Postepy psychiatrii neurologii最新文献_第2页

Polypharmacy's paradox: accelerated decline in a rare case of Lafora body disease. 多元药房的悖论：罕见的拉福拉体病加速衰退。

Postepy psychiatrii neurologii Pub Date : 2026-06-01 Epub Date: 2026-05-13 DOI: 10.5114/ppn.2026.161380

Tasneem Hussain, Krishna Gupta, Ashutosh Tiwari, Pooja S Mishra

{"title":"Polypharmacy's paradox: accelerated decline in a rare case of Lafora body disease.","authors":"Tasneem Hussain, Krishna Gupta, Ashutosh Tiwari, Pooja S Mishra","doi":"10.5114/ppn.2026.161380","DOIUrl":"10.5114/ppn.2026.161380","url":null,"abstract":"Purpose: Lafora body disease (LBD) is a rare autosomal recessive progressive myoclonic epilepsy characterized by neurodegene-ration due to an intracellular accumulation of poorly branched polyglucosan inclusions. Effective pharmacological management remains challenging due to the risk of drug-induced exacerbation of symptoms and adverse interactions.Case description: We present the case of an 18-year-old male with intractable seizures, myoclonus, and cognitive regression. Electroencephalogram showed frequent generalized polyspike discharges, and histopathology confirmed Lafora bodies. The patient was initially prescribed a broad polypharmacy regimen including sodium valproate, carbamazepine, phenytoin, and phenobarbitone - leading to detrimental pharmacokinetic and pharmacodynamic interactions, worsening his neurological status. A stepwise revision with withdrawal of contraindicated agents and rational introduction of levetiracetam, clobazam, and perampanel improved seizure control and alertness.Comment: This case highlights the hazards of unstructured polypharmacy in LBD and stresses the need for individualized pharmacotherapy. Novel disease-modifying options like metformin, targeting glycogen metabolism, offer future therapeutic potential in altering disease trajectory.","PeriodicalId":74481,"journal":{"name":"Postepy psychiatrii neurologii","volume":"35 2","pages":"141-145"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13237742/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148201474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Suicide attempts among youth attending special education centres: risk and protective factors. 在特殊教育中心就读的青少年的自杀企图：风险和保护因素。

Postepy psychiatrii neurologii Pub Date : 2026-06-01 Epub Date: 2026-05-13 DOI: 10.5114/ppn.2026.161372

Agnieszka Pisarska, Anna Borucka, Krzysztof Ostaszewski

{"title":"Suicide attempts among youth attending special education centres: risk and protective factors.","authors":"Agnieszka Pisarska, Anna Borucka, Krzysztof Ostaszewski","doi":"10.5114/ppn.2026.161372","DOIUrl":"10.5114/ppn.2026.161372","url":null,"abstract":"Purpose: Adolescents studying in special education centres are a group at particular risk of suicidal behaviour. The aim of this cross-sectional study was to identify risk/protective factors associated with suicide attempts among students aged 12-19 years (N = 1730) who attended Youth Sociotherapy Centres (YSC) and Youth Correctional Centres (YCC) in Poland.Methods: Auditory self- administered surveys were conducted as part of school lessons with procedures in place to ensure anonymity and confidentiality of the data. Hierarchical linear regression was used to analyse the relationship between the frequency of suicide attempts and a set of risk and protective factors.Results: The results indicate that the risk factors identified as associated with the frequency of suicide attempts were depressive symptoms, sensation-seeking tendencies and having experienced violence and cyberbullying from peers. Among the risk factors confirmed only for boys were the ongoing use of medication for stomach ache, and also listening to music in leisure time. In turn, the risk factors that were confirmed only among girls were domestic conflicts/violence and the use of medicine for nega-tive emotional states. Playing computer games appeared to be a protective factor, but only for boys; no protective factors were identified for girls.Conclusions: Preventive efforts should be aimed at early identification of youth at risk of depression, peer or domestic violence as well as training YSC/YCC staff in brief interventions addressed to young people at risk of suicide.","PeriodicalId":74481,"journal":{"name":"Postepy psychiatrii neurologii","volume":"35 2","pages":"94-105"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13237745/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148201389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The relationship between autism and gender dysphoria, and their co-occurrence with transgender identity: research conditions and implications. 自闭症与性别焦虑的关系及其与跨性别认同的共发：研究条件与启示。

