Parasites, hosts and diseases最新文献_第6页

In vitro immunoregulatory role of recombinant Ancylostoma ceylanicum calreticulin. 重组麦地那龙线虫钙网蛋白的体外免疫调节作用。

Parasites, hosts and diseases Pub Date : 2024-02-01 Epub Date: 2024-02-23 DOI: 10.3347/PHD.23108

Tingting Zhuang, Asmaa M I Abuzeid, Xiaoyu Chen, Shilan Zhu, Guoqing Li

引用次数: 0

Morphological and molecular characteristics of Paralecithodendrium longiforme (Digenea: Lecithodendriidae) adults and cercariae from Chinese pipistrelle bats and viviparid snails in Thailand. 来自泰国中国琵琶蝠和蜗牛的 Paralecithodendrium longiforme（Digenea: Lecithodendriidae）成虫和头蚴的形态学和分子特征。

Parasites, hosts and diseases Pub Date : 2024-02-01 Epub Date: 2024-02-23 DOI: 10.3347/PHD.23106

Thitichai Arttra, Pheravut Wongsawad, Chalobol Wongsawad, Nattawadee Nantarat, Preeyaporn Butboonchoo, Jong-Yil Chai

{"title":"Morphological and molecular characteristics of Paralecithodendrium longiforme (Digenea: Lecithodendriidae) adults and cercariae from Chinese pipistrelle bats and viviparid snails in Thailand.","authors":"Thitichai Arttra, Pheravut Wongsawad, Chalobol Wongsawad, Nattawadee Nantarat, Preeyaporn Butboonchoo, Jong-Yil Chai","doi":"10.3347/PHD.23106","DOIUrl":"10.3347/PHD.23106","url":null,"abstract":"This study aimed to describe the morphological and molecular characteristics of Paralecithodendrium longiforme (Digenea: Lecithodendriidae) adults and cercariae isolated in Thailand. Adult flukes were isolated from the Chinese pipistrelle bat (Hypsugo sp.), and cercariae were detected in the viviparid snail (Filopaludina martensi martensi) from Chiang Mai province. The morphological characteristics were observed and described using conventional methods, and the molecular characteristics with internal transcribed spacer 2 (ITS2) and 28S rDNA gene sequences. The adult flukes were fusiform, 0.84-0.98 mm in length, and 0.37-0.49 mm in width, and were distinguishable from other species by the presence of longitudinal uterine coils. The cercariae were nonvirgulate xiphidiocercariae, with the oral sucker bigger than the acetabulum, the tail without fin fold, a body size of 117.5-138.3 × 48.3-52.2 µm, and a tail size of 100.7-103.7 × 15.0-18.9 µm. Molecular studies revealed that the adults and cercariae shared 99.3% (ITS2) and 99.6% (28S rDNA) homology with each other. They were phylogenetically close to P. longiforme with an identity of 94.5% for ITS2 and 98.7% for 28S rDNA. This study provides new information on the natural definitive host and first intermediate host of P. longiforme in Thailand. The discovery of its cercarial stage in Filopaludina snails highlights the importance of monitoring the associated second intermediate host and prevention and control of this potentially zoonotic trematode.","PeriodicalId":74397,"journal":{"name":"Parasites, hosts and diseases","volume":"62 1","pages":"85-97"},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10915260/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140041145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of the antimalarial activity of SAM13-2HCl with morpholine amide (SKM13 derivative) against antimalarial drug-resistant Plasmodium falciparum and Plasmodium berghei infected ICR mice. 评估 SAM13-2HCl 与吗啉酰胺（SKM13 衍生物）对抗疟药物耐药性恶性疟原虫和疟原虫感染的 ICR 小鼠的抗疟活性。

Parasites, hosts and diseases Pub Date : 2024-02-01 Epub Date: 2024-02-23 DOI: 10.3347/PHD.23093

Hyelee Hong, Kwonmo Moon, Thuy-Tien Thi Trinh, Tae-Hui Eom, Hyun Park, Hak Sung Kim, Seon-Ju Yeo

