Porto biomedical journal最新文献

{"title":"Effective VTE prophylaxis with enoxaparin after elective THR or TKR: a retrospective observational study.","authors":"Diogo Nóbrega Catelas,&nbsp;Filipa Cordeiro,&nbsp;Luís Loureiro,&nbsp;Adélio Vilaça,&nbsp;Ivone Silva","doi":"10.1097/j.pbj.0000000000000222","DOIUrl":"https://doi.org/10.1097/j.pbj.0000000000000222","url":null,"abstract":"<p><strong>Background: </strong>Orthopedic patients are at the highest risk for venous thromboembolism (VTE). Nowadays, with VTE prophylaxis as a routine in patients undergoing total hip replacement (THR) and total knee replacement (TKR), fatal pulmonary embolism (PE) is rare and the rates of symptomatic VTE within 3 months dropped to 1.3%-10%, compared with the rates of 50%-70% before VTE prophylaxis implementation. In this study, we aim to evaluate the VTE prophylaxis and incidence in patients who underwent THR and TKR in Centro Hospitalar Universitário de Santo António (CHUdSA).</p><p><strong>Methods: </strong>We included 483 patients who underwent elective THR or TKR in CHUdSA from March 2019 to February 2020 and who were under enoxaparin as a VTE prophylaxis drug. All data related to prescribed enoxaparin were collected from the nationwide common electronic drug prescription system (PEM).</p><p><strong>Results: </strong>Of the 483 eligible patients, 192 (39.75%) underwent elective THR and 291 (60.25%) underwent TKR. Enoxaparin was prescribed for 31.86 ± 5.98 and 30.28 ± 5.97 days, on average, for the THR and TKR groups, respectively (<i>P</i> = .005). Patients completed, on average, 29.38 ± 8.12 days and 28.20 ± 7.32 days of VTE prophylaxis with enoxaparin in the THR and TKR groups, respectively (<i>P</i> = .098). The incidence of VTE was approximately 3.13% and 0.69% in the THR and TKR groups, respectively (<i>P</i> = .064).</p><p><strong>Conclusion: </strong>In CHUdSA, we usually prescribe enoxaparin 40 mg once daily for up to 35 days for VTE prophylaxis after THR or TKR. High therapeutic compliance rates resulted in very few events.</p>","PeriodicalId":74479,"journal":{"name":"Porto biomedical journal","volume":"8 4","pages":"e222"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/be/d1/pj9-8-e222.PMC10400049.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10007367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The platelet-to-lymphocyte ratio as an indirect outcome predictor in primary hypertension: a retrospective study.","authors":"Rita Pinho,&nbsp;Rui Ribeiro,&nbsp;Diana Ferrão,&nbsp;Rui Medeiros,&nbsp;Maria João Lima,&nbsp;Jorge Almeida,&nbsp;Margarida Freitas-Silva","doi":"10.1097/j.pbj.0000000000000220","DOIUrl":"https://doi.org/10.1097/j.pbj.0000000000000220","url":null,"abstract":"<p><strong>Background: </strong>Nondipper hypertensive patients have higher levels of platelet-to-lymphocyte ratio, a new studied inflammatory biomarker in primary hypertension. Furthermore, these patients have a higher risk of cardiovascular morbidity and mortality. This study aimed to assess the relationship between platelet-to-lymphocyte ratio and hypertensive pattern (dipper vs nondipper) and the association between the hypertensive pattern and major adverse cardiovascular events.</p><p><strong>Methods: </strong>A retrospective analysis was performed. One hundred fifty-three patients were included and classified as dipper or nondipper according to 24-hour ambulatory blood pressure measurements. Platelet-to-lymphocyte ratio was calculated based on complete blood count data.</p><p><strong>Results: </strong>The dipper group included 109 patients, and the nondipper group included 44 patients. Nondipper patients have 2.11 more risk of presenting a higher platelet-to-lymphocyte ratio than dipper individuals (odds ratio [OR] = 2.11; 95% CI, 1.220-3.664; <i>P</i> = .007). Nondipper patients also registered earlier cardiovascular events, such as acute myocardial infarction and stroke (<i>P</i> < .001).</p><p><strong>Conclusions: </strong>Nondipper hypertensive individuals registered higher levels of platelet-to-lymphocyte ratio and earlier cardiovascular events than dipper patients. Therefore, platelet-to-lymphocyte ratio could be used as an indirect predictor of cardiovascular risk in primary hypertension and contribute to optimize preventive strategies.