Osteoarthritis imaging最新文献

{"title":"Trapeziometacarpal joint movement during pinching measured by ultrasonography","authors":"David B. Jordan ,&nbsp;Sohail Daulat ,&nbsp;Trevour Greene ,&nbsp;John C. Elfar ,&nbsp;C. Kent Kwoh ,&nbsp;Zong-Ming Li","doi":"10.1016/j.ostima.2024.100252","DOIUrl":"10.1016/j.ostima.2024.100252","url":null,"abstract":"<div><h3>Objective</h3><div>Functional hand activity induces complex motion of the trapeziometacarpal (TMC) joint. Analyzing the TMC joint motion in vivo can aid in understanding joint behavior and lead to advancements in joint health evaluation. The purpose of this study was to quantify TMC joint motion during pinching using ultrasonography.</div></div><div><h3>Design</h3><div>Healthy participants (<em>n</em> = 10) held a pinch meter in key pinch configuration and pinched to three prescribed force levels. Ultrasonography was used to record the motion of the TMC joint. The position and rotation of the first metacarpal were calculated. Repeated measures one-way ANOVAs were used for comparisons (α = 0.05).</div></div><div><h3>Results</h3><div>When the pinch force was increased from 0 to 10, 20 and 30 N, the first metacarpal translated in the dorsal(+)/volar(-) direction -0.3 mm [95 % CI: (-0.5 mm, -0.1 mm); <em>p</em> = 0.0151], -0.5 mm [95 % CI: (-0.8 mm, -0.1 mm); <em>p</em> = 0.0113] and -0.8 mm [95 % CI: (-1.4 mm, -0.2 mm); <em>p</em> = 0.0146]. Significance was not observed for proximal(+)/distal(-) translation (<em>p</em> = 0.224). The metacarpal rotated in the abduction(+)/adduction(-) direction 0.7° [95 % CI: (-0.8°, 2.1°); <em>p</em> = 0.3239], 2.6° [95 % CI: (0.1°, 5.1°); <em>p</em> = 0.0416] and 3.3° [95 % CI: (0.2°, 6.3°); <em>p</em> = 0.0393], at pinch forces of 10, 20 and 30 N, respectively.</div></div><div><h3>Conclusions</h3><div>The TMC joint undergoes volar translation and abduction rotation during pinch tasks. Ultrasonography can be used to quantify this motion and aid in the advancement of joint behavioral study.</div></div>","PeriodicalId":74378,"journal":{"name":"Osteoarthritis imaging","volume":"4 4","pages":"Article 100252"},"PeriodicalIF":0.0,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142593279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Standardized maps – an emerging approach to leverage quantitative information in knee imaging","authors":"Paul Margain ,&nbsp;Julien Favre ,&nbsp;Brigitte M. Jolles ,&nbsp;Patrick Omoumi","doi":"10.1016/j.ostima.2024.100251","DOIUrl":"10.1016/j.ostima.2024.100251","url":null,"abstract":"<div><h3>Objective</h3><div>Property maps, which capture spatial variations across the entire joint, are emerging as a powerful means for extracting and analyzing quantitative information from knee 3D imaging datasets, particularly from CT and MRI data. This perspective paper aims to discuss the processing pipelines used so far, as well as the results they have enabled with respect to osteoarthritis.</div></div><div><h3>Design</h3><div>The key methodological steps for obtaining property maps, including segmentation, property calculation, and standardization are presented and analysis methods are discussed. Representative studies are also examined to illustrate the state-of-the-art in this field.</div></div><div><h3>Results</h3><div>Three main processing pipelines have been used, with the segmentation, property calculation, and standardization steps occurring in different orders. Many methods have been successfully considered for ordering these steps, without any looking generally preferable to the others. Thanks to recent advances in segmentation and standardization techniques, routine processing of property maps appears conceivable in the near future. Maps have been analyzed for multiple purposes, including group comparisons, pattern recognition, and cross-property modelling. Mostly maps of cartilage thickness and composition, as well as maps of bone shape and mineral density have been reported. They revealed distinct patterns associated with osteoarthritis severity, achieved high diagnostic accuracy, and identified relationships among tissue properties.