Oxford open neuroscience最新文献_第5页

Serotonin facilitates late-associative plasticity via synaptic tagging/cross-tagging and capture at hippocampal CA2 synapses in male rats. 羟色胺通过突触标记/交叉标记和捕获雄性大鼠海马CA2突触促进晚期关联可塑性的形成

Oxford open neuroscience Pub Date : 2022-05-04 eCollection Date: 2022-01-01 DOI: 10.1093/oons/kvac002

Amrita Benoy, Lik-Wei Wong, Niha Ather, Sreedharan Sajikumar

{"title":"Serotonin facilitates late-associative plasticity via synaptic tagging/cross-tagging and capture at hippocampal CA2 synapses in male rats.","authors":"Amrita Benoy, Lik-Wei Wong, Niha Ather, Sreedharan Sajikumar","doi":"10.1093/oons/kvac002","DOIUrl":"10.1093/oons/kvac002","url":null,"abstract":"Synaptic plasticity in the hippocampal Cornu Ammonis (CA) subfield, CA2, is tightly regulated. However, CA2 receives projections from several extra-hippocampal modulatory nuclei that release modulators that could serve to fine-tune plasticity at CA2 synapses. Considering that there are afferent projections from the serotonergic median raphe to hippocampal CA2, we hypothesized that the neuromodulator serotonin (5-hydroxytryptamine; 5-HT) could modulate CA2 synaptic plasticity. Here, we show that bath-application of serotonin facilitates the persistence of long-term depression (LTD) at the CA3 Schaffer collateral inputs to CA2 neurons (SC-CA2) when coupled to a weak low frequency electrical stimulation, in acute rat hippocampal slices. The observed late-LTD at SC-CA2 synapses was protein synthesis- and N-methyl-D-aspartate receptor (NMDAR)-dependent. Moreover, this late-LTD at SC-CA2 synapses paves way for the associative persistence of transient forms of LTD as well as long-term potentiation to long-lasting late forms of plasticity through synaptic tagging and cross-tagging respectively, at the entorhinal cortical synapses of CA2. We further observe that the 5-HT-mediated persistence of activity-dependent LTD at SC-CA2 synapses is blocked in the presence of the brain-derived neurotrophic factor scavenger, TrkB/Fc.","PeriodicalId":74386,"journal":{"name":"Oxford open neuroscience","volume":"1 1","pages":"kvac002"},"PeriodicalIF":0.0,"publicationDate":"2022-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10913837/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"61458811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Non-autonomous regulation of neurogenesis by extrinsic cues: a Drosophila perspective. 外在线索对神经发生的非自主调控：果蝇的视角。

Oxford open neuroscience Pub Date : 2022-05-04 eCollection Date: 2022-01-01 DOI: 10.1093/oons/kvac004

Phuong-Khanh Nguyen, Louise Y Cheng

引用次数: 0

A pragmatic reevaluation of the efficacy of nonhuman primate optogenetics for psychiatry. 非人类灵长类动物光遗传学对精神病学疗效的实用再评价

Oxford open neuroscience Pub Date : 2022-04-29 eCollection Date: 2022-01-01 DOI: 10.1093/oons/kvac006

Eliza Bliss-Moreau, Vincent D Costa, Mark G Baxter

{"title":"A pragmatic reevaluation of the efficacy of nonhuman primate optogenetics for psychiatry.","authors":"Eliza Bliss-Moreau, Vincent D Costa, Mark G Baxter","doi":"10.1093/oons/kvac006","DOIUrl":"10.1093/oons/kvac006","url":null,"abstract":"Translational neuroscience is committed to generating discoveries in the laboratory that ultimately can improve human lives. Optogenetics has received considerable attention because of its demonstrated promise in rodent brains to manipulate cells and circuits. In a recent report, Tremblay et al. [28] introduce an open resource detailing optogenetic studies of the nonhuman primate (NHP) brain and make robust claims about the translatability of the technology. We propose that their quantitative (e.g. a 91% success rate) and theoretical claims are questionable because the data were analyzed at a level relevant to the rodent but not NHP brain. Injections were clustered within a few monkeys in a few studies in a few brain regions, and their definitions of success were not clearly relevant to human neuropsychiatric disease. A reanalysis of the data with a modified definition of success that included a behavioral and biological effect revealed a 62.5% success rate that was lower when considering only strong outcomes (53.1%). This calls into question the current efficacy of optogenetic techniques in the NHP brain and suggests that we are a long way from being able to leverage them in 'the service of patients with neurological or psychiatric conditions' as the Tremblay report claims.","PeriodicalId":74386,"journal":{"name":"Oxford open neuroscience","volume":" ","pages":"kvac006"},"PeriodicalIF":0.0,"publicationDate":"2022-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10939311/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49083513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adolescent fluoxetine exposure increases ERK-related signaling within the prefrontal cortex of adult male Sprague-Dawley rats. 青少年氟西汀暴露增加了成年雄性Sprague-Dawley大鼠前额皮质内erk相关信号。

Oxford open neuroscience Pub Date : 2022-01-01 DOI: 10.1093/oons/kvac015

Anapaula Themann, Minerva Rodriguez, Israel Garcia-Carachure, Omar Lira, Sergio D Iñiguez

引用次数: 2