Pediatric health, medicine and therapeutics最新文献

{"title":"Survival Time and Determinants of Mortality Among Children Receiving Mechanical Ventilation in Pediatric Intensive Care Units at Selected Hospitals in Kigali, Rwanda - A Retrospective Follow-up Study.","authors":"Marie Claire Nishimwe, Girum Sebsibie Teshome, Murekatete Ancille, Philomene Uwimana, Priscille Musabirema, Elizabeth Ntirenganya, Jeanine Uwineza","doi":"10.2147/PHMT.S637605","DOIUrl":"https://doi.org/10.2147/PHMT.S637605","url":null,"abstract":"<p><strong>Background: </strong>Mechanical ventilation is one of the life-saving therapies offered to critically ill pediatric patients admitted in pediatric intensive care units (PICUs). Despite high mortality among mechanically ventilated children, evidence on duration of survival and determinants of mortality among ventilated children from low- or middle-income countries remains limited.</p><p><strong>Objective: </strong>This study aims to assess survival time and determinants of mortality among mechanically ventilated children admitted to the Pediatric Intensive Care Units at selected hospitals in Kigali, Rwanda.</p><p><strong>Methods: </strong>A retrospective follow-up study of 300 medical records of children aged between 29 days and 14 years that underwent mechanical ventilation admitted to the PICUs of Kigali University Teaching Hospital and Rwanda Military teaching Hospital between January 2022 and December 2025 was conducted. Data was extracted using structured checklist. SPSS version 31 was used to analyze the data. Survival probability was estimated using Kaplan-Meier curve. Variables with p < 0.25 with bivariate cox regression analysis were fitted into multivariable regression model. Results were presented as adjusted hazard ratios (AHRs) with corresponding 95% confidence intervals (CIs), and statistical significance was considered at a p-value < 0.05.</p><p><strong>Results: </strong>Among the 300 mechanically ventilated children, 169 (56.3%) died while 131 (43.7%) were censored. The median survival time was 7 days CI [5.7, 8.3], while the mean duration of survival was 19 days CI [1.025, 28.20]. Respiratory distress (AHR = 1.42, 95% CI [1.01, 2.01], p = 0.046), post-operative period (AHR = 1.73[1.03, 2.90], p = 0.039) and vasopressor support (AHR = 1.73 [1.03, 2.62], p = 0.036) were determinants for increased mortality. Determinants associated with decreased mortality were tracheostomy (AHR = 0.25, 95% CI [0.08, 0.82], p = 0.023] and sedation (AHR = 0.40, 95% CI [0.23, 0.71], p = 0.001).</p><p><strong>Conclusion: </strong>Mortality among mechanically ventilated children in PICU was high. Respiratory failure, postoperative condition, and vasopressor support were associated for increased mortality, while tracheostomy and sedation was associated with lower mortality.</p>","PeriodicalId":74410,"journal":{"name":"Pediatric health, medicine and therapeutics","volume":"17 ","pages":"637605"},"PeriodicalIF":1.8,"publicationDate":"2026-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13653522/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149170448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Delayed Cord Clamping Practice in the Delivery Rooms of a Regional Referral Hospital and Two Lower Health Centres in Uganda: A Facility-Based Cross-Sectional Study.","authors":"Winfred Mutaki, Vivian Mutaki, Francis Mbolwa, Jacob Otile, Patrick James Kalanga, Moses Mawanda, James Ditai","doi":"10.2147/PHMT.S619406","DOIUrl":"https://doi.org/10.2147/PHMT.S619406","url":null,"abstract":"<p><strong>Background: </strong>World Health Organization (WHO) recommends delayed umbilical cord clamping (DCC) by 1-3 minutes to improve infant iron status and reduce anaemia. Few countries have adopted policies on this practice. We assessed the practice of DCC among skilled birth attendants in resource-limited delivery rooms at three levels of the health care system in Mbale district, Uganda.</p><p><strong>Methods: </strong>This facility-based, analytical cross-sectional study directly observed 379 births and their skilled birth attendants at Mbale Regional Referral, Namatala Health Centre IV, and Nakaloke Health Centre III in Mbale, eastern Uganda. Research assistants used a stopwatch to record the delivery-to-cord-clamping interval. Timing was compared overall and by birth attendant category (Doctors, midwives, and students) and mode of delivery.