Parasites, hosts and diseases最新文献_第5页

Dipylidiasis cases in Japan-an update by literature survey. 日本的双孢子虫病病例--最新文献调查。

Parasites, hosts and diseases Pub Date : 2024-05-01 Epub Date: 2024-05-27 DOI: 10.3347/PHD.23118

Yukifumi Nawa, Akinori Furusawa, Mio Tanaka, Masahide Yoshikawa

引用次数: 0

Development of the head collar and collar spines during the larval stages of Isthmiophora hortensis (Digenea: Echinostomatidae). Isthmiophora hortensis（Digenea: Echinostomatidae）幼虫阶段头领和领刺的发育。

Parasites, hosts and diseases Pub Date : 2024-02-01 Epub Date: 2024-02-23 DOI: 10.3347/PHD.23122

Woon-Mok Sohn, Won-Jae Jung, Eun-Hee Shin, Jong-Yil Chai

{"title":"Development of the head collar and collar spines during the larval stages of Isthmiophora hortensis (Digenea: Echinostomatidae).","authors":"Woon-Mok Sohn, Won-Jae Jung, Eun-Hee Shin, Jong-Yil Chai","doi":"10.3347/PHD.23122","DOIUrl":"10.3347/PHD.23122","url":null,"abstract":"It is uncertain when the head collar and collar spines of Isthmiophora hortensis (Digenea: Echinostomatidae), a zoonotic echinostome species in Far Eastern Asia, develop during its larval stages. In this study, the appearance of the head collar and collar spines was studied using light and scanning electron microscopy in cercariae and metacercariae experimentally obtained from freshwater snails (Lymnaea pervia) and tadpoles (Rana nigromaculata), respectively. The cercariae were shed from the snail on day 30 after exposure to laboratory-hatched miracidia. Metacercariae were obtained from the experimental tadpoles at 3, 6, 12, 15, 20, 24, 26, and 30 h after exposure to the cercariae. The head collar was already visible in the cercarial stage, although its degree of development was weak. However, collar spines did not appear in the cercarial stage and even in the early metacercarial stage less than 24 h postinfection in tadpoles. Collar spines became visible in the metacercariae when they grew older than 24 h. It was concluded that the head collar of I. hortensis developed early in the cercarial stage, but the development of collar spines did not occur until the worms became 24-h-old metacercariae in our experimental setting. Counting the number of collar spines was concluded as an unfeasible diagnostic method for I. hortensis cercariae when they are shed from the snail host.","PeriodicalId":74397,"journal":{"name":"Parasites, hosts and diseases","volume":"62 1","pages":"145-150"},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10915261/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140041033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diversity of midgut microbiota in ticks collected from white-tailed deer (Odocoileus virginianus) from northern Mexico. 从墨西哥北部白尾鹿（Odocoileus virginianus）身上采集的蜱虫中肠微生物群的多样性。

Parasites, hosts and diseases Pub Date : 2024-02-01 Epub Date: 2024-02-23 DOI: 10.3347/PHD.23006

Zinnia Judith Molina-Garza, Mariana Cuesy-León, Lidia Baylón-Pacheco, José Luis Rosales-Encina, Lucio Galaviz-Silva

