Porto biomedical journal最新文献

{"title":"Transfusion practices in patients with advanced cancer: a retrospective study in a palliative care service.","authors":"Sara Marote,&nbsp;Joana Marinho,&nbsp;Maria Cândida Silva,&nbsp;José Ferraz Gonçalves","doi":"10.1097/j.pbj.0000000000000195","DOIUrl":"https://doi.org/10.1097/j.pbj.0000000000000195","url":null,"abstract":"<p><strong>Background: </strong>Anemia is highly prevalent in patients with advanced cancer and adversely affects the quality of life. There are limited data on the frequency, clinical utility, and effectiveness of red blood cell (RBC) transfusions, and no randomized controlled clinical trials or clinical practice guidelines are available. The aim of this study was to evaluate clinician practices on RBC transfusion in an oncologic palliative care service and its impact on patients' symptoms, adverse events, and overall survival.</p><p><strong>Methods: </strong>This is a retrospective analysis of all patients with advanced cancer who received RBC transfusions admitted for 3 years. Preblood counts, the reason for transfusion, subjective benefit, and objective outcomes were listed.</p><p><strong>Results: </strong>We identified 179 patients who underwent RBC transfusions. The mean age was 67 years, and 60% were male. We found a total of 435 RBC units in 301 transfusion episodes. Asthenia/fatigue was the most frequent symptom (68%). The mean pretransfusion hemoglobin (Hb) was 6.85 g/dL, and 48% of patients had a Hb above 7 g/dL. The symptomatic benefit was achieved in 36% of patients. Adverse events were reported in 4%, with a 30-day survival rate of 57%. A statistically significant association was found between Eastern Cooperative Oncology Group performance status (ECOG-PS) and the symptomatic benefit (<i>P</i> = .005). Hb level pretransfusion, ECOG-PS, and symptomatic benefits with transfusions were significantly associated with survival.</p><p><strong>Conclusion: </strong>This study suggests that patients with advanced cancer with a higher functioning level may benefit more from RBC transfusion. Post-transfusion symptomatic benefits and pretransfusion ECOG-PS and Hb levels are independent predictors of survival. Further studies are needed to develop validated measures of objective functional changes to evaluate transfusions' clinical impact and identify patients most likely to benefit from it.</p>","PeriodicalId":74479,"journal":{"name":"Porto biomedical journal","volume":"7 6","pages":"e195"},"PeriodicalIF":0.0,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/3d/6e/pj9-7-e195.PMC10158856.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9430259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outbreak of KPC-producing <i>Klebsiella pneumoniae</i> at a Portuguese university hospital: Epidemiological characterization and containment measures.","authors":"David Peres,&nbsp;Paulo Figueiredo,&nbsp;Paulo Andrade,&nbsp;Nuno Rocha-Pereira,&nbsp;Cláudia Carvalho,&nbsp;Rita Ferraz,&nbsp;Raquel Duro,&nbsp;Arnaldo Dias,&nbsp;Abel Gomes,&nbsp;Cláudia Pereira,&nbsp;Gisélia Braga,&nbsp;Virginia Pereira,&nbsp;Lino Azevedo,&nbsp;Edgar Moniz,&nbsp;Manuela Ribeiro,&nbsp;Eugénia Ferreira,&nbsp;Vera Manageiro,&nbsp;José Teixeira,&nbsp;Tiago Guimarães,&nbsp;Manuela Caniça,&nbsp;Carlos Alves","doi":"10.1097/j.pbj.0000000000000186","DOIUrl":"https://doi.org/10.1097/j.pbj.0000000000000186","url":null,"abstract":"<p><strong>Background: </strong>KPC-producing <i>K pneumoniae</i> (KPC-Kp) is a public health problem with important clinical and epidemiological implications. We describe an outbreak of KPC-Kp at vascular surgery and neurosurgery wards in a central hospital in Porto, Portugal.</p><p><strong>Methods: </strong>A case of KPC-Kp was considered to be a patient positive for KPC-Kp with strong epidemiological plausibility of having acquired this microorganism in the affected wards and/or with genetic relationship ≥92% between KPC-Kp isolates. Active surveillance cultures (ASCs) and real-time polymerase chain reaction were used for the detection of carbapenemase genes through rectal swab in a selected population. Molecular analysis was performed using pulsed-field gel electrophoresis at the National Reference Laboratory. Patient risk factors were collected from the electronic medical record system. Information regarding outbreak containment strategy was collected from the Infection Control Unit records.</p><p><strong>Results: </strong>Of the 16 cases, 11 (69%) were identified through active screening, representing 1.4% of the total 766 ASCs collected. The most frequent risk factors identified were previous admission (63%), antibiotic exposure in the past 6 months (50%), and immunodepression (44%). The length of stay until KPC-Kp detection was high (0-121 days, mean 35.6), as was the total length of stay (5-173 days, mean 56.6). Three patients (19%) were infected by KPC-Kp, 2 of whom died. One previously colonized patient died later because of KPC-Kp infection.