{"title":"Evaluation of the antimalarial activity of SAM13-2HCl with morpholine amide (SKM13 derivative) against antimalarial drug-resistant Plasmodium falciparum and Plasmodium berghei infected ICR mice.","authors":"Hyelee Hong, Kwonmo Moon, Thuy-Tien Thi Trinh, Tae-Hui Eom, Hyun Park, Hak Sung Kim, Seon-Ju Yeo","doi":"10.3347/PHD.23093","DOIUrl":"10.3347/PHD.23093","url":null,"abstract":"Antimalarial drugs are an urgently need and crucial tool in the campaign against malaria, which can threaten public health. In this study, we examined the cytotoxicity of the 9 antimalarial compounds chemically synthesized using SKM13-2HCl. Except for SKM13-2HCl, the 5 newly synthesized compounds had a 50% cytotoxic concentration (CC50) > 100 µM, indicating that they would be less cytotoxic than SKM13-2HCl. Among the 5 compounds, only SAM13-2HCl outperformed SKM13-2HCl for antimalarial activity, showing a 3- and 1.3-fold greater selective index (SI) (CC50/IC50) than SKM13-2HCl in vitro against both chloroquine-sensitive (3D7) and chloroquine -resistant (K1) Plasmodium falciparum strains, respectively. Thus, the presence of morpholine amide may help to effectively suppress human-infectious P. falciparum parasites. However, the antimalarial activity of SAM13-2HCl was inferior to that of the SKM13-2HCl template compound in the P. berghei NK65-infected mouse model, possibly because SAM13-2HCl had a lower polarity and less efficient pharmacokinetics than SKM13-2HCl. SAM13-2HCl was more toxic in the rodent model. Consequently, SAM13-2HCl containing morpholine was selected from screening a combination of pharmacologically significant structures as being the most effective in vitro against human-infectious P. falciparum but was less efficient in vivo in a P. berghei-infected animal model when compared with SKM13-2HCl. Therefore, SAM13-2HCl containing morpholine could be considered a promising compound to treat chloroquine-resistant P. falciparum infections, although further optimization is crucial to maintain antimalarial activity while reducing toxicity in animals.","PeriodicalId":74397,"journal":{"name":"Parasites, hosts and diseases","volume":"62 1","pages":"42-52"},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10915268/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140041035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pathological fracture induced by Halicephalobus gingivalis (Nematoda: Rhabditida) in a horse limb. 马肢体上的齿龈光头虫（线虫纲：横纹线虫）诱发的病理性骨折。

Parasites, hosts and diseases Pub Date : 2024-02-01 Epub Date: 2024-02-23 DOI: 10.3347/PHD.23066

Ticiana Meireles Sousa, Hugo Shisei Toma, Antonio de Pádua Lima, Antonio Carlos Cunha Lacreta Junior, Maira Meira Nunes, Ana Paula Cassiano da Silva, Daniel Wouters, Adriana Silva Albuquerque, Mary Suzan Varaschin, Djeison Lutier Raymundo, Claudia Dias Monteiro Toma, Fernando Arévalo Batista

{"title":"Pathological fracture induced by Halicephalobus gingivalis (Nematoda: Rhabditida) in a horse limb.","authors":"Ticiana Meireles Sousa, Hugo Shisei Toma, Antonio de Pádua Lima, Antonio Carlos Cunha Lacreta Junior, Maira Meira Nunes, Ana Paula Cassiano da Silva, Daniel Wouters, Adriana Silva Albuquerque, Mary Suzan Varaschin, Djeison Lutier Raymundo, Claudia Dias Monteiro Toma, Fernando Arévalo Batista","doi":"10.3347/PHD.23066","DOIUrl":"10.3347/PHD.23066","url":null,"abstract":"Halicephalobus gingivalis is a free-living nematode that occasionally causes infections in horses. We report a rare case of limb fracture of horse caused by infection with H. gingivalis. An 8-year-old mare was referred to the Veterinary Hospital of the Federal University of Lavras with claudication grade 5 of the right hind limb, that had been started 3 months ago. The patient had aseptic arthritis in the tarsal joint and edema that extended to the quartile. The radiographic examination showed punctate osteolysis with exacerbation of bone trabeculation along the calcaneus, talus, proximal epiphysis of the third metatarsal and distal epiphysis of the tibia. Treatment for arthritis was initiated, and the animal showed a slight improvement in limb function. However, 21 days after hospitalization, due to a comminuted fracture of the tibia, it was euthanized. At necropsy, yellowish masses were found from the metatarsal to the tibia, and around the tarsal bones and joint. Similar masses were also found in the left kidney. Numerous nematodes compatible with H. gingivalis were identified. This is the first description of a pathological fracture caused by H. gingivalis infection in an equine limb.","PeriodicalId":74397,"journal":{"name":"Parasites, hosts and diseases","volume":"62 1","pages":"131-138"},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10915270/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140041146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Paleoparasitology research on ancient helminth eggs and larvae in the Republic of Korea. 韩国古蠕虫卵和幼虫的古寄生虫学研究。

