Ozgun Yetkin, Anna Sojka, Yasmin Bartosik, Barbara Steinborn, Barbara Dorocka-Bobkowska, Marcin Zarowski
{"title":"Exploring the roles of ghrelin and nesfatin-1 as potential biomarkers in human epilepsy: a systematic review.","authors":"Ozgun Yetkin, Anna Sojka, Yasmin Bartosik, Barbara Steinborn, Barbara Dorocka-Bobkowska, Marcin Zarowski","doi":"10.5114/ppn.2026.164128","DOIUrl":"10.5114/ppn.2026.164128","url":null,"abstract":"<p><strong>Purpose: </strong>Epilepsy affects approximately 50 million people worldwide, with approximately 30% of patients exhibiting pharmacoresistance. Identifying reliable biomarkers for diagnosis, predicting treatment response, and monitoring disease progression is essential for improving epilepsy management. Neuropeptides such as ghrelin and nesfatin-1 have emerged as potential candidates owing to their roles in neuroprotection and metabolic regulation.</p><p><strong>Views: </strong>We systematically reviewed studies on ghrelin and nesfatin-1 in human epilepsy by searching PubMed, Embase and Web of Science. Inclusion criteria comprised original research reporting neuropeptide levels in patients with epilepsy. Data extraction and study selection followed PRISMA guidelines, and the protocol was registered with PROSPERO (CRD42024567659). Thirty-two studies published between 2005 and 2025 were included (27 on ghrelin and five on nesfatin-1). Ghrelin levels showed heterogeneous patterns - 37.1% of studies reported decreases, 29.6% reported increases, and 33.3% reported no change in epilepsy patients. Higher ghrelin levels were observed in focal epilepsy and in patients responding to anti-seizure medications (ASMs). Nesfatin-1 was elevated in 80% of studies, particularly in untreated or active epilepsy, but decreased in drug-resistant temporal lobe epilepsy and after long-term treatment. Evidence suggests that nesfatin-1 correlates with seizure burden and prognosis. Both neuropeptides show potential as biomarkers of disease severity and treatment response.</p><p><strong>Conclusions: </strong>Ghrelin and nesfatin-1 exhibit dynamic changes in relation to the type of epilepsy, seizure activity, and treatment. These neuropeptides may serve as non-invasive biomarkers and therapeutic targets, with near-term clinical potential for monitoring adverse side effects of ASM, differentiating between seizure types, and predicting drug resistance. However, validation studies are needed to establish clinical utility before routine implementation.</p>","PeriodicalId":74481,"journal":{"name":"Postepy psychiatrii neurologii","volume":"35 2","pages":"180-193"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13678375/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149225606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Andrzej Silczuk, Agata Olearczyk, Mirosława Palak, Agnieszka Kamińska, Łukasz Czyżewski
{"title":"Drug-facilitated sexual assault (spiking) in Poland: risk perception, knowledge, and bystander intentions.","authors":"Andrzej Silczuk, Agata Olearczyk, Mirosława Palak, Agnieszka Kamińska, Łukasz Czyżewski","doi":"10.5114/ppn.2026.164881","DOIUrl":"10.5114/ppn.2026.164881","url":null,"abstract":"<p><strong>Purpose: </strong>To estimate the prevalence of self-reported suspicion of spiking among adults in Poland and to examine sociodemographic determinants of suspicion, concern, symptom recognition, and preventive knowledge in the context of drug-facilitated sexual assault.</p><p><strong>Methods: </strong>A nationwide cross-sectional survey was conducted between 18 and 27 March 2025 using computer-assisted web interviewing (CAWI). A stratified quota sample of 1,000 adults was drawn to reflect the national distribution by sex, age, and place of residence. A structured questionnaire assessed suspected exposure to a \"date rape drug\" (spiking), frequency of concern at social events, knowledge of intoxication symptoms, preventive knowledge, and intended bystander actions. Multivariable logistic regression models were used to estimate adjusted odds ratios (aORs) with 95% confidence intervals (CIs) for associations with sex, age, education, sexual orientation, and place of residence.