</p><p><strong>Results: </strong>Overall, half (52.0%, 197/379) (95% CI: 46.9% - 57.0%) of newborns had their cords clamped after at least 60seconds, a practice of delayed cord clamping (DCC). The remaining half (182/379; 48.0%) were clamped before 60s, and about a quarter (26.1%; 99/379) were clamped before 30s. The median (5^th, 95^th percentile) cord clamping time was 65seconds (8.35, 393.79) overall, but varied within the birth attendant category: 124.0 (22, 408.7) s for midwives, 22.45 (5.5, 80) s for doctors, and 56.8 (11.8, 471.7) s for students. The prevalence of DCC was far higher among midwives (crude PR 9.2; 95% CI:4.7-18.0) and students (crude PR 5.7; 95% CI:2.8-11.7) than doctors; this attenuated to non-significance after adjusting for mode of delivery (adjusted PR 2.1 for both, p=0.061).</p><p><strong>Conclusion: </strong>Only about half of newborns received DCC in these delivery rooms. The large crude difference between doctors and midwives reflected doctors performing nearly all caesarean sections, where ICC predominated, rather than provider practice alone. This study describes the timing of cord clamping among skilled birth attendants in resource-limited delivery rooms.</p>","PeriodicalId":74410,"journal":{"name":"Pediatric health, medicine and therapeutics","volume":"17 ","pages":"619406"},"PeriodicalIF":1.8,"publicationDate":"2026-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13653525/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149167667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Association Between Depression and Tourette Syndrome: A Bibliometric Analysis of Research Hotspots and Emerging Trends from 2001 to 2025.","authors":"Jin Dai, Mingyuan Xu, Hai Wang, Hong Huo, Tiegang Wang","doi":"10.2147/PHMT.S634863","DOIUrl":"https://doi.org/10.2147/PHMT.S634863","url":null,"abstract":"<p><strong>Background: </strong>Depression is a clinically relevant comorbidity of Tourette syndrome (TS), yet the organization and development of research on this topic remain poorly characterized. This study aimed to map the knowledge structure, research hotspots, and emerging trends in the literature on TS and depression. It also sought to identify questions that warrant further investigation.</p><p><strong>Methods: </strong>English-language articles and reviews published from 2001 to 2025 were retrieved from the Web of Science Core Collection and Scopus. Bibliometrix, VOSviewer, and CiteSpace were used to analyze publication and citation trends, collaboration networks, co-cited references, keyword co-occurrence, and temporal patterns. A narrative comparison of selected clinical studies informed the interpretation of these findings.</p><p><strong>Results: </strong>After database-specific screening, 3024 records were combined, and 2311 publications remained after duplicate removal. Publication output increased overall, with the United States, the United Kingdom, and China contributing the most publications. Research themes expanded from tic control and pharmacological treatment to psychiatric comorbidities, mental health, quality of life, and functional outcomes. TS, tic disorders, obsessive-compulsive disorder, attention-deficit/hyperactivity disorder, depression, comorbidity, and neuromodulation formed the core keyword network.</p><p><strong>Conclusion: </strong>Research on TS and depression increasingly addresses psychiatric comorbidity and functional outcomes. These findings support assessing depressive symptoms alongside tic severity and including depression and functional outcomes in future TS research.