Parasites, hosts and diseases Pub Date : 2023-11-01 Epub Date: 2023-11-28 DOI: 10.3347/PHD.23085

Jong-Yil Chai, Min Seo, Dong Hoon Shin

{"title":"Paleoparasitology research on ancient helminth eggs and larvae in the Republic of Korea.","authors":"Jong-Yil Chai, Min Seo, Dong Hoon Shin","doi":"10.3347/PHD.23085","DOIUrl":"10.3347/PHD.23085","url":null,"abstract":"Paleoparasitology is a discipline that applies existing conventional and molecular techniques to study parasites found in ancient ruins. This review focuses on the history of the discovery of parasites (mostly helminth eggs and larvae) in archaeological soil samples and mummies in Korea from the Three Kingdoms Period to the Joseon Dynasty (100 BCE-1910 CE). We also briefly review important milestones in global paleoparasitology. The helminth species reported so far in Korea included Ascaris lumbricoides, Trichuris trichiura, Strongyloides stercoralis (larva), Trichostrongylus sp. (larva), Paracapillaria philippinensis (syn. Capillaria philippinensis), Enterobius vermicularis, Fasciola hepatica, dicrocoeliids, Paragonimus westermani, Clonorchis sinensis, Metagonimus yokogawai, Pygidiopsis summa, Gymnophalloides seoi, Isthmiophora hortensis, Dibothriocephalus nihonkaiensis (syn. Diphyllobothrium nihonkaiense), and Taenia spp. tapeworms. The findings obtained by Korean paleoparasitologists/archaeologists have brought about deep insight into the status of helminthic infections in Korea's past populations. Continued paleoparasitological research is essential for further understanding of ancient parasites and parasitic diseases in Korea.","PeriodicalId":74397,"journal":{"name":"Parasites, hosts and diseases","volume":"61 4","pages":"345-387"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10693964/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138479754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Morphological studies of fly puparia (Diptera: Calliphoridae) in the soil from a Joseon Dynasty grave in Korea. 朝鲜墓土中褐蝇的形态研究(双翅目:褐蝇科)。

Parasites, hosts and diseases Pub Date : 2023-11-01 Epub Date: 2023-11-28 DOI: 10.3347/PHD.23047

In-Yong Lee, Ju Yeong Kim, Jung-Min Park, Ji Ho Seo, Bo-Young Jeon, Tai-Soon Yong, Min Seo

引用次数: 0

In vitro anti-Trypanosoma cruzi activity of methanolic extract of Bidens pilosa and identification of active compounds by gas chromatography-mass spectrometry analysis. 毛拜登甲醇提取物体外抗克氏锥虫活性及有效成分的气相色谱-质谱分析鉴定。

Parasites, hosts and diseases Pub Date : 2023-11-01 Epub Date: 2023-11-28 DOI: 10.3347/PHD.23069

Gabriel Enrique Cázares-Jaramillo, Zinnia Judith Molina-Garza, Itza Eloisa Luna-Cruz, Luisa Yolanda Solís-Soto, José Luis Rosales-Encina, Lucio Galaviz-Silva

{"title":"In vitro anti-Trypanosoma cruzi activity of methanolic extract of Bidens pilosa and identification of active compounds by gas chromatography-mass spectrometry analysis.","authors":"Gabriel Enrique Cázares-Jaramillo, Zinnia Judith Molina-Garza, Itza Eloisa Luna-Cruz, Luisa Yolanda Solís-Soto, José Luis Rosales-Encina, Lucio Galaviz-Silva","doi":"10.3347/PHD.23069","DOIUrl":"10.3347/PHD.23069","url":null,"abstract":"Chagas disease, caused by Trypanosoma cruzi parasite, is a significant but neglected tropical public health issue in Latin America due to the diversity of its genotypes and pathogenic profiles. This complexity is compounded by the adverse effects of current treatments, underscoring the need for new therapeutic options that employ medicinal plant extracts without negative side effects. Our research aimed to evaluate the trypanocidal activity of Bidens pilosa fractions against epimastigote and trypomastigote stages of T. cruzi, specifically targeting the Brener and Nuevo León strains-the latter isolated from Triatoma gerstaeckeri in General Terán, Nuevo León, México. We processed the plant's aerial parts (stems, leaves, and flowers) to obtain a methanolic extract (Bp-mOH) and fractions with varying solvent polarities. These preparations inhibited more than 90% of growth at concentrations as low as 800 μg/ml for both parasite stages. The median lethal concentration (LC50) values for the Bp-mOH extract and its fractions were below 500 μg/ml. Tests for cytotoxicity using Artemia salina and Vero cells and hemolytic activity assays for the extract and its fractions yielded negative results. The methanol fraction (BPFC3MOH1) exhibited superior inhibitory activity. Its functional groups, identified as phenols, enols, alkaloids, carbohydrates, and proteins, include compounds such as 2-hydroxy-3-methylbenzaldehyde (50.9%), pentadecyl prop-2-enoate (22.1%), and linalool (15.4%). Eight compounds were identified, with a match confirmed by the National Institute of Standards and Technology (NIST-MS) software through mass spectrometry analysis.","PeriodicalId":74397,"journal":{"name":"Parasites, hosts and diseases","volume":"61 4","pages":"405-417"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10693971/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138479751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genetic polymorphism of merozoite surface protein 1 and antifolate-resistant genes in Plasmodium falciparum from Mali and Niger. 马里和尼日尔恶性疟原虫merozoite表面蛋白1和抗叶酸抗性基因的遗传多态性

