Osteoarthritis imaging最新文献

{"title":"Associations between habitual walking speed and in vivo tibial cartilage strain in individuals with anterior cruciate ligament reconstruction","authors":"Caroline Lisee ,&nbsp;David Lalush ,&nbsp;Cortney Armitano-Lago ,&nbsp;Elizabeth Bjornsen ,&nbsp;Jason R. Franz ,&nbsp;Jeffrey T. Spang ,&nbsp;Matthew E. Dausch ,&nbsp;Brian Pietrosimone","doi":"10.1016/j.ostima.2025.100390","DOIUrl":"10.1016/j.ostima.2025.100390","url":null,"abstract":"<div><h3>Objectives</h3><div>The purpose of the study was to determine associations between habitual walking speed and an in vivo magnetic resonance imagining (MRI) measure of tibial cartilage strain following primary anterior cruciate ligament reconstruction (ACLR).</div></div><div><h3>Methods</h3><div>Habitual walking speed was collected over ground in 12 individuals (5 Males/7 Females). Participants underwent an MRI of their ACLR knee to capture resting tibial articular cartilage thickness. Following the MRI, participants walked on a treadmill at their habitual walking speed for 3000 steps. Cartilage thickness was calculated for pre-loading and post-loading across the entire articulating surface and strain maps were created by calculating the change in thickness from pre- to post-loading thickness. Average cartilage strain was calculated in 6 evenly divided regions of interest (ROI) of the medial and lateral tibial cartilage. Spearman’s rank correlations and 95 % confidence intervals (CIs) (ρ) were used to assess associations between habitual walking speed and average tibial articular cartilage strain in each ROI.</div></div><div><h3>Results</h3><div>Slower habitual walking speed was moderately associated with greater strain in medial central inner tibial cartilage region (ρ=-0.67, <em>95 %CI=[-90,-0.14]</em>). All other associations between cartilage strain and medial (ρ range= -0.30 to 0.06, <em>95 %CI</em> range=-0.75 to 0.62) or lateral (ρ range= -0.42 to 0.28, <em>95 %CI</em> range=-0.81 to 0.74) tibial cartilage ROIs were weak to moderate.</div></div><div><h3>Conclusion</h3><div>Our study demonstrates a measurable in vivo link between slower habitual walking speeds and greater cartilage strain, which provides further rationale for evaluating the mechanistic link between modifying habitual walking speed to influence important biophysical changes in cartilage health.</div></div>","PeriodicalId":74378,"journal":{"name":"Osteoarthritis imaging","volume":"6 1","pages":"Article 100390"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147552487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing intra-rater reliability of peripheral quantitative computed tomography in knee joint bone evaluation on individuals with and without obesity: A GRRAS study","authors":"Reece Blay ,&nbsp;Christopher Wichman ,&nbsp;Yvonne M. Golightly ,&nbsp;Laura Bilek","doi":"10.1016/j.ostima.2026.100393","DOIUrl":"10.1016/j.ostima.2026.100393","url":null,"abstract":"<div><h3>Objective</h3><div>Common imaging approaches for knee osteoarthritis (KOA) do not reliably assess early bone changes. Obesity is a major KOA risk factor and can complicate imaging due to positioning and image quality. This pilot study primarily aimed to assess the intra-rater reliability of peripheral quantitative computed tomography (pQCT) for evaluating bone at the distal femur and proximal tibia, with a secondary objective of comparing reliability metrics between individuals with and without obesity.</div></div><div><h3>Design</h3><div>52 participants (81% female, mean age 50 [range 23-79] years) were matched by body mass index (BMI) (obese: BMI ≥ 30 kg/m², non-obese: BMI &lt; 30 kg/m²), within ± 5 years of age, sex, and &gt;5 kg/m² BMI difference. A single technician acquired two independent pQCT scans (Stratec XCT 3000) of the right tibiofemoral joint during one visit. Reliability was assessed using coefficient of variation root mean squared (CV_rms), reliability coefficient (R), and Bland-Altman analyses for repeated bone density (total, trabecular, cortical) and cross-sectional area (CSA) measures overall and by obesity group.</div></div><div><h3>Results</h3><div>pQCT demonstrated no systematic bias overall, with no substantial differences in reliability between obesity groups. Density measures showed excellent precision at all tibial regions and the medial femoral condyle. Tibial CSA measures showed no systematic bias but low precision. CSA measures at the medial femoral condyle were unreliable, and all measures at the lateral femoral condyle were unreliable due to inconsistent image capture.</div></div><div><h3>Conclusion</h3><div>pQCT is a potential tool to reliably detect early KOA-related bone changes, with no substantial differences in reliability between individuals with and without obesity.