</p><p><strong>Results: </strong>Suspicion of spiking was reported by 19.4% of respondents, and 18.1% expressed frequent or constant concern. Reco-gnition of symptoms was declared by 24.4%, while 51.2% were uncertain. Preventive knowledge was affirmed by 43.8%. Intended bystander responses most commonly included contacting friends (44.0%), relatives (42.9%), venue security (41.7%), the police (38.5%), or ambulance services (36.3%); 2.5% would not intervene. Younger age was associated with higher odds of reporting suspicion (18-29 years: aOR = 3.76; 95% CI: 1.58-8.99; 30-39 years: aOR = 3.49; 95% CI: 1.44-8.46; 40-49 years: aOR = 3.30; 95% CI: 1.34-8.13; reference ≥ 60). Female sex predicted greater concern (aOR = 2.81; 95% CI: 1.91-4.15) and higher preventive knowledge (aOR = 1.67; 95% CI: 1.29-2.18). Higher education was associated with better recognition of symptoms (aOR = 2.84; 95% CI: 1.10-7.36).</p><p><strong>Conclusions: </strong>Suspicion of spiking is relatively common, while confidence in recognizing symptoms remains low, supporting the need for structured prevention and trauma-informed response pathways.</p>","PeriodicalId":74481,"journal":{"name":"Postepy psychiatrii neurologii","volume":"35 2","pages":"170-179"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13678372/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149225621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aleksandra J Oracz, Maria Suprunowicz, Emilia Turczyńska, Paulina Grzeszczuk, Dominika Zarzycka, Maria Qaheri, Beata Konarzewska
{"title":"The role of adipokines in the inflammatory theory of depression: mechanisms and therapeutic applications.","authors":"Aleksandra J Oracz, Maria Suprunowicz, Emilia Turczyńska, Paulina Grzeszczuk, Dominika Zarzycka, Maria Qaheri, Beata Konarzewska","doi":"10.5114/ppn.2026.164932","DOIUrl":"10.5114/ppn.2026.164932","url":null,"abstract":"<p><strong>Purpose: </strong>To demonstrate the link between excessive fat tissue and depression. To discuss the role of adipokines as a bridge connecting increased fat tissue with inflammatory processes which influence the development of depression.</p><p><strong>Views: </strong>Disruptions in the activity of adipokines, molecules secreted by adipose tissue, can significantly influence inflammatory responses by modulating the production and balance of both pro-inflammatory and anti-inflammatory cytokines produced by immune cells. According to the inflammatory theory of depression, it is the chronic dysregulation of the Th1/Th2 immune response ratio, along with persistent low-grade inflammation, that together contribute to the development and persistence of depressive symptoms. Therefore, excessive amounts of adipose tissue and elevated adipokine secretion in patients appear to substantially increase the likelihood of depression.</p><p><strong>Conclusions: </strong>Research shows that elevated levels of pro-inflammatory adipokines, such as leptin and resistin, may be associated with depression by intensifying inflammatory processes in the brain and disrupting neurotransmitter balance. In contrast, adiponectin - a protein with anti-inflammatory properties - has a different effect. Determining the relationship between the amount of body fat in patients and depression may be useful for predicting and monitoring the progression of depression in individuals with excessive body weight. Early identification of depression risk in this group could enable timely medical intervention and treatment, potentially reducing dangerous behaviors and improving therapeutic outcomes.</p>","PeriodicalId":74481,"journal":{"name":"Postepy psychiatrii neurologii","volume":"35 2","pages":"207-217"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13678377/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149229433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gabriela Zdunek, Remigiusz Recław, Krzysztof Chmielowiec, Aleksandra Suchanecka, Ewelina Grywalska, Jolanta Chmielowiec, Dariusz Larysz, Anna Grzywacz