</div></div><div><h3>Conclusions</h3><div>Property maps represent a promising approach for leveraging the extensive information in imaging data. They are particularly interesting for standardizing complex spatial variations in tissue properties, enabling global analysis and modelling. Once challenging to obtain and interpret, current mapping methods are being improved to the point that property maps may well be in routine use in the near future.</div></div>","PeriodicalId":74378,"journal":{"name":"Osteoarthritis imaging","volume":"4 4","pages":"Article 100251"},"PeriodicalIF":0.0,"publicationDate":"2024-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142531492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"3D bone shape from CT-scans provides an objective measure of osteoarthritis severity: Data from the IMI-APPROACH study","authors":"James M Burlison ,&nbsp;Michael A Bowes ,&nbsp;Philip G Conaghan ,&nbsp;Alan D Brett","doi":"10.1016/j.ostima.2024.100250","DOIUrl":"10.1016/j.ostima.2024.100250","url":null,"abstract":"<div><div>Decisions regarding total knee arthroplasty are usually made using a patient's own assessment of pain and the structural disposition of the joint as seen on plain film radiographs. Pain severity can fluctuate, and radiographs can be misleading, with the apparent joint status affected by anatomical orientation. An important component of the surgical management of knee osteoarthritis (OA) is the timing of surgical intervention: knee arthroplasty performed too early in the course of the disease may increase the need for revision surgery.</div><div>Femoral 3D bone shape (B-score) from MR images is an objective measure of OA severity and has been correlated with current and future risk of pain. We aimed to derive the B-score from CT images and compare it against the B-score derived from MR images.</div><div>We used baseline and 24-month image data from the IMI-APPROACH 2-year prospective cohort study, comprising pairs of CT and MR images taken for each subject-timepoint. The femur was automatically segmented in both CT and MR modalities using an active appearance model, a machine-learning method, to measure the B-score. Linear regression was used to test for correlation between measures. Limits of agreement and bias were tested using Bland-Altman analysis.</div><div>CT-MR pairs of the same knee were available from 424 participants (78 % women). B-scores from CT and MR were strongly correlated (CCC = 0.980) with negligible bias of 0.0106 (95 % CI: −0. 0281, +0.0493).</div><div>The strong correlation and small B-score bias suggests that B-scores may be measured reliably using CT images. Since CT images are used in planning robot-assisted knee arthroplasty, with further study B-scores derived from CT surgical planning images could in principle provide a useful objective input to deciding the appropriateness, timing and type of knee arthroplasty.</div></div>","PeriodicalId":74378,"journal":{"name":"Osteoarthritis imaging","volume":"4 4","pages":"Article 100250"},"PeriodicalIF":0.0,"publicationDate":"2024-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772654124000849/pdfft?md5=da3a83169bad1fab4cc816775163312d&pid=1-s2.0-S2772654124000849-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142315842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Weight bearing 3-D joint space width distribution at the knee varies according to location and extent of meniscal extrusion: A MOST investigation","authors":"S.E. Ghobrial ,&nbsp;C.J. Tonkin ,&nbsp;N.A. Segal ,&nbsp;A.H. Gee ,&nbsp;G.M. Treece ,&nbsp;J.A. Lynch ,&nbsp;M.C. Nevitt ,&nbsp;K.E.S. Poole ,&nbsp;F.W. Roemer ,&nbsp;A. Guermazi ,&nbsp;T.D. Turmezei","doi":"10.1016/j.ostima.2024.100246","DOIUrl":"10.1016/j.ostima.2024.100246","url":null,"abstract":"<div><h3>Objective</h3><div>Extrusion of the meniscus is known to be a key factor in the development of knee osteoarthritis. Here, we investigate the precise relationship between meniscal extrusion and weight bearing 3-D joint space width (JSW) distribution.