Parasites, hosts and diseases最新文献

Therapeutic efficacy of an ivermectin dose of 200 μg/kg/day for 2 consecutive days to treat Strongyloides stercoralis infection: A serological evaluation in Vietnam. 伊维菌素200 μg/kg/天连续2天治疗粪圆线虫感染的疗效：越南血清学评价。

IF 1.3

Parasites, hosts and diseases Pub Date : 2026-04-22 DOI: 10.3347/PHD.25047

Van Hue Thi Tran, Chinh Duc Nguyen, Quang Hong Huynh

{"title":"Therapeutic efficacy of an ivermectin dose of 200 μg/kg/day for 2 consecutive days to treat Strongyloides stercoralis infection: A serological evaluation in Vietnam.","authors":"Van Hue Thi Tran, Chinh Duc Nguyen, Quang Hong Huynh","doi":"10.3347/PHD.25047","DOIUrl":"https://doi.org/10.3347/PHD.25047","url":null,"abstract":"Strongyloidiasis is a neglected infectious disease with diverse clinical manifestations that may lead to severe complications, including death in immunocompromised individuals. Uncomplicated infections can be diagnosed early using serological testing. Regarding treatment, the World Health Organization recommends ivermectin, thiabendazole, and albendazole as effective therapies against Strongyloides stercoralis. The objective of this study was to evaluate the therapeutic effectiveness of ivermectin 200 μg/kg/day for 2 consecutive days in patients infected with S. stercoralis, with the aim of optimizing treatment efficacy while shortening the duration of therapy compared with longer regimens. This before-and-after study assessed the therapeutic effectiveness of ivermectin 200 μg/kg/day for 2 consecutive days in patients with S. stercoralis infection. From January to October 2023, 3,814 patients with suspected S. stercoralis infection-presenting with symptoms such as urticaria, abdominal pain, and loose stools with seropositivity on an enzyme-linked immunosorbent assay for IgG antibodies against S. stercoralis-were screened, and 42 patients with uncomplicated S. stercoralis mono-infection were recruited. Symptoms, IgG optical density antibody titers against S. stercoralis, and eosinophils were assessed before and after treatment. Therapeutic effectiveness was evaluated based on cure rate and disease reduction after intervention. After 3 months of treatment, the overall effectiveness of ivermectin 200 μg/kg/day for 2 consecutive days reached 95.2%, of which 50% were completely cured, 9.5% had symptom resolution without improvement in paraclinical indicators, 21.4% experienced clear symptom reduction, and 14.3% had symptom recurrence. The regimen of ivermectin 200 μg/kg/day for 2 consecutive days demonstrated high effectiveness in the treatment of strongyloidiasis.","PeriodicalId":74397,"journal":{"name":"Parasites, hosts and diseases","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2026-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147791494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A case of human sparganosis caused by Spirometra erinaceieuropaei in Korea. 韩国由猪肺虫引起的人斯巴达病1例。

IF 1.3

Parasites, hosts and diseases Pub Date : 2026-04-13 DOI: 10.3347/PHD.25105

Seo Yeong Choi, Mi-Kyung Park, Yu Jin Jeong, Bong-Kwang Jung, Seungjin Lim, Hak Sun Yu

{"title":"A case of human sparganosis caused by Spirometra erinaceieuropaei in Korea.","authors":"Seo Yeong Choi, Mi-Kyung Park, Yu Jin Jeong, Bong-Kwang Jung, Seungjin Lim, Hak Sun Yu","doi":"10.3347/PHD.25105","DOIUrl":"https://doi.org/10.3347/PHD.25105","url":null,"abstract":"Sparganosis is a parasitic zoonosis caused by plerocercoid larvae of Spirometra species, commonly transmitted through ingestion of infected copepods or raw intermediate hosts. A 51-year-old man presented with a palpable mass in his right thigh. Surgical excision revealed a worm-like structure. Histopathological and serologic findings suggested sparganosis, and PCR amplification of the cox1 gene from paraffin-embedded tissue showed 99% sequence identity with Spirometra erinaceieuropaei (GenBank accession No. KJ599680.1). Praziquantel (75 mg/kg/day for 3 days) was administered, and the patient showed no evidence of recurrence during follow-up. Eosinophilia was not observed; however, positive sparganum antibodies supported the diagnosis. This case demonstrates that molecular identification using mitochondrial genes can be a valuable diagnostic tool, especially when morphological features are limited. Furthermore, it highlights the zoonotic potential of S. erinaceieuropaei and underscores the importance of food safety, hygiene education, and continuous epidemiological surveillance to prevent human sparganosis in endemic regions.","PeriodicalId":74397,"journal":{"name":"Parasites, hosts and diseases","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2026-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147679266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neutrophil reactive oxygen species response to Trichomonas vaginalis modulated by palmitic acid. 棕榈酸调节中性粒细胞活性氧对阴道毛滴虫的反应。