{"title":"<i>COMT</i> rs4680 polymorphism modulates openness to experience in women with alcohol use disorder.","authors":"Gabriela Zdunek, Remigiusz Recław, Krzysztof Chmielowiec, Aleksandra Suchanecka, Ewelina Grywalska, Jolanta Chmielowiec, Dariusz Larysz, Anna Grzywacz","doi":"10.5114/ppn.2026.164880","DOIUrl":"10.5114/ppn.2026.164880","url":null,"abstract":"<p><strong>Purpose: </strong>The objective of the study was to examine the association between <i>COMT</i> rs4680 genotypes, alcohol use disorder diagnosis, and differences in Five-Factor personality traits.</p><p><strong>Methods: </strong>We examined 213 adult women in total, including 101 with a diagnosis of alcohol use disorder (AUD) and 112 non-addicted controls. All participants completed the NEO Five-Factor Inventory (NEO-FFI) and were genotyped for the <i>COMT</i> rs4680 polymorphism using real-time PCR. Group comparisons and genotype × diagnosis interactions were analyzed using ANOVA and post hoc tests.</p><p><strong>Results: </strong>Women with AUD scored significantly higher on Neuroticism and Openness to Experience, and lower on Extraversion, Agreeableness, and Conscientiousness compared to controls. A significant interaction between <i>COMT</i> rs4680 genotype and group status was observed for Openness (<i>F</i>2,207 = 6.16, <i>p</i> = 0.0025), with alcohol-dependent women carrying the G/A or G/G genotype showing elevated Openness scores compared to genotype-matched controls.</p><p><strong>Conclusions: </strong>These findings suggest that dopaminergic genetic variation may moderate the expression of personality traits in the context of alcohol dependence. Openness to Experience, typically associated with cognitive flexibility, may represent both a vulnerability and an adaptation mechanism in addiction, depending on genetic background. This study emphasizes the importance of considering gene × personality interactions in female addiction research.</p>","PeriodicalId":74481,"journal":{"name":"Postepy psychiatrii neurologii","volume":"35 2","pages":"161-169"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13678373/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149225633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Katarzyna E Polanowska, Aleksandra J Zielińska-Michalak
{"title":"Differential language recovery in an English-Polish bilingual individual with severe aphasia: a four-year longitudinal case study.","authors":"Katarzyna E Polanowska, Aleksandra J Zielińska-Michalak","doi":"10.5114/ppn.2026.164947","DOIUrl":"10.5114/ppn.2026.164947","url":null,"abstract":"<p><strong>Purpose: </strong>The purpose of this case study is to present factors influencing therapeutic decisions and patterns of language recovery in bilingual post-stroke aphasia, focusing on the impact of single-language therapy on both the treated and untreated language.</p><p><strong>Case description: </strong>A 68-year-old right-handed English-Polish bilingual male with severe post-stroke aphasia received long-term English-based language therapy and was evaluated at four time points over four years. Language abilities were assessed using the Boston Diagnostic Aphasia Examination (BDAE) and the Aphasia Severity Rating Scale (ASRS). Both languages improved in specific functions (BDAE), but overall communicative effectiveness (ASRS) differed markedly. The patient regained basic conversational ability in English, whereas Polish remained nonfunctional, with pathological switching into English. The observed changes were analyzed with regard to the extent and possible limitations of cross-linguistic transfer.</p><p><strong>Comment: </strong>Recovery in bilingual aphasia may differ substantially between languages in specific linguistic functions and overall communicative effectiveness.</p>","PeriodicalId":74481,"journal":{"name":"Postepy psychiatrii neurologii","volume":"35 2","pages":"224-231"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13678369/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149225609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Agnieszka A Borowiec, Michał Bujalski, Jakub Stokwiszewski, Justyna I Klingemann