Postepy psychiatrii neurologii Pub Date : 2026-06-01 Epub Date: 2026-05-13 DOI: 10.5114/ppn.2026.161376

Karina Marciniec, Zuzanna Szczypińska, Adam Pawlak

{"title":"The relationship between autism and gender dysphoria, and their co-occurrence with transgender identity: research conditions and implications.","authors":"Karina Marciniec, Zuzanna Szczypińska, Adam Pawlak","doi":"10.5114/ppn.2026.161376","DOIUrl":"10.5114/ppn.2026.161376","url":null,"abstract":"Purpose: To discuss the relationship between autism and gender dysphoria (GD), and their co-occurrence with transgender identity, and to raise awareness of the specific needs of individuals with autism spectrum disorder (ASD) in gender-confirming clinics. PubMed, Scopus, Medline, and EBSCO databases were reviewed. Only peer-reviewed English-language articles were considered eligible. Priority was given to meta-analyses and original articles presenting quantitative results published within the last five years; For some unreplicated studies this period was extended. The databases were searched using the keywords: \"ASD\" and \"GD\", \"autism spectrum\" and \"transgender\", \"autism spectrum\" and \"gender dysphoria\".Views: An increasing number of studies show that ASD is overrepresented in people with GD as well as in gender-affirming secondary care clinics. This trend is observed in both young people and adults. People with overlapping diagnoses face higher anxiety, depression, risk of self-harm and the feeling of being a minority within a minority. Sensory disorders from ASD may cause difficulties in achieving gender congruence, while social communication deficits may delay the diagnosis of transgenderism.Conclusions: Transgenderism is more common among the ASD population than among neurotypical individuals. The reasons for this correlation are unclear, but they may be found in the theory of mind, extreme male brain theory, cerebral cortex structure, and cognitive inflexibility. Practitioners need training to uphold the dignity and autonomy of patients with comorbid transgender and autism spectrum diagnoses, enabling shared decision-making in treatment process and in co-defining the goals of therapy.","PeriodicalId":74481,"journal":{"name":"Postepy psychiatrii neurologii","volume":"35 2","pages":"126-131"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13237746/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148201487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagnostic utility of Addenbrooke's Cognitive Examination III in differentiating Alzheimer's disease dementia, vascular dementia, and mixed dementia. 阿登布鲁克认知检查III在鉴别阿尔茨海默病痴呆、血管性痴呆和混合性痴呆中的诊断效用

Postepy psychiatrii neurologii Pub Date : 2026-06-01 Epub Date: 2026-05-13 DOI: 10.5114/ppn.2026.161371

Anna Barczak

{"title":"Diagnostic utility of Addenbrooke's Cognitive Examination III in differentiating Alzheimer's disease dementia, vascular dementia, and mixed dementia.","authors":"Anna Barczak","doi":"10.5114/ppn.2026.161371","DOIUrl":"10.5114/ppn.2026.161371","url":null,"abstract":"Purpose: Differentiating between Alzheimer's disease (AD), vascular dementia (VaD), and mixed dementia (MD) remains a major clinical challenge, as overlapping symptoms and comorbid pathologies limit the diagnostic value of screening tools. The Addenbrooke's Cognitive Examination III (ACE-III) offers a multidomain assessment and may support differential diagnosis.Methods: The study included 138 Polish patients with mild dementia (46 AD, 46 VaD, 46 MD), matched for age, sex, and education, and diagnosed based on current clinical criteria. Group comparisons were conducted using the Kruskal-Wallis test with Dunn- Bonferroni post hoc analyses.Results: Total ACE-III scores did not differ significantly between the groups. Significant effects were observed only in the Memory domain, where VaD patients scored higher than both AD and MD, who did not differ from each other. Subtest analyses confirmed group differences in episodic memory tasks. Only Serial 7 Subtraction (Attention) and Letter Fluency differentiated between groups, with AD patients outperforming VaD patients. Within the Visuospatial domain, only Dot Counting differentiated between groups (AD > MD > VaD). The Language domain showed no group effects.Conclusions: While total ACE-III scores have limited diagnostic value, domain- and subtest-level analyses reveal distinct cognitive profiles supporting differential diagnosis. VaD is marked by preserved episodic memory but impaired attention and executive tasks, AD by severe episodic memory deficits, and MD by an AD-like profile with vascular contributions. Domain-focused interpretation of ACE-III may enhance diagnostic accuracy in clinical practice.","PeriodicalId":74481,"journal":{"name":"Postepy psychiatrii neurologii","volume":"35 2","pages":"85-93"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13237741/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148201431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Delayed encephalopathy after carbon monoxide poisoning in a 29-year-old female patient. 29岁女性一氧化碳中毒后迟发性脑病。

