Oxygen (Basel, Switzerland)最新文献_第6页

Molecular oxygen as a probe molecule in EPR spin-labeling studies of membrane structure and dynamics. 分子氧作为 EPR 自旋标记膜结构和动态研究的探针分子。

Oxygen (Basel, Switzerland) Pub Date : 2022-09-01 Epub Date: 2022-08-04 DOI: 10.3390/oxygen2030021

Witold K Subczynski, Justyna Widomska, Marija Raguz, Marta Pasenkiewicz-Gierula

{"title":"Molecular oxygen as a probe molecule in EPR spin-labeling studies of membrane structure and dynamics.","authors":"Witold K Subczynski, Justyna Widomska, Marija Raguz, Marta Pasenkiewicz-Gierula","doi":"10.3390/oxygen2030021","DOIUrl":"10.3390/oxygen2030021","url":null,"abstract":"Molecular oxygen (O2) is the perfect probe molecule for membrane studies carried out using the saturation recovery EPR technique. O2 is a small, paramagnetic, hydrophobic enough molecule that easily partitions into a membrane's different phases and domains. In membrane studies, the saturation recovery EPR method requires two paramagnetic probes: a lipid-analog nitroxide spin label and an oxygen molecule. The experimentally derived parameters of this method are the spin-lattice relaxation times (T 1s) of spin labels and rates of bimolecular collisions between O2 and the nitroxide fragment. Thanks to the long T 1 of lipid spin labels (from 1 to 10 μs), the approach is very sensitive to changes of the local (around the nitroxide fragment) O2 diffusion-concentration product. Small variations in the lipid packing affect O2 solubility and O2 diffusion, which can be detected by the shortening of T 1 of spin labels. Using O2 as a probe molecule and a different lipid spin label inserted into specific phases of the membrane and membrane domains allows data about the lateral arrangement of lipid membranes to be obtained. Moreover, using a lipid spin label with the nitroxide fragment attached to its head group or a hydrocarbon chain at different positions also enables data about molecular dynamics and structure at different membrane depths to be obtained. Thus, the method can be used to investigate not only the lateral organization of the membrane (i.e., the presence of membrane domains and phases), but also the depth-dependent membrane structure and dynamics, and, hence, the membrane properties in three dimensions.","PeriodicalId":74387,"journal":{"name":"Oxygen (Basel, Switzerland)","volume":"2 3","pages":"295-316"},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9965258/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10134812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Photosynthetic Production of Molecular Oxygen by Water Oxidation 水氧化作用下分子氧的光合作用

Oxygen (Basel, Switzerland) Pub Date : 2022-08-26 DOI: 10.3390/oxygen2030024

L. Björn

引用次数: 0

Correlation of the Isotropic NMR Chemical Shift with Oxygen Coordination Distances in Periodic Solids 周期固体中各向同性核磁共振化学位移与氧配位距离的关系

Oxygen (Basel, Switzerland) Pub Date : 2022-08-05 DOI: 10.3390/oxygen2030023

Jennifer Steinadler, O. E. Zeman, T. Bräuniger

{"title":"Correlation of the Isotropic NMR Chemical Shift with Oxygen Coordination Distances in Periodic Solids","authors":"Jennifer Steinadler, O. E. Zeman, T. Bräuniger","doi":"10.3390/oxygen2030023","DOIUrl":"https://doi.org/10.3390/oxygen2030023","url":null,"abstract":"In Nuclear Magnetic Resonance (NMR) spectroscopy, the isotropic chemical shift δiso is a measure of the electron density around the observed nuclide. For characterization of solid materials and compounds, it is desirable to find correlations between δiso and structural parameters such as coordination numbers and distances to neighboring atoms. Correlations of good quality are easier to find when the coordination sphere is formed by only one element, as the electron density is obviously strongly dependent on the atomic number. The current study is therefore restricted to nuclides in pure oxygen coordination. It is shown that the isotropic shift δiso correlates well with the average oxygen distances (as defined by the coordination sphere) for the nuclides 23Na (with spin I=3/2), 27Al (I=5/2), and 43Ca (I=7/2), using literature data for a range of periodic solids. It has been previously suggested for 207Pb (I=1/2) that δiso may alternatively be related to the shortest oxygen distance in the structure, and our study corroborates this also for the nuclides considered here. While the correlation with the minimal distance is not always better, it has the advantage of being uniquely defined. In contrast, the average distance is strongly dependent on the designation of the oxygen coordination sphere, which may be contentious in some crystal structures.","PeriodicalId":74387,"journal":{"name":"Oxygen (Basel, Switzerland)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45237760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Roles of Reactive Oxygen Species and Autophagy in the Pathogenesis of Cisplatin-Induced Acute Kidney Injury 活性氧和自噬在顺铂急性肾损伤发病机制中的作用