</div></div>","PeriodicalId":74378,"journal":{"name":"Osteoarthritis imaging","volume":"6 1","pages":"Article 100393"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147552488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disruption of the microenvironmental ecosystem in subchondral bone marrow lesions: Roles in osteoarthritis pathophysiology, pain and progression","authors":"Ali Mobasheri ,&nbsp;João Henriques ,&nbsp;Jamie E. Collins","doi":"10.1016/j.ostima.2025.100374","DOIUrl":"10.1016/j.ostima.2025.100374","url":null,"abstract":"<div><div>This narrative review explores the role of subchondral bone in the pathophysiology of osteoarthritis (OA), emphasizing the biomechanical and biochemical contributions that it makes to disease progression. A fresh perspective is presented by the authors in the form of a novel hypothesis that implicates mechano-inflammatory disruption of the bone marrow (BM) microenvironmental ecosystem (BM niche), unresolved inflammation, and fibrosis as key drivers of OA pathogenesis and pain. BMLs, detectable via magnetic resonance imaging (MRI), serve as dynamic imaging biomarkers that correlate with pain severity and structural deterioration, making them valuable in patient stratification for enhanced clinical trials and more effective therapeutic monitoring. Persistent inflammation within the BM microenvironmental niche exacerbates nociceptive signaling and structural joint damage. The parallels between OA, hematopoietic malignancies and immunological disorders of the BM underscore the potential for targeting inflammatory and fibrotic pathways within the BM niche as novel therapeutic strategies. Additionally, obesity-associated BM dysfunction raises the prospect of weight-loss interventions, including GLP-1 receptor agonists, as potential disease-modifying approaches for OA. We propose that the future research agenda should focus on integrating imaging biomarkers with genomic, molecular and clinical data to explore alterations in the BM microenvironmental ecosystem. This new knowledge may refine precision medicine strategies, improve early detection, enhance prognostic monitoring and develop targeted therapies aimed at successful modification of OA progression and effective control of pain mechanisms.</div></div>","PeriodicalId":74378,"journal":{"name":"Osteoarthritis imaging","volume":"6 1","pages":"Article 100374"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147552489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: Special issue imaging and pain","authors":"Mohamed Jarraya ,&nbsp;Mylène P Jansen","doi":"10.1016/j.ostima.2026.100392","DOIUrl":"10.1016/j.ostima.2026.100392","url":null,"abstract":"","PeriodicalId":74378,"journal":{"name":"Osteoarthritis imaging","volume":"6 1","pages":"Article 100392"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147552486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Healthy knee asymmetry is a potential risk factor for knee osteoarthritis: Data from the osteoarthritis initiative","authors":"Mikael J. Turunen ,&nbsp;Alexander Paz ,&nbsp;Lauri Stenroth ,&nbsp;Santtu Mikkonen ,&nbsp;Mimmi K. Liukkonen ,&nbsp;Mika E. Mononen","doi":"10.1016/j.ostima.2025.100385","DOIUrl":"10.1016/j.ostima.2025.100385","url":null,"abstract":"<div><h3>Objective</h3><div>Commonly used grading systems in knee osteoarthritis (OA) evaluation provide an overview of the disease severity with limited prognostic ability. Recently, efforts towards automated and objective deep- and machine-learning, and computational modeling-based prediction tools have been made, but they are complex and lack interpretability. This study aimed to identify knee joint morphology measures that can be easily quantified from plain radiographs and are indicative of the risk of radiographic OA development among subjects without definite radiographic OA, focusing especially on the asymmetry of the knees.</div></div><div><h3>Materials and Methods</h3><div>Knee joint dimensions and angles were measured from anterior-posterior weight-bearing knee radiographs at baseline and 8-year follow-up time point. The subjects were grouped based on Kellgren-Lawrence grades at the 8-year follow-up and compared with regard to the knee joint dimensions and angles and their asymmetries between the subjects’ knees.</div></div><div><h3>Results</h3><div>Absolute dimensions or angles at baseline were not associated with OA development. Instead, the asymmetry in the dimensions (relative difference between the left and right knee), was higher in subjects who developed radiographic knee OA during 8-year follow-up. The medial joint space asymmetry was associated with the development of advanced knee OA when it was over 10 % (OR = 1.87) or 15 % (OR = 3.27).</div></div><div><h3>Conclusions</h3><div>Medial joint space asymmetry between the left and right knee of over 10 % could be a potential risk factor for developing knee OA.