</p>","PeriodicalId":74410,"journal":{"name":"Pediatric health, medicine and therapeutics","volume":"17 ","pages":"634863"},"PeriodicalIF":1.8,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13634333/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149119881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alobar Holoprosencephaly with Severe Craniofacial Anomalies and Congenital Diaphragmatic Hernia: First Reported Case from Somalia.","authors":"Ibrahim Mohamed Osman, Abdikani Mohamednor Mohamed, Khalid Said Abdi, Nimo Mohamednor Mohamed","doi":"10.2147/PHMT.S625135","DOIUrl":"10.2147/PHMT.S625135","url":null,"abstract":"<p><p>Alobar holoprosencephaly (HPE) is a severe malformation where the embryonic forebrain fails to divide, characterized by profound midline facial defects and high mortality. We report a case of a term neonate born to a grand multigravida mother from a rural area with no prior antenatal screening. At birth, the neonate presented with severe midline craniofacial anomalies, including arrhinia and anophthalmia. Transcranial ultrasonography demonstrated findings highly suggestive of alobar HPE, including a single monoventricle and absence of key midline structures, while additional findings included a congenital diaphragmatic hernia and an Acyanotic perimembranous ventricular septal defect. Due to the severity of these multisystem malformations, the patient was managed with supportive care and succumbed to multisystem failure on the third day of life. Alobar holoprosencephaly has an extremely poor prognosis, with most affected neonates not surviving long after birth; therefore, management focuses on supportive care, such as respiratory stabilization, feeding, and comfort. This case highlights the crucial role of early prenatal screening, detailed ultrasound, and genetic counseling especially in resource-limited settings to allow for timely diagnosis, informed parental counseling, and better planning for neonatal care.</p>","PeriodicalId":74410,"journal":{"name":"Pediatric health, medicine and therapeutics","volume":"17 ","pages":"625135"},"PeriodicalIF":1.8,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13614316/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149066522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternal Folic Acid Supplementation and Neural Tube Defects in Northeast Iran: Insights for Developing Countries.","authors":"Veda Vakili, Sayed Mortaza Fayez","doi":"10.2147/PHMT.S629730","DOIUrl":"10.2147/PHMT.S629730","url":null,"abstract":"<p><strong>Background: </strong>Neural tube defects (NTDs) are among the most common severe congenital malformations, caused by incomplete closure of the neural tube in the third and fourth weeks after conception. This study aimed to investigate potential maternal and environmental risk factors associated with NTDs in newborns under the coverage of Mashhad University of Medical Sciences.</p><p><strong>Methods: </strong>A descriptive case-control study was conducted using the Integrated Health Information System. All NTDs newborns (n=126) were case identified while three times of the number of mothers of healthy newborns (n=378) were picked as controls. Maternal and neonatal factors like folic acid supplementation, maternal age, BMI, parity, smoking, passive smoking, consanguinity, and neonatal sex were collected and processed with SPSS 27 software. Chi-square, Fisher's exact test, and logistic regression were employed.</p><p><strong>Results: </strong>Among mothers of NTD-affected newborns, 20.6% reported folic acid supplementation versus 31.5% in controls (P=0.02). The gender of the newborn, mother's age, BMI, number of children, education level, kinship, history of having affected child, and history of stillbirth showed no significant difference between cases and controls. Logistic regression results showed that not taking folic acid increased the likelihood of NTDs by more than two times (OR=2.11, P=0.006).</p><p><strong>Conclusion: </strong>Maternal folic acid supplementation was significantly associated with reduced risk of NTDs. No significant relationship was found with the other factors studied.</p>","PeriodicalId":74410,"journal":{"name":"Pediatric health, medicine and therapeutics","volume":"17 ","pages":"629730"},"PeriodicalIF":1.8,"publicationDate":"2026-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13599795/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149042468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combined Laparoscopic and Colonoscopic Retrieval of Multiple Ingested Magnetic Beads Without Enterotomy in Children: A Case Report and Literature Review.","authors":"Chong Shen, Yaqiang Hong, Hailin Li, Hao Chen, Jingfeng Bao, Wenjun Zhuang","doi":"10.2147/PHMT.S619020","DOIUrl":"10.2147/PHMT.S619020","url":null,"abstract":"<p><strong>Background: </strong>Magnetic foreign body ingestion is one of the high-risk accidental injuries in pediatric emergency medicine. Especially when multiple magnets are swallowed, they can attract each other rapidly and cause sustained compression of the intervening intestinal walls, which may lead to necrosis and perforation. This report presents a successful pediatric case of retrieving multiple magnetic beads from the ileum using laparoscopy combined with colonoscopy without enterotomy, aiming to provide practical insights for individualized, organ-preserving management of these patients.