Postepy psychiatrii neurologii Pub Date : 2026-06-01 Epub Date: 2026-05-13 DOI: 10.5114/ppn.2026.161379

Anna Małopolska, Maciej Biernacki, Michał Romankiewicz, Rafał Stabrawa

{"title":"Delayed encephalopathy after carbon monoxide poisoning in a 29-year-old female patient.","authors":"Anna Małopolska, Maciej Biernacki, Michał Romankiewicz, Rafał Stabrawa","doi":"10.5114/ppn.2026.161379","DOIUrl":"10.5114/ppn.2026.161379","url":null,"abstract":"Purpose: The aim of this study is to present a case of delayed encephalopathy after acute carbon monoxide (CO) poisoning in a 29-year-old female patient, and to discuss the applied treatment strategies.Case description: A 29-year-old female patient was admitted to the Toxicology Department due to acute CO poisoning. Improvement was achieved following oxygen therapy, including hyperbaric oxygen therapy (HBOT). After 38 days, a decline in cognitive and functional status was observed. The patient was re-hospitalized in the Neurology Department, where delayed encephalopathy after acute CO poisoning (DEACMP) was diagnosed. Pharmacological treatment proved ineffective. Comprehensive therapy was applied in the Rehabilitation Department, including cognitive, motor, and speech therapy, along with hyperbaric oxygen therapy. This approach led to a significant improvement in the patient's neurological status.Comment: DEACMP is a serious complication that may occur after asymptomatic CO exposure or following transient clinical improvement. In the presented case, HBOT proved an effective treatment modality, both in the acute phase and during the management of long-term neurological sequelae.","PeriodicalId":74481,"journal":{"name":"Postepy psychiatrii neurologii","volume":"35 2","pages":"136-140"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13237743/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148201471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A novel missense variant Cys559Gly in NOTCH3 in CADASIL family and vascular lesions in patients with migraine. CADASIL家族NOTCH3中一个新的错义变异Cys559Gly与偏头痛患者的血管病变

Postepy psychiatrii neurologii Pub Date : 2026-06-01 Epub Date: 2026-05-13 DOI: 10.5114/ppn.2026.161377

Karol Jastrzębski, Łukasz Kępczyński, Agnieszka Plucińska, Monika Kowalska-Gałecka, Agata Gajos

{"title":"A novel missense variant Cys559Gly in NOTCH3 in CADASIL family and vascular lesions in patients with migraine.","authors":"Karol Jastrzębski, Łukasz Kępczyński, Agnieszka Plucińska, Monika Kowalska-Gałecka, Agata Gajos","doi":"10.5114/ppn.2026.161377","DOIUrl":"10.5114/ppn.2026.161377","url":null,"abstract":"Purpose: To report a novel NOTCH3 pathologic variant in a family presenting CADASIL (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy, OMIM #125310).Case description: Two affected sisters with dementia and ischemic stroke (only the proband) in their medical history, and the pro- band's daughter with migraine without aura underwent clinical and imaging evaluations. Magnetic resonance imaging revealed typical CADASIL lesions in both sisters. Next-generation sequencing and targeted Sanger sequencing were performed to link the phenotype to a variant in the NOTCH3.Comment: Sequencing data revealed a likely pathogenic variant in the NOTCH3 gene. Using ACMG guidelines, the variant was classified as likely pathogenic. We have described a new likely pathogenic NOTCH3 missense variant c.1675T>G p. (Cys559Gly) and linked it to the CADASIL phenotype, confirming the predictions of genetic analyses. We particularly emphasize co-occurring central vascular lesions in patients with migraine, which may be de facto caused by pathogenic NOTCH3 variants.","PeriodicalId":74481,"journal":{"name":"Postepy psychiatrii neurologii","volume":"35 2","pages":"132-135"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13237739/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148201411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Putting the nationwide reform into practice: a pre-post evaluation of the Community Mental Health Center model in two counties. 实施全国改革：两县社区精神卫生中心模式的前后评价

Postepy psychiatrii neurologii Pub Date : 2026-06-01 Epub Date: 2026-04-08 DOI: 10.5114/ppn.2026.160668

