Oxygen (Basel, Switzerland)最新文献_第7页

Biological Relevance of Free Radicals in the Process of Physiological Capacitation and Cryocapacitation 自由基在生理能化和低温能化过程中的生物学意义

Oxygen (Basel, Switzerland) Pub Date : 2022-05-27 DOI: 10.3390/oxygen2020014

F. Benko, M. Ďuračka, Štefan Baňas, N. Lukáč, E. Tvrdá

{"title":"Biological Relevance of Free Radicals in the Process of Physiological Capacitation and Cryocapacitation","authors":"F. Benko, M. Ďuračka, Štefan Baňas, N. Lukáč, E. Tvrdá","doi":"10.3390/oxygen2020014","DOIUrl":"https://doi.org/10.3390/oxygen2020014","url":null,"abstract":"Before fertilization, spermatozoa must undergo a process called capacitation in order to fulfill their fertilization potential. This includes a series of structural, biochemical, and functional changes before a subsequent acrosome reaction and fusion with the oocyte. However, low temperatures during cryopreservation may induce a premature activation of capacitation-like changes, also known as cryocapacitation, immediately after thawing, which may lead to a decreased viability, motility, and fertilization ability of cryopreserved spermatozoa. Furthermore, cryopreservation is responsible for the overgeneration of reactive oxygen species (ROS) such as superoxide, hydrogen peroxide, and hydroxyl radicals, which may result in the development of oxidative stress, cell membrane damage, and lipid peroxidation. Despite that, both capacitation and cryocapacitation are considered to be oxidative events; however, potential beneficial or detrimental effects of ROS depend on a wide array of circumstances. This review summarizes the available information on the role of free radicals in the process of capacitation and cryocapacitation of spermatozoa.","PeriodicalId":74387,"journal":{"name":"Oxygen (Basel, Switzerland)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42983206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Solid and Liquid Oxygen under Ultrahigh Magnetic Fields 超高磁场下的固态和液态氧

Oxygen (Basel, Switzerland) Pub Date : 2022-05-25 DOI: 10.3390/oxygen2020013

T. Nomura, Y. Matsuda, Tatsuo C. Kobayashi

引用次数: 0

Biological and Pharmacological Properties of Carbon Monoxide: A General Overview 一氧化碳的生物学和药理学性质:综述

Oxygen (Basel, Switzerland) Pub Date : 2022-05-24 DOI: 10.3390/oxygen2020012

Anna Bilska-Wilkosz, M. Górny, M. Iciek

{"title":"Biological and Pharmacological Properties of Carbon Monoxide: A General Overview","authors":"Anna Bilska-Wilkosz, M. Górny, M. Iciek","doi":"10.3390/oxygen2020012","DOIUrl":"https://doi.org/10.3390/oxygen2020012","url":null,"abstract":"Carbon monoxide (CO) is one of the most common causes of inhalation poisoning worldwide. However, it is also well known that CO is produced endogenously in the heme degradation reaction catalyzed by heme oxygenase (HO) enzymes. HO catalyzes the degradation of heme to equimolar quantities of CO, iron ions (Fe2+), and biliverdin. Three oxygen molecules (O2) and the electrons provided by NADPH-dependent cytochrome P450 reductase are used in the reaction. HO enzymes comprise three distinct isozymes: the inducible form, heme oxygenase-1 (HO-1); the constitutively expressed isozyme, heme oxygenase-2 (HO-2); and heme oxygenase-3 (HO-3), which is ubiquitously expressed but possesses low catalytic activity. According to some authors, HO-3 is rather a pseudogene originating from the HO-2 transcript, and it has only been identified in rats. Therefore, cellular HO activity is provided by two major isoforms—the inducible HO-1 and the constitutively expressed HO-2. For many years, endogenously generated CO was treated as a by-product of metabolism without any serious physiological or biochemical significance, while exogenous CO was considered only as an extremely toxic gas with lethal effects. Research in recent years has proven that endogenous and exogenous CO (which may be surprising, given public perceptions) acts not only as an agent that affects many intracellular pathways, but also as a therapeutic molecule. Hence, the modulation of the HO/CO system may be one option for a potential therapeutic strategy. Another option is the administration of CO by exogenous inhalation. As alternatives to gas administration, compounds known as CO-releasing molecules (CORMs) can be administered, since they can safely release CO in the body. The aim of this article is to provide a brief overview of the physiological and biochemical properties of CO and its therapeutic potential.","PeriodicalId":74387,"journal":{"name":"Oxygen (Basel, Switzerland)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42743923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Validation and Bias Correction of Monthly δ18O Precipitation Time Series from ECHAM5-Wiso Model in Central Europe 中欧ECHAM5-Wiso模式月δ18O降水时间序列的验证和偏误校正