{"title":"Diversity of midgut microbiota in ticks collected from white-tailed deer (Odocoileus virginianus) from northern Mexico.","authors":"Zinnia Judith Molina-Garza, Mariana Cuesy-León, Lidia Baylón-Pacheco, José Luis Rosales-Encina, Lucio Galaviz-Silva","doi":"10.3347/PHD.23006","DOIUrl":"10.3347/PHD.23006","url":null,"abstract":"Ticks host different pathogens as endosymbiont and nonpathogenic microorganisms and play an important role in reproductive fitness and nutrient provision. However, the bacterial microbiomes of white-tailed deer ticks have received minimal attention. This study aimed to examine the bacterial microbiome of ticks collected from Odocoileus virginianus on the Mexico-United States border to assess differences in microbiome diversity in ticks of different species, sexes, and localities. Five different tick species were collected: Rhipicephalus microplus, Dermacentor nitens, Otobius megnini, Amblyomma cajennense, and A. maculatum. The tick microbiomes were analyzed using next-generation sequencing. Among all tick species, the most predominant phylum was Proteobacteria, followed by Actinobacteria and Firmicutes. The ticks from Tamaulipas and Nuevo León presented the highest bacterial species diversity. Acinetobacter johnsonii and A. lwoffii were the common bacterial species in the microbiome of all ticks, Coxiella were present in R. microplus, and Dermacentor nitens also exhibited a Francisella-like endosymbiont. The microbiome of most females in D. nitens was less diverse than that of males, whereas R. microplus occurs in females, suggesting that microbiome diversity is influenced by sex. In the bacterial communities of A. maculatum and O. megnini, Candidatus Midichloria massiliensis, and Candidatus Endoecteinascidia fumentensis were the most predominant endosymbionts. These results constitute the initial report on these bacteria, and this is also the first study to characterize the microbiome of O. megnini.","PeriodicalId":74397,"journal":{"name":"Parasites, hosts and diseases","volume":"62 1","pages":"117-130"},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10915265/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140041034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genome-wide identification of histone lysine methyltransferases and their implications in the epigenetic regulation of eggshell formation-related genes in a trematode parasite Clonorchis sinensis. 在全基因组范围内鉴定组蛋白赖氨酸甲基转移酶及其在中华绒螯虫卵壳形成相关基因的表观遗传调控中的意义。

Parasites, hosts and diseases Pub Date : 2024-02-01 Epub Date: 2024-02-23 DOI: 10.3347/PHD.23116

Min-Ji Park, Woon-Mok Sohn, Young-An Bae

{"title":"Genome-wide identification of histone lysine methyltransferases and their implications in the epigenetic regulation of eggshell formation-related genes in a trematode parasite Clonorchis sinensis.","authors":"Min-Ji Park, Woon-Mok Sohn, Young-An Bae","doi":"10.3347/PHD.23116","DOIUrl":"10.3347/PHD.23116","url":null,"abstract":"Epigenetic writers including DNA and histone lysine methyltransferases (DNMT and HKMT, respectively) play an initiative role in the differentiation and development of eukaryotic organisms through the spatiotemporal regulation of functional gene expressions. However, the epigenetic mechanisms have long been suspected in helminth parasites lacking the major DNA methyltransferases DNMT1 and DNMT3a/3b. Very little information on the evolutionary status of the epigenetic tools and their role in regulating chromosomal genes is currently available in the parasitic trematodes. We previously suggested the probable role of a DNMT2-like protein (CsDNMT2) as a genuine epigenetic writer in a trematode parasite Clonorchis sinensis. Here, we analyzed the phylogeny of HKMT subfamily members in the liver fluke and other platyhelminth species. The platyhelminth genomes examined conserved genes for the most of SET domain-containing HKMT and Disruptor of Telomeric Silencing 1 subfamilies, while some genes were expanded specifically in certain platyhelminth genomes. Related to the high gene dosages for HKMT activities covering differential but somewhat overlapping substrate specificities, variously methylated histones were recognized throughout the tissues/organs of C. sinensis adults. The temporal expressions of genes involved in eggshell formation were gradually decreased to their lowest levels proportionally to aging, whereas those of some epigenetic tool genes were re-boosted in the later adult stages of the parasite. Furthermore, these expression levels were significantly affected by treatment with DNMT and HKMT inhibitors. Our data strongly suggest that methylated histones are potent epigenetic markers that modulate the spatiotemporal expressions of C. sinensis genes, especially those involved in sexual reproduction.","PeriodicalId":74397,"journal":{"name":"Parasites, hosts and diseases","volume":"62 1","pages":"98-116"},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10915263/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140041036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Infection characteristics of Metagonimus species (Digenea: Heterophyidae) metacercariae in fish from major rivers of Korea. 韩国主要河流鱼类中 Metagonimus 种（Digenea: Heterophyidae） metacercariae 的感染特征。

Parasites, hosts and diseases Pub Date : 2024-02-01 Epub Date: 2024-02-23 DOI: 10.3347/PHD.23096

