PLOS global public health最新文献

{"title":"Management of ocular adverse reactions to antiglaucoma medications-Survey of optometrists in Ghana.","authors":"Mohammed Abdul-Kabir, Prince Mintah, Michael Kwesi Asante, James Forson, Agnes Oppong, James Anin Odame, Gabriel Kwaku Agbeshie, Stephanie Obeng-Inkoom","doi":"10.1371/journal.pgph.0004251","DOIUrl":"10.1371/journal.pgph.0004251","url":null,"abstract":"<p><p>Glaucoma, characterized by chronic and progressive degeneration of retinal ganglion cells leading to a gradual decline in the visual field, poses a significant challenge in eye care delivery. Optometrists play a vital role in detecting and managing glaucoma. This study aims to determine how Ghanaian optometrists manage ocular adverse reactions (OADRs) in patients using antiglaucoma medications. A cross-sectional survey was conducted among 139 licensed optometrists using a pre-tested, semi-structured questionnaire. Data collected included socio-demographic characteristics, reported adverse reactions, and awareness of reporting or management protocols. Descriptive and inferential statistics were performed using SPSS version 25.0. Participants had a mean age of 31.6 ± 5.5 years and an average practice experience of 5.6 ± 4.5 years. Most respondents were female (71.2%), with 36.7% practicing in Greater Accra and 32.0% in private facilities. Nearly all participants (92.8%) reported encountering OADRs to AGMs. The most common symptoms were red eyes (36.0%), stinging (26.1%), burning sensation (25.4%), and itching (8.8%), while clinical signs included conjunctival hyperemia (45.5%), tear film deficiency (26.0%), and iris pigmentation changes (9.8%). Latanoprost (32.2%), timolol (23.7%), travoprost (17.6%), and brimonidine (10.2%) were the medications most frequently associated with these reactions. Optometrists primarily managed cases by switching to alternative medications (41.0%) or adjusting dosage and frequency (9.7%). However, 77.7% reported having no knowledge of existing protocols, and confidence in managing OADRs was moderately low (mean = 2.67 ± 0.49 on a 5-point scale). No significant association was found between OADR reporting and either age (p = 0.616) or years of practice (p = 0.974). These findings highlight that although OADRs are common in glaucoma management, optometrists in Ghana often lack standardized protocols and report low confidence in handling such cases. Targeted professional development and refresher training are needed to strengthen OADRs recognition, reporting, and management, ultimately improving patient eye care.</p>","PeriodicalId":74466,"journal":{"name":"PLOS global public health","volume":"5 10","pages":"e0004251"},"PeriodicalIF":2.5,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12510571/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145260049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oxidative stress in malaria and typhoid fever: A scoping review of the pathogenic mechanisms and therapeutic implications.","authors":"Palmer Masumbe Netongo, MacDonald Bin Eric, Severin Donald Kamdem, Ange Maxime Tchoutang, Wilfred Fon Mbacham","doi":"10.1371/journal.pgph.0005193","DOIUrl":"10.1371/journal.pgph.0005193","url":null,"abstract":"<p><p>Oxidative stress is a key factor in the pathogenesis of many infectious diseases, including typhoid fever and malaria. Co-infection with these diseases poses a particular challenge, as both are associated with increased production of reactive species that can damage tissues, trigger oxidative stress, and exacerbate disease. To cope with this oxidative insult, cells have a defense system consisting of antioxidant molecules that can terminate the oxygen radical cascade and render toxic metabolites innocuous. However, lack of complete understanding of the pathophysiology of malaria and typhoid fever continues to hinder efforts aimed at eradicating these diseases. In this review, we examine the current understanding of oxidative stress in the context of malaria and typhoid fever, and its implications for disease pathogenesis and treatment. The search and data extraction strategy used in this scoping review involved a structured approach to identify relevant studies related to the topic. Studies were included that investigated ROS production, antioxidant responses, and the effect of pharmacological interventions on oxidative stress markers. The search was conducted using electronic databases, including PubMed, ScienceDirect, and Directory of Open Access Journals (DOAJ), and involved an extensive literature search of studies published between January 2000 and May 2024. The review identified potential avenues for research with evidence that both malaria and typhoid fever elevate oxidative stress levels, which are further exacerbated in co-infections. The endogenous antioxidant response is activated but may not be sufficient to neutralize ROS completely. Moreover, commonly used antimalarial and antibacterial drugs influence oxidative and antioxidant dynamics, which may have implications for treatment efficacy and disease progression. Understanding the oxidative-antioxidant balance in malaria and/or typhoid fever may open new avenues for adjunctive therapies and vaccines targeting oxidative stress. It is thus important to consider the oxidative-antioxidant balance during treatment of malaria and typhoid fever patients.