Parasites, hosts and diseases Pub Date : 2023-11-01 Epub Date: 2023-11-28 DOI: 10.3347/PHD.23049

Mahaman Moustapha Lamine, Rabia Maman, Abdoul Aziz Maiga, Ibrahim Maman Laminou

{"title":"Genetic polymorphism of merozoite surface protein 1 and antifolate-resistant genes in Plasmodium falciparum from Mali and Niger.","authors":"Mahaman Moustapha Lamine, Rabia Maman, Abdoul Aziz Maiga, Ibrahim Maman Laminou","doi":"10.3347/PHD.23049","DOIUrl":"10.3347/PHD.23049","url":null,"abstract":"Since 2015, countries in the Sahel region have implemented large-scale seasonal malaria chemoprevention (SMC). However, the mass use of sulfadoxine-pyrimethamine (SP) plus amodiaquine impacts the genetic diversity of malaria parasites and their sensitivity to antimalarials. This study aimed to describe and compare the genetic diversity and SP resistance of Plasmodium falciparum strains in Mali and Niger. We collected 400 blood samples in Mali and Niger from children aged 3-59 months suspected of malaria. Of them, 201 tested positive (Niger, 111, 55.2%; Mali, 90, 44.8%). Polymorphism of merozoite surface protein 1 (msp1) genetic marker showed 201 allotypes. The frequency of the RO33 allotype was significantly higher in Niger (63.6%) than in Mali (39.3%). There was no significant difference in the frequency of the K1 and MAD20 allotypes between the 2 countries. The multiplicity of infection was 2 allotypes per patient in Mali and one allotype per patient in Niger. The prevalence of strains with the triple mutants Pfdhfr51I/Pfdhfr59R/Pfdhps436A/F/H and Pfdhfr51I/Pfdhfr59R/Pfdhps437G was 18.1% and 30.2%, respectively, and 7.7% carried the quadruple mutant Pfdhfr51I/Pfdhfr59R/Pfdhps436A/F/H/Pfdhps437G. Despite the significant genetic diversity of parasite populations, the level of SP resistance was comparable between Mali and Niger. The frequency of mutations conferring resistance to SP still allows its effective use in intermittent preventive treatment in pregnant women and in SMC.","PeriodicalId":74397,"journal":{"name":"Parasites, hosts and diseases","volume":"61 4","pages":"455-462"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10693970/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138479750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antiamoebic activities of flavonoids against pathogenic free-living amoebae, Naegleria fowleri and Acanthamoeba species. 黄酮类化合物对致病性自由活阿米巴、福氏奈格丽虫和棘阿米巴的抗阿米巴活性。

Parasites, hosts and diseases Pub Date : 2023-11-01 Epub Date: 2023-11-28 DOI: 10.3347/PHD.23078

Hương Giang Lê, Tuấn Cường Võ, Jung-Mi Kang, Thu Hằng Nguyễn, Buyng-Su Hwang, Young-Taek Oh, Byoung-Kuk Na

