Effectiveness of IL-23 Inhibitor Guselkumab in Real-World Chinese Patients with Psoriasis During a 20-Week Period.

IF 5.2 Q1 DERMATOLOGY
Psoriasis (Auckland, N.Z.) Pub Date : 2021-06-01 eCollection Date: 2021-01-01 DOI:10.2147/PTT.S312109
Yung Chan, Bik Sai Bessie Tong, Pui Yan Ngan, Chi Sum Au
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引用次数: 5

Abstract

Background: Interleukin-23 inhibitors are novel treatment options for psoriasis, and their efficacy and safety have been widely demonstrated in phase 3 clinical trials. Nonetheless, their real-world data remain limited, especially in Asia.

Objective: To evaluate the real-world effectiveness of interleukin-23 inhibitor guselkumab in Chinese patients with psoriasis.

Methods: In this retrospective single-center study, Chinese patients with psoriasis receiving a standard dose of guselkumab from November 2018 to May 2020 were included in the study cohort. Disease assessment was performed at baseline (Week 0), and at Week 4, 12, and 20 thereafter, using Psoriasis Area and Severity Index (PASI) score.

Results: Data of 68 adult patients with psoriasis were retrieved for analysis. At Week 20, 72.1%/47.1% of the patients achieved PASI 90/100 response respectively, and 76.5% achieved a PASI score <3. Baseline mean PASI score was 17.5, which significantly reduced to 2.0 at Week 20 (P=0.000). No previous use of biologics was a single significant factor associated with achieving PASI 90/100 and PASI score <3 responses at Week 20 (all Ps<0.05), while there were no statistically significant differences between males and females and body weight >75 and ≤75 kg in achieving these responses (all Ps>0.05). Adverse events were experienced by five patients (7.4%), and all were mild in severity.

Conclusion: In this first real-world study on guselkumab among Chinese patients with psoriasis, this biologics was shown to be safe and effective in reaching an optimal clinical response up to 20 weeks.

Abstract Image

IL-23抑制剂Guselkumab治疗中国银屑病患者20周的疗效
背景:白介素-23抑制剂是银屑病治疗的新选择,其有效性和安全性已在3期临床试验中得到广泛证实。尽管如此,他们的真实数据仍然有限,尤其是在亚洲。目的:评价白介素-23抑制剂guselkumab在银屑病患者中的实际疗效。方法:在这项回顾性单中心研究中,将2018年11月至2020年5月接受标准剂量guselkumab治疗的中国银屑病患者纳入研究队列。在基线(第0周)以及之后的第4、12和20周进行疾病评估,使用牛皮癣面积和严重程度指数(PASI)评分。结果:检索了68例成年牛皮癣患者的资料进行分析。第20周时,72.1%/47.1%的患者分别达到PASI 90/100缓解,76.5%的患者达到PASI评分75和≤75 kg(均p >0.05)。不良事件发生5例(7.4%),均为轻度。结论:在中国银屑病患者的首次实际研究中,该生物制剂在20周内达到最佳临床反应是安全有效的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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