Association of HLA Alleles and HLA Haplotypes with Psoriasis, Psoriatic Arthritis and Disease Severity in a Miscegenated Population.

IF 5.2 Q1 DERMATOLOGY
Psoriasis (Auckland, N.Z.) Pub Date : 2021-05-10 eCollection Date: 2021-01-01 DOI:10.2147/PTT.S258050
Flavia de Freire Cassia, Juliana Fernandes Cardoso, Luiz Cristovao Porto, Marcia Ramos-E-Silva, Sueli Carneiro
{"title":"Association of HLA Alleles and HLA Haplotypes with Psoriasis, Psoriatic Arthritis and Disease Severity in a Miscegenated Population.","authors":"Flavia de Freire Cassia,&nbsp;Juliana Fernandes Cardoso,&nbsp;Luiz Cristovao Porto,&nbsp;Marcia Ramos-E-Silva,&nbsp;Sueli Carneiro","doi":"10.2147/PTT.S258050","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>The study of HLA classes I and II in Brazilian psoriasis patients may contribute to a better understanding of their association with the disease.</p><p><strong>Objective: </strong>To describe HLA classes I and II of Brazilian patients with psoriasis, with or without arthritis, compare them to controls and correlate HLA markers with epidemiological and evolutional aspects of psoriasis.</p><p><strong>Methods: </strong>A total of 55 patients with more than 5 years of psoriasis, with or without arthritis, answered a questionnaire on ethnic background and disease severity. A total of 134 bone marrow donors were controls. HLA class I and II genotyping was determined by PCR-SSP.</p><p><strong>Results: </strong>Mean age was 42.4 years; 23 women and 32 men. HLA-B*57 was present in 23.6% patients and in 7.5% controls (p=0.00200, OR= 3.8381), and HLA-C*06 in 29.1% patients and in 16.4% controls (p= 0.04832, OR=2.0886). HLA-B*57 and HLA-C*18 were significantly present in patients with arthritis (p=0.00104, OR=6.6769 and p=0.00269, OR=16.50, respectively). HLA-B*57 was significantly present in patients with history of erythroderma (p=0.00548, OR= 5.1059), as was HLA-C*06 (p=0.02158, OR=3.0545). HLA-B*57 was also frequent in patients with history of hospital internment due to psoriasis (p= 0.00094, OR=7.8909) and in the ones with history of systemic treatment for psoriasis (p= 0.00011, OR= 5.3733). Haplotype HLA-A*02 B*57 C*06 DRB1*07DQB1*03 was the most common among the patients (p= 0.00069, OR= 3.528).</p><p><strong>Conclusion: </strong>HLA-B*57 and HLA-C*06 were significantly increased in the patients indicating risk for psoriasis. HLA-B*57 remained high in patients with history of erythroderma, hospital internment, systemic treatment, and psoriatic arthritis, showing association with disease severity. HLA-C*18 was significantly high only in patients with psoriatic arthritis. HLA-B*57 and HLA-C*06 and haplotype HLA-A*02B*57Cw*06DRB1*07 DQB1*03 seen in this study were already described before, associated with psoriasis. HLA-Cw*18 was not described in other populations in association with psoriasis.</p>","PeriodicalId":74589,"journal":{"name":"Psoriasis (Auckland, N.Z.)","volume":"11 ","pages":"41-51"},"PeriodicalIF":5.2000,"publicationDate":"2021-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/42/83/ptt-11-41.PMC8121669.pdf","citationCount":"3","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Psoriasis (Auckland, N.Z.)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2147/PTT.S258050","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2021/1/1 0:00:00","PubModel":"eCollection","JCR":"Q1","JCRName":"DERMATOLOGY","Score":null,"Total":0}
引用次数: 3

Abstract

Background: The study of HLA classes I and II in Brazilian psoriasis patients may contribute to a better understanding of their association with the disease.

Objective: To describe HLA classes I and II of Brazilian patients with psoriasis, with or without arthritis, compare them to controls and correlate HLA markers with epidemiological and evolutional aspects of psoriasis.