</p>","PeriodicalId":74479,"journal":{"name":"Porto biomedical journal","volume":"8 4","pages":"e220"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/6c/8f/pj9-8-e220.PMC10400061.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10007370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"May-Thurner syndrome: a case report.","authors":"Mariana L Matos,&nbsp;Maria Inês T S Matos,&nbsp;Carlos M S P M Grijó,&nbsp;Marta F S Patacho,&nbsp;António J S Almeida","doi":"10.1097/j.pbj.0000000000000224","DOIUrl":"https://doi.org/10.1097/j.pbj.0000000000000224","url":null,"abstract":"May-Thurner syndrome (MTS) was first described in 1957 as a rare vascular condition in which chronic pulsations of the right common iliac artery (RCIA), which overlies the left common iliac vein (LCIV), lead to spur formation along the wall of this vein. This anatomic condition is not uncommon in healthy individuals, according to both autopsies and imaging studies in asymptomatic populations, and affects most commonly women in their third to fifth decade of life. Some patients will have symptoms of chronic venous disease (CVD) with extremity pain, swelling, and varicose vein ulcerations. However, the prevalence of associated deep vein thrombosis (DVT) is relatively rare (2%–3%), suggesting that the presence of this anatomic finding alone may not increase the risk of DVT. In situations with hypercoagulable status, endothelial injury, and venous stasis (present in this condition), there is increased risk to DVT, as postulated in the Virchow Triad. Although there are no standardized diagnostic criteria, imaging has an important role in identifying this condition in patients with signs and symptoms of MTS. Because of its noninvasive character, ultrasound is frequently the first chosen modality in patients with DVT. However, visualization of common iliac vein segments is technically challenging, and ultrasound may miss the diagnosis of MTS. Although the gold standard for the diagnosis of MTS is conventional venography with intravenous ultrasound (IVUS), the most common and useful imaging scan is computed tomography (CT) scan because of its sensitivity and availability. Invasive catheter-based strategies have gained interest because of high association of MTS and iliofemoral thrombosis with postthrombotic syndrome (PTS). Endovascular stent may be performed acutely after initial catheter-directed thrombolysis or in chronic symptomatic patients, namely after PTS development. This case illustrates this condition as well as its challenging diagnosis and treatment. We report a 19-year-old woman, presenting in the emergency room (ER) with dyspnea, pleuritic chest pain, fever, and mushy stools, lasting for two weeks. The patient had no relevant medical history and was only medicated with oral anticonception. The clinical examination at the ER revealed a hemodynamically stable patient, with a slight tachycardia of 110 bpm. The remaining physical examination was unremarkable. The electrocardiogram showed a sinus rhythm, with no abnormalities. The chest X-ray presented a normal cardiothoracic index and no abnormal mass or consolidation. Laboratory study showed a microcytic anemia (10.6 g/dL [12.0–16.0g/dL]) and elevated C-reactive protein (182 mg/L [,3 mg/L]). Blood and urine cultures were obtained, and the patient was admitted to the Infectious Diseases ward because of initial suspicion of infectious colitis. The maintenance of tachycardia and pleuritic chest pain and the development of left lower limb enlargement and pain (not mentioned before) led to the perf","PeriodicalId":74479,"journal":{"name":"Porto biomedical journal","volume":"8 4","pages":"e224"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/db/84/pj9-8-e224.PMC10400067.