Oxygen (Basel, Switzerland) Pub Date : 2022-08-05 DOI: 10.3390/oxygen2030022

Sayuri Yoshikawa, Kurumi Taniguchi, Haruka Sawamura, Yuka Ikeda, Ai Tsuji, Satoru Matsuda

{"title":"Roles of Reactive Oxygen Species and Autophagy in the Pathogenesis of Cisplatin-Induced Acute Kidney Injury","authors":"Sayuri Yoshikawa, Kurumi Taniguchi, Haruka Sawamura, Yuka Ikeda, Ai Tsuji, Satoru Matsuda","doi":"10.3390/oxygen2030022","DOIUrl":"https://doi.org/10.3390/oxygen2030022","url":null,"abstract":"Cisplatin-induced acute kidney injury (AKI) is the main factor restraining the clinical application of cisplatin. The AKI is associated with high mortality and morbidity, but no effective pharmacological treatment is available at present. As increased levels of reactive oxygen species (ROS) may promote the progression of the injury, the elimination of ROS has been considered as an effective method to prevent the cisplatin-induced AKI. In addition, it has been revealed that an inducer of autophagy could protect kidney cells in the autophagy dependent manner. Induction of autophagy could also modulate the production of ROS in cases of renal injury. Therefore, kidney-targeted antioxidants and/or autophagy are urgently required for the better treatment of AKI. Accumulating evidence has indicated the important roles of gut microbiota in the pathogenesis of AKI. In addition, there is a scientific basis for considering future clinical applications of probiotics and/or prebiotics to treat cisplatin-induced AKI. Thus, gut microbiota might be a promising therapeutic target via the alteration of autophagy for the cancer therapy-induced nephrotoxicity.","PeriodicalId":74387,"journal":{"name":"Oxygen (Basel, Switzerland)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49424148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Correlation between Microbial Population and Oxidative Stability of the Yogurt-Based Tzatziki Salad 酸奶沙拉中微生物种群和氧化稳定性的相关性

Oxygen (Basel, Switzerland) Pub Date : 2022-07-28 DOI: 10.3390/oxygen2030020

Eleni Bozinou, V. Athanasiadis, Theodoros G. Chatzimitakos, C. Salakidou, V. Dourtoglou, S. Lalas

{"title":"Correlation between Microbial Population and Oxidative Stability of the Yogurt-Based Tzatziki Salad","authors":"Eleni Bozinou, V. Athanasiadis, Theodoros G. Chatzimitakos, C. Salakidou, V. Dourtoglou, S. Lalas","doi":"10.3390/oxygen2030020","DOIUrl":"https://doi.org/10.3390/oxygen2030020","url":null,"abstract":"Tzatziki is a deli salad widely consumed in the Eastern Mediterranean and Balkan countries, and it is acknowledged for its health benefits. So far, it is proved to exhibit extreme resistance to microbial spoilage by (pathogenic) microorganisms and microbial self-stabilization, but no research was carried out regarding its oxidative stability despite the fact that it contains a large amount of lipids. In this study, the factor that affects the oxidative stability of tzatziki was exploited. Different samples of tzatziki salad were prepared and stored for 16 or 27 days, depending on the conducted experiment. They varied in the type of yogurt (set yogurt or traditional Greek-style yogurt), the type of oil (olive oil or soybean oil), and the addition or not of preservatives, garlic, and cucumber. Samples were analyzed in terms of oxidative stability (by the Rancimat method), colony-forming units, and tocopherol content throughout the storage period. Among the examined parameters, no correlation between the tocopherol content and oxidative stability was recorded. However, a strong correlation between the microbial population and the oxidative stability was recorded. Therefore, this correlation can be used to prepare tzatziki salads with increased shelf life and decreased flavor deterioration (due to oxidation). Moreover, such correlations should be further exploited for other foods so as to promote their stability.","PeriodicalId":74387,"journal":{"name":"Oxygen (Basel, Switzerland)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47002544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Reactive Oxygen Species Signaling Pathways: Arbiters of Evolutionary Conflict? 活性氧信号通路:进化冲突的仲裁者?