{"title":"Co-occurrence of alcohol use disorder and mood disorders in the adult population in Poland: results from the EZOP II study.","authors":"Agnieszka A Borowiec, Michał Bujalski, Jakub Stokwiszewski, Justyna I Klingemann","doi":"10.5114/ppn.2026.164828","DOIUrl":"10.5114/ppn.2026.164828","url":null,"abstract":"<p><strong>Purpose: </strong>The study aimed to assess the prevalence and determinants of co-occurring mood disorders (MD) (depression, dysthymia, mania, neurasthenia) and alcohol use disorders (AUD) in the adult population in Poland.</p><p><strong>Methods: </strong>The analysis was conducted based on data obtained from the EZOP II study, carried out in 2018-2019 using the CAPI method. The study employed a nationally representative random sample of 11,998 individuals. The Composite International Diagnostic Interview (CIDI) v.21.1.4 questionnaire was used for diagnostic assessments. Statistical analysis was performed using the cross-tabulations with confidence intervals, phi correlation coefficients, and multivariate logistic regression.</p><p><strong>Results: </strong>The proportion of individuals in the general population diagnosed with co-occurring AUD and MD is 0.79%. AUD was associated with a 2.5-fold increased risk of MD in the entire sample and 2.7-fold increase in men. Among individuals with comorbid disorders, the average age of onset of AUD was lower than the average age of onset of MD. Significant predictors of co-occurrence included gender - women were significantly less likely to experience both disorders concurrently (OR = 0.163; <i>p</i> ≤ 0.01). Among men, risk factors included unemployment (OR = 5.131, <i>p</i> ≤ 0.05), separation or divorce (OR = 12.714; <i>p</i> ≤ 0.01), and being in an informal relationship (OR = 6.821; <i>p</i> ≤ 0.01).</p><p><strong>Conclusions: </strong>Given the well-documented gendered nature of MD diagnosis, current estimates of AUD-MD comorbidity may underestimate its true prevalence. Population-based study indicates that men aged 30-39, who are unemployed, divorced, separated, or cohabiting, and have a basic vocational education are at highest risk of the co-occurrence of MD and AUD.</p>","PeriodicalId":74481,"journal":{"name":"Postepy psychiatrii neurologii","volume":"35 2","pages":"147-160"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13678370/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149229430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Anna Lojko-Dankowska, Tomasz Dynowski, Michał Machała, Anna Płotka, Adam A Niezgoda, Anna Wache, Lidia A Gil
{"title":"Irreversible paraplegia due to transverse myelitis as a rare complication of CAR T-cell therapy in a patient with B-cell lymphoma.","authors":"Anna Lojko-Dankowska, Tomasz Dynowski, Michał Machała, Anna Płotka, Adam A Niezgoda, Anna Wache, Lidia A Gil","doi":"10.5114/ppn.2026.164944","DOIUrl":"10.5114/ppn.2026.164944","url":null,"abstract":"<p><strong>Purpose: </strong>To report a rare case of irreversible paraplegia due to transverse myelitis as a severe neurotoxic complication of chimeric antigen receptor (CAR) T-cell therapy.</p><p><strong>Case description: </strong>A 45-year-old woman with primary mediastinal B-cell lymphoma received axicabtagene ciloleucel. She deve-loped Grade 4 neurotoxicity with seizures requiring intubation. Upon regaining consciousness, she presented with flaccid paralysis of the lower limbs, sensory loss, and sphincter dysfunction. Magnetic resonance imaging revealed longitudinally extensive spinal cord lesions. Despite treatment with corticosteroids, anakinra, and intravenous immunoglobulin, no neurological improvement was observed. One year after the therapy, the patient remained in complete remission from lymphoma but was wheelchair-dependent, with persistent paralysis and spinal cord atrophy.</p><p><strong>Comment: </strong>This case highlights a rare and severe form of CAR T-cell-related neurotoxicity, manifesting as transverse myelitis in the absence of a marked inflammatory response. The refractory course and lack of standard treatment options underscore the need for greater awareness, reporting, and further research into atypical neurological complications of CAR T-cell therapy.</p>","PeriodicalId":74481,"journal":{"name":"Postepy psychiatrii neurologii","volume":"35 2","pages":"218-223"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13678371/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149229394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Patryk Osiński, Alicja B Roztocka, Karolina M Trojnar, Izabella Brykczyńska, Izabela Stefaniak
