Correlation Between Psoriasis Severity and Nonalcoholic Fatty Liver Disease Degree Measured Using Controlled Attenuation Parameter.

IF 5.2 Q1 DERMATOLOGY
Psoriasis (Auckland, N.Z.) Pub Date : 2020-10-20 eCollection Date: 2020-01-01 DOI:10.2147/PTT.S272286
Nico Gandha, Larisa Paramitha Wibawa, Tjut Nurul Alam Jacoeb, Andri Sanityoso Sulaiman
{"title":"Correlation Between Psoriasis Severity and Nonalcoholic Fatty Liver Disease Degree Measured Using Controlled Attenuation Parameter.","authors":"Nico Gandha,&nbsp;Larisa Paramitha Wibawa,&nbsp;Tjut Nurul Alam Jacoeb,&nbsp;Andri Sanityoso Sulaiman","doi":"10.2147/PTT.S272286","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>A growing body of evidence links psoriasis to several metabolic disorders, but the causal relationship between psoriasis and nonalcoholic fatty liver disease (NAFLD) remains understudied.</p><p><strong>Purpose: </strong>To measure the correlation between the severity of psoriasis and the degree of NAFLD.</p><p><strong>Patients and methods: </strong>A cross-sectional study was conducted on adult patients with psoriasis in the Dermatovenereology Outpatient Clinic of Cipto Mangunkusumo Hospital from December 2017 through February 2018. Psoriasis severity (psoriasis area and severity index [PASI] and body surface area [BSA]) was recorded and compared with NAFLD degree measured by controlled attenuation parameter (CAP).</p><p><strong>Results: </strong>A total of 36 subjects were enrolled with an average age of 49.08 years (±15.52 years). The proportions of mild, moderate, and severe psoriasis were 50%, 27.8%, and 22.2%, respectively. Median of PASI was 6.1 (2-38.4) and BSA was 7.5 (2-93). The proportion of NAFLD was 77.8%. The mean of the CAP score was 250.03±45.64. There was no statistically significant correlation between psoriasis severity based on PASI and CAP score (r = 0.258; p = 0.128). However, if the degree of psoriasis was based on BSA, a significant correlation was found (r = 0.382; p = 0.021). The body mass index (BMI) and abdominal circumference were significantly correlated with CAP score (r = 0.448, p = 0.006 and r = 0.485, p = 0.003, respectively).</p><p><strong>Conclusion: </strong>Psoriasis extension correlates with NAFLD severity; further studies should assess in detail the effect of therapies on this pathophysiological link.</p>","PeriodicalId":74589,"journal":{"name":"Psoriasis (Auckland, N.Z.)","volume":null,"pages":null},"PeriodicalIF":5.2000,"publicationDate":"2020-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2147/PTT.S272286","citationCount":"4","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Psoriasis (Auckland, N.Z.)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2147/PTT.S272286","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2020/1/1 0:00:00","PubModel":"eCollection","JCR":"Q1","JCRName":"DERMATOLOGY","Score":null,"Total":0}
引用次数: 4

Abstract

Background: A growing body of evidence links psoriasis to several metabolic disorders, but the causal relationship between psoriasis and nonalcoholic fatty liver disease (NAFLD) remains understudied.

Purpose: To measure the correlation between the severity of psoriasis and the degree of NAFLD.

Patients and methods: A cross-sectional study was conducted on adult patients with psoriasis in the Dermatovenereology Outpatient Clinic of Cipto Mangunkusumo Hospital from December 2017 through February 2018. Psoriasis severity (psoriasis area and severity index [PASI] and body surface area [BSA]) was recorded and compared with NAFLD degree measured by controlled attenuation parameter (CAP).

Results: A total of 36 subjects were enrolled with an average age of 49.08 years (±15.52 years). The proportions of mild, moderate, and severe psoriasis were 50%, 27.8%, and 22.2%, respectively. Median of PASI was 6.1 (2-38.4) and BSA was 7.5 (2-93). The proportion of NAFLD was 77.8%. The mean of the CAP score was 250.03±45.64. There was no statistically significant correlation between psoriasis severity based on PASI and CAP score (r = 0.258; p = 0.128). However, if the degree of psoriasis was based on BSA, a significant correlation was found (r = 0.382; p = 0.021). The body mass index (BMI) and abdominal circumference were significantly correlated with CAP score (r = 0.448, p = 0.006 and r = 0.485, p = 0.003, respectively).

Conclusion: Psoriasis extension correlates with NAFLD severity; further studies should assess in detail the effect of therapies on this pathophysiological link.

控制衰减参数测定银屑病严重程度与非酒精性脂肪性肝病程度的相关性
背景:越来越多的证据表明牛皮癣与几种代谢紊乱有关,但牛皮癣与非酒精性脂肪性肝病(NAFLD)之间的因果关系仍未得到充分研究。目的:探讨银屑病严重程度与NAFLD程度的相关性。患者和方法:对2017年12月至2018年2月在Cipto Mangunkusumo医院皮肤性病门诊就诊的成年牛皮癣患者进行了横断面研究。记录银屑病严重程度(银屑病面积及严重程度指数[PASI]和体表面积[BSA]),并与控制衰减参数(CAP)测定的NAFLD程度进行比较。结果:共纳入36例受试者,平均年龄49.08岁(±15.52岁)。轻度、中度和重度牛皮癣的比例分别为50%、27.8%和22.2%。PASI中位数为6.1 (2-38.4),BSA中位数为7.5(2-93)。NAFLD比例为77.8%。CAP评分平均值为250.03±45.64。基于PASI的银屑病严重程度与CAP评分之间无统计学意义的相关性(r = 0.258;P = 0.128)。然而,如果以牛皮癣的程度为基础,则发现显著相关(r = 0.382;P = 0.021)。体重指数(BMI)和腹围与CAP评分有显著相关(r = 0.448, p = 0.006和r = 0.485, p = 0.003)。结论:银屑病扩展与NAFLD严重程度相关;进一步的研究应详细评估治疗对这种病理生理联系的影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
自引率
0.00%
发文量
0
审稿时长
16 weeks
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信