</div></div><div><h3>Design</h3><div>Weight-bearing computed tomography (WBCT) images were acquired at the 144-month visit in the Multicenter Osteoarthritis Study. For each knee, 3-D JSW maps were created. MRI data from the same visit were assessed for both medial and lateral meniscal extrusion grade determined by the MRI Osteoarthritis Knee Score. Statistical parametric mapping (SPM) was used to test for any significant dependence of 3-D JSW distribution on meniscal extrusion grade by location.</div></div><div><h3>Results</h3><div>568 knees were included in the analysis. SPM demonstrated significant differences in 3-D JSW distribution according to the extent of both medial and anterior extrusion of the medial meniscus in a pattern that suggested a posteromedial shift of the femur on the tibia. Medial extrusion of the medial meniscus was also associated with significantly lower JSW across the central-to-posterior medial joint space. The low prevalence of lateral meniscus extrusion meant that results for this may be underpowered or unrepresentative.</div></div><div><h3>Conclusion</h3><div>Establishing links between 3-D JSW and meniscal extrusion is an important step in developing the clinical utility of WBCT for the evaluation of osteoarthritis. Further study is required to establish whether 3-D JSW is sensitive enough to detect meniscal extrusion before articular cartilage damage has occurred, to develop this as a biomarker for early disease.</div></div>","PeriodicalId":74378,"journal":{"name":"Osteoarthritis imaging","volume":"4 4","pages":"Article 100246"},"PeriodicalIF":0.0,"publicationDate":"2024-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142432369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantification of macrophage activity in knee synovial tissue using [18F]FEPPA positron emission tomography","authors":"Zachary J. Koudys ,&nbsp;Brent A. Lanting ,&nbsp;Garth Blackler ,&nbsp;Joseph Daniel Klapak ,&nbsp;Matthew Fox ,&nbsp;C. Thomas Appleton ,&nbsp;Jonathan D. Thiessen ,&nbsp;Matthew G. Teeter","doi":"10.1016/j.ostima.2024.100245","DOIUrl":"10.1016/j.ostima.2024.100245","url":null,"abstract":"<div><h3>Objective</h3><p>Inflammation in knee osteoarthritis (OA) is mediated primarily by synovial tissue macrophages, but non-invasive measurement of macrophage activity in vivo is a challenge. Activated macrophages markedly increase expression of the translocator protein (TSPO). In the context of other diseases TSPO-PET using the [¹⁸F]FEPPA tracer (binding to TSPO) has been reported to be an effective method for imaging macrophages in vivo. The goal of this study was to validate the use of [¹⁸F]FEPPA PET radiotracer to accurately measure macrophage activation in knee synovial tissue.</p></div><div><h3>Design</h3><p>Ten participants with late-stage OA scheduled for knee replacement surgery were recruited. Prior to surgery, 5 of the participants underwent a clinical [¹⁸F]FEPPA PET/MRI scan and the standard uptake value (SUV) in the suprapatellar synovial region was calculated. Suprapatellar synovial tissue samples were collected from all participants at the time of surgery and were imaged ex vivo with [¹⁸F]FEPPA autoradiography. Tracer uptake was compared to TSPO antibody immunostaining in serial tissue sections. The correlation between the [¹⁸F]FEPPA uptake and gold standard TSPO fluorescent intensity was measured.</p></div><div><h3>RESULTS</h3><p>The autoradiography [¹⁸F]FEPPA signal in the synovial lining was correlated with the TSPO signal in the. lining macrophages measured by immunohistochemistry (<em>r</em> = 0.81, <em>p</em> = 0.0040, CI [0.37, 0.95]). Similarly, PET/MRI scans demonstrated similar correlation between SUV in synovial tissues in vivo and in situ TSPO signal in lining macrophages {<em>r</em> = 0.90, <em>p</em> = 0.083, CI [0.086, 0.99])</p></div><div><h3>Conclusion</h3><p>[¹⁸F]FEPPA uptake in knee synovial tissue is strongly correlated to the expression of TSPO in synovial lining macrophages, suggesting that clinical [¹⁸F]FEPPA PET/MRI may be a valid measure of true macrophage activity in synovial tissues in knee OA. [¹⁸F]FEPPA may be an effective tool to assess macrophage activation both ex vivo and in vivo<em>,</em> and should be investigated further to assess its performance and measurement properties in different clinical contexts of knee OA including disease states and responses to treatment.