Ezedin Mohammed Hiyar, Girum Sebsibie Teshome, Feven Mulugeta Ashagre, Solomon Hailesilassie Bisrat, Terefe Keto, Mehuba Hassen Ali
{"title":"埃塞俄比亚亚的斯亚贝巴两所公立医院神经管缺陷新生儿的死亡时间和预测因素：一项回顾性随访研究","authors":"Ezedin Mohammed Hiyar, Girum Sebsibie Teshome, Feven Mulugeta Ashagre, Solomon Hailesilassie Bisrat, Terefe Keto, Mehuba Hassen Ali","doi":"10.2147/PHMT.S527499","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Neural tube defects are a collection of intricate congenital abnormalities that affect the central nervous system. Neural tube defects cause 88,000 deaths globally and 29% in developing countries. Neural tube defects take a significant portion of the congenital anomalies in Ethiopia. This study aimed to assess the time to death, as hazard and predictors among neonates with neural tube defects in two public hospitals, Addis Ababa, Ethiopia.</p><p><strong>Methods: </strong>A retrospective cohort study was conducted by reviewing medical charts of 410 randomly selected neonates with neural tube defects, registered from 2018 to 2022 in Addis Ababa, Ethiopia. Data collection and entry was done from February 20 to March 20/2023 using KoboCollect v2022.4.4. STATA/14 was used for data screening, and SPSS/27 was used for analysis. The Kaplan-Meier survival analysis and Cox proportional hazards model were used for inferential analysis. Findings with p ≤ 0.05 were observed as statistically significant.</p><p><strong>Results: </strong>A total of 410 neonates were followed for 4100 person-days of risk time and 35 (8.54%) of neonates expired. The overall incidence rate of mortality was 8.54 per 1000 neonate days of observation with a median survival time of 25 days (95% CI: 22.7-27.3). Being preterm, Adjusted Hazard Ratio (AHR) = 2.62, (95% CI 1.12, 6.14), having low birth weight (AHR: 2.62, 95% CI 1.13, 6.10), encephalocele (AHR: 3.77, 95% CI 1.65, 8.62), cervical and occipital lesion level (AHR: 3.97, 95% CI, 1.17, 13.49), presence of hydrocephalus (AHR: 3.98, 95% CI 1.55, 10.21), and Chiari-II malformation (AHR: 2.40, 95% CI 1.03, 5.57) were demonstrated to be statistically significant predictors of time to death.</p><p><strong>Conclusion: </strong>The cumulative incidence of death of neonates diagnosed with neural tube defects was observed. Early diagnosis and timely management of patients is decisive in lowering the mortality.</p>","PeriodicalId":74410,"journal":{"name":"Pediatric health, medicine and therapeutics","volume":"16 ","pages":"195-208"},"PeriodicalIF":1.7000,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12306550/pdf/","citationCount":"0","resultStr":"{\"title\":\"Time to Death and Predictors Among Neonates with Neural Tube Defects in Two Public Hospitals, Addis Ababa, Ethiopia: A Retrospective Follow-Up Study.\",\"authors\":\"Ezedin Mohammed Hiyar, Girum Sebsibie Teshome, Feven Mulugeta Ashagre, Solomon Hailesilassie Bisrat, Terefe Keto, Mehuba Hassen Ali\",\"doi\":\"10.2147/PHMT.S527499\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Neural tube defects are a collection of intricate congenital abnormalities that affect the central nervous system. Neural tube defects cause 88,000 deaths globally and 29% in developing countries. Neural tube defects take a significant portion of the congenital anomalies in Ethiopia. This study aimed to assess the time to death, as hazard and predictors among neonates with neural tube defects in two public hospitals, Addis Ababa, Ethiopia.</p><p><strong>Methods: </strong>A retrospective cohort study was conducted by reviewing medical charts of 410 randomly selected neonates with neural tube defects, registered from 2018 to 2022 in Addis Ababa, Ethiopia. Data collection and entry was done from February 20 to March 20/2023 using KoboCollect v2022.4.4. STATA/14 was used for data screening, and SPSS/27 was used for analysis. The Kaplan-Meier survival analysis and Cox proportional hazards model were used for inferential analysis. Findings with p ≤ 0.05 were observed as statistically significant.