</p>","PeriodicalId":74466,"journal":{"name":"PLOS global public health","volume":"5 10","pages":"e0005193"},"PeriodicalIF":2.5,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12510597/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145260077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preferences for long-acting injectable HIV pre-exposure prophylaxis service delivery among male and female sex workers in Uganda: A discrete choice experiment.","authors":"Richard Muhindo, Rachel King, Andrew Mujugira, Whitney Irie, Patience Muwanguzi, Flavia Dhikusooka, Joseph Musaazi, Barbara Castelnuovo","doi":"10.1371/journal.pgph.0004798","DOIUrl":"10.1371/journal.pgph.0004798","url":null,"abstract":"<p><p>In Sub-Saharan Africa, limited data exist on the delivery of injectable HIV pre-exposure prophylaxis (PrEP). We explored service delivery preferences for injectable cabotegravir (CAB-LA) among heterosexual male sex workers (MSWs) and female sex workers (FSWs) in Uganda. We conducted a discrete choice experiment (DCE) among HIV-negative sex workers in two high HIV-prevalence Ugandan cities between October and December 2024. Participants selected from alternatives varying by location, waiting time, provider gender, and additional services. A mixed logit model identified the most valued attributes influencing preferences for CAB-LA delivery. We enrolled 251 sex workers (SWs), comprising 52 (20.7%) MSWs. MSWs were more likely to have higher education (26.9% vs 4.5%), while FSWs had been in the industry longer (24 months vs 18 months). PrEP awareness was lower among MSWs than FSWs (86.5% vs. 95.5%, p = 0.027). Overall, 39.4% reported current PrEP use. Injectable PrEP was the most preferred formulation (77.3%), and willingness to use PrEP among non-users was higher in MSWs (67.3% vs. 45.7%, p = 0.001). Regarding service delivery preferences, MSWs and FSWs both prioritized dispensing location (relative importance 81.1% MSWs, 82.9% FSWs) and provision of additional services (10.8% MSWs, 9% FSWs). In contrast, clinic waiting time and provider gender were considered the least important, with both groups assigning them a relative importance of 4%. Nevertheless, the three top-ranked CAB-LA delivery models prioritized access through private pharmacies or clinics with short waiting times, female or peer providers, and integrated health services. The preferred extra services included psychosocial support, cancer screening, and risk reduction counseling. Expanding injectable PrEP through private sector channels may improve access among SWs. Still, implementation research is needed to guide integration of supportive services and SWs' willingness to pay or co-pay for pharmacy or private clinic-based delivery.</p>","PeriodicalId":74466,"journal":{"name":"PLOS global public health","volume":"5 10","pages":"e0004798"},"PeriodicalIF":2.5,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12510523/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145260000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determinants of cholera fatalities in Malawi: A case-control study of patient-level and clinical management factors in the 2022-23 outbreak.","authors":"Ronald Chitatanga, Alex Thawani, Hope Chadwala, Amon Chirwa, Collins Mitambo","doi":"10.1371/journal.pgph.0004335","DOIUrl":"10.1371/journal.pgph.0004335","url":null,"abstract":"<p><p>Malawi experienced its deadliest cholera outbreak in 2022, reporting over 50,000 cases and more than 1,700 deaths. This situation was further exacerbated by the Tropical Cyclone Freddy, which caused widespread damage to health infrastructure and strained Malawi's limited healthcare resources. Despite the scale of the outbreak, no evaluations were conducted to identify risk factors associated with cholera-related mortality among hospitalized individuals. This study filled that gap by characterizing the clinical and treatment-related factors contributing to cholera mortality in Malawi. A retrospective matched case-control study was conducted