</div></div>","PeriodicalId":74378,"journal":{"name":"Osteoarthritis imaging","volume":"5 4","pages":"Article 100385"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145712169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analytic challenges in defining structural phenotypes in OA clinical trials: a perspective","authors":"Samantha Chin ,&nbsp;Jamie E. Collins","doi":"10.1016/j.ostima.2025.100273","DOIUrl":"10.1016/j.ostima.2025.100273","url":null,"abstract":"<div><div>Knee osteoarthritis (OA) is a disease that can cause substantial pain and disability in patients. The progression of OA has been linked to inflammatory, mechanical, genetic, and metabolic factors, yet patterns of symptoms and structural damage vary considerably between knee OA patients. The heterogeneity of the disease presents a need for identifying and understanding patient subgroups to inform more personalized treatments. Identifying anatomical morphotypes, a type of classification defined by anatomical and morphological attributes, is critical for identifying subgroups of patients who are most likely to benefit from particular treatments. Cluster analysis is an unsupervised learning method that can be used to uncover subgroups in datasets without labeled outcomes to guide the analysis. In this perspective, we will review analytic challenges in identifying anatomical morphotypes using clustering methods, including finding patterns that are not clinically relevant, navigating the unique correlation structure of anatomical data, and working with high dimensional data. With the exciting applications of clustering methods to improve personalized medicine in knee OA, it is essential to consider these analytic challenges to ensure that analyses yield clinically actionable insights.</div></div>","PeriodicalId":74378,"journal":{"name":"Osteoarthritis imaging","volume":"5 4","pages":"Article 100273"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145712170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum regarding missing Declaration of interests and Ethical approval statements in the previously published articles","authors":"","doi":"10.1016/j.ostima.2025.100375","DOIUrl":"10.1016/j.ostima.2025.100375","url":null,"abstract":"","PeriodicalId":74378,"journal":{"name":"Osteoarthritis imaging","volume":"5 4","pages":"Article 100375"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145712500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative evaluation of weight-bearing cone beam CT arthrography and supine 3T MRI in knee osteoarthritis","authors":"Antti Kemppainen ,&nbsp;Vilja Kotkaranta ,&nbsp;Olli Nykänen ,&nbsp;Mika T. Nevalainen","doi":"10.1016/j.ostima.2025.100382","DOIUrl":"10.1016/j.ostima.2025.100382","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the agreement of cone-beam computed tomography arthrography (CBCTA) and magnetic resonance imaging (MRI) in detecting osteoarthritic changes of the knee.</div></div><div><h3>Design</h3><div>This comparative study included 58 knee joints in 54 symptomatic subjects with suspicion of knee osteoarthritis (OA). The symptomatic joints were imaged using CBCTA and 3T MRI and graded using the MRI Osteoarthritis Knee Score (MOAKS). Agreement between modalities was assessed using prevalence and bias adjusted kappa (PABAK), percentages of exact (PEA) and close agreement (PCA) of ±1 in MOAKS grades and participant-specific comparisons.</div></div><div><h3>Results</h3><div>CBCTA was performed with acceptable intra-articular concentration in 86.2 % (<em>n</em> = 50) knees in 48 subjects (68.6 % women, mean age 58.7 years). Definite tibiofemoral and patellofemoral OA was identified on MRI in 76 % (<em>n</em> = 38). For all cartilage lesions, PABAKs ranged between 0.80 and 0.96 (mean 0.90), with mean PEAs of 68.4 % and mean PCAs of 90.2 %. Full-thickness cartilage lesions demonstrated particularly strong agreement. Osteophyte detection yielded PABAKs between 0.92 and 0.98 (mean 0.95), mean PEA of 65.8 % and mean PCA of 99 %. For meniscal pathology, PABAKs ranged from 0.84 to 0.98 (mean 0.90), with mean PCA of 74.7 % and mean PEA of 81.7 %. For the anterior cruciate ligament, Baker cyst, and synovial hypertrophy, PABAKs were 0.97, 0.63, and 0.65, with high PEAs.</div></div><div><h3>Conclusions</h3><div>CBCTA demonstrates moderate to almost perfect agreement with 3T MRI for knee OA findings. Although 13.8 % of the arthrographies had failed in our study, CBCTA offers a practical alternative when MRI is contraindicated or unavailable.</div></div>","PeriodicalId":74378,"journal":{"name":"Osteoarthritis imaging","volume":"5 4","pages":"Article 100382"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145712498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of quantified knee positioning on the measurement of minimal joint space width using statistical shape models: A cross-sectional and longitudinal analysis in the IMI-APPROACH","authors":"Eva A. Bax ,&nbsp;H. Chien Nguyen ,&nbsp;Roel J.H. Custers ,&nbsp;Vahid Arbabi ,&nbsp;Hassan Rayegan ,&nbsp;Willem Paul Gielis ,&nbsp;Claudia Lindner ,&nbsp;Tim F. Cootes ,&nbsp;Margreet Kloppenburg ,&nbsp;Francisco J Blanco ,&nbsp;Ida K. Haugen ,&nbsp;Francis Berenbaum ,&nbsp;Mylène P. Jansen ,&nbsp;Simon C. Mastbergen ,&nbsp;Frank W. Roemer ,&nbsp;Felix Eckstein ,&nbsp;Wolfgang Wirth ,&nbsp;Moyo C. Kruyt ,&nbsp;Harrie Weinans","doi":"10.1016/j.ostima.2025.100357","DOIUrl":"10.1016/j.ostima.2025.100357","url":null,"abstract":"<div><h3>Objective</h3><div>Correlations between minimum joint space width (mJSW) and MRI-based cartilage thickness are strong in cross-sectional analyses and moderate in longitudinal analyses, possibly due to knee rotation and flexion. This study investigates the effect of knee positioning during radiographic acquisition on the difference between mJSW and MRI-based cartilage thickness.