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10309314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The \"<i>ghost sign</i>\": focal paleness as a novel marker of an inverted colonic diverticulum.","authors":"Vincent Zimmer","doi":"10.1097/j.pbj.0000000000000221","DOIUrl":"https://doi.org/10.1097/j.pbj.0000000000000221","url":null,"abstract":"To the Editor: A 59-year-old male patient presented for surveillance colonoscopy on an outpatient basis. During scope advancement, besides a multitude of inconspicuous diverticula in the sigmoid with only occasional typical diverticula in the higher colon, a pale elevated lesion was noted behind a fold in the ascending colon (Fig. 1A). Further characterization on withdrawal indicated a normal mucosal appearance and a central umbilication on white light (Fig. 1B) and narrow-band imaging (Fig. 1C), likewise, however, highlighting the change in color in comparison with the background mucosa. To unequivocally demonstrate the nature of the lesion as an inverted diverticulum, we cautiously “deinverted” the diverticulum with the tip of a standard biopsy forceps (Fig. 1D). Albeit not per se mutually exclusive, clear-cut differentiation of polys from polypoid inverted colonic diverticula (ICD) as their typical endoscopic presentation is usually straightforward and essential to avoid undue endoscopic resection with inadvertent perforation, entailing potentially serious medical and medicolegal sequelae. Some endoscopic features, such as surrounding","PeriodicalId":74479,"journal":{"name":"Porto biomedical journal","volume":"8 4","pages":"e221"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10400048/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10309313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence, length, and patterns of Anterior Loop among the South Indian population: A comparative study between Panoramic Radiography and Cone Beam Computed Tomography.","authors":"Anju Mathew,&nbsp;Mohan N","doi":"10.1097/j.pbj.0000000000000216","DOIUrl":"https://doi.org/10.1097/j.pbj.0000000000000216","url":null,"abstract":"<p><strong>Purpose: </strong>To assess the prevalence, length, and patterns of the anterior loop of the inferior alveolar nerve by panoramic radiography and cone beam computed tomography (CBCT).</p><p><strong>Materials and methodology: </strong>A prospective study was conducted on 300 mental foramen regions by exposing them to panoramic radiography and CBCT scan. Two individual observers evaluated the images to assess the presence of an anterior loop, the mean length of the loop, and the most frequent pattern of the loop in our population.</p><p><strong>Result analysis: </strong>The prevalence of the anterior loop for male patients and female patients by panoramic radiography was 34% and 32% on the right side and 30% and 36% on left side, respectively. By CBCT, the corresponding values were 69% and 72% on the right and left side, respectively, for male patients, and 73% and 81% on the right and left side, for female patients, respectively.</p><p><strong>Conclusion: </strong>The results from our study strongly emphasize the need for CBCT imaging before planning for procedures in the mental foramen region because the prevalence, length, and pattern of loop significantly varies with respect to age, sex, and population.</p>","PeriodicalId":74479,"journal":{"name":"Porto biomedical journal","volume":"8 3","pages":"e216"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/bd/f9/pj9-8-e216.PMC10289755.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9715987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Breast cancer in young women: a rising threat: A 5-year follow-up comparative study.","authors":"Urânia Fernandes,&nbsp;Gonçalo Guidi,&nbsp;Daniela Martins,&nbsp;Bruno Vieira,&nbsp;Clara Leal,&nbsp;Carolina Marques,&nbsp;Francisca Freitas,&nbsp;Margarida Dupont,&nbsp;Juliana Ribeiro,&nbsp;Carina Gomes,&nbsp;Rita Marques,&nbsp;Paulo Avelar,&nbsp;Ana Sofia Esteves,&nbsp;João Pinto-de-Sousa","doi":"10.1097/j.pbj.0000000000000213","DOIUrl":"https://doi.org/10.1097/j.pbj.0000000000000213","url":null,"abstract":"<p><strong>Introduction: </strong>Breast cancer in young women is usually considered as breast cancer occurring in women younger than 40 years and is the most frequent cancer-related cause of death in these patients. In the past few years, there seems to be an increasing trend in the prevalence of breast cancer in young women, which, associated with poorer prognosis, more aggressive histologic features, and more frequent recurrence rates, makes it a rising threat to young women. This study aimed to evaluate the biological behavior of breast cancer in young women in our institution.