Postepy psychiatrii neurologii最新文献

{"title":"The diagnosis of myotonic dystrophy type 2 in a patient with calpainopathy requires the determination of CCTG expansion.","authors":"Josef Finsterer","doi":"10.5114/ppn.2025.149985","DOIUrl":"https://doi.org/10.5114/ppn.2025.149985","url":null,"abstract":"","PeriodicalId":74481,"journal":{"name":"Postepy psychiatrii neurologii","volume":"34 1","pages":"58-59"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12076131/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144082655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ukrainian refugee crisis center at the University Hospital's Psychiatric Clinic for Adults, Children and Adolescents in Krakow.","authors":"Daria Rozynek, Natalia Śmierciak, Barbara Wojszel, Weronika Rodak, Małgorzata Bagieńska, Alina Valynets-Cyganik, Veronika Slabucho, Sabir Talybov, Krzysztof Wojtasik-Bakalarz, Marta Szwajca, Bartłomiej Guzik, Maciej Pilecki","doi":"10.5114/ppn.2025.149874","DOIUrl":"https://doi.org/10.5114/ppn.2025.149874","url":null,"abstract":"<p><strong>Purpose: </strong>Since 2022, Poland, particularly Krakow, has been at the forefront of providing assistance to Ukrainian refugees, displaced by military operations. The mental health impact of war trauma, notably post-traumatic stress disorder and acute stress reaction (ASR), necessitated immediate psychiatric interventions. To provide psychological support for refugees, a team of nine specialists was formed within the Department of Adult, Child, and Adolescent Psychiatry at the University Hospital in Krakow. This study aims to present the functioning of our crisis center and challenges it has faced, while comparing our approach to mental health care for refugees in other countries.</p><p><strong>Methods: </strong>Data were collected from the center's activities and collaborations with partners, focusing on psychiatric care for Ukrainian refugees. Each patient was diagnosed by a psychiatrist based on ICD-10 classification.</p><p><strong>Results: </strong>107 visits were held, primarily with females aged 8 to 75 and males aged 2.5 to 65. The visits mostly took place at the crisis center. Patients presented with mental health concerns including suicidal ideation, sleep disorders, and self-mutilation. Among females, the most common diagnoses were ASR (45.45%), autism spectrum disorder (14.29%), depressive disorder, and recurrent depression (total 14.29%). For males, these were ASR (35.00%), autism spectrum disorder (35.00%), and attention deficit hyperactivity disorder (20.00%). Challenges such as language barriers and the fact that the center was unprepared for the influx of refugees were identified.</p><p><strong>Conclusions: </strong>Given the considerable challenges encountered, the study emphasizes the need for mental health support for refugees and indicates the need to integrate the preparation for refugee crises into civil protection strategies.</p>","PeriodicalId":74481,"journal":{"name":"Postepy psychiatrii neurologii","volume":"34 1","pages":"11-18"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12076129/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144082688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functional magnetic resonance imaging and diffuse tensor imaging diagnostic values in central post-stroke pain.","authors":"Robert E Djojoseputro, Angela F Ciaves, I Putu E Widyadharma","doi":"10.5114/ppn.2025.149952","DOIUrl":"https://doi.org/10.5114/ppn.2025.149952","url":null,"abstract":"<p><strong>Purpose: </strong>This review aims to emphasize the diagnostic value of functional magnetic resonance imaging (fMRI) and diffusion tensor imaging (DTI) tractography in detecting and diagnosing central post-stroke pain (CPSP).</p><p><strong>Views: </strong>CPSP is a debilitating form of chronic neuropathic pain that develops in patients with a history of stroke. CPSP has a wide range of onset and non-specific clinical presentations, making it difficult to detect. Until now, CPSP has been considered a diagnosis of exclusion, often leading to delays in the initiation of the appropriate treatment plan. fMRI and DTI tractography are valuable tools for assessing cerebral metabolic activity and the structural characteristics of the spinothalamic tracts, respectively. By combining these sets of information, physicians can detect CPSP early and implement more effective treatment strategies.