Oxford open neuroscience最新文献

Brain-Computer Interface tool use and the Contemplation Conundrum: a blueprint of mental action, agency, and control. 脑机接口工具的使用和沉思难题：心理行为、代理和控制的蓝图。

Oxford open neuroscience Pub Date : 2025-06-11 eCollection Date: 2025-01-01 DOI: 10.1093/oons/kvaf002

Dvija Mehta

引用次数: 0

Computational anatomy: the cerebellar microzone computation. 计算解剖学：小脑微区计算。

Oxford open neuroscience Pub Date : 2025-05-16 eCollection Date: 2025-01-01 DOI: 10.1093/oons/kvaf001

Mike Gilbert, Anders Rasmussen

引用次数: 0

Social defeat stress induces an anxiety-like outcome in male prairie voles (Microtus ochrogaster). 社会失败压力在雄性草原田鼠（Microtus ochrogaster）中引起了类似焦虑的结果。

Oxford open neuroscience Pub Date : 2024-11-23 eCollection Date: 2024-01-01 DOI: 10.1093/oons/kvae012

Minerva Rodriguez, Anapaula Themann, Daniel E Calvo, Jessica A Garcia, Omar Lira, Israel Garcia-Carachure, Sergio D Iñiguez

{"title":"Social defeat stress induces an anxiety-like outcome in male prairie voles (Microtus ochrogaster).","authors":"Minerva Rodriguez, Anapaula Themann, Daniel E Calvo, Jessica A Garcia, Omar Lira, Israel Garcia-Carachure, Sergio D Iñiguez","doi":"10.1093/oons/kvae012","DOIUrl":"10.1093/oons/kvae012","url":null,"abstract":"Anxiety-related illnesses constitute one of the leading causes of disability across the globe. Consequently, the need for validated preclinical models to uncover the etiology of anxiety phenotypes remains essential. Given the link between social stress experience and the manifestation of anxiogenic-like outcomes, we evaluated whether social defeat stress (SDS) reduces open-space exploratory behavior in prairie voles (Microtus ochrogaster). Thus, we exposed adult sexually-naïve male voles to 10 consecutive days of SDS episodes and evaluated responses to the anxiogenic environment of the light/dark box test or the elevated plus-maze, 24 hours later. We found that, when compared to non-stressed controls, SDS-exposed voles displayed longer latency to enter the light compartment of the light/dark box. Similarly, on the elevated plus-maze, SDS-exposed voles displayed decreases in the number of entries into the open arms, while spending more time in the closed arms of the maze. No differences in locomotor activity were noted between the experimental groups. Collectively, these data indicate that chronic SDS exposure induces anxiety-like responses in adult male prairie voles, thus, providing a preclinical model for the study of social stress-induced anxiogenic phenotypes.","PeriodicalId":74386,"journal":{"name":"Oxford open neuroscience","volume":"3 ","pages":"kvae012"},"PeriodicalIF":0.0,"publicationDate":"2024-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11629977/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142808590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Machine learning-based prediction of one-year mortality in ischemic stroke patients. 基于机器学习的缺血性中风患者一年死亡率预测。

Oxford open neuroscience Pub Date : 2024-11-14 eCollection Date: 2024-01-01 DOI: 10.1093/oons/kvae011

Ahmad Abujaber, Said Yaseen, Yahia Imam, Abdulqadir Nashwan, Naveed Akhtar

{"title":"Machine learning-based prediction of one-year mortality in ischemic stroke patients.","authors":"Ahmad Abujaber, Said Yaseen, Yahia Imam, Abdulqadir Nashwan, Naveed Akhtar","doi":"10.1093/oons/kvae011","DOIUrl":"10.1093/oons/kvae011","url":null,"abstract":"Background: Accurate prediction of mortality following an ischemic stroke is essential for tailoring personalized treatment strategies. This study evaluates the effectiveness of machine learning models in predicting one-year mortality after an ischemic stroke.Methods: Five machine learning models were trained using data from a national stroke registry, with logistic regression demonstrating the highest performance. The SHapley Additive exPlanations (SHAP) analysis explained the model's outcomes and defined the influential predictive factors.Results: Analyzing 8183 ischemic stroke patients, logistic regression achieved 83% accuracy, 0.89 AUC, and an F1 score of 0.83. Significant predictors included stroke severity, pre-stroke functional status, age, hospital-acquired pneumonia, ischemic stroke subtype, tobacco use, and co-existing diabetes mellitus (DM).Discussion: The model highlights the importance of predicting mortality in enhancing personalized stroke care. Apart from pneumonia, all predictors can serve the early prediction of mortality risk which supports the initiation of early preventive measures and in setting realistic expectations of disease outcomes for all stakeholders. The identified tobacco paradox warrants further investigation.Conclusion: This study offers a promising tool for early prediction of stroke mortality and for advancing personalized stroke care. It emphasizes the need for prospective studies to validate these findings in diverse clinical settings.","PeriodicalId":74386,"journal":{"name":"Oxford open neuroscience","volume":"3 ","pages":"kvae011"},"PeriodicalIF":0.0,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11576476/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142683658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Astrocytic GPCR signaling in the anterior cingulate cortex modulates decision making in rats. 前扣带回皮层中的星形胶质细胞 GPCR 信号调节大鼠的决策制定。