</p></div>","PeriodicalId":74378,"journal":{"name":"Osteoarthritis imaging","volume":"4 3","pages":"Article 100245"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772654124000795/pdfft?md5=e198849a0a2076df8315d14464855381&pid=1-s2.0-S2772654124000795-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142168509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent developments in computational modelling of the knee","authors":"Kaiwen Yang,&nbsp;Marcus G. Pandy","doi":"10.1016/j.ostima.2024.100244","DOIUrl":"10.1016/j.ostima.2024.100244","url":null,"abstract":"<div><h3>Objective</h3><p>Model calculations of knee joint loading range from an assumption of perfectly rigid articular surfaces to more realistic simulations of cartilage and meniscal deformation. Rigid-body musculoskeletal models simulate knee contact mechanics using the ‘bed of springs’ method from elastic foundation theory whereas finite-element models discretise each structure into a series of interconnected elements and ascribe material properties to each element. This mini-review describes some of the most recent developments in computational modelling of knee contact mechanics and suggests possible avenues for future improvements.</p></div><div><h3>Design</h3><p>Narrative mini-review.</p></div><div><h3>Results</h3><p>Muscle and joint contact forces can be calculated synchronously at a reasonable computational cost (typically a few hours of CPU time) using rigid-body models and elastic foundation theory whereas similar calculations using fully deformable finite-element models can take several days and even weeks. The main computational expense incurred in finite-element musculoskeletal modelling is the solution of a muscle-force optimization problem.</p></div><div><h3>Conclusion</h3><p>Calculation of muscle and joint contact forces within the framework of a finite-element musculoskeletal model remains challenging. Integrating biomechanical data from human motion experiments with fully deformable finite-element models to simulate knee contact mechanics during dynamic activity is an evolving science. Future work should explore the use of efficient methods such as direct collocation to perform muscle-driven dynamic optimization simulations of movement using finite-element musculoskeletal models. Dynamic optimization may be combined with finite-element modelling to enable predictive simulations of movement so that the effects of changes in musculoskeletal anatomy on knee contact mechanics can be studied more systematically.</p></div>","PeriodicalId":74378,"journal":{"name":"Osteoarthritis imaging","volume":"4 3","pages":"Article 100244"},"PeriodicalIF":0.0,"publicationDate":"2024-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772654124000783/pdfft?md5=010d2ee559cceee7bc4708f42a2a6b34&pid=1-s2.0-S2772654124000783-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142076466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Semi-quantitative weight-bearing assessment of knee osteoarthritis: COAKS (CT Osteoarthritis Knee Score) reliability","authors":"Neil A. Segal ,&nbsp;Zehra Akkaya ,&nbsp;Justyn H Jeon ,&nbsp;Tom Turmezei","doi":"10.1016/j.ostima.2024.100243","DOIUrl":"10.1016/j.ostima.2024.100243","url":null,"abstract":"<div><h3>Objective</h3><p>Our aims were to 1) introduce the semi-quantitative CT Osteoarthritis Knee Score (COAKS); and 2) report intra- and inter-observer reproducibility.</p></div><div><h3>Design</h3><p>Weight-bearing CT (WBCT) images of 106 participants were reviewed to develop the COAKS system and create a standardized atlas. Images of 10 knees were used to train musculoskeletal radiologists with the atlas. Once trained, two radiologists independently scored 35 knees on two occasions using reformatted images in orthogonal planes. Joint space narrowing (JSN), osteophytes, subchondral cysts and subchondral sclerosis were scored (0–3 scale) in the medial tibiofemoral, lateral tibiofemoral, patellofemoral, and proximal tibiofibular compartments. Weighted kappa statistics were calculated for intra- and inter-observer reliability. Compartment feature scores were plotted as heat maps for each knee to illustrate OA severity and location.