</p><p><strong>Conclusions: </strong>Multifactorial strategy based on contact precautions (with patient and healthcare professional cohorts) and ASC, as well as Antibiotic Stewardship Program reinforcement, allowed to contain this KPC-Kp outbreak.</p>","PeriodicalId":74479,"journal":{"name":"Porto biomedical journal","volume":"7 6","pages":"e186"},"PeriodicalIF":0.0,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10158887/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9435511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnosis of pathological conditions through electronic nose analysis of urine samples: a systematic review and meta-analysis.","authors":"Helga A S Afonso,&nbsp;Mariana V Farraia,&nbsp;Mónica A Vieira,&nbsp;João Cavaleiro Rufo","doi":"10.1097/j.pbj.0000000000000188","DOIUrl":"https://doi.org/10.1097/j.pbj.0000000000000188","url":null,"abstract":"<p><p>Currently available urinalysis methods are often applied for screening and monitoring of several pathologies. However, traditionally analyzed biomarkers in urinalysis still lack sensitivity and specificity to accurately diagnose some diseases. Several studies have proposed the use of electronic noses (eNoses) for the analysis of volatile organic compounds in urine samples that may, directly or indirectly, correlate with certain pathologies. Hence, the aim of this study was to perform a systematic review and meta-analysis of studies concerning the use of portable electronic noses for diagnosis or monitoring of pathologies through analysis of urine samples. A systematic review of the literature was held according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Twenty-four articles met the inclusion criteria and were included in the analysis. The results of the revised studies showed that there are various volatile organic compound profiles, identified through eNose analysis, that may be applied for diagnosis or monitoring of several diseases, such as diabetes, urinary tract infection, inflammatory bowel disease, and kidney disease. A meta-analysis was conducted taking into consideration the data of 10 of the initial 24 articles. The pooled sensitivity, specificity, and diagnostic odds ratio were 84% (95% CI, 0.72-0.92), 85% (95% CI, 0.75-0.91), and 24.17 (95% CI: 7.85-74.41), respectively. The area under the receiver operating characteristic curve was 0.897. These results suggest that eNose technology has adequate diagnostic accuracy for several pathologies and could be a promising screening tool for clinical settings. However, more studies are needed to reduce heterogeneity between results.</p>","PeriodicalId":74479,"journal":{"name":"Porto biomedical journal","volume":"7 6","pages":"e188"},"PeriodicalIF":0.0,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/35/6b/pj9-7-e188.PMC10158878.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9798964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The prognostic impact of magnesium in acute heart failure is different according to the presence of diabetes mellitus.","authors":"Catarina Cidade-Rodrigues,&nbsp;Filipe M Cunha,&nbsp;Catarina Elias,&nbsp;Marta Carreira,&nbsp;Isaac Barroso,&nbsp;Paulo Bettencourt,&nbsp;Patrícia Lourenço","doi":"10.1097/j.pbj.0000000000000197","DOIUrl":"https://doi.org/10.1097/j.pbj.0000000000000197","url":null,"abstract":"<p><strong>Background: </strong>Hypermagnesemia predicts mortality in chronic heart failure (HF); however, in acute HF, magnesium does not seem to be outcome-associated. Diabetes mellitus (DM) frequently associates with altered magnesium status. We hypothesized that DM might influence the prognostic impact of magnesium in acute HF.</p><p><strong>Methods: </strong>This is a retrospective cohort study of hospitalized patients with acute HF. Patients without data on admission serum magnesium were excluded. Follow-up: 1 year from hospital admission. Primary end point: all-cause mortality. Patients were divided according to median serum magnesium (1.64 mEq/L). The Kaplan-Meier survival method was used to determine survival curves according to magnesium levels. The analysis was stratified according to the presence of DM. A multivariable Cox regression analysis was used to study the prognostic impact of magnesium.