IF 1.3

Parasites, hosts and diseases Pub Date : 2026-04-10 DOI: 10.3347/PHD.25089

Julieta Sepúlveda-Angulo, Luis Mario Olmos-Ortiz, Bernardo Franco-Bárcenas, Eva E Avila, Patricia Cuéllar-Mata

{"title":"Neutrophil reactive oxygen species response to Trichomonas vaginalis modulated by palmitic acid.","authors":"Julieta Sepúlveda-Angulo, Luis Mario Olmos-Ortiz, Bernardo Franco-Bárcenas, Eva E Avila, Patricia Cuéllar-Mata","doi":"10.3347/PHD.25089","DOIUrl":"https://doi.org/10.3347/PHD.25089","url":null,"abstract":"This study aimed to investigate the role of palmitic acid (PA) in modulating the neutrophil response during Trichomonas vaginalis infection. A human neutrophil-like cell model (nHL-60) was established by differentiating the human promyelocytic leukemia cell line HL-60 with 1.3% dimethyl sulfoxide. The expressions of the genes IL-8, NF-κB, MyD88, and TLR4 and the production of reactive oxygen species (ROS) of differentiated cells were compared, using end-point RT-PCR and nitroblue tetrazolium reduction, in the presence or absence of 1 mM PA and 100 μM of docosahexaenoic acid. Additionally, oxidative burst activity was also evaluated in response to T. vaginalis stimulation in the presence of either PA or docosahexaenoic acid. nHL-60 cells showed increased expression of key mediators of the TLR4 signaling pathway, and enhanced ROS production upon phorbol 12-myristate 13-acetate stimulation. Peripheral blood neutrophils exposed to T. vaginalis in the presence of PA exhibited higher ROS production than neutrophils stimulated by the parasite only. These findings indicate that PA enhances neutrophil activation to a secondary stimulus with T. vaginalis. They provide new insights into the role of metabolic factors in host-pathogen interactions.","PeriodicalId":74397,"journal":{"name":"Parasites, hosts and diseases","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2026-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147647538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A giant neurocysticercosis diagnosed by Western blotting. 用免疫印迹法诊断的巨型神经囊虫病。

IF 1.3

Parasites, hosts and diseases Pub Date : 2026-04-10 DOI: 10.3347/PHD.26004

Chang Sub Lee, Young Ah Lee, Hyun Min Koh, Young-Bae Chung

引用次数: 0

Purification of Kudoa septempunctata myxospores by using trypsin and fluorescence activated cell sorting. 胰蛋白酶和荧光活化细胞分选纯化七星苦蛾黏液孢子。

IF 1.3

Parasites, hosts and diseases Pub Date : 2026-04-06 DOI: 10.3347/PHD.25097

Hyun Ki Hong, Youngjun Park, Sang Phil Shin

{"title":"Purification of Kudoa septempunctata myxospores by using trypsin and fluorescence activated cell sorting.","authors":"Hyun Ki Hong, Youngjun Park, Sang Phil Shin","doi":"10.3347/PHD.25097","DOIUrl":"https://doi.org/10.3347/PHD.25097","url":null,"abstract":"Kudoa septempunctata, a myxozoan, has been identified as the causative agent of foodborne illnesses associated with the consumption of raw olive flounder. To develop effective control methods against this parasite, fundamental research-including viability determination, transcriptome analysis, and antigenicity assessment of K. septempunctata myxospores-is required. This research necessitates the purification of the parasites. Sequential trypsin digestion, followed by density gradient purification, was performed to isolate the K. septempunctata myxospores. Further purification was achieved through fluorescence-activated cell sorting at a concentration of 106 to 107 myxospores/ml. The results demonstrated that the combination of trypsin digestion and density gradient methods consistently produced approximately 40 times more viable myxospores than the density gradient method alone. Additionally, the fluorescence-activated cell sorting method enhanced the purity of the myxospores by approximately 10%. The procedures described in this study will support research (such as RNA-sequencing, proteomics, vaccine antigen preparation) aimed at developing control methods for K. septempunctata including the fundamental research.","PeriodicalId":74397,"journal":{"name":"Parasites, hosts and diseases","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2026-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147624904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mitochondrial genome characterization of the stomach nematode Mastophorus muris (Nematoda: Spiruroidea) and phylogenetic relationships with nematodes. 胃线虫Mastophorus muris（线虫纲：螺旋体总科）线粒体基因组特征及其与线虫的系统发育关系。