in August 2023 across four high-burden cholera districts: Blantyre, Mangochi, Lilongwe, and Nkhatabay. Medical records of 174 laboratory-confirmed cholera patients admitted between March 2022 and September 2023 were reviewed, including 87 matched pairs of deceased (cases) and surviving (controls) patients by age group and district. Data were extracted using a standardized mortality audit tool capturing socio-demographic characteristics, care-seeking behaviour, clinical status, and treatment received. Conditional logistic regression was used to identify factors associated with cholera mortality. Inadequate intravenous fluid management within the first 6 hours of admission was the strongest predictor of mortality (adjusted OR = 45.26, 95% CI: 9.09-225.30, p < 0.001). Other factors such as clinical status on admission showed a trend toward association but did not reach statistical significance. Timely and appropriate intravenous fluid administration within the first 6 hours of care is critical to reducing cholera mortality. We highlight an urgent need to strengthen the early response capacity in cholera treatment units, particularly during climate-related public health emergencies.</p>","PeriodicalId":74466,"journal":{"name":"PLOS global public health","volume":"5 10","pages":"e0004335"},"PeriodicalIF":2.5,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12510554/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145260054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: WHO target product profile for TB detection at peripheral settings: 2024 update.","authors":"Mikashmi Kohli, Alexei Korobitsyn, Nazir Ismail, Matteo Zignol, Tereza Kasaeva, Puneet Dewan, Morten Ruhwald","doi":"10.1371/journal.pgph.0005315","DOIUrl":"10.1371/journal.pgph.0005315","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1371/journal.pgph.0004612.].</p>","PeriodicalId":74466,"journal":{"name":"PLOS global public health","volume":"5 10","pages":"e0005315"},"PeriodicalIF":2.5,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12510484/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145260035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global and regional burden and inequalities of oral conditions in children, adolescents, and young adults (0-39 years), 1990 to 2021.","authors":"Yue Chen, Zhishen Jiang, Liu Liu, Jian Pan, Yubin Cao, Wenli Lai, Hu Long","doi":"10.1371/journal.pgph.0005274","DOIUrl":"10.1371/journal.pgph.0005274","url":null,"abstract":"<p><p>Previous Global Burden of Disease studies often encompassed the entire age spectrum or treated adolescents and young adults as a single cohort. This methodology has limited the opportunity for a detailed analysis and modelling of oral health within specific subgroups of the younger population. This study examines the lifecycle-specific burden, trends, and inequalities of oral disorders among children, adolescents, and young adults from 1990 to 2021, utilizing data from the Global Burden of Disease 2021. Age-standardized Years Lived with Disability (YLD) rates were calculated by sex, age subgroups, and sociodemographic index (SDI) quintiles, followed by incidence and prevalence calculations. The study utilized Joinpoint regression, decomposition analysis, slope/concentration index, and sociodemographic attribution analysis to assess the epidemiology of oral disorders. As a result, in 2021, there were 6.22 (3.40-10.57) million YLDs associated with oral disorders among children, adolescents, and young adults globally. Temporal trends indicated a post-pandemic rise in deciduous caries among children. The number of YLDs of caries in children, adolescents, and young adults has all increased despite declining age-standardized YLD rates in 1990-2021 due to population growth in lower-SDI locations. The number and age-standardized YLD rates of periodontal disease and edentulism have risen among adolescents and young adults, exacerbated by worsened epidemiology and population growth. Despite improvements in 2021 compared to 1990, inequalities in periodontal disease burdens persist, disproportionately affecting lower SDI locations. Findings of this study reveal that oral disorder epidemiological metrics among individuals aged 0-39 have generally improved for caries but worsened for periodontal diseases and edentulism. Population growth in lower-SDI locations primarily drove the global increased burdens. SDI-related inequalities disproportionately concentrated periodontal disease burdens in lower-SDI locations. Targeted healthcare resource allocation is essential for youth population to address the increased burdens and inequalities and enhance universal health coverage.