</p><p><strong>Case presentation: </strong>A 4-year and 11-month-old boy presented to the emergency department approximately 1 hour after ingesting four high-powered magnetic beads. Initial emergency upper gastrointestinal endoscopy revealed no foreign body in the esophagus, stomach, or duodenum. Conservative management was initiated with close clinical and radiographic monitoring. Serial abdominal radiographs over three consecutive days demonstrated persistent localization of the magnetic beads in the right lower abdomen without migration. To avoid the risks such as prolonged intestinal compression and subsequent necrosis, we performed an emergency laparoscopic exploration. Intraoperatively, the intestinal tract was examined and gently manipulated to ensure the magnetic beads passed smoothly through the ileocecal valve as a whole, allowing complete removal through colonoscopy. Oral intake of fluids was resumed on postoperative day 1, and the child was discharged on postoperative day 3 without any complications.</p><p><strong>Conclusion: </strong>Multiple magnetic foreign bodies retained in proximity to the ileocecal valve without intestinal wall compression or necrosis may be suitable candidates for combined laparoscopic and endoscopic retrieval without enterotomy, thereby optimizing intestinal preservation and facilitating patient recovery.</p>","PeriodicalId":74410,"journal":{"name":"Pediatric health, medicine and therapeutics","volume":"17 ","pages":"619020"},"PeriodicalIF":1.8,"publicationDate":"2026-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13590254/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149019041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Problematic Social Media Use and Self-Perception of Dental Aesthetics in Adolescents: Associations with Body Esteem, Social Anxiety and Gender.","authors":"María Victoria Pérez Suárez, Ana Ruíz Guillén, María José González-Olmo, Marta Olmos Valverde, Martín Romero Maroto, María Carrillo Díaz","doi":"10.2147/PHMT.S640257","DOIUrl":"10.2147/PHMT.S640257","url":null,"abstract":"<p><strong>Background: </strong>Body esteem and self-perceived dental aesthetics play an important role in adolescents' psychosocial well-being. Problematic social media use may be associated with greater comparison with idealised aesthetic standards. However, evidence regarding the association between problematic social media use, body esteem, and self-perceived dental aesthetics remains limited.</p><p><strong>Objective: </strong>The aims of this study were to examine the associations among problematic social media use, body esteem, social anxiety and self-perceived dental aesthetics in adolescents and to evaluate the roles that Fear of Negative Evaluation (FNE), Body Mass Index (BMI), and gender play in these relationships.</p><p><strong>Methods: </strong>This cross-sectional study included 393 adolescents aged 13-18 years. They were asked to complete the Social Media Disorder Scale (SMD), body esteem (BESAA), self-perceived dental aesthetics (PIDAQ), and fear of negative evaluation (FNE) questionnaires, and BMI was calculated. Multiple linear regression and gender moderation analyses were performed.</p><p><strong>Results: </strong>Problematic social media use was significantly associated with lower body esteem (r = -0.165, p =0.013) and poorer dental self-image (r =0.288, p <0.001). In the final regression model, FNE (β = -0.429, p <0.001) and BMI (β = -0.332, p <0.001) were significant predictors of lower body esteem, whereas problematic social media use was no longer significant (β = -0.066, p =0.267). The final model explained 29.6% of the variance in body esteem. Gender significantly moderated the relationship between problematic social media use and dental self-image (p =0.05). Among females, problematic social media use predicted higher PIDAQ scores (b = 2.99, p <0.001), whereas this relationship was not significant among males (b = 0.53, p =0.62).