</p><p><strong>Results: </strong>We studied 606 patients. The mean age was 76 ± 12 years, 44.1% were male, 50.7% had DM, and 232 (38.3%) died during follow-up. Median magnesium was 1.64 (1.48-1.79) mEq/L. Patients with magnesium ≥1.64 mEq/L had higher 1-year mortality [141 (46.4%) vs 91 (30.1%), <i>P</i> < .001]. After adjustments for age, sex, history of atrial fibrillation, systolic blood pressure, heart rate, ischemic etiology, B-type natriuretic peptide, estimated glomerular filtration rate, alcohol consumption, antihyperglycaemic agents or glycated hemoglobin, admission glycemia, New York Heart Association class IV, and severe left ventricle systolic dysfunction, serum magnesium ≥1.64 mEq/L was associated with higher mortality only in patients with DM: HR 1.89 (95% confidence interval: 1.19-3.00), <i>P</i> = .007, and 1.27 (95% confidence interval: 0.83-1.94) and <i>P</i> = .26 for non-DM patients. The results were similar if magnesium was analyzed as a continuous variable. Per 0.1 mEq/L increase in magnesium levels, patients with DM had 13% increased risk of 1-year mortality.</p><p><strong>Conclusions: </strong>Higher magnesium levels were associated with worse prognosis only in HF patients with DM.</p>","PeriodicalId":74479,"journal":{"name":"Porto biomedical journal","volume":"7 6","pages":"e197"},"PeriodicalIF":0.0,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/a1/9d/pj9-7-e197.PMC10158881.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9423056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recall of delirium and related distress in elderly hospitalized patients: A prospective study.","authors":"Maria Leonor Moura,&nbsp;Sónia Martins,&nbsp;Raquel Correia,&nbsp;Elika Pinho,&nbsp;Cristiana Paulo,&nbsp;Maria João Silva,&nbsp;Ana Teixeira,&nbsp;Liliana Fontes,&nbsp;Luís Lopes,&nbsp;José Artur Paiva,&nbsp;Luís Filipe Azevedo,&nbsp;Lia Fernandes","doi":"10.1097/j.pbj.0000000000000196","DOIUrl":"https://doi.org/10.1097/j.pbj.0000000000000196","url":null,"abstract":"<p><p><b>Background:</b> Delirium is a very common neuropsychiatric disorder in the elderly, with a significant physical and psychological burden. Much is still unknown about its psychological effects. This study aims to identify the proportion of patients who recall delirium and to analyze the distress caused by it. In addition, this study aims to analyze the association between delirium recall and related distress and global psychological distress regarding hospitalization. <b>Methods:</b> This is a prospective study with elderly hospitalized patients in level-2 units of intensive care medicine department of a university hospital. Exclusion criteria were a Glasgow Coma Scale total ≤11, brain injury, blindness, deafness, or inability to communicate. Delirium was daily assessed with the Confusion Assessment Method. Delirium recall and related distress in patients were measured using the Delirium Experience Questionnaire. Global psychological distress was assessed with the Kessler Psychological Distress Scale. <b>Results:</b> From 105 patients, 38 (36.2%) developed delirium. Most patients did not remember the delirium episode (64.7%). Among those who remembered (35.3%), most described delirium as a distressing experience (75%). Delirium recall was associated with high global psychological distress (<i>P</i> = .029)<i>.</i> <b>Conclusions:</b> Distress related to delirium is high, namely in patients who recall the episode. Global psychological distress during hospitalization is associated with delirium recall. This study highlights the need to assess the experience of delirium in these patients, as well as the importance of providing support and psychological interventions to minimize the associated distress.</p>","PeriodicalId":74479,"journal":{"name":"Porto biomedical journal","volume":"7 6","pages":"e196"},"PeriodicalIF":0.0,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/36/60/pj9-7-e196.PMC10158885.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9798963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of perioperative chemotherapy in the treatment of patients with gastric cancer.","authors":"Telma Fonseca,&nbsp;Mariana Coimbra,&nbsp;Hugo Santos-Sousa,&nbsp;Elisabete Barbosa,&nbsp;José Barbosa","doi":"10.1097/j.pbj.0000000000000180","DOIUrl":"https://doi.org/10.1097/j.pbj.0000000000000180","url":null,"abstract":"<p><strong>Background: </strong>Perioperative chemotherapy (PeriCh) is the current standard of care for stage II/III gastric cancer tumors in Europe. However, when it concerns patients who endure complications during PeriCh it is unclear if it increases the risk of postoperative complications and other poorer surgical outcomes. We aim to demonstrate if there is an association between having complications during PeriCh and postoperative complications and histopathological response.