</p><p><strong>Conclusion: </strong>Diagnosing CPSP has been challenging for physicians due to its complex nature. However, fMRI and DTI have the potential in enabling earlier detection of CPSP, giving physicians more time to initiate treatment. This review highlights the capacities of fMRI and DTI in identifying alterations in the spinothalamic pathways associated with CPSP.</p>","PeriodicalId":74481,"journal":{"name":"Postepy psychiatrii neurologii","volume":"34 1","pages":"44-53"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12076134/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144082623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent insights into depression from transcriptomic analysis.","authors":"Melih Günay, Meliha M Çiçekliyurt","doi":"10.5114/ppn.2025.149873","DOIUrl":"https://doi.org/10.5114/ppn.2025.149873","url":null,"abstract":"<p><strong>Purpose: </strong>Depression is a widespread mood disorder with a high rate of relapse and chronicity that can be affected by gender, and caused by traumatic or stressful events. Transcriptome analysis measures gene expression heterogeneity in cells, tissues, organs, and the whole body. The purpose of the study was to investigate both gender-specific and tissue-specific variations in gene expression regarding depression based on transcriptomic analysis using RNA-Seq data.</p><p><strong>Methods: </strong>The depression datasets GSE190518 and GSE214921 were downloaded from the Gene Expression Omnibus database provided by the NCBI. The GSE190518 datasets include peripheral blood samples (4 patients, 4 healthy controls), and the GSE214921 datasets contain human postmortem orbitofrontal cortex bulk tissue (20 patients, 19 healthy controls). All datasets were analyzed separately with the DESeq2 package in R. Later, GO and KEGG enrichment analyses of differentially expressed genes were performed using the clusterProfiler package in R.</p><p><strong>Results: </strong>Our results reveal that depression stimulates genes linked to the immune system, which is a common denominator in both brain tissue and blood samples. Overall, tissue-specific factors contribute to the association between depression and the immune system via distinct genes. Furthermore, gene ontology analyses revealed that <i>HSPA6, HSPA7, HSPA1L, HSPA1A</i>, and <i>HSPA1B</i> genes are co-represented in different pathways involved in molecular function, biological processes, and cellular components.</p><p><strong>Conclusions: </strong>Comparative transcriptomic evidence supports the immune hypothesis of depression in different tissue samples. Gender-specific depression may be triggered by protein misfolding.</p>","PeriodicalId":74481,"journal":{"name":"Postepy psychiatrii neurologii","volume":"34 1","pages":"1-10"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12076128/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144082648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to the Letter to the Editor on \"The diagnosis of myotonic dystrophy type 2 in a patient with calpainopathy requires the determination of CCTG expansion\" [].","authors":"Wiktoria Radziwonik-Frączyk, Anna Sułek, Ewelina Elert-Dobkowska","doi":"10.5114/ppn.2025.149986","DOIUrl":"https://doi.org/10.5114/ppn.2025.149986","url":null,"abstract":"","PeriodicalId":74481,"journal":{"name":"Postepy psychiatrii neurologii","volume":"34 1","pages":"60-61"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12076136/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144082653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The real-life reliability of the modified Rankin scale used in a stroke unit and a rehabilitation ward.","authors":"Natalia A Pożarowszczyk, Iwona Kurkowska-Jastrzębska, Iwona M Sarzyńska-Długosz, Maciej Nowak, Michał Karliński","doi":"10.5114/ppn.2025.149879","DOIUrl":"https://doi.org/10.5114/ppn.2025.149879","url":null,"abstract":"<p><strong>Purpose: </strong>The modified Rankin scale (mRS) is the gold standard for measuring stroke-related disability in clinical trials and everyday practice. However, inter-observer variability is a source of bias that may undermine the reliability of retrospective studies. It may also depend on clinical backgrounds of different assessing physician. Our aim was to prospectively assess real-life consistency between stroke unit physicians (SUPs) and physical and rehabilitation medicine physicians (PRMPs) using mRS in patients transferred directly from a stroke unit (SU) to a rehabilitation ward (RW).