</p><p><strong>Conclusion: </strong>Problematic social media use was associated with poorer dental self-image, particularly among females, whereas body esteem was mainly associated with FNE and BMI. These findings suggest that psychosocial factors and the digital environment may play a relevant role in adolescents' psychosocial well-being and oral health.</p>","PeriodicalId":74410,"journal":{"name":"Pediatric health, medicine and therapeutics","volume":"17 ","pages":"640257"},"PeriodicalIF":1.8,"publicationDate":"2026-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13584941/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148992937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cytomegalovirus-Associated Thrombocytopenia in an Immunocompetent Infant: A Case Report.","authors":"Xiaomei Wan","doi":"10.2147/PHMT.S622086","DOIUrl":"https://doi.org/10.2147/PHMT.S622086","url":null,"abstract":"<p><strong>Background: </strong>Cytomegalovirus (CMV) is a β-herpesvirus. In immunocompromised individuals, CMV infection can cause life-threatening complications such as encephalitis, pneumonia, hepatitis and organ rejection. In contrast, immunocompetent children often present with mild infection, with thrombocytopenia being a common hematological complication.</p><p><strong>Methods: </strong>A 2-month-18-day-old female infant was transferred to a tertiary hospital due to a 2-day fever and 1-day generalized petechiae. Physical examination revealed scattered skin petechiae without lymphadenopathy, hepatosplenomegaly or other systemic symptoms. Laboratory tests showed moderate thrombocytopenia with a platelet count of 35 × 10⁹/L, and platelet transfusion was not required, elevated liver transaminases, positive CMV IgM and IgG, and detectable peripheral CMV-DNA load, confirming acute CMV infection. The infant received only hepatoprotective treatment during an 8-day hospitalization, without intravenous immunoglobulin or antiviral agents.</p><p><strong>Results: </strong>The platelet count and liver function improved gradually during hospitalization. At two-week follow-up after discharge, blood cell parameters and liver enzymes returned to normal, and peripheral CMV-DNA declined to undetectable levels. Platelet counts remained stable in the subsequent 2-month follow-up.</p><p><strong>Conclusion: </strong>CMV-associated thrombocytopenia in immunocompetent infants is usually self-limiting. Close dynamic monitoring of hematological and hepatic indicators is essential. Antiviral therapy should be prescribed cautiously, and individualized management is recommended for mild CMV infection in young infants.</p>","PeriodicalId":74410,"journal":{"name":"Pediatric health, medicine and therapeutics","volume":"17 ","pages":"622086"},"PeriodicalIF":1.8,"publicationDate":"2026-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13580653/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148992906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence, Risk Factors and Mortality of Hospitalization Among Late Preterm Neonates at Jinja and Kayunga Regional Referral Hospitals, Eastern Uganda, Prospective Study.","authors":"Mohamed Abdullahi Ahmed, Mohamed Abdi Hassan, Walyedin Elnour Mohamed Elfakey, Jolly Nankunda, Abishir Mohamud Hirsi, Mohamed Jayte, Mohamed Mohamud Farah, Zakaria Abdi Said, Hamdi Mohamed Yusuf, Martin Nduwimana","doi":"10.2147/PHMT.S600465","DOIUrl":"10.2147/PHMT.S600465","url":null,"abstract":"<p><strong>Background: </strong>In Uganda, prematurity is the main cause of newborn fatalities, accounting for 41% of all annual newborn deaths. There are limited studies in Uganda that have explored preterm births. This study aimed to assess the incidence, risk factors for admission and outcomes of late preterm Neonates at Kayunga and Jinja Regional Referral Hospitals (KRRH and JRRH).</p><p><strong>Methods: </strong>This was a prospective cohort study in which late preterm babies were enrolled at birth. Late preterm neonates (born at 34 weeks and 0 days through 36 weeks and 6 days) at KRRH and JRRH during the study period were enrolled. They were followed up from the time of birth till 4 weeks of life for hospital admission and mortality. Modified Poisson regression in stata version 14 was done to determine the significant risk factors.