Woon-Mok Sohn

{"title":"Infection characteristics of Metagonimus species (Digenea: Heterophyidae) metacercariae in fish from major rivers of Korea.","authors":"Woon-Mok Sohn","doi":"10.3347/PHD.23096","DOIUrl":"10.3347/PHD.23096","url":null,"abstract":"This article analyzed the infection characteristics of metacercariae of Metagonimus spp. (MsMc) in fish from 9 major water systems in Korea. A total of 19,568 fish in 87 species were examined over a period of 10 years (2011-2020). MsMc were detected in fish from all 44 survey areas in 9 water systems. Most of the surveyed sites showed very low and low infection levels (66.7%), while 33.3% of the areas, such as Tamjin-gang and Seomjin-gang, revealed moderate and high infection levels. High endemicity depends on the abundance of susceptible fish species, especially sweet smelt (Plecoglosus altivelis). The susceptibility index (SI) with MsMc in index fish, Zacco spp., was very low and low levels in 62.0%, moderate in 28.0%, and high in 10.0% regions. The SI was highest in the following order: Yeongam-cheon (283.8), Hoeng-cheon (192.3), Togyo-jeosuji (131.2), Deokcheon-gang (119.1), and Joyang-gang (106.3). The recent infection status of MsMc in P. altivelis was analyzed by the survey localities. In addition, except for P. altivelis, 9 fish species were highly infected with MsMc in some survey areas, including Zacco platypus, Z. koreanus, Z. temminckii, Opsariichthys uncirostris, Rhynchocypris oxycephalus, Carassius auratus, Acheilognathus rhombeus, Onchorhynchus masou, and Tribolodon hakonensis. In Korea, 74 fish species (15 families) are collectively listed as second intermediate hosts of Metagonimus spp. This review provides several novel characteristics of MsMc infection and clarifies the fish species of second intermediate host of Metagonimus spp. in this country.","PeriodicalId":74397,"journal":{"name":"Parasites, hosts and diseases","volume":"62 1","pages":"1-29"},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10915262/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140041038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Latitude and seasons influence the prevalence of Theileria orientalis and affect the hematology of non-grazed dairy cows in Korea. 纬度和季节影响东方丝虫病的流行，并影响韩国非放牧奶牛的血液学。

Parasites, hosts and diseases Pub Date : 2024-02-01 Epub Date: 2024-02-23 DOI: 10.3347/PHD.23087

Hector Espiritu, Hee-Woon Lee, Md Shohel Al Faruk, Su-Jeong Jin, Sang-Suk Lee, Yong-Il Cho

{"title":"Latitude and seasons influence the prevalence of Theileria orientalis and affect the hematology of non-grazed dairy cows in Korea.","authors":"Hector Espiritu, Hee-Woon Lee, Md Shohel Al Faruk, Su-Jeong Jin, Sang-Suk Lee, Yong-Il Cho","doi":"10.3347/PHD.23087","DOIUrl":"10.3347/PHD.23087","url":null,"abstract":"This pilot study aimed to investigate the effects of regional and seasonal variations on the prevalence of Theileria orientalis and the hematological profile of non-grazed dairy cows in Korea. A total of 365 clinically healthy lactating Holstein Friesian cows from 26 dairy farms in 7 provinces that were categorized into northern, central, and southern regions were sampled during the warm period from July to August and the cold period from October to December. The detection of T. orientalis major piroplasm surface protein gene and the hematology non-grazed dairy cows were analyzed using peripheral blood samples. The T. orientalis prevalence was 20.0% (73/365). The prevalence in the southern region was 35.9%, which was significantly higher than that in the central (21.6%) and northern (12.9%) regions (P < 0.05). The prevalence during warm period was higher (43.0%) than that during the cold season (13.5%). The infected cows showed significantly lower erythrocyte counts in the southern region (5.8 ± 0.6 M/µl) and during the warm period (5.8 ± 0.7 M/µl) compared with those in the central and northern regions and during the cold season, which affected the extended RBC parameters, including hematocrit and hemoglobin concentrations. Our findings revealed the prevalence of T. orientalis in Korea, highlighting its high occurrence during warm periods and in certain geographical regions. Climatic factors could contribute to the health and productivity of cattle, as evidenced by the prevalence of T. orientalis and its negative impact on animals.","PeriodicalId":74397,"journal":{"name":"Parasites, hosts and diseases","volume":"62 1","pages":"64-74"},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10915266/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140041039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular detection and characterization of Acanthamoeba infection in dogs and its association with keratitis in Korea. 韩国犬类棘阿米巴感染的分子检测和特征描述及其与角膜炎的关联。