</p><p><strong>Methods: </strong>We enrolled 48 consented stroke patients transferred within the same hospital from SU to RW. Patients were scored in mRS by a SUP and a PRMP at the day of transfer as a standard of care. The reference mRS score (REF) was obtained by a single- blinded stroke physician using the Rankin Focused Assessment form to guide an interview.</p><p><strong>Results: </strong>An mRS score was reported for all patients admitted to the RW and 33 patients discharged from the SU. The overall agreement was 75.8% between the assessments of SUPs and PRMPs (κ = 0.58), 72.7% between SUPs and the REF (κ = 0.55) and 70.0% between PRMPs and the REF (κ = 0.49). A similar agreement was observed for PRMPs and the REF in the sensitivity cohort of 48 patients (66.7%; κ = 0.46). Patients with the REF mRS of 2 (<i>n</i> = 6) were often scored as 3 both by SUPs (4/6) and PRMPs (5/6). In patients with the REF mRS of 3 or 4 there was no clear tendency towards overrating disability.</p><p><strong>Conclusions: </strong>The reliability of mRS scoring in everyday practice is modest and does not seem to depend on clinical background of assessing physician.</p>","PeriodicalId":74481,"journal":{"name":"Postepy psychiatrii neurologii","volume":"34 1","pages":"19-25"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12076130/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144082682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transient shortening of activated partial thromboplastin time and prothrombin time associated with transient global amnesia.","authors":"Dariusz Dziubek, Karolina Dziubek, Marcelina Stodolak","doi":"10.5114/ppn.2025.149970","DOIUrl":"https://doi.org/10.5114/ppn.2025.149970","url":null,"abstract":"<p><strong>Purpose: </strong>Transient global amnesia (TGA) manifests as acute short-term memory disturbances lasting up to 24 hours. The pathophysiology of the disease remains unclear. This paper presents the case of a patient with recurrent TGA, in whom a shortening of coagulation times and high blood pressure peaks were observed during each acute phase of the disease, suggesting transient increased blood coagulability and transient dysregulation of autonomic blood pressure control.</p><p><strong>Case description: </strong>A 59-year-old patient with medical history of migraine and arterial hypertension was diagnosed with recurrent TGA (two episodes within a year). Each time, upon admission to hospital, high blood pressure peaks were recorded and activated partial thromboplastin time (aPTT) and prothrombin time (PT) were shortened with gradual normalization over the following days.</p><p><strong>Comment: </strong>The shortening of aPTT and PT may suggest a relationship between TGA and transient blood coagulation disorders in the acute phase.</p>","PeriodicalId":74481,"journal":{"name":"Postepy psychiatrii neurologii","volume":"34 1","pages":"54-57"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12076132/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144082685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Value stream mapping in healthcare - the case of stroke patients treatment at Institute of Psychiatry and Neurology.","authors":"Mira Lisiecka-Biełanowicz, Daria Biechowska","doi":"10.5114/ppn.2025.149940","DOIUrl":"https://doi.org/10.5114/ppn.2025.149940","url":null,"abstract":"<p><strong>Purpose: </strong>The purpose of this article is to assess the potential and usefulness of applying value stream mapping (VSM) in the process of treating stroke patients in the Polish healthcare system, using the Institute of Psychiatry and Neurology (IPiN) as an example.</p><p><strong>Methods: </strong>The applied VSM method allows for a detailed identification of service delivery points (SDPs), which are the areas of potential organizational and structural changes in the stroke patient treatment process.</p><p><strong>Results: </strong>The IPiN VSM of the stroke patients treatment process illustrates the course of the process, taking into consideration all potential opportunities for improvement, as identified during the analytical work. It was determined that improvements require addressing issues, such as excessive patient transport times caused by the distance between the most critical SDPs, i.e., the reception, imaging diagnostics, and the stroke unit and also their location on different floors of the hospital building.