Oxygen (Basel, Switzerland) Pub Date : 2022-05-03 DOI: 10.3390/oxygen2020010

V. Salamalikis, A. Argiriou

{"title":"Validation and Bias Correction of Monthly δ18O Precipitation Time Series from ECHAM5-Wiso Model in Central Europe","authors":"V. Salamalikis, A. Argiriou","doi":"10.3390/oxygen2020010","DOIUrl":"https://doi.org/10.3390/oxygen2020010","url":null,"abstract":"Simulated stable oxygen isotopic composition (δ18O) of precipitation from isotope-enabled GCMs (iGCMs) have gained significant visibility nowadays. This study evaluates bias correction techniques to reduce the systematic and dispersion biases of the modelled δ18O by the ECHAM5-wiso model compared to the Global Network of Isotopes in Precipitation (GNIP) observations over Central Europe. mean bias error (MBE) and Root Mean Square Error (RMSE) are substantially reduced by more than 70% and 10%, respectively, depending on the bias correction scheme, with better results for Generalized Additive Model (GAM) and linear scaling approach (SCL) methods. The bias-corrected δ18OECHAM5-wiso values successfully describe the long-term isotopic composition of precipitation and the isotopic amplitude with the best performances for the EQM method. The necessity of applying bias correction algorithms is verified by the excellent agreement between the corrected δ18OECHAM5-wiso with GNIP in high-altitude areas where ECHAM5-wiso fails to reproduce the observed isotopic variability. The results are expected to bring valuable insights into the utilization of iGCMs’ relationships in climate studies for understanding the present and past water cycle under the isotopic perspective.","PeriodicalId":74387,"journal":{"name":"Oxygen (Basel, Switzerland)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49330048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Spectrophotometric and Electrochemical Assessment of the Antioxidant Capacity of Aqueous and Ethanolic Extracts of Citrus Flavedos 柑桔黄酮水提液和醇提液抗氧化能力的分光光度法和电化学评价

Oxygen (Basel, Switzerland) Pub Date : 2022-04-26 DOI: 10.3390/oxygen2020009

M. Moreno, J. M. Rodríguez Mellado

引用次数: 2

Cell Localization of DPI-Dependent Production of Superoxide in Reproductive Tissues of the Olive Tree (Olea europaea L.) 橄榄树（Olea europaea L.）生殖组织中DPI依赖性超氧化物产生的细胞定位

Oxygen (Basel, Switzerland) Pub Date : 2022-04-19 DOI: 10.3390/oxygen2020007

M. J. Jiménez-Quesada, A. Castro, E. Lima-Cabello, J. Alché

{"title":"Cell Localization of DPI-Dependent Production of Superoxide in Reproductive Tissues of the Olive Tree (Olea europaea L.)","authors":"M. J. Jiménez-Quesada, A. Castro, E. Lima-Cabello, J. Alché","doi":"10.3390/oxygen2020007","DOIUrl":"https://doi.org/10.3390/oxygen2020007","url":null,"abstract":"Reactive Oxygen Species (ROS) are compounds derived from oxygen with important implications in biological processes in plants, some of them related to reproduction. Among ROS, superoxide is the primary oxidant, since an array of other ROS are eventually derived from this anion. Therefore, analysis of the molecular systems able to generate this molecule and the cellular compartmentalization of these events is of paramount importance. We have used the fluorochrome DCFH2-DA and the chromogenic substrate NBT in association with DPI (a specific inhibitor of Rboh enzymes generating superoxide in plants) in combination with confocal microscopy and stereomicroscopy, respectively to identify cell localization of ROS in general, and superoxide accumulation in olive reproductive tissues. A significant production of both ROS and superoxide has been described, showing a fairly precise spatial and temporal location throughout olive flower development. The reduction of the NBT signal after the addition of DPI suggests that the generation of superoxide is largely due to Rboh or other flavin oxidase activity. At the subcellular level, accumulation of O2●− has been located in the plasma membrane of mature pollen and germinated pollen, as well as in the rough endoplasmic reticulum and in mitochondria.","PeriodicalId":74387,"journal":{"name":"Oxygen (Basel, Switzerland)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45255250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pulsed Electric Field-Based Extraction of Total Polyphenols from Sideritis raiseri Using Hydroethanolic Mixtures 基于脉冲电场的氢乙醇混合物提取葡萄干黄豆中总多酚的研究