Parasites, hosts and diseases Pub Date : 2024-02-01 Epub Date: 2024-02-23 DOI: 10.3347/PHD.23112

Subin Lee, Badriah Alkathiri, Ji Seung Jung, Nanyoung Kang, Jiyi Hwang, Sang-Eun Park, Yeonchul Hong, Kyung-Mee Park, Seung-Hun Lee

引用次数: 0

Molecular detection of Borrelia theileri in cattle in Korea. 韩国牛群中 Borrelia theileri 的分子检测。

Parasites, hosts and diseases Pub Date : 2024-02-01 Epub Date: 2024-02-23 DOI: 10.3347/PHD.23105

Hyeon-Ji Hyung, Yun-Sil Choi, Jinho Park, Kwang-Jun Lee, Jun-Gu Kang

{"title":"Molecular detection of Borrelia theileri in cattle in Korea.","authors":"Hyeon-Ji Hyung, Yun-Sil Choi, Jinho Park, Kwang-Jun Lee, Jun-Gu Kang","doi":"10.3347/PHD.23105","DOIUrl":"10.3347/PHD.23105","url":null,"abstract":"Bovine borreliosis, caused by Borrelia theileri which is transmitted via hard tick bites, is associated with mild clinical symptoms, such as fever, lethargy, hemoglobinuria, anorexia, and anemia. Borrelia theileri infects various animals, such as cattle, deer, horses, goats, sheep, and wild ruminants, in Africa, Australia, and South America. Notably, no case of B. theileri infection has been reported in Korean cattle to date. In this study, 101 blood samples were collected from a Korean indigenous cattle breed, among which 1.98% tested positive for B. theileri via nested PCR. The obtained sequences exhibited high homology with B. theileri strains identified in other regions. Phylogenetic analysis of 16S rRNA confirmed the B. theileri group affiliation; however, flagellin B sequences exhibited divergence, potentially due to regional evolutionary differences. This study provides the first molecular confirmation of B. theileri infection in Korean livestock. Further isolation and nucleotide sequence analyses are necessary to better understand the presence of B. theileri strains in cows in Korea.","PeriodicalId":74397,"journal":{"name":"Parasites, hosts and diseases","volume":"62 1","pages":"151-156"},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10915267/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140041144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The protective effects of BMSA1 and BMSA5-1-1 proteins against Babesia microti infection. BMSA1 和 BMSA5-1-1 蛋白对小巴贝斯虫感染的保护作用。

Parasites, hosts and diseases Pub Date : 2024-02-01 Epub Date: 2024-02-23 DOI: 10.3347/PHD.23077