</p><p><strong>Material and methods: </strong>A retrospective, unicentric, cohort study was conducted between 2012 and 2016. All consecutive patients with breast cancer were enrolled in the study. Cases were divided into two groups: case group, those younger than 40 years, and control group, those 40 years or older. The exclusion criterion was nonoperative treatment. Several clinical and pathologic parameters were evaluated, as well as were overall survival time and disease-free survival time.</p><p><strong>Results: </strong>The incidence of breast cancer in young women presented a rising tendency over the study period. Significant differences were observed in the comparison of the groups according to body mass index, age at menarche, age at birth of the first child, and proliferation rate. There were no differences in overall survival and disease-free survival rates between the groups.</p><p><strong>Conclusions: </strong>Young women had a more symptomatic presentation, a greater tumor proliferation rate, but similar outcomes compared with older patients. Greater multicentric studies are needed to confirm or refute these results.</p>","PeriodicalId":74479,"journal":{"name":"Porto biomedical journal","volume":"8 3","pages":"e213"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/39/ba/pj9-8-e213.PMC10289488.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9771003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinicopathological characteristics and prognostic factors of small bowel lymphomas: a retrospective single-center study.","authors":"Emanuel Dias,&nbsp;Renato Medas,&nbsp;Margarida Marques,&nbsp;Patrícia Andrade,&nbsp;Hélder Cardoso,&nbsp;Guilherme Macedo","doi":"10.1097/j.pbj.0000000000000217","DOIUrl":"https://doi.org/10.1097/j.pbj.0000000000000217","url":null,"abstract":"<p><strong>Background: </strong>There is little information on diagnosis and management of small bowel lymphomas, and optimal management strategies are still undefined. This study aims to describe their main clinical and pathological characteristics and identify poor prognostic factors.</p><p><strong>Methods: </strong>A retrospective observational study of all patients with histological diagnosis of small bowel lymphoma between January 2010 and December 2020 was performed.</p><p><strong>Results: </strong>We included 40 patients, with male predominance (60%) and mean age of 60.7 years. The ileum was the most common location, and the most common histological subtypes were follicular lymphoma and diffuse large B-cell lymphoma. Clinical presentation was variable from asymptomatic patients (30%) to acute surgical complications (35%) including perforation, intestinal obstruction, ileal intussusception, or severe bleeding. Diagnosis was established by endoscopy in 22 patients (55%), and the most common findings included polyps, single mass, diffuse infiltration, or ulceration, whereas 18 (45%) required surgery because of acute presentations or tumor resection, and lymphoma was diagnosed postoperatively. Surgery was curative in one-third of those patients. Median survival was 52 months. Acute presentation (<i>P</i> = 0.001), symptomatic disease (<i>P</i> = 0.003), advanced stage (<i>P</i> = 0.008), diffuse large B-cell lymphoma (<i>P</i> = 0.007), anemia (<i>P</i> = 0.006), hypoalbuminemia (<i>P</i> < 0.001), elevated lactate dehydrogenase (<i>P</i> = 0.02), elevated C-reactive protein (<i>P</i> < 0.001), and absence of treatment response (<i>P</i> < 0.001) were significant predictors of mortality.</p><p><strong>Conclusion: </strong>Small bowel lymphoma is a rare malignancy with diverse clinical and endoscopic presentations that require a high index of suspicion. Primary factors associated with worse outcome included acute presentation, advanced stage, histological subtype, biochemical abnormalities, and absence of treatment response.</p>","PeriodicalId":74479,"journal":{"name":"Porto biomedical journal","volume":"8 3","pages":"e217"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/5b/a5/pj9-8-e217.PMC10289779.