IF 1.3

Parasites, hosts and diseases Pub Date : 2026-04-06 DOI: 10.3347/PHD.25064

Yingna Jian

{"title":"Mitochondrial genome characterization of the stomach nematode Mastophorus muris (Nematoda: Spiruroidea) and phylogenetic relationships with nematodes.","authors":"Yingna Jian","doi":"10.3347/PHD.25064","DOIUrl":"https://doi.org/10.3347/PHD.25064","url":null,"abstract":"Mastophorus muris is a prevalent nematode parasite of rodents that can cause pathogenic manifestations or mortality. As the only 1 species in the genus Mastophorus and the sole member of the family Spirocercidae, its biology, molecular identification, and population genetic structure remain poorly studied. In this study, the complete mitochondrial genome of M. muris was fully assembled and annotated through high-fidelity next-generation sequencing for the first time, to resolve its molecular architecture with nucleotide-level precision. The 13,668 bp mitogenome encodes 36 genes, including 12 protein-coding genes (PCGs), 22 transfer RNAs, and 2 ribosomal RNAs (s-rRNA and l-rRNA). The 10,384 bp PCGs account for 76.0% of the mitogenome, with AT (71.7%) and GC (28.3%) contents, AT skew (-0.494) and GC skew (0.477), indicating pronounced nucleotide bias. Analysis of 12 PCGs revealed that TTG, ATT, ATA, or GTG were the common start codons. TAA was the predominant termination codon, while some PCGs (cob, nad1, and nad3) were deduced to end with an incomplete codon T. T-rich codons such as TTT-Phe (16.3%), TTG-Leu (8.5%), GTT-Val (6.7%), ATT-Ile (6.3%), TAT-Tyr (5.6%), TTA-Leu (4.6%), and TCT-Ser (4.3%) were used more frequently. Phylogenetic analysis using the concatenated nucleotide sequences of 12 PCGs, and the NJ tree analysis results showed that M. muris was more closely related to the genus Gongylonema, which indicated that the family Spirocercidae was more closely associated with Gongylonematidae. This study provides valuable mitogenomic data for nematode phylogeny, diagnostics, population genetics, and comparative mitogenomics.","PeriodicalId":74397,"journal":{"name":"Parasites, hosts and diseases","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2026-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147624875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

High prevalence of soilborne and waterborne parasitic infections among schoolchildren, Belén District, Loreto Region, Peru. 秘鲁洛雷托大区bel<s:1>县学龄儿童中土传和水传寄生虫感染高发。

IF 1.3

Parasites, hosts and diseases Pub Date : 2026-03-24 DOI: 10.3347/PHD.25088

Jong-Yil Chai, Woon-Mok Sohn, Dong-Chan Kim, Sehyeon Regina Kim, Eunseo Kim, Hae Ram Lee, Sangmi Lee, Sangmoon Shin, Dong Yub Suh, Cesar Renato Tuesta Rojas, César Vladimir Munayco