{"title":"Psychopathological and psychosexual profile and therapy for patients with androgen insensitivity syndrome: a narrative review.","authors":"Patryk Osiński, Alicja B Roztocka, Karolina M Trojnar, Izabella Brykczyńska, Izabela Stefaniak","doi":"10.5114/ppn.2026.164930","DOIUrl":"10.5114/ppn.2026.164930","url":null,"abstract":"<p><strong>Purpose: </strong>The objective of this review is to present androgen insensitivity syndrome as a multidimensional disorder, with a focus on psychological issues, gender identity, and sexual functioning. It also discusses therapeutic options, such as psychological and psychiatric support.</p><p><strong>Views: </strong>Androgen insensitivity syndrome is a rare disorder of sex development that occurs in individuals with an XY karyotype. It is caused by a mutation in the androgen receptor gene, leading to reduced sensitivity to androgens. There are three forms: mild, partial, and complete androgen insensitivity syndrome. Individuals with a 46,XY karyotype may exhibit female, male, or ambiguous phy-sical characteristics. This condition is associated with medical, psychological, sexual, and gender identity difficulties. Those affected may experience depression, anxiety, and suicidal thoughts. Those with complete androgen insensitivity syndrome usually identify as female, while those with partial androgen insensitivity syndrome often experience gender identity conflicts and sexual dysfunction.</p><p><strong>Conclusions: </strong>Patients with androgen insensitivity syndrome experience issues with sexuality, gender identity, and mental health. Every patient needs a personalized approach that includes medical and psychological support. The diagnosis and treatment of androgen insensitivity syndrome should not only consider medical interventions. A long-term care model is necessary that considers spheres of life such as identity, sexuality, and mental health. A comprehensive approach can improve quality of life and minimize the risk of future psychological and psychosexual problems.</p>","PeriodicalId":74481,"journal":{"name":"Postepy psychiatrii neurologii","volume":"35 2","pages":"194-206"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13678374/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149225563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nurgül Kale Budak, Feyzanur Erdem, Seçil Günher Arıca
{"title":"The effect of health literacy on health anxiety among young women.","authors":"Nurgül Kale Budak, Feyzanur Erdem, Seçil Günher Arıca","doi":"10.5114/ppn.2026.161373","DOIUrl":"10.5114/ppn.2026.161373","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to examine the relationship between health literacy (HL) and health anxiety (HA) among young women and to evaluate how variations in HL influence anxiety and related health outcomes.</p><p><strong>Methods: </strong>A cross-sectional survey was conducted with 245 women aged 18-45 years attending the Prof. Dr. Cemil Taşcıoğlu City Hospital Training and Research Family Health Center. The questionnaire included 13 sociodemographic items, the 14-item Health Literacy Scale, and the 18-item Health Anxiety Inventory. Higher scores reflected higher levels of literacy or anxiety. Data were analyzed using SPSS 25, with <i>p</i> < 0.05 considered statistically significant.</p><p><strong>Results: </strong>Of 245 participants, 66.8% were married and 61.2% had children. Higher education was associated with higher HL, whereas lower education, obesity, chronic disease, and regular medication use were associated with lower literacy scores (<i>p</i> < 0.05). HA was negatively correlated with the level of education and HL but positively correlated with the number of doctor visits.</p><p><strong>Conclusions: </strong>HL increases with the level of education, while HA decreases. Enhancing HL in primary care settings may help reduce health-related anxiety and unnecessary healthcare use among young women.</p>","PeriodicalId":74481,"journal":{"name":"Postepy psychiatrii neurologii","volume":"35 2","pages":"106-112"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13237744/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148201429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}