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9717229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Practice of debriefing of critical events: a survey-based cross-sectional study of Portuguese anesthesiologists.","authors":"Daniel Teles,&nbsp;Mariana Silva,&nbsp;Joana Berger-Estilita,&nbsp;Helder Pereira","doi":"10.1097/j.pbj.0000000000000215","DOIUrl":"https://doi.org/10.1097/j.pbj.0000000000000215","url":null,"abstract":"<p><p>Debriefing is an essential procedure for identifying medical errors, improving communication, reviewing team performance, and providing emotional support after a critical event. This study aimed to describe the current practice and limitations of debriefing and gauge opinions on the best timing, effectiveness, need for training, use of established format, and expected goals of debriefing among Portuguese anesthesiologists.</p><p><strong>Methods: </strong>We performed a national cross-sectional online survey exploring the practice of anesthesiologists' debriefing practice after critical events in Portuguese hospitals. The questionnaire was distributed using a snowball sampling technique from July to September 2021. Data were descriptively and comparatively analyzed.</p><p><strong>Results: </strong>We had replies from 186 anesthesiologists (11.3% of the Portuguese pool). Acute respiratory event was the most reported type of critical event (96%). Debriefing occurred rarely or never in 53% of cases, 59% of respondents needed more training in debriefing, and only 4% reported having specific tools in their institutions to carry it out. There was no statistical association between having a debriefing protocol and the occurrence of critical events (<i>P</i>=.474) or having trained personnel (<i>P</i>=.95). The existence of protocols was associated with lower frequencies of debriefing (<i>P</i>=.017).</p><p><strong>Conclusions: </strong>Portuguese anesthesiologists know that debriefing is an essential process that increases patient safety, but among those surveyed, there is a need for an adequate debriefing culture or practice.</p><p><strong>Trial registration: </strong>Research registry 7741 (https://www.researchregistry.com/browse-the-registry#home).</p>","PeriodicalId":74479,"journal":{"name":"Porto biomedical journal","volume":"8 3","pages":"e215"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10289546/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10105147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intraoperative fluoroscopic radiation in orthopedic trauma: correlation with surgery type and surgeon experience.","authors":"Luís Fabião,&nbsp;Ana Ribau,&nbsp;Carolina Lemos,&nbsp;Ricardo Rodrigues-Pinto","doi":"10.1097/j.pbj.0000000000000218","DOIUrl":"https://doi.org/10.1097/j.pbj.0000000000000218","url":null,"abstract":"<p><strong>Background: </strong>While fluoroscopy is widely used in orthopedic trauma surgeries, it is associated with harmful effects and should, therefore, be minimized. However, reference values for these surgeries have not been defined, and it is not known how surgeon experience affects these factors. The aims of this study were to analyze the radiation emitted and exposure time for common orthopedic trauma surgeries and to assess whether they are affected by surgeon experience.</p><p><strong>Methods: </strong>Data from 1842 trauma orthopedic procedures were retrospectively analyzed. A total of 1421 procedures were included in the analysis. Radiation dose and time were collected to identify reference values for each surgery and compared for when the lead surgeon was a young resident, a senior resident, or a specialist.