{"title":"High prevalence of soilborne and waterborne parasitic infections among schoolchildren, Belén District, Loreto Region, Peru.","authors":"Jong-Yil Chai, Woon-Mok Sohn, Dong-Chan Kim, Sehyeon Regina Kim, Eunseo Kim, Hae Ram Lee, Sangmi Lee, Sangmoon Shin, Dong Yub Suh, Cesar Renato Tuesta Rojas, César Vladimir Munayco","doi":"10.3347/PHD.25088","DOIUrl":"https://doi.org/10.3347/PHD.25088","url":null,"abstract":"The Belén District in Loreto Region, Peru, is known for its extensive riverfront areas, where many houses are built on stilts and float during the rainy season. We conducted fecal examinations on 997 schoolchildren (ages 4-14 years; 488 boys, 497 girls) across 4 schools in Belén using the Kato-Katz thick smear and formalin-ethyl acetate sedimentation techniques. The results revealed high rates of soilborne helminths and waterborne protozoan infections, with an overall parasite-positive rate of 79.7%. The primary helminth species were Ascaris lumbricoides (39.2%), Trichuris trichiura (33.2%), Hymenolepis nana (3.4%), hookworms (2.1%), and Enterobius vermicularis (1.5%). The main pathogenic protozoans were Giardia lamblia (20.9%) and Entamoeba histolytica/E. dispar (14.2%), along with Cryptosporidium-like coccidian (4.6%). Non-pathogenic protozoans included Entamoeba coli (31.5%), Endolimax nana (15.1%), and Blastocystis hominis (3.7%). The intensity of soilborne helminth infections was very high for A. lumbricoides (average eggs per gram of feces per child: 18,589), followed by T. trichiura (1,501) and hookworms (160). The prevalence of anemia, often associated with malnutrition, was moderate at 33.1% (298 anemic children among 901 examined). Mass deworming was initiated with albendazole 400 mg, 3 times a year, in conjunction with health education and environmental sanitation. Metronidazole was administered once at a dose of 200 mg 3 times daily for 10 days. A notable finding in this study was that soilborne and waterborne parasites are both highly prevalent among schoolchildren in the floating villages of the Belén District, Loreto Region. Sustained mass deworming is urgently needed and the WASH program is crucial.","PeriodicalId":74397,"journal":{"name":"Parasites, hosts and diseases","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2026-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147505562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular evidence for human Metagonimus kogai and M. saitoi infection in Korea: detection of COI genes in the feces of riverside people along the Seomjin‑gang (river). 韩国人感染古改巨胞虫和齐藤原胞虫的分子证据：在清津江沿岸居民粪便中检测COI基因。

IF 1.3

Parasites, hosts and diseases Pub Date : 2026-03-16 DOI: 10.3347/PHD.25071

Eunsol Lee, Jong-Hun Choi, Yeong-Ju Lee, Seon-Ok Baek, Hee-Il Lee, Jung-Won Ju, Myeong-Ro Lee, Tae Yun Kim

{"title":"Molecular evidence for human Metagonimus kogai and M. saitoi infection in Korea: detection of COI genes in the feces of riverside people along the Seomjin‑gang (river).","authors":"Eunsol Lee, Jong-Hun Choi, Yeong-Ju Lee, Seon-Ok Baek, Hee-Il Lee, Jung-Won Ju, Myeong-Ro Lee, Tae Yun Kim","doi":"10.3347/PHD.25071","DOIUrl":"https://doi.org/10.3347/PHD.25071","url":null,"abstract":"Until now, 3 Metagonimus spp. (M. yokogawai, M. takahashii, and M. miyatai) causing human metagonimiasis have been reported in Korea. In this study, we investigated the possible presence of Metagonimus spp. other than these 3 species using human fecal samples from an endemic area in Korea. DNA was extracted from Metagonimus egg-positive fecal samples collected from residents of Gurye-gun, Jeollanam-do. A total of 21 representative mitochondrial cytochrome c oxidase subunit I sequences were obtained by PCR and cloning, and sequencing. Phylogenetic analysis revealed 1 cluster corresponding to M. yokogawai (n=10) and 2 additional distinct clusters corresponding to M. kogai (n=8) and M. saitoi (n=3), which were proposed as new species in Japan in 2022. Pairwise cytochrome c oxidase subunit I distances were low for M. yokogawai and M. kogai (mean Kimura 2-parameter: 0.005-0.006), whereas M. saitoi showed higher Korea-Japan values (~0.029), a pattern consistent with geographic structuring. In conclusion, we provide the first molecular evidence for the occurrence of M. kogai and M. saitoi in human fecal samples in Korea. Further confirmation using adult morphology, additional nuclear markers, and ecological surveys are needed to clarify metagonimiasis transmission in the Seomjin-gang (river) basin.","PeriodicalId":74397,"journal":{"name":"Parasites, hosts and diseases","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2026-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147464051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quantitative PCR surveillance of Perkinsus marinus in Crassostrea virginica and Magallana gigas across the USA, Mexico, Brazil, and Korea. 美国、墨西哥、巴西、韩国等地的美洲红毛蚶和大黄毛蚶中marinsus的定量PCR检测。

