Astrocytic GPCR signaling in the anterior cingulate cortex modulates decision making in rats.

Oxford open neuroscience Pub Date : 2024-06-22 eCollection Date: 2024-01-01 DOI:10.1093/oons/kvae010
Mastura Akter, Zhongqi Fu, Xianlin Zheng, Zafar Iqbal, Na Zhang, Anwarul Karim, Ying Li
{"title":"Astrocytic GPCR signaling in the anterior cingulate cortex modulates decision making in rats.","authors":"Mastura Akter, Zhongqi Fu, Xianlin Zheng, Zafar Iqbal, Na Zhang, Anwarul Karim, Ying Li","doi":"10.1093/oons/kvae010","DOIUrl":null,"url":null,"abstract":"<p><p>Decision making is a process of selecting a course of action by assessing the worth or value of the potential consequences. Rat Gambling Task (RGT) is a well-established behavioral paradigm that allows for assessment of the decision-making performance of rats. Astrocytes are emerging as key players in modulating cognitive functions. Using repeated RGTs with short intersession time intervals (48 h), the current study demonstrates that G<sub>i</sub> pathway activation of astrocytes in the anterior cingulate cortex (ACC) leads to impaired decision-making in consistently good decision-making rats. On the other hand, ACC astrocytic G<sub>q</sub> pathway activation improves decision-making in a subset of rats who are not consistently good decision-makers. Furthermore, we show that astrocytic G<sub>q</sub> activation is associated with an increase in the L-lactate level in the extracellular fluid of the ACC. Together, these results expand our knowledge of the role of astrocytic GPCR signaling in modulating cognitive functions.</p>","PeriodicalId":74386,"journal":{"name":"Oxford open neuroscience","volume":"3 ","pages":"kvae010"},"PeriodicalIF":0.0000,"publicationDate":"2024-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11194462/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Oxford open neuroscience","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1093/oons/kvae010","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/1/1 0:00:00","PubModel":"eCollection","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

Abstract

Decision making is a process of selecting a course of action by assessing the worth or value of the potential consequences. Rat Gambling Task (RGT) is a well-established behavioral paradigm that allows for assessment of the decision-making performance of rats. Astrocytes are emerging as key players in modulating cognitive functions. Using repeated RGTs with short intersession time intervals (48 h), the current study demonstrates that Gi pathway activation of astrocytes in the anterior cingulate cortex (ACC) leads to impaired decision-making in consistently good decision-making rats. On the other hand, ACC astrocytic Gq pathway activation improves decision-making in a subset of rats who are not consistently good decision-makers. Furthermore, we show that astrocytic Gq activation is associated with an increase in the L-lactate level in the extracellular fluid of the ACC. Together, these results expand our knowledge of the role of astrocytic GPCR signaling in modulating cognitive functions.

前扣带回皮层中的星形胶质细胞 GPCR 信号调节大鼠的决策制定。
决策是一个通过评估潜在后果的价值来选择行动方案的过程。大鼠赌博任务(RGT)是一种成熟的行为范式,可用于评估大鼠的决策能力。星形胶质细胞正在成为调节认知功能的关键角色。本研究利用短间隔时间(48 小时)重复进行 RGT,证明前扣带回皮层(ACC)星形胶质细胞的 Gi 通路激活会导致决策能力一贯良好的大鼠决策能力受损。另一方面,前扣带回皮层星形胶质细胞 Gq 通路激活可改善决策能力不佳的亚组大鼠的决策能力。此外,我们还发现星形胶质细胞 Gq 的激活与 ACC 细胞外液中 L-乳酸盐水平的增加有关。这些结果拓展了我们对星形胶质细胞 GPCR 信号在调节认知功能中的作用的认识。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信