</p><p><strong>Results: </strong>The most performed surgeries requiring fluoroscopy were proximal femur short intramedullary nailing (n = 401), ankle open reduction and internal fixation (ORIF) (n = 141), distal radius ORIF (n = 125), and proximal femur dynamic hip screw (DHS) (n = 114). Surgeries using higher radiation dose were proximal femur long intramedullary nailing (mean dose area [DAP]): 1361.35 mGycm²), proximal femur DHS (1094.81 mGycm²), and proximal femur short intramedullary nailing (891.41 mGycm²). Surgeries requiring longer radiation time were proximal humerus and/or humeral shaft intramedullary nailing (02 mm:20 ss), proximal femur long intramedullary nailing (02 mm:04 ss), and tibial shaft/distal tibia intramedullary nailing (01 mm:49 ss). Senior residents required shorter radiation time when performing short intramedullary nailing of the proximal femur than young residents. Specialists required more radiation dose than residents when performing tibial nailing and tibial plateau ORIF and required longer radiation time than young residents when performing tibial nailing.</p><p><strong>Conclusions: </strong>This study presents mean values of radiation dose and time for common orthopedic trauma surgeries. Orthopedic surgeon experience influences radiation dose and time values. Contrary to expected, less experience is associated with lower values in some of the cases analyzed.</p>","PeriodicalId":74479,"journal":{"name":"Porto biomedical journal","volume":"8 3","pages":"e218"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/0e/26/pj9-8-e218.PMC10289723.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10093491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spontaneous reporting of adverse reactions associated with the COVID-19 vaccine in health care professionals: A descriptive observational study conducted in a Portuguese hospital.","authors":"Vanessa S G Teófilo,&nbsp;Paulo R A Pinho,&nbsp;Gonçalo J Cordeiro,&nbsp;Nuno A F Saldanha,&nbsp;Pedro M M Matos,&nbsp;Rui A M Ribeiro,&nbsp;Salomé M Moreira,&nbsp;Mariana S F Miller,&nbsp;Andreia R M Dias,&nbsp;Marta F R Couto,&nbsp;Pedro M P N S Norton","doi":"10.1097/j.pbj.0000000000000219","DOIUrl":"https://doi.org/10.1097/j.pbj.0000000000000219","url":null,"abstract":"<p><strong>Background: </strong>The coronavirus disease 2019 (COVID-19) was classified as a pandemic in March 2020 by the World Health Organization. The Pfizer-BioNTech COVID-19 vaccine was the first to be authorized in the European Union, based on data from phase 1, 2, and 3 clinical trials of limited duration. Concerns have been raised regarding the vaccine's safety profile. Some of the adverse drug reactions (ADRs) associated with vaccines may not have been identified during clinical trials. This study aimed to identify ADRs associated with the Pfizer-BioNTech vaccine in health care professionals at a Portuguese tertiary university hospital.</p><p><strong>Methods: </strong>The data used in this analysis consist of ADRs reported through a spontaneous notification system from vaccines administered between December 27, 2020, and January 31, 2021. ADRs were categorized according to the MedDRA terminology.</p><p><strong>Results: </strong>A total of 8,605 Pfizer-BioNTech vaccines were administered to 4568 health care professionals. ADRs were reported among 520 of the vaccines, with an incidence of 13.56% in women and 5.31% in men. The mean age of the population reporting ADRs was 41.52 years, with a standard deviation of 9.83 years. The most frequent ADRs were myalgia (n = 274), headache (n = 199), pyrexia (n = 164), injection site pain (n = 160), fatigue (n = 84), nausea (n = 81), chills (n = 65), lymphadenopathy (n = 64), and arthralgia (n = 53). Hypersensitivity reactions occurred in 15 health care professionals, with no anaphylactic reactions observed. A total of four Important Medical Events were observed, which consisted of two cases of syncope, one case of sudden hearing loss, and one case of transverse myelitis.</p><p><strong>Conclusion: </strong>The vaccine was well-tolerated among the study participants. Reactogenicity was greater after the second dose. The incidence of ADRs was higher in women and individuals aged between 40 to 49 years. Systemic adverse reactions were most frequently reported. Systematic monitoring of ADRs of COVID-19 vaccines in real-life context is essential for a more robust establishment of its safety profile.</p>","PeriodicalId":74479,"journal":{"name":"Porto biomedical journal","volume":"8 3","pages":"e219"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/36/f8/pj9-8-e219.PMC10299789.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10096403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}