IF 1.3

Parasites, hosts and diseases Pub Date : 2026-03-11 DOI: 10.3347/PHD.25075

Seung-Hyeon Kim, Hye-Mi Lee, Donghyun Lee, Hyoun Joong Kim, S D N K Bathige, José Manuel Grijalva-Chon, Patricia Mirella da Silva, Kyung-Il Park

{"title":"Quantitative PCR surveillance of Perkinsus marinus in Crassostrea virginica and Magallana gigas across the USA, Mexico, Brazil, and Korea.","authors":"Seung-Hyeon Kim, Hye-Mi Lee, Donghyun Lee, Hyoun Joong Kim, S D N K Bathige, José Manuel Grijalva-Chon, Patricia Mirella da Silva, Kyung-Il Park","doi":"10.3347/PHD.25075","DOIUrl":"https://doi.org/10.3347/PHD.25075","url":null,"abstract":"Perkinsus marinus is a significant pathogen in oyster aquaculture with expanding host and geographic ranges. This study evaluated the prevalence and infection intensity of P. marinus in major oyster farming regions across the USA, Mexico, Brazil, and Korea using a quantitative PCR (P. marinus-specific TaqMan quantitative PCR assay, Pm-qPCR) assay. Eastern oysters (Crassostrea virginica) were sampled from 7 USA sites, while Pacific oysters (Magallana gigas) were collected from Mexico, Brazil, and Korea. Compared to conventional PCR, the Pm-qPCR assay demonstrated significantly higher sensitivity, detecting P. marinus in >80.0% of samples at most sites and up to 100.0% in Port Norris, USA. Lower prevalence was found in Wellfleet, USA (58.0%) and Korean sites (63.0%-70.0%). The lowest infection intensities (<1,000 copies) were recorded at a high-energy open-water site in Buan, Korea. The assay's specificity was confirmed using negative control oysters from Canada. These findings provide critical baseline data on P. marinus distribution and emphasize the superior diagnostic value of Pm-qPCR for early detection. As P. marinus spreads globally, sensitive and standardized tools like this assay are essential for disease surveillance and aquaculture biosecurity.","PeriodicalId":74397,"journal":{"name":"Parasites, hosts and diseases","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2026-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147438043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transcriptomic profiling reveals Trichinella spiralis-mediated attenuation of respiratory syncytial virus-induced inflammation in mice. 转录组学分析揭示旋毛虫介导的小鼠呼吸道合胞病毒诱导的炎症衰减。

IF 1.3

Parasites, hosts and diseases Pub Date : 2026-01-01 Epub Date: 2026-01-22 DOI: 10.3347/PHD.25067

Ki Back Chu, Fu-Shi Quan

{"title":"Transcriptomic profiling reveals Trichinella spiralis-mediated attenuation of respiratory syncytial virus-induced inflammation in mice.","authors":"Ki Back Chu, Fu-Shi Quan","doi":"10.3347/PHD.25067","DOIUrl":"10.3347/PHD.25067","url":null,"abstract":"Helminth-mediated immunomodulation has been extensively studied in animal models, demonstrating its potential as both a prophylactic and therapeutic option for inflammatory lung diseases. However, its role in attenuating respiratory virus-induced inflammation remains largely unexplored. In this study, we examined whether pre-existing infection with the helminth Trichinella spiralis confers protection against pulmonary pathology induced by respiratory syncytial virus (RSV) infection in mice. Mice with prior T. spiralis infection exhibited reduced pulmonary inflammation and lower viral titers in the lungs compared with RSV-infected controls. Transcriptomic profiling of lung tissue using RNA sequencing identified 407 differentially expressed genes. Among these, enrichment was observed in categories associated with the Gene Ontology (GO) terms \"inflammatory response\" (GO:0006954) and \"defense response to virus\" (GO:0051607). Selected genes from these categories were further validated by quantitative real-time PCR. Validation confirmed that co-exposure to T. spiralis and RSV resulted in attenuated expression of inflammation-related genes. Collectively, these findings demonstrate that pre-existing T. spiralis infection can alleviate virus-induced pulmonary pathology and inflammation, highlighting its potential as a novel therapeutic approach for respiratory inflammatory diseases.","PeriodicalId":74397,"journal":{"name":"Parasites, hosts and diseases","volume":"64 1","pages":"7-17"},"PeriodicalIF":1.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12890556/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146159621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0