Methods: A total of 55 patients with more than 5 years of psoriasis, with or without arthritis, answered a questionnaire on ethnic background and disease severity. A total of 134 bone marrow donors were controls. HLA class I and II genotyping was determined by PCR-SSP.

Results: Mean age was 42.4 years; 23 women and 32 men. HLA-B*57 was present in 23.6% patients and in 7.5% controls (p=0.00200, OR= 3.8381), and HLA-C*06 in 29.1% patients and in 16.4% controls (p= 0.04832, OR=2.0886). HLA-B*57 and HLA-C*18 were significantly present in patients with arthritis (p=0.00104, OR=6.6769 and p=0.00269, OR=16.50, respectively). HLA-B*57 was significantly present in patients with history of erythroderma (p=0.00548, OR= 5.1059), as was HLA-C*06 (p=0.02158, OR=3.0545). HLA-B*57 was also frequent in patients with history of hospital internment due to psoriasis (p= 0.00094, OR=7.8909) and in the ones with history of systemic treatment for psoriasis (p= 0.00011, OR= 5.3733). Haplotype HLA-A*02 B*57 C*06 DRB1*07DQB1*03 was the most common among the patients (p= 0.00069, OR= 3.528).

Conclusion: HLA-B*57 and HLA-C*06 were significantly increased in the patients indicating risk for psoriasis. HLA-B*57 remained high in patients with history of erythroderma, hospital internment, systemic treatment, and psoriatic arthritis, showing association with disease severity. HLA-C*18 was significantly high only in patients with psoriatic arthritis. HLA-B*57 and HLA-C*06 and haplotype HLA-A*02B*57Cw*06DRB1*07 DQB1*03 seen in this study were already described before, associated with psoriasis. HLA-Cw*18 was not described in other populations in association with psoriasis.

HLA等位基因和HLA单倍型与混种人群银屑病、银屑病关节炎和疾病严重程度的关系
背景:对巴西银屑病患者HLA I和II类的研究可能有助于更好地了解它们与该疾病的关系。目的:描述巴西伴有或不伴有关节炎的牛皮癣患者的HLA I和II级,将其与对照组进行比较,并将HLA标记与牛皮癣流行病学和进化方面的相关性进行比较。方法:对55例伴有或不伴有关节炎的5年以上银屑病患者进行种族背景和病情严重程度问卷调查。共有134名骨髓捐献者作为对照。采用PCR-SSP法测定HLAⅰ、ⅱ类基因分型。结果:平均年龄42.4岁;23名女性和32名男性。23.6%的患者和7.5%的对照组中存在HLA-B*57 (p=0.00200, OR= 3.8381), 29.1%的患者和16.4%的对照组中存在HLA-C*06 (p= 0.04832, OR=2.0886)。HLA-B*57和HLA-C*18在关节炎患者中显著存在(p=0.00104, OR=6.6769和p=0.00269, OR=16.50)。有红皮病病史的患者中存在HLA-B*57 (p=0.00548, OR= 5.1059)、HLA-C*06 (p=0.02158, OR=3.0545)。HLA-B*57在有银屑病住院史的患者中(p= 0.00094, OR=7.8909)和有银屑病全身治疗史的患者中也较为常见(p= 0.00011, OR= 5.3733)。单倍型HLA-A*02 B*57 C*06 DRB1*07DQB1*03最常见(p= 0.00069, OR= 3.528)。结论:银屑病高危人群HLA-B*57、HLA-C*06明显增高。HLA-B*57在有红皮病、住院、全身治疗和银屑病关节炎病史的患者中保持高水平,与疾病严重程度相关。HLA-C*18仅在银屑病关节炎患者中显著升高。本研究中发现的HLA-B*57、HLA-C*06和单倍型HLA-A*02B*57Cw*06DRB1*07 DQB1*03均与银屑病相关。HLA-Cw*18未在其他人群中与牛皮癣相关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
自引率
0.00%
发文量
0
审稿时长
16 weeks
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信