Oxygen (Basel, Switzerland) Pub Date : 2022-04-19 DOI: 10.3390/oxygen2020008

V. Athanasiadis, Vasileios M. Pappas, D. Palaiogiannis, Theodoros G. Chatzimitakos, Eleni Bozinou, D. Makris, S. Lalas

{"title":"Pulsed Electric Field-Based Extraction of Total Polyphenols from Sideritis raiseri Using Hydroethanolic Mixtures","authors":"V. Athanasiadis, Vasileios M. Pappas, D. Palaiogiannis, Theodoros G. Chatzimitakos, Eleni Bozinou, D. Makris, S. Lalas","doi":"10.3390/oxygen2020008","DOIUrl":"https://doi.org/10.3390/oxygen2020008","url":null,"abstract":"Polyphenols are an important class of compounds, due to their excellent antioxidant properties. Lately, much effort has been placed into developing new extraction techniques and optimizing them, so that polyphenols can be retrieved more efficiently from the plant materials. One of the most recent advances in extraction techniques is pulsed electric field extraction (PEF). This new technique is environmentally friendly and has the potential to maximize the recovery of compounds from plant tissues. Although the efficiency of PEF depends, among others, on the nature of the solvent used, up to date, there are no reports on the optimization of the PEF extraction of polyphenols, using hydroethanolic solutions of varying content in ethanol. In this study, three hydroethanolic solutions, water, and ethanol were used for the PEF-based extraction of total polyphenols from Sideritis raiseri. Results were conclusive that the 1:1 mixture of ethanol and water can increase by up to 146% the yield of polyphenols in the extract, highlighting the need to study more extensively, in the future, mixtures of solvents and not just plain water.","PeriodicalId":74387,"journal":{"name":"Oxygen (Basel, Switzerland)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48934658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14

Free Radical Properties, Source and Targets, Antioxidant Consumption and Health 自由基的性质，来源和目标，抗氧化剂的消耗和健康

Oxygen (Basel, Switzerland) Pub Date : 2022-04-12 DOI: 10.3390/oxygen2020006

G. Martemucci, C. Costagliola, M. Mariano, L. D’andrea, P. Napolitano, A. D’Alessandro

引用次数: 123

Lung Diffusing Capacity in Dutch Special Operations Forces Divers Exposed to Oxygen Rebreathers over 18 Years 荷兰特种作战部队潜水员暴露于氧气再呼吸装置18年的肺扩散能力

Oxygen (Basel, Switzerland) Pub Date : 2022-03-31 DOI: 10.3390/oxygen2020005

Tom H.B. den Ouden, T. Wingelaar, E. Endert, P. V. van Ooij

{"title":"Lung Diffusing Capacity in Dutch Special Operations Forces Divers Exposed to Oxygen Rebreathers over 18 Years","authors":"Tom H.B. den Ouden, T. Wingelaar, E. Endert, P. V. van Ooij","doi":"10.3390/oxygen2020005","DOIUrl":"https://doi.org/10.3390/oxygen2020005","url":null,"abstract":"Exposure to hyperoxic conditions can induce pulmonary oxygen toxicity (POT). Divers of the Special Operations Forces (SOF) use oxygen rebreather systems during dives, and therefore are frequently exposed to hyperoxic conditions. Few studies have reported on POT in this population. This study reports on long-term pulmonary function tests (PFTs) and diffusing capacity in SOF divers to test the hypothesis that these measures of pulmonary function do not change clinically significantly during their career. The Royal Netherlands Navy performs yearly medical assessments of its military divers. All PFT and diffusing capacity data of SOF divers between the years 2000 and 2020 were analyzed using generalized estimating equations. The study included 257 SOF divers (median age, 27; interquartile range, 24–32), with 1612 dive medical assessments and a maximum follow-up time of 18.8 years. Alveolar volume (VA) and the diffusing capacity of carbon monoxide (TLCO) were significantly lower at baseline in smokers. Although these parameters were within the normal range, they declined over time and were significantly associated with age and years of diving. Smoking additionally affected TLCO and the transfer coefficient for carbon monoxide (KCO). TLCO and KCO were reduced by years of diving with oxygen rebreathers, albeit over clinically insignificant ranges, but smoking increased these changes by factors of 10 and 15, respectively.","PeriodicalId":74387,"journal":{"name":"Oxygen (Basel, Switzerland)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42703696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

A Brief History of Oxygen: 250 Years on 《氧气简史:250年

Oxygen (Basel, Switzerland) Pub Date : 2022-03-15 DOI: 10.3390/oxygen2010004

J. Hancock

引用次数: 2