Oxygen (Basel, Switzerland) Pub Date : 2022-07-17 DOI: 10.3390/oxygen2030019

N. Blackstone

{"title":"Reactive Oxygen Species Signaling Pathways: Arbiters of Evolutionary Conflict?","authors":"N. Blackstone","doi":"10.3390/oxygen2030019","DOIUrl":"https://doi.org/10.3390/oxygen2030019","url":null,"abstract":"In the history of life, cooperation between biological units has led to increased complexity, e.g., eukaryotic cells and multicellular organisms. Cooperation requires limiting the gains of “defectors” in favor of the cooperative higher-level unit. Early in an evolutionary transition, bioenergetics and reactive oxygen species (ROS) may play a large role in managing these evolutionary conflicts. Chemiosmosis can be thought of as a poorly insulated wire—when supply exceeds demand, electrons are cast off and can form ROS. ROS signaling may thus lead to the dispersal of the excess products into the environment. These products may lead to groups and the formation of higher-level units that can subsequently be targeted by selection. Examining modern symbioses such as those between corals and photosynthetic dinoflagellates provides useful insight in this context. While ROS are an important factor in coral bleaching, little is known of the function of ROS under other circumstances, although some data suggest that ROS may modulate cooperation. ROS may have functioned similarly in the origin of eukaryotes, involving chemiosmotic mitochondria and chloroplasts. ROS may act as “arbiters” of evolutionary conflict, leading to cooperation via signaling pathways that favor the emergence of the higher-level unit.","PeriodicalId":74387,"journal":{"name":"Oxygen (Basel, Switzerland)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44524898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Roles of Reactive Oxygen Species in Vascular Complications of Diabetes: Therapeutic Properties of Medicinal Plants and Food 活性氧在糖尿病血管并发症中的作用:药用植物和食物的治疗特性

Oxygen (Basel, Switzerland) Pub Date : 2022-07-02 DOI: 10.3390/oxygen2030018

Yi Tan, Meng Sam Cheong, W. Cheang

{"title":"Roles of Reactive Oxygen Species in Vascular Complications of Diabetes: Therapeutic Properties of Medicinal Plants and Food","authors":"Yi Tan, Meng Sam Cheong, W. Cheang","doi":"10.3390/oxygen2030018","DOIUrl":"https://doi.org/10.3390/oxygen2030018","url":null,"abstract":"The rising prevalence of chronic metabolic disorders, such as obesity and type 2 diabetes, most notably associated with cardiovascular diseases, has emerged as a major global health concern. Reactive oxygen species (ROS) play physiological functions by maintaining normal cellular redox signaling. By contrast, a disturbed balance occurring between ROS production and detoxification of reactive intermediates results in excessive oxidative stress. Oxidative stress is a critical mediator of endothelial dysfunction in obesity and diabetes. Under a hyperglycemic condition, the antioxidant enzymes are downregulated, resulting in an increased generation of ROS. Increases in ROS lead to impairment of endothelium-dependent vasodilatations by reducing NO bioavailability. Chronic treatments with antioxidants were reported to prevent the development of endothelial dysfunction in diabetic patients and animals; however, the beneficial effects of antioxidant treatment in combating vascular complications in diabetes remain controversial as antioxidants do not always reverse endothelial dysfunction in clinical settings. In this review, we summarize the latest progress in research focused on the role of ROS in vascular complications of diabetes and the antioxidant properties of bioactive compounds from medicinal plants and food in animal experiments and clinical studies to provide insights for the development of therapeutic strategies.","PeriodicalId":74387,"journal":{"name":"Oxygen (Basel, Switzerland)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43737674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

Lost in Translation: Exploring microRNA Biogenesis and Messenger RNA Fate in Anoxia-Tolerant Turtles 迷失在翻译中：探索耐缺氧海龟的微小RNA生物发生和信使RNA命运

Oxygen (Basel, Switzerland) Pub Date : 2022-06-17 DOI: 10.3390/oxygen2020017

Sarah A. Breedon, K. Storey

{"title":"Lost in Translation: Exploring microRNA Biogenesis and Messenger RNA Fate in Anoxia-Tolerant Turtles","authors":"Sarah A. Breedon, K. Storey","doi":"10.3390/oxygen2020017","DOIUrl":"https://doi.org/10.3390/oxygen2020017","url":null,"abstract":"Red-eared slider turtles face natural changes in oxygen availability throughout the year. This includes long-term anoxic brumation where they reduce their metabolic rate by ~90% for months at a time, which they survive without apparent tissue damage. This metabolic rate depression (MRD) is underlaid by various regulatory mechanisms, including messenger RNA (mRNA) silencing via microRNA (miRNA), leading to mRNA decay or translational inhibition in processing bodies (P-bodies) and stress granules. Regulation of miRNA biogenesis was assessed in red-eared slider turtle liver and skeletal muscle via immunoblotting. Hepatic miRNA biogenesis was downregulated in early processing steps, while later steps were upregulated. These contradictory findings indicate either overall decreased miRNA biogenesis, or increased biogenesis if sufficient pre-miRNA stores were produced in early anoxia. Conversely, muscle showed clear upregulation of multiple biogenesis steps indicating increased miRNA production. Additionally, immunoblotting indicated that P-bodies may be favoured by the liver for mRNA storage/decay during reoxygenation with a strong suppression of stress granule proteins in anoxia and reoxygenation. Muscle however showed downregulation of P-bodies during anoxia and reoxygenation, and upregulation of stress granules for mRNA storage during reoxygenation. This study advances our understanding of how these champion anaerobes regulate miRNA biogenesis to alter miRNA expression and mRNA fate during prolonged anoxia.","PeriodicalId":74387,"journal":{"name":"Oxygen (Basel, Switzerland)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49235560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Conquering Space with Crops That Produce Ample Oxygen and Antioxidants 用富含氧气和抗氧化剂的作物征服太空