Oxford open neuroscience Pub Date : 2024-06-22 eCollection Date: 2024-01-01 DOI: 10.1093/oons/kvae010

Mastura Akter, Zhongqi Fu, Xianlin Zheng, Zafar Iqbal, Na Zhang, Anwarul Karim, Ying Li

引用次数: 0

Modulation of marble-burying behavior in adult versus adolescent C57BL/6J mice of both sexes by ethologically relevant chemosensory stimuli 伦理相关化学感官刺激对成年与青春期 C57BL/6J 雌雄小鼠埋大理石行为的调节作用

Oxford open neuroscience Pub Date : 2024-05-24 DOI: 10.1093/oons/kvae009

C. L. J. Chavez, K. Szumlinski

{"title":"Modulation of marble-burying behavior in adult versus adolescent C57BL/6J mice of both sexes by ethologically relevant chemosensory stimuli","authors":"C. L. J. Chavez, K. Szumlinski","doi":"10.1093/oons/kvae009","DOIUrl":"https://doi.org/10.1093/oons/kvae009","url":null,"abstract":"\u0000 The marble-burying test is a pharmacologically validated paradigm used to study anxiety-like behaviors in laboratory rodents. Our laboratory has employed this assay as part of a behavioral screen to examine drug-induced negative affective states. Historically, the majority of our prior binge alcohol-drinking studies employed male subjects exclusively and reliably detected adolescent-adult differences in both basal and alcohol withdrawal-induced negative affect. However, age-related differences in marble-burying behavior were either absent or opposite those observed in our prior work when female subjects were included in the experimental design. As chemosensory cues from females are reported to be anxiolytic in males, the present study examined how odors from adult members of the opposite and same sex (obtained from soiled bedding) influence marble-burying behavior in adult, as well as adolescent, mice. Control studies examined the responsiveness of mice in the presence of novel neutral (vanilla) and aversive (tea tree) odors. Adult males exhibited reduced signs of anxiety-like behavior in the presence of female-soiled bedding, while adult females and adolescent mice of both sexes increased marble-burying behavior in the presence of both male- and female-soiled bedding. All mice exhibited increased burying in the presence of an aversive odor, while only adolescents increased marble-burying in response to the novel neutral odor. These data indicate sex by age interactions in the effects of volatile and nonvolatile odors from sexually-naive adult conspecifics on indices of anxiety-like behavior in the marble-burying test of relevance to the experimental design and procedural timing of experiments including sex as a biological variable.","PeriodicalId":74386,"journal":{"name":"Oxford open neuroscience","volume":"13 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141102681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction to: Retina regeneration: lessons from vertebrates 更正为视网膜再生：脊椎动物的经验教训

Oxford open neuroscience Pub Date : 2024-05-21 DOI: 10.1093/oons/kvae008

引用次数: 0

Altered neuroepithelial morphogenesis and migration defects in iPSC-derived cerebral organoids and 2D neural stem cells in familial bipolar disorder 家族性躁郁症中 iPSC 衍生的脑器官组织和二维神经干细胞的神经上皮形态发生改变和迁移缺陷

Oxford open neuroscience Pub Date : 2024-04-03 DOI: 10.1093/oons/kvae007

Kruttika Phalnikar, M. Srividya, S. Mythri, N. S. Vasavi, Archisha Ganguly, Aparajita Kumar, Padmaja S, Kishan Kalia, Srishti S Mishra, S. Dhanya, P. Paul, B. Holla, Suhas Ganesh, Puli Chandramouli Reddy, R. Sud, B. Viswanath, Bhavana Muralidharan