</p>","PeriodicalId":74466,"journal":{"name":"PLOS global public health","volume":"5 10","pages":"e0005274"},"PeriodicalIF":2.5,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12510561/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145260047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Influence of women's legal status on pregnancy outcomes and quality of care: Findings from the Pregnancy of Migrants in Switzerland (PROMISES) program.","authors":"Eugénie de Weck, Clara Noble, Jessica Sormani, Monique Lamuela Naulin, Cyril Jaksic, Sara Arsever, Begoña Martinez de Tejada, Nicole C Schmidt, Anya Levy Guyer, Anne-Caroline Benski","doi":"10.1371/journal.pgph.0005303","DOIUrl":"10.1371/journal.pgph.0005303","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1371/journal.pgph.0004217.].</p>","PeriodicalId":74466,"journal":{"name":"PLOS global public health","volume":"5 10","pages":"e0005303"},"PeriodicalIF":2.5,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12510480/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145260021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Self-management of chronic conditions including multimorbidity in sub-Saharan Africa: A systematic and meta-synthesis review with focus on diabetes, hypertension, chronic kidney disease, and HIV.","authors":"Sangwani Nkhana Salimu, Melissa Taylor, Stephen A Spencer, Nicola Desmond, Deborah Nyirenda, Ben Morton","doi":"10.1371/journal.pgph.0003836","DOIUrl":"10.1371/journal.pgph.0003836","url":null,"abstract":"<p><p>The increasing prevalence of multimorbidity in sub-Saharan Africa (SSA) is an urgent concern for health service delivery, yet little is known about how best to support self-management- the tasks patients and carers take to maintain physical and mental health in this context. This review synthesized qualitative evidence that describes self-management of four chronic conditions- HIV, diabetes, chronic kidney disease, and hypertension, including multimorbidity among patients and their carers in SSA. We systematically searched five databases and grey literature for studies published between January 2000 and to March 2025 and conducted a thematic synthesis of findings. Twenty-three studies met inclusion criteria, three of which focused on multimorbidity. Across conditions, patients negotiated self-management based on immediacy of needs and available family support. Patients are motivated to apply biomedical management but are limited by factors such as drug stock-outs and out-of-pocket expenditure. Limited knowledge and low self-efficacy toward self-management of multimorbidity impact decision making and problem solving. We found that diabetes and chronic kidney disease imposed the greatest treatment burden, making them the most challenging conditions for patients to manage. Temporal discontinuation of medications was more prevalent amongst patients with hypertension; and patients with multimorbidity are frequently hypervigilant about their health, more likely to suffer from stress and to seek healthcare. This review synthesised qualitative evidence on self-management of HIV, diabetes, hypertension, and chronic kidney disease in SSA, and considered insights for multimorbidity. Most studies focused on individual conditions, yet our findings reveal strikingly similar challenges across all four conditions: limited health literacy, low self-efficacy, and inadequate structural support. These barriers are likely amplified with multimorbidity, further complicating decision-making and self-management. Addressing these gaps will require context-sensitive interventions that strengthen patient literacy, build confidence to increase patient autonomy and expand the range of resources available to manage chronic disease.</p>","PeriodicalId":74466,"journal":{"name":"PLOS global public health","volume":"5 10","pages":"e0003836"},"PeriodicalIF":2.5,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12510608/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145260015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Iranian livestock breeders' knowledge, attitude, practice, and behavioral determinants related to brucellosis prevention.","authors":"Farhad Bahadori, Fazlollah Ghofranipour, Fatemeh Zarei, Saeideh Ghaffarifar, Reza Ziaei","doi":"10.1371/journal.pgph.0004693","DOIUrl":"10.1371/journal.pgph.0004693","url":null,"abstract":"<p><p>Brucellosis is a zoonotic disease that affects animals and humans. Its transmission to humans occurs through various routes such as consumption of infected animal products or unprotected close contact with secretions or different parts of live or dead infected animals. This study aims to report Iranian livestock