</p><p><strong>Methods: </strong>We conducted a retrospective, transversal, and observational study, including all patients with diagnosed gastric cancer who underwent PeriCh followed by surgical resection during the period of eight years.</p><p><strong>Results: </strong>We included 80 patients with a median age of 64.0years (min 24, max 78). Eighty-eight-point eight percent ended the chemotherapy regime proposed, with a median duration of 42 days, and were also submitted to gastric resection: 58.8% total gastrectomy and 41.2% distal gastrectomy. Twelve-point five percent of the patients had no complications during the PeriCh period and 16.3% had >2 complications. Twenty-five percent of patients had a histological response of <10% of tumor burden, but in 41.3% only regression of <50% could be obtained. No significant association was found between complications during PeriCh and adverse surgical outcomes (<i>P</i> = .497). Patients with complications during PeriCh had slightly higher median time difference from end of PeriCh until surgery, but with no statistical significance (<i>P</i> = .575).</p><p><strong>Conclusions: </strong>In our sample, the existence of association between complications during PeriCh and postoperative complications or histological response was not demonstrated.</p>","PeriodicalId":74479,"journal":{"name":"Porto biomedical journal","volume":"7 6","pages":"e180"},"PeriodicalIF":0.0,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/1a/bf/pj9-7-e180.PMC10158857.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9798960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Concept of older person autonomy: phenomenological study of the opinion of specialist nurses.","authors":"Andreia Maria Novo Lima,&nbsp;Maria Manuela Ferreira da Silva Martins,&nbsp;Maria Salomé Martins Ferreira,&nbsp;Carla Sílvia Fernandes,&nbsp;Soraia Dornelles Schoeller,&nbsp;Adriana Raquel Neves Coelho,&nbsp;Vítor Sérgio Oliveira Parola","doi":"10.1097/j.pbj.0000000000000178","DOIUrl":"https://doi.org/10.1097/j.pbj.0000000000000178","url":null,"abstract":"<p><p><b>Background:</b> The concept of autonomy is composed of several components, making it a multidimensional concept. This includes cognitive ability, intellectual ability, emotional intelligence, social situation, and physical ability skills. This study aimed to describe the experiences attributed to the meaning of the concept of autonomy, by specialist nurses. <b>Methods:</b> A descriptive phenomenological study was carried out, according to the Giorgi method. Eighteen nurses were recruited at a hospital in Portugal. Data were collected through individual interviews. <b>Results:</b> The 18 specialist nurses work on average as nurses for 16years and are specialist nurses; for an average of 5.9years, most are specialist nurses in rehabilitation nursing. From the data analysis, six themes emerged: ability to do, ability to resolve, decision ability, cognitive ability, social integration, and emotional intelligence. <b>Conclusions:</b> Most professionals perceive the concept as the ability to perform activities of daily living and the ability to make decisions, especially concerning informed consent. It is necessary to raise awareness of the breadth of this concept since the quality of life and dignity of the elderly person depends on autonomy.</p>","PeriodicalId":74479,"journal":{"name":"Porto biomedical journal","volume":"7 6","pages":"e178"},"PeriodicalIF":0.0,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10158865/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9430263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The value of surgeon's perception during transurethral resection of bladder tumors: can we trust in our eyes and experience to predict grade and staging?","authors":"Luís Vale,&nbsp;José Sousa,&nbsp;Pedro Abreu-Mendes,&nbsp;Pedro Vale,&nbsp;Nuno Dias,&nbsp;Paulo Dinis,&nbsp;Tiago Antunes-Lopes,&nbsp;João Silva","doi":"10.1097/j.pbj.0000000000000179","DOIUrl":"https://doi.org/10.1097/j.pbj.0000000000000179","url":null,"abstract":"<p><p>Transurethral resection of newly diagnosed bladder tumors (TURBT) is a hallmark ¡n the treatment of bladder cancer. We evaluated the surgeon capacity to predict bladder tumor stage (T), grade, and presence of muscular layer based upon cystoscopic characteristics during primary TURBT.</p><p><strong>Methods: </strong>Prospective study enrolling 100 consecutive patients undergoing primary TURBT for newly diagnosed bladder cancers. Cystoscop¡c tumor characteristics at the time of TURBT was evaluated by an urology senior and a resident regarding histological grade, invasion (T stage), and presence of muscular layer in the specimen. We analyzed the surgeon's accuracy in predicting these parameters using the final histology as gold standard. In addition, the predictive capacity between seniors and residents was compared.