Natalia W Lipińska-Kandarian, Jan G Barganowski, Eryk Kandarian, Sławomir Murawiec

{"title":"Putting the nationwide reform into practice: a pre-post evaluation of the Community Mental Health Center model in two counties.","authors":"Natalia W Lipińska-Kandarian, Jan G Barganowski, Eryk Kandarian, Sławomir Murawiec","doi":"10.5114/ppn.2026.160668","DOIUrl":"10.5114/ppn.2026.160668","url":null,"abstract":"Purpose: This study aimed to evaluate the local impact of implementing the Mental Health Center (MHC) model in the Malbork and Sztum counties in 2024. The analysis focused on comparing patient numbers, types of services provided, and diagnostic patterns before and after the introduction of the MHC.Methods: A retrospective quantitative analysis was conducted using data from psychiatric outpatient clinics and the psychiatric day ward for 2023 (pre-reform) and 2024 (post-reform). Variables included the total number of patients, individuals initiating psychiatric treatment, service types, and the most frequently recorded ICD-10 diagnoses.Results: In 2024, the total number of patients increased by 12.9%, while the number of individuals initiating psychiatric care rose by 49.8%. The overall number of services grew by 22.4%, with the most notable increases observed in psychotherapy sessions (+230.5%) and initial diagnostic assessments coded as Z03. Psychological consultations declined by 15.5%. The newly established psychiatric day ward showed a consistent upward trend in utilization. There was a shift in the distribution of diagnoses, with a rise in F41.2 and F43.2 cases, and the emergence of F00.1 among the most commonly assigned.Conclusions: In summary, our findings indicate that implementation in the Malbork and Sztum counties of the Mental Health Center model was associated with enhanced accessibility, earlier diagnosis, improved coordination, and a more comprehensive approach to psychiatric care. These outcomes are consistent with the guiding principles of Poland's mental health reform and align with previous national evaluations, underscoring the practical value of community-based mental health services.","PeriodicalId":74481,"journal":{"name":"Postepy psychiatrii neurologii","volume":"35 2","pages":"119-125"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13237738/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148201438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Communication skills and their association with depression, anxiety, and stress among dental students in Ahvaz city, Iran: a cross-sectional study. 伊朗阿瓦士市牙科学生的沟通技巧及其与抑郁、焦虑和压力的关系：一项横断面研究。

Postepy psychiatrii neurologii Pub Date : 2026-06-01 Epub Date: 2026-05-13 DOI: 10.5114/ppn.2026.161375

Fatemeh Babadi, Ali Mottaghi Fard, Maria Cheraghi

{"title":"Communication skills and their association with depression, anxiety, and stress among dental students in Ahvaz city, Iran: a cross-sectional study.","authors":"Fatemeh Babadi, Ali Mottaghi Fard, Maria Cheraghi","doi":"10.5114/ppn.2026.161375","DOIUrl":"10.5114/ppn.2026.161375","url":null,"abstract":"Purpose: Dentists' communication skills are a vital component of facilitating the provision of better health information for patients, and meeting their needs and expectations. High levels of stress, anxiety, and depression - caused by work pressure, non-cooperative patients, and financial issues - may be associated with dentist-patient communication. This study assessed communication skills and their relationship with depression, anxiety, and stress among dental students.Methods: This cross-sectional study involved 210 third year and above dentistry students at Ahvaz Jundishapur University of Medi-cal Sciences, Ahvaz, Iran, in 2024. The participants were selected using a census sampling method. They all completed the Queendom Communication Skills Test-Revised (CSTR) and the Depression, Anxiety and Stress Scale - 21 Items (DASS-21). Statistical analysis was performed using SPSS 27.Results: The mean (± SD) communication skills score was 104.20 ± 13.17. The logistic regression model revealed that anxiety and depression were positively associated with some components of communication skills, including emotional control, listening skills, and the ability to receive and send messages. In contrast, the level of stress was only associated with assertive communication.Conclusions: The results indicated a high level of communication skills among the dental students. However, it is recommended that interventions be designed, especially to improve depression and anxiety, and to examine their impact on enhancing communication skills.","PeriodicalId":74481,"journal":{"name":"Postepy psychiatrii neurologii","volume":"35 2","pages":"113-118"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13237740/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148201453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Body, mind, and weather: mechanisms of interaction - a narrative review. 身体、精神和天气：相互作用的机制——叙述回顾。