</p></div><div><h3>Results</h3><p>Scoring for nearly all features in all compartments had substantial to near-perfect reliability (0.61–1.00). Both inter- and intra-observer results combined across all compartments demonstrated near-perfect agreement for JSN (0.87 and 0.86) and subchondral cysts (0.84 for both) and substantial agreement for osteophytes (0.79 and 0.74) and subchondral sclerosis (0.66 and 0.67).</p></div><div><h3>Conclusions</h3><p>COAKS is a feasible, multiplanar, semi-quantitative, compartment-by-compartment WBCT-based knee OA scoring system that demonstrates substantial to near-perfect intra- and inter-observer reliability. The capacity of COAKS to characterize the location and severity of OA in the weight-bearing knee could enable patient stratification, selection, and longitudinal monitoring of structural disease severity in clinical trials and cohort studies.</p></div>","PeriodicalId":74378,"journal":{"name":"Osteoarthritis imaging","volume":"4 3","pages":"Article 100243"},"PeriodicalIF":0.0,"publicationDate":"2024-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772654124000771/pdfft?md5=529f86ecca65191570981943f26980f5&pid=1-s2.0-S2772654124000771-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141951044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolic bone imaging and its relationship with biomechanics","authors":"Ananya Goyal ,&nbsp;Lauren Watkins ,&nbsp;Olivia Bruce ,&nbsp;Anthony Gatti ,&nbsp;Feliks Kogan","doi":"10.1016/j.ostima.2024.100242","DOIUrl":"https://doi.org/10.1016/j.ostima.2024.100242","url":null,"abstract":"<div><h3>Objective</h3><p>This mini review delves into the mechanisms of [¹⁸F]Sodium Fluoride positron emission tomography ([¹⁸F]NaF PET), which, by interrogating areas of newly mineralizing bone, provides a valuable tool to study the joint response to loading and areas of altered whole-joint function in osteoarthritis (OA).</p></div><div><h3>Design</h3><p>The review consolidates and discusses findings from both preclinical and clinical studies that utilize [¹⁸F]NaF PET to evaluate the bone response to various loading paradigms. It also briefly reviews technical considerations for PET imaging and discusses its strong potential as a tool in the quest to understand bone metabolism in the context of loading and osteoarthritis.</p></div><div><h3>Results</h3><p>While considering previous studies, technical considerations and potential new applications of this methodology are also discussed. [¹⁸F]NaF PET/MRI reveals localized, load-related bone responses after exercise, providing insights into early OA progression. In human studies, significant increases in tracer uptake are observed in areas affected by OA pathology, driven by bone perfusion and blood volume. Future work to examine the relationship between metabolic bone response to exercise and the bone loading environment is needed.</p></div><div><h3>Conclusions</h3><p>Integrating [¹⁸F]NaF PET/MRI with advanced biomechanical modeling holds promise for guiding clinical management of OA, primarily by examining the relationship between bone, soft tissues of the joint, and loading forces.