</p><p><strong>Conclusions: </strong>At this stage, the VSM analysis reveals significant opportunities to improve process efficiency using lean management, without adding extra costs for the hospital. It is important to consider dividing stroke patients into two streams: standard patients (fast track, those without complications) and non-standard patients (slow track, those with complications).</p>","PeriodicalId":74481,"journal":{"name":"Postepy psychiatrii neurologii","volume":"34 1","pages":"26-32"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12076135/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144082731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intravenous tissue plasminogen activator in functional stroke mimics.","authors":"Magdalena M Kowalska, Małgorzata M Michałowska, Marta M Leńska-Mieciek","doi":"10.5114/ppn.2025.149942","DOIUrl":"https://doi.org/10.5114/ppn.2025.149942","url":null,"abstract":"<p><strong>Purpose: </strong>Time pressure in the treatment of acute ischemic stroke patients generates difficult decisions for neurologists, sometimes resulting in stroke mimic patients receiving intravenous thrombolytic therapy. Proper diagnosis and appropriate treatment for these patients are crucial, yet incredibly challenging in cases of functional stroke mimics (FSM).</p><p><strong>Views: </strong>Functional neurological disorders, including FSM, are increasingly diagnosed. However, their pathophysiology and underlying mechanisms are poorly understood, even though the diagnostic criteria for diagnosing FSM exist, and various clinical indicators support them. Functional neurological symptoms often result in serious disability for patients but the effective treatment is unknown. Neurologists need to examine the symptoms and the key clinical findings to distinguish between FSM and stroke. The intravenous thrombolytic therapy appears safe for FSM, but the potential harm of thrombolysis should be a concern. FSMdiagnosed patients require long-term treatment, starting with open and clear communication about their condition and followed by psychoeducation and physiotherapy.</p><p><strong>Conclusions: </strong>FSM should be diagnosed using the diagnostic criteria. Electronic health information exchange among healthcare providers is necessary to avoid unnecessary thrombolytic treatments in this group of patients.</p>","PeriodicalId":74481,"journal":{"name":"Postepy psychiatrii neurologii","volume":"34 1","pages":"33-43"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12076133/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144082647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mommy, am I good? Case report of a 12-year-old boy with abused child syndrome.","authors":"Oliwia Froń, Rafał Szmajda, Aleksandra Lewandowska","doi":"10.5114/ppn.2024.147367","DOIUrl":"10.5114/ppn.2024.147367","url":null,"abstract":"<p><strong>Purpose: </strong>Abused child syndrome remains a significant public health concern with profound physical and psychological implications.</p><p><strong>Case description: </strong>We present a case report of a 12-year-old child who was admitted to the child inpatient psychiatric unit of a paediatric hospital with signs and symptoms of abuse. The child was malnourished but did not exhibit physical injuries. A detailed medical history revealed inconsistent explanations regarding the diets used by the mother, allegedly recommended by a neurologist. Diagnostic evaluation, including medical examination, laboratory tests, and imaging studies supported the suspicion of child maltreatment. The case was reported to the police and the court. Appropriate interventions were initiated, including treatment, social work involvement, and psychosocial support.</p><p><strong>Comment: </strong>This case highlights the importance of early recognition, comprehensive assessment, and multidisciplinary cooperation in addressing child abuse. Medical professionals play a critical role in child safety and should be vigilant in identifying and reporting suspected cases of child abuse and neglect. How they respond and whether they notify the justice authorities may determine the child's future fate and even his or her life.</p>","PeriodicalId":74481,"journal":{"name":"Postepy psychiatrii neurologii","volume":"33 1","pages":"267-271"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11891752/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143607335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}