Postepy psychiatrii neurologii Pub Date : 2026-03-01 DOI: 10.5114/ppn.2026.159802

Krystian Konieczny

{"title":"Body, mind, and weather: mechanisms of interaction - a narrative review.","authors":"Krystian Konieczny","doi":"10.5114/ppn.2026.159802","DOIUrl":"10.5114/ppn.2026.159802","url":null,"abstract":"Purpose: This review investigates the extant literature concerning the association between meteorological conditions and the presentation of psychiatric and somatic symptoms. Particular attention was given to meteoropathy and meteosensitivity, as well as their proposed associations with affective disorders, psychotic disorders, and medically unexplained symptoms (MUS).Views: This review synthesizes findings from medical biometeorology, psychopathology, psychoneuroimmunology, and psychoendocrinology. The literature analyzed indicates that weather-related symptom patterns may involve dysregulation of the hypothalamic- pituitary-adrenal axis, a hypothesized seasonal modulation of Th1/Th2 immune responses, potential alterations in neurotransmitter activity, and disruptions in circadian rhythms. The immunoseasonal theory of psychiatric disorders posits an interaction between environmental factors and immune regulation in seeking to account for seasonal variations in mood and psychotic symptoms. However, evidence supporting these mechanisms remains limited and predominantly theoretical. The relationship between meteoropathy and MUS is also examined as a potential but unverified overlap of symptom patterns.Conclusions: The findings currently available suggest that weather-related phenomena may constitute an under-recognized factor influencing mental and physical health. Most reviewed data are derived from observational studies, often characterized by methodolo-gical limitations, inconsistent findings, and a lack of standardized diagnostic criteria. These gaps underscore the necessity for longitudinal research and the development of validated assessment tools that can elucidate causal relationships. A more comprehensive understanding of these processes could guide future investigations and eventually inform targeted diagnostic and therapeutic approaches, particularly in the context of meteoropathy.","PeriodicalId":74481,"journal":{"name":"Postepy psychiatrii neurologii","volume":"35 1","pages":"57-64"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13019899/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147576860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Memory and learning impairments in deficit and non-deficit schizophrenia: a scoping review. 记忆和学习障碍在缺陷和非缺陷精神分裂症：一个范围回顾。

Postepy psychiatrii neurologii Pub Date : 2026-03-01 Epub Date: 2026-03-12 DOI: 10.5114/ppn.2026.159800

Piotr Plichta, Monika Mak, Jerzy Samochowiec, Ernest M Tyburski

{"title":"Memory and learning impairments in deficit and non-deficit schizophrenia: a scoping review.","authors":"Piotr Plichta, Monika Mak, Jerzy Samochowiec, Ernest M Tyburski","doi":"10.5114/ppn.2026.159800","DOIUrl":"10.5114/ppn.2026.159800","url":null,"abstract":"Purpose: The evidence available indicates that patients with deficit schizophrenia experience more pronounced global cognitive impairments than non-deficit patients. Whether this syndrome is also marked by disproportionately greater difficulties in memory and learning remains unclear. This scoping review aimed to map the existing literature on differences in memory and learning between deficit and non-deficit schizophrenia patients, relative to healthy controls.Views: We systematically searched PsycINFO, ERIC, Health Source: Nursing/Academic Edition, and MEDLINE for studies published from January 1980 through June 2025. Methodology according to the PRISMA 2020 was applied. Thirty-nine studies met the inclusion criteria. Nineteen assessed working memory; as a condition, deficit schizophrenia showed greater impairments than non-deficit schizophrenia in verbal working memory in 5 studies (33.3%) and in visual working memory in 3 studies (37.5%). Twenty-nine studies examined episodic memory and learning; deficit schizophrenia showed greater deficits than non-deficit schizophrenia in verbal episodic memory/learning in 14 studies (48.3%) and in visual episodic memory/learning in 5 studies (38.5%). In most of the studies that included healthy controls, both patient groups performed worse than the controls.Conclusions: The evidence available supports the presence of memory and learning impairments in deficit schizophrenia; however, current data are insufficient to determine whether impairments of working and episodic memory are more prevalent in deficit than in non-deficit schizophrenia. This review highlights existing gaps in the literature and suggests directions for future research as well as discussing practical implications.","PeriodicalId":74481,"journal":{"name":"Postepy psychiatrii neurologii","volume":"35 1","pages":"28-51"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13019888/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147576814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0