</div></div><div><h3>Methods</h3><div>Radiographic mJSW from the index knee was determined from baseline (265 patients) and 24-month follow-up (165 patients) on fixed-flexion radiographs from IMI-APPROACH (multicenter OA study) patients using automated software. Statistical Shape Models were used to quantify knee rotation and flexion on radiographs. Cartilage thickness was assessed by manual segmentation from MRI. Differences between mJSW (radiographs) and cartilage thickness (MRI) were assessed at baseline and follow-up. Multivariable linear regression was used to evaluate the impact of knee flexion and rotation on the difference between mJSW and cartilage thickness.</div></div><div><h3>Results</h3><div>In cross-sectional analysis, differences between X-ray and MRI were significantly influenced by knee rotation (β = -0.18, P &lt; 0.001). Longitudinal change in differences between X-ray and MRI were associated with changes in knee flexion (β = 0.19, P=0.002). Increases of one standard deviation in internal rotation and extension at follow-up resulted in a 0.2 mm false surrogate measurement of cartilage changes on radiographs.</div></div><div><h3>Conclusion</h3><div>Quantified knee positioning significantly affects differences between mJSW measured on radiographs and MRI-based cartilage thickness. The longitudinal analyses revealed that knee flexion was related to these differences, while knee rotation was only related to cross-sectional differences. These findings highlight the importance of knee positioning during radiographic acquisition in contributing to false surrogate measurement of cartilage status and cartilage change.</div></div>","PeriodicalId":74378,"journal":{"name":"Osteoarthritis imaging","volume":"5 4","pages":"Article 100357"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145712502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Superb microvascular imaging in the assessment of persistent synovitis after anterior cruciate ligament reconstruction","authors":"Emily K Wright ,&nbsp;Stacy E Smith ,&nbsp;Molly Zgoda ,&nbsp;Eric M Berkson ,&nbsp;Simon Goertz ,&nbsp;Morgan H Jones ,&nbsp;Elizabeth G Matzkin ,&nbsp;Bethany Wilcox ,&nbsp;Christian Lattermann ,&nbsp;Cale Jacobs","doi":"10.1016/j.ostima.2025.100378","DOIUrl":"10.1016/j.ostima.2025.100378","url":null,"abstract":"<div><h3>Objective</h3><div>The purposes of this study were to evaluate the prevalence of persistent postoperative synovitis three months after anterior cruciate ligament reconstruction (ACLR) using ultrasonographic superb microvascular imaging (SMI) and evaluate the intra-rater reliability of SMI synovitis and the level of agreement with other ultrasound synovitis assessment methods.</div></div><div><h3>Design</h3><div>Twenty-three individuals who had undergone primary ACLR took part in this prospective, IRB-approved study (11 females, 12 males; age=28.7±9.7 y; BMI=25.6±3.3 kg/m²). Three months after surgery, longitudinal and transverse ultrasound scans of the suprapatellar recess were performed at midline, medial to midline, and lateral to the midline. In addition to Power Doppler and B mode measures of synovitis and effusion, SMI was graded on two separate occasions at least two weeks apart. SMI intra-rater reliability was assessed with weighted Kappa analyses, and Kappa analyses were also used to assess the agreement between SMI synovitis and Power Doppler synovitis and B mode effusion.</div></div><div><h3>Results</h3><div>Three months following ACLR, 2 (8.7%) participants had no SMI synovitis, 9 (39.1%) participants had mild synovitis, and 12 (52.2%) had moderate synovitis. SMI synovitis grades demonstrated excellent intra-rater reliability (Kappa=0.93 [95%CI: 0.80, 1.06]) but demonstrated little agreement with Power Doppler synovitis grades (Kappa=0.29) or B mode effusion grades (Kappa=0.14).</div></div><div><h3>Conclusions</h3><div>Persistent postoperative synovitis was common with half of patients demonstrating moderate synovitis. SMI synovitis grading was reliable, but little agreement was noted between SMI and other ultrasound grades of synovitis or effusion suggesting that the different techniques are identifying distinct features of postoperative inflammation.</div></div>","PeriodicalId":74378,"journal":{"name":"Osteoarthritis imaging","volume":"5 4","pages":"Article 100378"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145712110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}