</p><p><strong>Results: </strong>The resident's arm correctly predicted tumor invasiveness in 76% of cases, while seniors correctly predicted 87% of cases. Regarding tumor grade, high grade cancer was reported in 78% of the specimens and 75% and 77% of them were correctly predicted by residents and seniors, respectively. Finally, 80% of the TURBT specimens had muscle representativeness. In nearly 75% of the cases, both resident and senior correctly predicted the TURBT resection depth (presence of detrusor muscle in the specimen). The positive predictive value for this parameter was 79% for the resident, and 81% for the senior, and the negative predictive value was 25% and 40%, respectively.</p><p><strong>Conclusion: </strong>The surgeon's naked eye analysis showed a good, but limited predictive ability to detect non-muscle invasive and high-grade bladder tumors in TURBT specimens. Positive predictive value for muscle representativeness is around 80%, which reinforces the need of carrying out a careful and extensive TURBT, irrespective of the surgeon experience.</p>","PeriodicalId":74479,"journal":{"name":"Porto biomedical journal","volume":" ","pages":"e179"},"PeriodicalIF":0.0,"publicationDate":"2022-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9521761/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40389488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the Editor-Extensive aortic thrombosis in a patient with diabetes mellitus and COVID-19.","authors":"Catarina Cidade-Rodrigues,&nbsp;Pedro Palma,&nbsp;Rogério Ruas,&nbsp;Rita Ferraz","doi":"10.1097/j.pbj.0000000000000156","DOIUrl":"https://doi.org/10.1097/j.pbj.0000000000000156","url":null,"abstract":"","PeriodicalId":74479,"journal":{"name":"Porto biomedical journal","volume":" ","pages":"e156"},"PeriodicalIF":0.0,"publicationDate":"2022-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9521758/pdf/pj9-7-e156.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40389935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anxiety in heart failure patients and its association with socio-demographic and clinical characteristics: a cross-sectional study.","authors":"Filipa M D Costa,&nbsp;Sónia P V Martins,&nbsp;Emilia C T D Moreira,&nbsp;José C M S Cardoso,&nbsp;Lia P N S Fernandes","doi":"10.1097/j.pbj.0000000000000177","DOIUrl":"https://doi.org/10.1097/j.pbj.0000000000000177","url":null,"abstract":"<p><p>Anxiety is one of the most frequent psychiatric disorders in heart failure (HF) patients. However, it is often neglected in clinical practice and studies about the particular relationship with the New York Heart Association (NYHA) classes for HF are scarce. In this context, this study aims to analyze the presence of anxiety symptoms in HF outpatients and also its association with sociodemographic and clinical characteristics of these patients.</p><p><strong>Methods: </strong>This cross-sectional study is part of the longitudinal Deus Ex-Machina project (NORTE-01-0145-FEDER-000026). HF patients were recruited at an outpatient clinic at a University Hospital. Patients with inability to communicate, severe visual/hearing impairment, or NYHA class IV were excluded. Sociodemographic data and NYHA class were registered. Anxiety was assessed with the 7-item Generalized Anxiety Disorders Scale (with a score ≥10 clinically relevant anxiety). Patients with and without anxiety were compared regarding socio-demographic and clinical variables.</p><p><strong>Results: </strong>The sample (n = 136) had a median age of 59years (Q₁: 49; Q₃: 68), 66.2% were male and 31.6% presented clinically relevant anxiety. A higher percentage of HF patients with anxiety had psychiatric disorders (58.1% vs 26.9%; <i>P</i> = .001), psychotropic medication (62.8% vs 30.1%; <i>P</i> = .001), and depression (60.5% vs 9.7%; <i>P</i>< .001). No significant differences were found regarding the remaining variables, including NYHA classes.</p><p><strong>Conclusions: </strong>A substantial proportion of HF patients present clinically relevant anxiety, particularly those with psychiatric history, depressive symptoms, or under psychotropic medication. Therefore, integrating routine screening and treatment of this comorbidity in clinical practice is of utmost importance. Further studies are needed to clarify the association of anxiety with HF.</p>","PeriodicalId":74479,"journal":{"name":"Porto biomedical journal","volume":" ","pages":"e177"},"PeriodicalIF":0.0,"publicationDate":"2022-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9521754/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40389937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}