</p><p><strong>Results: </strong>A total of 410 neonates were followed for 4100 person-days of risk time and 35 (8.54%) of neonates expired. The overall incidence rate of mortality was 8.54 per 1000 neonate days of observation with a median survival time of 25 days (95% CI: 22.7-27.3). Being preterm, Adjusted Hazard Ratio (AHR) = 2.62, (95% CI 1.12, 6.14), having low birth weight (AHR: 2.62, 95% CI 1.13, 6.10), encephalocele (AHR: 3.77, 95% CI 1.65, 8.62), cervical and occipital lesion level (AHR: 3.97, 95% CI, 1.17, 13.49), presence of hydrocephalus (AHR: 3.98, 95% CI 1.55, 10.21), and Chiari-II malformation (AHR: 2.40, 95% CI 1.03, 5.57) were demonstrated to be statistically significant predictors of time to death.</p><p><strong>Conclusion: </strong>The cumulative incidence of death of neonates diagnosed with neural tube defects was observed. Early diagnosis and timely management of patients is decisive in lowering the mortality.</p>\",\"PeriodicalId\":74410,\"journal\":{\"name\":\"Pediatric health, medicine and therapeutics\",\"volume\":\"16 \",\"pages\":\"195-208\"},\"PeriodicalIF\":1.7000,\"publicationDate\":\"2025-07-25\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12306550/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Pediatric health, medicine and therapeutics\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.2147/PHMT.S527499\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q2\",\"JCRName\":\"PEDIATRICS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pediatric health, medicine and therapeutics","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2147/PHMT.S527499","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"PEDIATRICS","Score":null,"Total":0}
引用次数: 0
摘要
背景：神经管缺陷是影响中枢神经系统的复杂先天性异常的集合。神经管缺陷导致全球88,000人死亡，其中29%在发展中国家。在埃塞俄比亚，神经管缺陷占先天性畸形的很大一部分。本研究旨在评估埃塞俄比亚亚的斯亚贝巴两所公立医院神经管缺陷新生儿的死亡时间，作为危险因素和预测因素。方法：回顾性队列研究，随机选取2018 - 2022年在埃塞俄比亚亚的斯亚贝巴登记的410例神经管缺陷新生儿的病历。使用KoboCollect v2022.4.4从2月20日到2023年3月20日完成数据收集和输入。数据筛选采用STATA/14，分析采用SPSS/27。采用Kaplan-Meier生存分析和Cox比例风险模型进行推理分析。p≤0.05为差异有统计学意义。结果：410例新生儿随访4100人日，死亡35例（8.54%）。总死亡率为8.54 / 1000新生儿观察天，中位生存时间为25天（95% CI: 22.7-27.3）。早产，校正风险比(AHR) = 2.62, (95% CI 1.12, 6.14)，低出生体重（AHR: 2.62, 95% CI 1.13, 6.10），脑膨出（AHR: 3.77, 95% CI 1.65, 8.62），颈椎和枕部病变程度（AHR: 3.97, 95% CI 1.17, 13.49），脑积水（AHR: 3.98, 95% CI 1.55, 10.21），以及ii型chiari畸形（AHR: 2.40, 95% CI 1.03, 5.57）被证明是死亡时间有统计学意义的预测因素。结论：观察新生儿神经管缺损的累积死亡率。早期诊断和及时治疗是降低死亡率的关键。
Time to Death and Predictors Among Neonates with Neural Tube Defects in Two Public Hospitals, Addis Ababa, Ethiopia: A Retrospective Follow-Up Study.
Background: Neural tube defects are a collection of intricate congenital abnormalities that affect the central nervous system. Neural tube defects cause 88,000 deaths globally and 29% in developing countries. Neural tube defects take a significant portion of the congenital anomalies in Ethiopia. This study aimed to assess the time to death, as hazard and predictors among neonates with neural tube defects in two public hospitals, Addis Ababa, Ethiopia.
Methods: A retrospective cohort study was conducted by reviewing medical charts of 410 randomly selected neonates with neural tube defects, registered from 2018 to 2022 in Addis Ababa, Ethiopia. Data collection and entry was done from February 20 to March 20/2023 using KoboCollect v2022.4.4. STATA/14 was used for data screening, and SPSS/27 was used for analysis. The Kaplan-Meier survival analysis and Cox proportional hazards model were used for inferential analysis. Findings with p ≤ 0.05 were observed as statistically significant.
Results: A total of 410 neonates were followed for 4100 person-days of risk time and 35 (8.54%) of neonates expired. The overall incidence rate of mortality was 8.54 per 1000 neonate days of observation with a median survival time of 25 days (95% CI: 22.7-27.3). Being preterm, Adjusted Hazard Ratio (AHR) = 2.62, (95% CI 1.12, 6.14), having low birth weight (AHR: 2.62, 95% CI 1.13, 6.10), encephalocele (AHR: 3.77, 95% CI 1.65, 8.62), cervical and occipital lesion level (AHR: 3.97, 95% CI, 1.17, 13.49), presence of hydrocephalus (AHR: 3.98, 95% CI 1.55, 10.21), and Chiari-II malformation (AHR: 2.40, 95% CI 1.03, 5.57) were demonstrated to be statistically significant predictors of time to death.
Conclusion: The cumulative incidence of death of neonates diagnosed with neural tube defects was observed. Early diagnosis and timely management of patients is decisive in lowering the mortality.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
