Postepy psychiatrii neurologii最新文献

{"title":"Anti-LGI1-antibody autoimmune encephalitis as a neurological paraneoplastic syndrome associated with gastrointestinal stromal tumour: a case report.","authors":"Anna D Kwaszewska, Marta Betka, Karol Jastrzębski","doi":"10.5114/ppn.2025.150016","DOIUrl":"10.5114/ppn.2025.150016","url":null,"abstract":"<p><strong>Purpose: </strong>The aim of the case is to present the significance of a thorough analysis of the cases of patients with newly developed memory disorders accompanied by epileptic seizures.</p><p><strong>Case description: </strong>We present a case of a 61-year-old male patient who was admitted to the hospital due to unexplained memory disorders and seizures. Further examination showed the presence of anti-LGI1 (leucine-rich glioma-inactivated 1) antibodies. Computed tomography of the abdominal cavity revealed a mass located between the stomach and the spleen. Histopathological examination identified the mass as a gastrointestinal tumour (GIST). After the surgical removal of the tumour the symptoms were significantly reduced. The early diagnosis and treatment of the tumour contributed to favourable neurological and oncological outcomes for the patient.</p><p><strong>Comment: </strong>Paraneoplastic neurological syndrome is a clinical condition in which the functioning of the nervous system is impaired, not resulting from local tumour growth or metastases. The currently recognized underlaying mechanism of this condition is an autoimmune reaction occurring in the patient's body. In response to the presence of tumour, the antibodies called onconeural antibodies are produced, which are then directed against antigens present on the nervous system cells. To the best of our knowledge this is the first and so far only anti-LGI1-antibody autoimmune encephalitis as a neurological paraneoplastic syndrome associated with GIST.</p>","PeriodicalId":74481,"journal":{"name":"Postepy psychiatrii neurologii","volume":"34 2","pages":"108-115"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12257616/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144644345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The BASIC Ph model in communication and building individual and group resilience in crises. An example of use during the refugee crisis in Poland.","authors":"Lidia Zabłocka-Żytka, Mooli Lahad","doi":"10.5114/ppn.2025.151781","DOIUrl":"10.5114/ppn.2025.151781","url":null,"abstract":"<p><strong>Purpose: </strong>Everyday difficulties, but also new threats experienced by individuals and whole societies, are sources of stress that, due to their intensity, occurrence over time and in the absence of adequate support, can trigger crises and traumatic experiences. Examples of the latter are COVID-19 or military action in Europe, among other things, and the related wave of refugees who have sought refuge in many Western European countries since February 2022 in particular. This is why it is so important to cultivate resilience and the ability to cope effectively cope with stress not only at the individual level but also in entire social groups, and to nurture the resources not only of those already experiencing crises and mental health disorders, but also of entire populations.</p><p><strong>Views: </strong>The BASIC Ph model devised by Prof. Mooli Lahad (2013) is a tool for effective crisis communication and thus building individual and social resilience. It has been successfully implemented for several decades in the process of educating individuals and social groups about stress and forming new, effective ways of coping with it, thereby building mental resilience in situations such as natural disasters, epidemics, wars, migration, and refugee crises.</p><p><strong>Conclusions: </strong>The article presents the application of the BASIC Ph model in the example of the refugee crisis and its use for people experiencing the trauma of war and forced migration, as well as citizens of host and migrant-supporting countries.</p>","PeriodicalId":74481,"journal":{"name":"Postepy psychiatrii neurologii","volume":"34 2","pages":"93-98"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12257611/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144644353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Damage to the entire deep brain stimulation system after the standard replacement of an implantable pulse generator, probably due to self-injurious behavior in a patient with advanced Parkinson's disease.","authors":"Karol Piwowarski, Michał Sobstyl, Karol Karamon","doi":"10.5114/ppn.2025.151784","DOIUrl":"10.5114/ppn.2025.151784","url":null,"abstract":"<p><strong>Purpose: </strong>Deep brain stimulation for Parkinson's disease (PD) is an established treatment modality for disabling Parkinsonian motor symptoms in off medication condition and levodopa-induced dyskinesia in on medication condition.</p><p><strong>Case description: </strong>We report on the case of a 70-year-old woman with a 22-year history of PD diagnosis who had been treated with dopaminergic medication over this period. At age of 59, she underwent a staged bilateral implantation of deep brain stimulation (DBS) leads targeting the subthalamic nucleus (STN) with good control of Parkinsonian motor symptoms and the reduction of her daily levodopa dose by 50% after bilateral STN DBS. The patient damaged her DBS system after the standard replacement of a depleted left implantable pulse generator, which resulted in the removal of the entire deep brain stimulation system on the left side.</p><p><strong>Comment: </strong>To our knowledge, this is the first report of probably self-injurious behavior in the context of a deep brain stimulation system related to the longstanding dopaminergic treatment of PD. Patients in advanced stages of PD require special care for the follow- up maintenance of sophisticated treatment modalities like DBS.