{"title":"Antiamoebic activities of flavonoids against pathogenic free-living amoebae, Naegleria fowleri and Acanthamoeba species.","authors":"Hương Giang Lê, Tuấn Cường Võ, Jung-Mi Kang, Thu Hằng Nguyễn, Buyng-Su Hwang, Young-Taek Oh, Byoung-Kuk Na","doi":"10.3347/PHD.23078","DOIUrl":"10.3347/PHD.23078","url":null,"abstract":"Free-living amoebae (FLA) rarely cause human infections but can invoke fatal infections in the central nervous system (CNS). No consensus treatment has been established for FLA infections of the CNS, emphasizing the urgent need to discover or develop safe and effective drugs. Flavonoids, natural compounds from plants and plant-derived products, are known to have antiprotozoan activities against several pathogenic protozoa parasites. The anti-FLA activity of flavonoids has also been proposed, while their antiamoebic activity for FLA needs to be emperically determined. We herein evaluated the antiamoebic activities of 18 flavonoids against Naegleria fowleri and Acanthamoeba species which included A. castellanii and A. polyphaga. These flavonoids showed different profiles of antiamoebic activity against N. fowleri and Acanthamoeba species. Demethoxycurcumin, kaempferol, resveratrol, and silybin (A+B) showed in vitro antiamoebic activity against both N. fowleri and Acanthamoeba species. Apigenin, costunolide, (‒)-epicatechin, (‒)-epigallocatechin, rosmarinic acid, and (‒)-trans-caryophyllene showed selective antiamoebic activity for Acanthamoeba species. Luteolin was more effective for N. fowleri. However, afzelin, berberine, (±)-catechin, chelerythrine, genistein, (+)-pinostrobin, and quercetin did not exhibit antiamoebic activity against the amoeba species. They neither showed selective antiamoebic activity with significant cytotoxicity to C6 glial cells. Our results provide a basis for the anti-FLA activity of flavonoids, which can be applied to develope alternative or supplemental therapeutic agents for FLA infections of the CNS.","PeriodicalId":74397,"journal":{"name":"Parasites, hosts and diseases","volume":"61 4","pages":"449-454"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10693969/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138479747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Update on the risk factors for opisthorchiasis and cholangiocarcinoma in Thailand. 泰国血吸虫病和胆管癌危险因素的最新情况。

Parasites, hosts and diseases Pub Date : 2023-11-01 Epub Date: 2023-11-28 DOI: 10.3347/PHD.23032

Sattrachai Prasopdee, Thittinan Rojthongpond, Yanwadee Chitkoolsamphan, Montinee Pholhelm, Siraphatsorn Yusuk, Junya Pattaraarchachai, Kritiya Butthongkomvong, Jutharat Kulsantiwong, Teva Phanaksri, Anthicha Kunjantarachot, Smarn Tesana, Thanakrit Sathavornmanee, Veerachai Thitapakorn

{"title":"Update on the risk factors for opisthorchiasis and cholangiocarcinoma in Thailand.","authors":"Sattrachai Prasopdee, Thittinan Rojthongpond, Yanwadee Chitkoolsamphan, Montinee Pholhelm, Siraphatsorn Yusuk, Junya Pattaraarchachai, Kritiya Butthongkomvong, Jutharat Kulsantiwong, Teva Phanaksri, Anthicha Kunjantarachot, Smarn Tesana, Thanakrit Sathavornmanee, Veerachai Thitapakorn","doi":"10.3347/PHD.23032","DOIUrl":"10.3347/PHD.23032","url":null,"abstract":"This study aimed to identify the recent risk factors for Opisthorchis viverrini infection and cholangiocarcinoma (CCA) to improve disease prevention. The participants were divided into the following 3 groups based on their health status: healthy control (nonOV and nonCCA), those with O. viverrini infection (OV), and those with CCA. A questionnaire was used to explore their lifestyle and behaviors. Multivariate logistic regression and backward elimination were used to identify the significant risk factors. The results showed that the significant risk factors for both O. viverrini infection and CCA were age>50 years (odd ratio (OR)=8.44, P<0.001, 95% confidence intervals (CI) 2.98-23.90 and OR=43.47, P=0.001, 95% CI 14.71-128.45, respectively) and raw fish consumption (OR=8.48, P< 0.001, 95% CI 3.18-22.63 and OR=3.15, P=0.048, 95% CI 1.01-9.86, respectively). A history of O. viverrini infection was identified as an additional risk factor for CCA (OR=20.93, P=0.011, 95% CI 2.04-215.10). This study provided an update on the risk factors for O. viverrini infection and CCA. Asymptomatic patients with O. viverrini infection, particularly those>50 years old, should be carefully monitored to prevent CCA.","PeriodicalId":74397,"journal":{"name":"Parasites, hosts and diseases","volume":"61 4","pages":"463-470"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10693972/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138479757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0