Anticoccidial activities of a multicomplex mineral-based diet in broilers infected with Eimeria acervulina.

Abstract

Poultry coccidiosis, caused by 7 Eimeria species, has a significant economic impact on the poultry industry and is managed mainly by chemotherapeutic drugs. However, alternative control measures are needed due to the emergence of drug-resistant strains. This study aimed to evaluate the anticoccidial effects of a multicomplex mineral-based diet in broilers infected with Eimeria acervulina. Broilers were fed a multicomplex mineral-based diet and infected with E. acervulina. Fecal oocyst shedding was 39.0% lower in the E. acervulina-infected broilers treated with the multicomplex mineral compared to that in untreated-infected broilers (365.7×106±45.7 versus 599.8×106±8.7, P<0.05). On day 6 post-infection, body weight gain was significantly higher in treated-infected chickens than untreated chickens (103.2±1.5% versus 94.1±1.7%, P<0.001). The lesion scores were similar between the 2 groups. Histopathological observations revealed that the width of the villi in the treated-infected chickens (286±9.5 μm) was significantly increased by 19.1% (240±10.8 μm, P<0.05) and 34.9% (212±7.3 μm, P<0.001) compared to those in the untreated-uninfected and untreated-infected groups, respectively. However, the villous height and crypt depth were similar between the untreated- and treated-infected groups. The positive effects of the dietary multicomplex mineral, including reduced fecal oocyst shedding, increased weight gain, and increased villi width, suggest its potential application in mitigating the adverse effects of Eimeria infection in both conventional and organic chicken industries.