</p>","PeriodicalId":74481,"journal":{"name":"Postepy psychiatrii neurologii","volume":"34 2","pages":"124-129"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12257614/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144644348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CLIPPERS syndrome: a case report and differential diagnosis review.","authors":"Piotr Olejnik, Beata Szyluk, Beata Zakrzewska-Pniewska, Anna Kostera-Pruszczyk, Aleksandra Golenia","doi":"10.5114/ppn.2025.151785","DOIUrl":"10.5114/ppn.2025.151785","url":null,"abstract":"<p><strong>Purpose: </strong>Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS) syndrome is a rare autoimmune disorder affecting brainstem structures and the cerebellum, first described in 2010. Its characteristic feature is a particularly good response to glucocorticoid treatment.</p><p><strong>Case description: </strong>A 65-year-old male presented with double vision and dizziness of approximately five weeks duration prior to hospital admission. Brain magnetic resonance imaging (MRI) with gadolinium enhancement revealed a T2-weighted hyperintense, diffused lesion in the brainstem, with no evidence of restricted diffusion. The clinical presentation and the MRI features indicated CLIPPERS syndrome, which was diagnosed after excluding other causes of brainstem encephalitis.</p><p><strong>Comment: </strong>Considering the fact that CLIPPERS syndrome is a rare and under-researched condition, it is important to include it in the differential diagnosis of numerous brainstem disorders, especially when the patient exhibits characteristic symptoms and radiological features. As CLIPPERS syndrome is a treatable disease, it cannot be neglected.</p>","PeriodicalId":74481,"journal":{"name":"Postepy psychiatrii neurologii","volume":"34 2","pages":"130-137"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12257615/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144644347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The diagnosis of myotonic dystrophy type 2 in a patient with calpainopathy requires the determination of CCTG expansion.","authors":"Josef Finsterer","doi":"10.5114/ppn.2025.149985","DOIUrl":"https://doi.org/10.5114/ppn.2025.149985","url":null,"abstract":"","PeriodicalId":74481,"journal":{"name":"Postepy psychiatrii neurologii","volume":"34 1","pages":"58-59"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12076131/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144082655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ukrainian refugee crisis center at the University Hospital's Psychiatric Clinic for Adults, Children and Adolescents in Krakow.","authors":"Daria Rozynek, Natalia Śmierciak, Barbara Wojszel, Weronika Rodak, Małgorzata Bagieńska, Alina Valynets-Cyganik, Veronika Slabucho, Sabir Talybov, Krzysztof Wojtasik-Bakalarz, Marta Szwajca, Bartłomiej Guzik, Maciej Pilecki","doi":"10.5114/ppn.2025.149874","DOIUrl":"https://doi.org/10.5114/ppn.2025.149874","url":null,"abstract":"<p><strong>Purpose: </strong>Since 2022, Poland, particularly Krakow, has been at the forefront of providing assistance to Ukrainian refugees, displaced by military operations. The mental health impact of war trauma, notably post-traumatic stress disorder and acute stress reaction (ASR), necessitated immediate psychiatric interventions. To provide psychological support for refugees, a team of nine specialists was formed within the Department of Adult, Child, and Adolescent Psychiatry at the University Hospital in Krakow. This study aims to present the functioning of our crisis center and challenges it has faced, while comparing our approach to mental health care for refugees in other countries.</p><p><strong>Methods: </strong>Data were collected from the center's activities and collaborations with partners, focusing on psychiatric care for Ukrainian refugees. Each patient was diagnosed by a psychiatrist based on ICD-10 classification.</p><p><strong>Results: </strong>107 visits were held, primarily with females aged 8 to 75 and males aged 2.5 to 65. The visits mostly took place at the crisis center. Patients presented with mental health concerns including suicidal ideation, sleep disorders, and self-mutilation. Among females, the most common diagnoses were ASR (45.45%), autism spectrum disorder (14.29%), depressive disorder, and recurrent depression (total 14.29%). For males, these were ASR (35.00%), autism spectrum disorder (35.00%), and attention deficit hyperactivity disorder (20.00%). Challenges such as language barriers and the fact that the center was unprepared for the influx of refugees were identified.</p><p><strong>Conclusions: </strong>Given the considerable challenges encountered, the study emphasizes the need for mental health support for refugees and indicates the need to integrate the preparation for refugee crises into civil protection strategies.</p>","PeriodicalId":74481,"journal":{"name":"Postepy psychiatrii neurologii","volume":"34 1","pages":"11-18"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12076129/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144082688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functional magnetic resonance imaging and diffuse tensor imaging diagnostic values in central post-stroke pain.","authors":"Robert E Djojoseputro, Angela F Ciaves, I Putu E Widyadharma","doi":"10.5114/ppn.2025.149952","DOIUrl":"https://doi.org/10.5114/ppn.2025.149952","url":null,"abstract":"<p><strong>Purpose: </strong>This review aims to emphasize the diagnostic value of functional magnetic resonance imaging (fMRI) and diffusion tensor imaging (DTI) tractography in detecting and diagnosing central post-stroke pain (CPSP).