriasis: pathophysiology and current treatment perspectives.","authors":"Rasnik K Singh, Kristina M Lee, Derya Ucmak, Merrick Brodsky, Zaza Atanelov, Benjamin Farahnik, Michael Abrouk, Mio Nakamura, Tian Hao Zhu, Wilson Liao","doi":"10.2147/PTT.S101232","DOIUrl":"10.2147/PTT.S101232","url":null,"abstract":"Erythrodermic psoriasis (EP) is a rare and severe variant of psoriasis vulgaris, with an estimated prevalence of 1%-2.25% among psoriatic patients. The condition presents with distinct histopathologic and clinical findings, which include a generalized inflammatory erythema involving at least 75% of the body surface area. The pathogenesis of EP is not well understood; however, several studies suggest that the disease is associated with a predominantly T helper 2 (Th2) phenotype. Given the morbidity and potential mortality associated with the condition, there is a need for a better understanding of its pathophysiology. The management of EP begins with a comprehensive assessment of the patient's presentation and often requires multidisciplinary supportive measures. In 2010, the medical board of the US National Psoriasis Foundation published consensus guidelines advocating the use of cyclosporine or infliximab as first-line therapy in unstable cases, with acitretin and methotrexate reserved for more stable cases. Since the time of that publication, additional information regarding the efficacy of newer agents has emerged. We review the latest data with regard to the treatment of EP, which includes biologic therapies such as ustekinumab and ixekizumab.","PeriodicalId":74589,"journal":{"name":"Psoriasis (Auckland, N.Z.)","volume":"6 ","pages":"93-104"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/43/19/ptt-6-093.PMC5572467.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35360378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Links and risks associated with psoriasis and metabolic syndrome. 牛皮癣和代谢综合征的联系和风险。

Psoriasis (Auckland, N.Z.) Pub Date : 2015-11-02 eCollection Date: 2015-01-01 DOI: 10.2147/PTT.S54089

Aikaterini I Liakou, Christos C Zouboulis

引用次数: 11

Update on the treatment of psoriasis and psoriatic arthritis - role of apremilast. 银屑病和银屑病关节炎的治疗进展-阿普司特的作用。

Psoriasis (Auckland, N.Z.) Pub Date : 2015-09-07 eCollection Date: 2015-01-01 DOI: 10.2147/PTT.S69476

Stephan Forchhammer, Kamran Ghoreschi

引用次数: 6