</p></div>","PeriodicalId":74378,"journal":{"name":"Osteoarthritis imaging","volume":"4 3","pages":"Article 100242"},"PeriodicalIF":0.0,"publicationDate":"2024-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S277265412400076X/pdfft?md5=5ed00bc1bc7dff299d04a806e11302f7&pid=1-s2.0-S277265412400076X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141605423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A minireview of four-dimensional CT and joint biomechanics","authors":"Elena Ghotbi ,&nbsp;Hamza Ahmed Ibad ,&nbsp;Roham Hadidchi ,&nbsp;Francis Baffour ,&nbsp;Shadpour Demehri","doi":"10.1016/j.ostima.2024.100241","DOIUrl":"10.1016/j.ostima.2024.100241","url":null,"abstract":"<div><p>Since its introduction, four dimensional computed tomography (4D CT) has improved the precision of a variety of diagnostic challenges such as radiation therapy in oncology and has also been expanded into cardiovascular assessments as well. Its use in musculoskeletal imaging marks a breakthrough in peripheral joint imaging, enabling detailed analysis of joint biomechanics and stability across various joints such as the knee, wrist, shoulder, and ankle. Studies employing 4D CT have offered new insights into normative and altered joint biomechanics, contributing to the diagnosis of joint pathologies and aiding in surgical planning. Looking ahead, artificial intelligence and photon-counting CT systems are poised to further refine 4D CT's capabilities, potentially leading to personalized diagnostic and therapeutic approaches based on individualized biomechanical characteristics. This review delves into the transformative role of four-dimensional computed tomography in musculoskeletal imaging, particularly its applications in understanding joint biomechanics.</p></div>","PeriodicalId":74378,"journal":{"name":"Osteoarthritis imaging","volume":"4 3","pages":"Article 100241"},"PeriodicalIF":0.0,"publicationDate":"2024-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772654124000758/pdfft?md5=666c7c178a569653b57e78b179c9b0b6&pid=1-s2.0-S2772654124000758-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141638647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fluoroscopy: Taking a closer look at joint motion in osteoarthritis","authors":"N.B.J. Dur ,&nbsp;M.G.H. Wesseling ,&nbsp;E.M. Macri ,&nbsp;J. Runhaar","doi":"10.1016/j.ostima.2024.100240","DOIUrl":"https://doi.org/10.1016/j.ostima.2024.100240","url":null,"abstract":"<div><h3>Background</h3><p>Knowledge of joint biomechanics is crucial for understanding the pathophysiology of osteoarthritis (OA). Biomechanical changes, especially in early-stage OA, are subtle and therefore require highly accurate and precise ways of measuring joint loading (i.e., forces) and kinematics (i.e., motion). Most OA research investigating kinematics to date using conventional measurement methods, has been restricted either to measures of functional, weight-bearing activities with limited precision, or to highly precise measures of non-functional activities. X-ray fluoroscopy, however, is a medical imaging modality that can be used to precisely measure high-speed dynamic human movement in vivo under weight-bearing conditions.</p></div><div><h3>Objective</h3><p>To illustrate the potential of fluoroscopy to measure human movement and study joint biomechanics in OA by highlighting several exemplary applications in studies on knee OA.</p></div><div><h3>Design</h3><p>We searched PubMed to identify a selection of relevant studies with fluoroscopic evaluation of joint mechanics in individuals with, or at risk of developing, knee OA.</p></div><div><h3>Results</h3><p>Fluoroscopy has been utilized in biomechanical studies in populations with early stages of knee OA or at risk of developing knee OA, as well as in studies evaluating conservative treatment strategies for knee OA. Due to its ability to capture highly accurate and precise kinematic measures, fluoroscopy holds great promise in providing new insights in the role of biomechanics in OA pathogenesis.</p></div><div><h3>Conclusions</h3><p>The use of fluoroscopy in larger cohorts and longitudinal (interventional) studies may lead to more robust and generalizable results and could clarify the mediation pathways of joint biomechanics in the onset and progression of OA.</p></div>","PeriodicalId":74378,"journal":{"name":"Osteoarthritis imaging","volume":"4 3","pages":"Article 100240"},"PeriodicalIF":0.0,"publicationDate":"2024-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772654124000746/pdfft?md5=37c3750062edc63dcb27c2aac22f8119&pid=1-s2.0-S2772654124000746-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141596576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}