</p><p><strong>Views: </strong>CPSP is a debilitating form of chronic neuropathic pain that develops in patients with a history of stroke. CPSP has a wide range of onset and non-specific clinical presentations, making it difficult to detect. Until now, CPSP has been considered a diagnosis of exclusion, often leading to delays in the initiation of the appropriate treatment plan. fMRI and DTI tractography are valuable tools for assessing cerebral metabolic activity and the structural characteristics of the spinothalamic tracts, respectively. By combining these sets of information, physicians can detect CPSP early and implement more effective treatment strategies.</p><p><strong>Conclusion: </strong>Diagnosing CPSP has been challenging for physicians due to its complex nature. However, fMRI and DTI have the potential in enabling earlier detection of CPSP, giving physicians more time to initiate treatment. This review highlights the capacities of fMRI and DTI in identifying alterations in the spinothalamic pathways associated with CPSP.</p>","PeriodicalId":74481,"journal":{"name":"Postepy psychiatrii neurologii","volume":"34 1","pages":"44-53"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12076134/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144082623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent insights into depression from transcriptomic analysis.","authors":"Melih Günay, Meliha M Çiçekliyurt","doi":"10.5114/ppn.2025.149873","DOIUrl":"https://doi.org/10.5114/ppn.2025.149873","url":null,"abstract":"<p><strong>Purpose: </strong>Depression is a widespread mood disorder with a high rate of relapse and chronicity that can be affected by gender, and caused by traumatic or stressful events. Transcriptome analysis measures gene expression heterogeneity in cells, tissues, organs, and the whole body. The purpose of the study was to investigate both gender-specific and tissue-specific variations in gene expression regarding depression based on transcriptomic analysis using RNA-Seq data.</p><p><strong>Methods: </strong>The depression datasets GSE190518 and GSE214921 were downloaded from the Gene Expression Omnibus database provided by the NCBI. The GSE190518 datasets include peripheral blood samples (4 patients, 4 healthy controls), and the GSE214921 datasets contain human postmortem orbitofrontal cortex bulk tissue (20 patients, 19 healthy controls). All datasets were analyzed separately with the DESeq2 package in R. Later, GO and KEGG enrichment analyses of differentially expressed genes were performed using the clusterProfiler package in R.</p><p><strong>Results: </strong>Our results reveal that depression stimulates genes linked to the immune system, which is a common denominator in both brain tissue and blood samples. Overall, tissue-specific factors contribute to the association between depression and the immune system via distinct genes. Furthermore, gene ontology analyses revealed that <i>HSPA6, HSPA7, HSPA1L, HSPA1A</i>, and <i>HSPA1B</i> genes are co-represented in different pathways involved in molecular function, biological processes, and cellular components.</p><p><strong>Conclusions: </strong>Comparative transcriptomic evidence supports the immune hypothesis of depression in different tissue samples. Gender-specific depression may be triggered by protein misfolding.</p>","PeriodicalId":74481,"journal":{"name":"Postepy psychiatrii neurologii","volume":"34 1","pages":"1-10"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12076128/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144082648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to the Letter to the Editor on \"The diagnosis of myotonic dystrophy type 2 in a patient with calpainopathy requires the determination of CCTG expansion\" [].","authors":"Wiktoria Radziwonik-Frączyk, Anna Sułek, Ewelina Elert-Dobkowska","doi":"10.5114/ppn.2025.149986","DOIUrl":"10.5114/ppn.2025.149986","url":null,"abstract":"","PeriodicalId":74481,"journal":{"name":"Postepy psychiatrii neurologii","volume":"34 1","pages":"60-61"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12076136/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144082653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Value stream mapping in healthcare - the case of stroke patients treatment at Institute of Psychiatry and Neurology.","authors":"Mira Lisiecka-Biełanowicz, Daria Biechowska","doi":"10.5114/ppn.2025.149940","DOIUrl":"https://doi.org/10.5114/ppn.2025.149940","url":null,"abstract":"<p><strong>Purpose: </strong>The purpose of this article is to assess the potential and usefulness of applying value stream mapping (VSM) in the process of treating stroke patients in the Polish healthcare system, using the Institute of Psychiatry and Neurology (IPiN) as an example.</p><p><strong>Methods: </strong>The applied VSM method allows for a detailed identification of service delivery points (SDPs), which are the areas of potential organizational and structural changes in the stroke patient treatment process.</p><p><strong>Results: </strong>The IPiN VSM of the stroke patients treatment process illustrates the course of the process, taking into consideration all potential opportunities for improvement, as identified during the analytical work. It was determined that improvements require addressing issues, such as excessive patient transport times caused by the distance between the most critical SDPs, i.e., the reception, imaging diagnostics, and the stroke unit and also their location on different floors of the hospital building.</p><p><strong>Conclusions: </strong>At this stage, the VSM analysis reveals significant opportunities to improve process efficiency using lean management, without adding extra costs for the hospital. It is important to consider dividing stroke patients into two streams: standard patients (fast track, those without complications) and non-standard patients (slow track, those with complications).</p>","PeriodicalId":74481,"journal":{"name":"Postepy psychiatrii neurologii","volume":"34 1","pages":"26-32"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12076135/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144082731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}