自由基的性质，来源和目标，抗氧化剂的消耗和健康

Oxygen (Basel, Switzerland) Pub Date : 2022-04-12 DOI:10.3390/oxygen2020006

G. Martemucci, C. Costagliola, M. Mariano, L. D’andrea, P. Napolitano, A. D’Alessandro

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引用次数: 123

摘要

自由基在生物学和医学领域的重要性与日俱增。它们在许多不同的内源性和外源性过程中产生。线粒体是细胞水平产生内源性活性氧(ROS)的主要来源。自由基的过量产生会破坏大分子，如核酸、蛋白质和脂质。这导致各种慢性和退行性疾病的组织损伤。抗氧化剂在人体抵御自由基方面起着至关重要的作用。本文综述了自由基的主要性质、来源和有害作用。它强调了膳食补充抗氧化剂的潜在作用，并讨论了抗氧化剂补充剂在预防和治疗疾病方面尚未解决的问题。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Free Radical Properties, Source and Targets, Antioxidant Consumption and Health

Free radicals have acquired growing importance in the fields of biology and medicine. They are produced during many different endogenous and exogenous processes. Mitochondria are the main source of endogenous reactive oxygen species (ROS) produced at cell level. The overproduction of free radicals can damage macromolecules such as nucleic acids, proteins and lipids. This leads to tissue damage in various chronic and degenerative diseases. Antioxidants play a crucial role in the body’s defense against free radicals. This review concerns the main properties of free radicals, their sources and deleterious effects. It highlights the potential role of the dietary supplementation of antioxidants and discusses unsolved problems regarding antioxidant supplements in the prevention and therapy of diseases.

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Oxygen (Basel, Switzerland)

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