{"title":"Altered neuroepithelial morphogenesis and migration defects in iPSC-derived cerebral organoids and 2D neural stem cells in familial bipolar disorder","authors":"Kruttika Phalnikar, M. Srividya, S. Mythri, N. S. Vasavi, Archisha Ganguly, Aparajita Kumar, Padmaja S, Kishan Kalia, Srishti S Mishra, S. Dhanya, P. Paul, B. Holla, Suhas Ganesh, Puli Chandramouli Reddy, R. Sud, B. Viswanath, Bhavana Muralidharan","doi":"10.1093/oons/kvae007","DOIUrl":"https://doi.org/10.1093/oons/kvae007","url":null,"abstract":"Abstract Bipolar disorder (BD) is a severe mental illness that can result from neurodevelopmental aberrations, particularly in familial BD, which may include causative genetic variants. In the present study, we derived cortical organoids from BD patients and healthy (control) individuals from a clinically dense family in the Indian population. Our data reveal that the patient organoids show neurodevelopmental anomalies, including organisational, proliferation and migration defects. The BD organoids show a reduction in both the number of neuroepithelial buds/cortical rosettes and the ventricular zone size. Additionally, patient organoids show a lower number of SOX2-positive and EdU-positive cycling progenitors, suggesting a progenitor proliferation defect. Further, the patient neurons show abnormal positioning in the ventricular/intermediate zone of the neuroepithelial bud. Transcriptomic analysis of control and patient organoids supports our cellular topology data and reveals dysregulation of genes crucial for progenitor proliferation and neuronal migration. Lastly, time-lapse imaging of neural stem cells in 2D in vitro cultures reveals abnormal cellular migration in BD samples. Overall, our study pinpoints a cellular and molecular deficit in BD patient-derived organoids and neural stem cell cultures.","PeriodicalId":74386,"journal":{"name":"Oxford open neuroscience","volume":"103 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140747022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of group size on movement patterns and clustering dynamics in rats 群体大小对大鼠运动模式和集群动态的影响

Oxford open neuroscience Pub Date : 2024-04-02 DOI: 10.1093/oons/kvae005

M. Monfils, Michael Pasala, Cassidy A. Malone, L. Agee, R. Roquet, Lawrence Cormack

{"title":"Effects of group size on movement patterns and clustering dynamics in rats","authors":"M. Monfils, Michael Pasala, Cassidy A. Malone, L. Agee, R. Roquet, Lawrence Cormack","doi":"10.1093/oons/kvae005","DOIUrl":"https://doi.org/10.1093/oons/kvae005","url":null,"abstract":"Abstract Environment is a determining factor that can facilitate or hinder social interactions. A precursor to meaningfully engaging with conspecifics is being exposed to opportunistic encounters with others. Increasing the number of individuals in a given space (thus increasing density) would, statistically speaking, increase the likelihood of accidental encounters. This might have consequences on the formation of social networks—an idea that has not reliably been explored. If true, we would expect that increasing density would lead to an increase in the number and the duration of ‘clusters’ of animals. Here, we examined whether varying the number of rats in an open field environment differentially affected their movement dynamics or their propensity to aggregate into clusters and, if so, whether such effects are dependent solely on statistical factors due to increases in density, the potential for actively-sought social interactions, or both. We found that the number of rats in an environment impacts ambulation speed, distance traveled, cluster formation and approaches, and that number and duration of clusters are highly dependent on the propensity for the rats to engage in social interactions.","PeriodicalId":74386,"journal":{"name":"Oxford open neuroscience","volume":"178 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140755106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Having a chat and then watching a movie: how social interaction synchronises our brains during co-watching 先聊天再看电影：在共同观看电影的过程中，社交互动是如何使我们的大脑同步的

Oxford open neuroscience Pub Date : 2024-03-25 DOI: 10.1093/oons/kvae006

S. De Felice, U. Hakim, N. Gunasekara, P. Pinti, I. Tachtsidis, A. Hamilton

{"title":"Having a chat and then watching a movie: how social interaction synchronises our brains during co-watching","authors":"S. De Felice, U. Hakim, N. Gunasekara, P. Pinti, I. Tachtsidis, A. Hamilton","doi":"10.1093/oons/kvae006","DOIUrl":"https://doi.org/10.1093/oons/kvae006","url":null,"abstract":"\u0000 How does co-presence change our neural experience of the world? Can a conversation change how we synchronise with our partner during later events? Using fNIRS hyperscanning, we measured brain activity from 27 pairs of familiar adults simultaneously over frontal, temporal and parietal regions bilaterally, as they co-watched two different episodes of a short cartoon. In-between the two episodes, each pair engaged in a face-to-face conversation on topics unrelated to the cartoon episodes. Brain synchrony was calculated using wavelet transform coherence and computed separately for real pairs and shuffled (pseudo) pairs. Findings reveal that real pairs showed increased brain synchrony over right Dorso-Lateral Pre-Frontal cortex (DLPFC) and right Superior Parietal Lobe (SPL), compared to pseudo pairs (who had never seen each other and watched the same movie at different times; uncorrected for multiple comparisons). In addition, co-watching after a conversation was associated with greater synchrony over right TPJ compared to co-watching before a conversation, and this effect was significantly higher in real pairs (who engaged in conversation with each other) compared to pseudo pairs (who had a conversation with someone else; uncorrected for multiple comparisons). The present study has shed the light on the role of social interaction in modulating brain synchrony across people not just during social interaction, but even for subsequent non-social activities. These results have implications in the growing domain of naturalistic neuroimaging and interactive neuroscience.","PeriodicalId":74386,"journal":{"name":"Oxford open neuroscience","volume":"112 21","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140381344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0