breeders' awareness, attitude, practice, and behavioral determinants related to Brucellosis prevention. A cross-sectional study was conducted in 2019 among 450 livestock breeders in Beyraq, a suburb of Tabriz city. The Brucellosis Prevention Questionnaire (BPQ) was used to collect data. Statistical analysis performed using SPSS-23. The BPQ, consisting of 53 items, had acceptable psychometric properties (Content Validity Index = 0.90, Content Validity Ratio = 0.74, Impact Score = 4.30, Intra-class Correlation Coefficient = 0.885, Composite Reliability = 0.895, and Standard Error of Measurement = 5.448). The study surveyed 450 livestock breeders, with an average age of 51.68 ± 16.4 years.. Participants with a history of brucellosis reported that their last occurrence of the disease, on average, was 7.03 ± 5.83 years ago.Livestock breeders had moderate knowledge levels (mean score = 17.13) and positive attitudes (mean score = 3.86) towards Brucellosis prevention, but their practice level was relatively low (mean score = 15.9). Significant differences were observed in awareness (p-value <0.001), attitude (p-value = 0.03), and practice (p-value <0.001) scores between those who had undergone previous prevention measures compared to those who did not. Participants with a higher education level had higher awareness, attitude, and practice scores. An analysis of variance test (ANOVA) showed that job level had a significant effect on awareness (p-value <0.001) and practice (p-value <0.001) scores, with free jobs having higher scores than other jobs. Findings suggest that Iranian livestock breeders have insufficient knowledge about Brucellosis prevention despite positive attitudes and practices. To prevent the spread of Brucellosis, it is necessary to increase awareness and educate livestock breeders about preventive measures.</p>","PeriodicalId":74466,"journal":{"name":"PLOS global public health","volume":"5 10","pages":"e0004693"},"PeriodicalIF":2.5,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12507205/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145253928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeted vaccination is effective for mpox clade Ib in England despite increased household transmission: Predictions from a modelling study.","authors":"Ellen Brooks-Pollock, Leon Danon","doi":"10.1371/journal.pgph.0005188","DOIUrl":"10.1371/journal.pgph.0005188","url":null,"abstract":"<p><p>Mpox is an emerging infectious disease with increasing global relevance. In 2024, a new clade, mpox clade Ib, was associated with high household attack rates and case fatality, raising concerns about sustained human-to-human transmission outside endemic areas. We developed and applied an individual-based probabilistic framework for mpox incorporating sexual and household contact patterns using data from the National Survey of Sexual Attitudes and Lifestyles 3 (NATSAL3). Individual and population-level reproduction numbers were estimated using setting-specific secondary attack rates. Vaccination impact was assessed across scenarios varying household attack rates, vaccine effectiveness, and distribution strategies. We predict that fewer than 3 out of 100 individuals generated more than one secondary case of clade Ib in England, with a population reproduction number of 0.69 (95%CI 0.66 - 0.71). Individuals reporting both same-sex and opposite sexual contact disproportionately contributed to transmission potential. Increasing household secondary attack rates led to modest increases in the population reproduction number due to individuals with the highest reproduction numbers having lower than average numbers of household contacts. Targeted vaccination, focused on individuals with higher numbers of sexual contacts, consistently outperformed non-targeted strategies, requiring lower vaccine coverage to achieve control even under elevated household transmission. Vaccine effectiveness against infection and onward transmission critically influenced the success of vaccination programs. Despite higher household transmission risks, targeted vaccination remains an effective strategy for controlling mpox clade Ib in England. Transmission dynamics are strongly shaped by underlying contact structures, emphasizing the importance of network-informed interventions. Rapid, network-informed models can provide valuable early guidance for emerging infectious diseases.</p>","PeriodicalId":74466,"journal":{"name":"PLOS global public health","volume":"5 10","pages":"e0005188"},"PeriodicalIF":2.5,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12507221/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145254014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}