</p><p><strong>Results: </strong>In this study, we enrolled 329 late preterm neonates. Slightly more than half were males (59.9%). The distributions in the gestational ages slightly increased with gestation age with 31.9%, 33.4% and 34.7% born at 34, 35 and 36 weeks of gestation respectively. Of the 329 late preterm neonates enrolled in this study, 72 were admitted, representing an incidence proportion of 21.9% (219 admission per 1,000 live late preterm births). In the multivariable analysis, maternal age between 35-45 years, monthly income less than 200,000 Uganda shillings, less than two antenatal care visits, duration of labour greater than 24 hours, and presence of perinatal complications were significant. The overall mortality rate was 1.8% and admission mortality of 8.3%.</p><p><strong>Conclusion: </strong>The incidence of hospital admission among late preterm Neonates was high with maternal and neonatal factors being significant at multivariate analysis. More research with longer follow up should be done to assess the long-term outcomes among late preterms.</p>","PeriodicalId":74410,"journal":{"name":"Pediatric health, medicine and therapeutics","volume":"17 ","pages":"600465"},"PeriodicalIF":1.8,"publicationDate":"2026-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13571616/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148964051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence and Risk Factors of Mortality Among Under Five Children with Severe Acute Malnutrition Admitted at Hoima Regional Referral Hospital in Uganda.","authors":"Ahmed Hassan Mohamud, Martin Nduwimana, Zakaria Abdi Said, Hamdi Mohamed Yusuf, Sadia Mahad Mohamed, Abdiwahid Mohamed Ahmed Mohamed, Elfakey E M Walyeldin, Theoneste Hakizimana, Joanitor Nakisuyi, Jolly Nankunda, Tom Didimus Ediamu","doi":"10.2147/PHMT.S586641","DOIUrl":"10.2147/PHMT.S586641","url":null,"abstract":"<p><strong>Introduction: </strong>Studies conducted in Northern, Central, and Eastern Uganda revealed concerning case fatality rates for children with severe acute malnutrition (SAM). However, there is a lack of research specifically addressing mortality rates among children with SAM in Western Uganda. This study aimed to assess the mortality rates, weight change trends and risk factors for mortality among children with SAM in Midwestern Uganda.</p><p><strong>Methods: </strong>This was a prospective cohort at Hoima Regional Referral Hospital in which children aged below five years admitted with SAM were enrolled and followed up for 6 weeks. The relevant data was obtained via history taking, physical examination and laboratory investigations. The percentage of children that died within 6 weeks was computed. Poisson regression was done to determine the independent predictors. P-values <0.05 were considered significant.</p><p><strong>Findings: </strong>In this study, 146 participants were enrolled. About half of the participants were aged 13-36 months (50.7%). Of the 144 that completed the 6 week follow up, 12 died, expressing a mortality of 8.3% (83 per 1000 children); with majority of deaths (83.3%) occurring in the first 48 hours of admission. In the multivariable analysis, the independent risk factors for mortality were vomiting, lower respiratory tract infection, malaria and hypoglycemia (P<0.05 for all).</p><p><strong>Conclusion: </strong>Mortality among children with SAM in Western Uganda remains high, with most deaths occurring within 48 hours. Early detection and management of vomiting, respiratory infections, malaria, and hypoglycemia are critical to reducing mortality. The relevant data was obtained via history taking, physical examination and laboratory investigations. Bi-variable and multivariate was used, and Poisson regression was done to determine the independent predictors. P-values <0.05 were considered significant.</p>","PeriodicalId":74410,"journal":{"name":"Pediatric health, medicine and therapeutics","volume":"17 ","pages":"586641"},"PeriodicalIF":1.8,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13549172/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148908147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}