Oxygen (Basel, Switzerland) Pub Date : 2022-06-06 DOI: 10.3390/oxygen2020016

S. K. Polutchko, W. W. Adams, Christine M. Escobar, B. Demmig-Adams

{"title":"Conquering Space with Crops That Produce Ample Oxygen and Antioxidants","authors":"S. K. Polutchko, W. W. Adams, Christine M. Escobar, B. Demmig-Adams","doi":"10.3390/oxygen2020016","DOIUrl":"https://doi.org/10.3390/oxygen2020016","url":null,"abstract":"Sustainable long-term space missions require regenerative life support from plants. Traditional crop plants lack some features desirable for use in space environments. The aquatic plant family Lemnaceae (duckweeds) has enormous potential as a space crop, featuring (i) fast growth, with very high rates of O2 production and CO2 sequestration, (ii) an exceptional nutritional quality (with respect to radiation-fighting antioxidants and high-quality protein), (iii) easy propagation and high productivity in small spaces, and (iv) resilience to the stresses (radiation, microgravity, and elevated CO2) of the human-inhabited space environment. These traits of Lemnaceae are placed into the context of their unique adaptations to the aquatic environment. Furthermore, an overview is provided of the challenges of galactic cosmic radiation to plant and human physiology and the mechanisms involved in oxidative injury and the prevention/mitigation of such effects by antioxidant micronutrients. A focus is placed on the carotenoid zeaxanthin accumulated by Lemnaceae in unusually high amounts and its role in counteracting system-wide inflammation, cognitive dysfunction, and other oxidative injuries in humans.","PeriodicalId":74387,"journal":{"name":"Oxygen (Basel, Switzerland)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43398441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Oxidative Stress and Its Role in Cd-Induced Epigenetic Modifications: Use of Antioxidants as a Possible Preventive Strategy 氧化应激及其在镉诱导的表观遗传学修饰中的作用：使用抗氧化剂作为一种可能的预防策略

Oxygen (Basel, Switzerland) Pub Date : 2022-05-29 DOI: 10.3390/oxygen2020015

E. Hernández-Cruz, Yalith Lyzet Arancibia-Hernández, Deyanira Yael Loyola-Mondragón, J. Pedraza-Chaverri

{"title":"Oxidative Stress and Its Role in Cd-Induced Epigenetic Modifications: Use of Antioxidants as a Possible Preventive Strategy","authors":"E. Hernández-Cruz, Yalith Lyzet Arancibia-Hernández, Deyanira Yael Loyola-Mondragón, J. Pedraza-Chaverri","doi":"10.3390/oxygen2020015","DOIUrl":"https://doi.org/10.3390/oxygen2020015","url":null,"abstract":"Oxidative stress (OS) represents one of the main mechanisms of toxicity induced by environmental pollutants such as cadmium (Cd). OS is a natural physiological process where the presence of oxidants, such as reactive oxygen-derived species (ROS), outweighs the strategy of antioxidant defenses, culminating in the interruption of signaling and redox control. It has been suggested that Cd increases ROS mainly by inducing damage to the electron transport chain and by increasing the activity of nicotinamide adenine dinucleotide hydrogen phosphate (NADPH) oxidase (NOX) and the concentration of free iron (Fe), as well as causing a decrease in antioxidant defense. On the other hand, OS has been related to changes in the biology of the epigenome, causing adverse health effects. Recent studies show that Cd generates alterations in deoxyribonucleic acid (DNA) methylation, histone modifications, and noncoding RNA (ncRNA) expression. However, the role of OS in Cd-induced epigenetic modifications is still poorly explored. Therefore, this review provides an update on the basic concepts of OS and its relationship with Cd-induced epigenetic changes. Furthermore, the use of antioxidant compounds is proposed to mitigate Cd-induced epigenetic alterations.","PeriodicalId":74387,"journal":{"name":"Oxygen (Basel, Switzerland)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41730037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5