Yu Chun Cai, Chun Li Yang, Peng Song, Muxin Chen, Jia Xu Chen

{"title":"The protective effects of BMSA1 and BMSA5-1-1 proteins against Babesia microti infection.","authors":"Yu Chun Cai, Chun Li Yang, Peng Song, Muxin Chen, Jia Xu Chen","doi":"10.3347/PHD.23077","DOIUrl":"10.3347/PHD.23077","url":null,"abstract":"The intracellular parasite Babesia microti is among the most significant species causing human babesiosis and is an emerging threat to human health worldwide. Unravelling the pathogenic molecular mechanisms of babesiosis is crucial in developing new diagnostic and preventive methods. This study assessed how priming with B. microti surface antigen 1 (BHSA 1) and seroreactive antigen 5-1-1 (BHSA 5-1-1) mediate protection against B. microti infection. The results showed that 500 µg/ml rBMSA1 and rBMSA5-1-1 partially inhibited the invasion of B. microti in vitro by 42.0 ± 3.0%, and 48.0 ± 2.1%, respectively. Blood smears revealed that peak infection at 7 days post-infection (dpi) was 19.6%, 24.7%, and 46.7% in the rBMSA1, rBmSA5-1-1, compared to the control groups (healthy mice infected with B. microti only), respectively. Routine blood tests showed higher white blood cell, red blood cell counts, and haemoglobin levels in the 2 groups (BMSA1 and BMSA5 5-1-1) than in the infection control group at 0-28 dpi. Moreover, the 2 groups had higher serum interferon-γ, tumor necrosis factor-α and Interleukin-17A levels, and lower IL-10 levels than the infection control group throughout the study. These 2 potential vaccine candidate proteins partially inhibit in vitro and in vivo B. microti infection and enhance host immunological response against B. microti infection.","PeriodicalId":74397,"journal":{"name":"Parasites, hosts and diseases","volume":"62 1","pages":"53-63"},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10915264/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140041147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Toxoplasma gondii IST suppresses inflammatory and apoptotic responses by inhibiting STAT1-mediated signaling in IFN-γ/TNF-α-stimulated hepatocytes. 弓形虫 IST 通过抑制 IFN-γ/TNF-α 刺激的肝细胞中 STAT1 介导的信号传导，抑制炎症和细胞凋亡反应。

Parasites, hosts and diseases Pub Date : 2024-02-01 Epub Date: 2024-02-23 DOI: 10.3347/PHD.23129

Seung-Hwan Seo, Ji-Eun Lee, Do-Won Ham, Eun-Hee Shin

{"title":"Toxoplasma gondii IST suppresses inflammatory and apoptotic responses by inhibiting STAT1-mediated signaling in IFN-γ/TNF-α-stimulated hepatocytes.","authors":"Seung-Hwan Seo, Ji-Eun Lee, Do-Won Ham, Eun-Hee Shin","doi":"10.3347/PHD.23129","DOIUrl":"10.3347/PHD.23129","url":null,"abstract":"The dense granule protein of Toxoplasma gondii, inhibitor of signal transducer and activator of transcription 1 (IST) is an inhibitor of signal transducer and activator of transcription 1 (STAT1) transcriptional activity that binds to STAT1 and regulates the expression of inflammatory molecules in host cells. A sterile inflammatory liver injury in pathological acute liver failures occurs when excessive innate immune function, such as the massive release of IFN-γ and TNF-α, is activated without infection. In relation to inflammatory liver injury, we hypothesized that Toxoplasma gondii inhibitor of STAT1 transcription (TgIST) can inhibit the inflammatory response induced by activating the STAT1/IRF-1 mechanism in liver inflammation. This study used IFN-γ and TNF-α as inflammatory inducers at the cellular level of murine hepatocytes (Hepa-1c1c7) to determine whether TgIST inhibits the STAT1/IRF-1 axis. In stable cells transfected with TgIST, STAT1 expression decreased with a decrease in interferon regulatory factor (IRF)-1 levels. Furthermore, STAT1 inhibition of TgIST resulted in lower levels of NF-κB and COX2, as well as significantly lower levels of class II transactivator (CIITA), iNOS, and chemokines (CLXCL9/10/11). TgIST also significantly reduced the expression of hepatocyte proapoptotic markers (Caspase3/8/9, P53, and BAX), which are linked to sterile inflammatory liver injury. TgIST also reduced the expression of adhesion (ICAM-1 and VCAM-1) and infiltration markers of programmed death-ligand 1 (PD-L1) induced by hepatocyte and tissue damage. TgIST restored the cell apoptosis induced by IFN-γ/TNF-α stimulation. These results suggest that TgIST can inhibit STAT1-mediated inflammatory and apoptotic responses in hepatocytes stimulated with proinflammatory cytokines.","PeriodicalId":74397,"journal":{"name":"Parasites, hosts and diseases","volume":"62 1","pages":"30-41"},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10915271/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140041148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0