American Journal of Men's Health最新文献

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Infant Sleep Behavior Practices and Knowledge of Fathers: An Exploratory and Descriptive Study. 婴儿睡眠行为实践与父亲知识:一项探索性和描述性研究。
IF 2.4 4区 医学
American Journal of Men's Health Pub Date : 2026-01-01 Epub Date: 2026-02-27 DOI: 10.1177/15579883261427173
Levi Funches, James E Slaven, Nancy Swigonski
{"title":"Infant Sleep Behavior Practices and Knowledge of Fathers: An Exploratory and Descriptive Study.","authors":"Levi Funches, James E Slaven, Nancy Swigonski","doi":"10.1177/15579883261427173","DOIUrl":"10.1177/15579883261427173","url":null,"abstract":"<p><p>Sudden unexpected infant death (SUID) is a term for any sudden death occurring under 1 year of age. SIDS (sudden infant death syndrome) is the sudden death of an infant that is unexplained after an investigation and often occurs during sleep or in the infant sleep area. In Indianapolis, 130 infants died in 2022 before their first birthday, and 17% were from SUIDs. Fathers' understanding of infant safe-sleep knowledge and behaviors is mostly unknown. This study aims to describe fathers' infant safe-sleep knowledge and behaviors. Study participants were recruited via promotional flyers from 2019 to 2024. Volunteers completed a survey on their infant safe-sleep knowledge and behaviors. Responses were entered via secure, web-based data-collection tool either directly by QR code accessible survey or manually by the research team. Frequency and comparative analyses were performed, and results described. Eighty-five fathers completed the survey. The lowest reported knowledge for safe-sleep practices was for breastfeeding, and wearable blankets being protective against SUID. A smaller percentage of fathers reported their baby never slept in the same bed as someone else and similarly reported never placing their baby to sleep in an adult bed. Fewer fathers correctly reported practicing room-sharing and pacifier usage. Interactive learning geared toward male caregivers on AAP recommendations for preventing sleep-related deaths is key. Focusing efforts with fathers on the risk of soft bedding, benefit of breastfeeding, pacifier usage, and room-sharing will be important to lowering SUID rates and helping men in their role as fathers.</p>","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"20 1","pages":"15579883261427173"},"PeriodicalIF":2.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12950853/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147300818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Epigenetic Disruption as a Molecular Signature in Idiopathic Nonobstructive Azoospermia. 表观遗传破坏作为特发性非阻塞性无精子症的分子特征。
IF 2.4 4区 医学
American Journal of Men's Health Pub Date : 2025-11-01 Epub Date: 2025-11-17 DOI: 10.1177/15579883251389793
Amir Masoud Firouzabadi, Samaneh Harimi, Parisa Heydari, Farangis Demehri, Seyyed Amir Hossein Mirghanizadeh Bafghi, Farzaneh Fesahat
{"title":"Epigenetic Disruption as a Molecular Signature in Idiopathic Nonobstructive Azoospermia.","authors":"Amir Masoud Firouzabadi, Samaneh Harimi, Parisa Heydari, Farangis Demehri, Seyyed Amir Hossein Mirghanizadeh Bafghi, Farzaneh Fesahat","doi":"10.1177/15579883251389793","DOIUrl":"10.1177/15579883251389793","url":null,"abstract":"<p><p>Idiopathic nonobstructive azoospermia (iNOA) is defined as the absence of sperm in the ejaculate with no identifiable cause after thorough physical, hormonal, and genetic evaluations. This study aimed to investigate the differential gene expression of key epigenetic regulators-<i>DNA methyltransferase (DNMT) 1 (DNMT1), DNMT3A, DNMT3B, and Zinc Finger CCHC-Type Containing 13 (ZCCHC13)</i>-in patients with iNOA compared with those with obstructive azoospermia (OA). Sixty infertile men diagnosed with azoospermia were equally divided into iNOA (case group) and OA (control group). Participants with iNOA were further subdivided into iNOA⁺ (successful sperm retrieval, <i>n</i> = 10) and iNOA⁻ (unsuccessful retrieval, <i>n</i> = 20) based on microdissection testicular sperm extraction (micro-TESE) outcomes. The relative expression of <i>DNMT1, DNMT3A, DNMT3B</i>, and <i>ZCCHC13</i> was analyzed in testicular tissue samples using quantitative real-time PCR. Expression levels of <i>DNMT1</i> and <i>ZCCHC13</i> were significantly lower in the iNOA group compared with OA (<i>p</i> = .01), while <i>DNMT3B</i> expression was significantly higher in iNOA, particularly in the iNOA⁻ subgroup (<i>p</i> < .0001). Receiver operating characteristic (ROC) analysis revealed DNMT3B had the highest diagnostic accuracy (AUC = 0.84, <i>p</i> < .0001), followed by ZCCHC13 (Area under the curve (AUC) = 0.69) and DNMT1 (AUC = 0.68). Our findings indicate that epigenetic dysregulation contributes to impaired spermatogenesis in iNOA, which can be molecularly distinguished from OA. Epigenetic biomarkers such as <i>DNMT3B</i> and <i>ZCCHC13</i> may offer reliable diagnostic tools for idiopathic cases of azoospermia and serve as potential targets for future epigenetic therapies.</p>","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"19 6","pages":"15579883251389793"},"PeriodicalIF":2.4,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12623614/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145538182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
15 Years of the National Policy for Comprehensive Men's Health Care in Brazil: Perception of Strengths and Opportunities. 巴西男子综合保健国家政策的15年:对优势和机会的认识。
IF 2.4 4区 医学
American Journal of Men's Health Pub Date : 2025-11-01 Epub Date: 2025-12-09 DOI: 10.1177/15579883251368315
Nilo Manoel Pereira Vieira Barreto, Jeferson Santos Araújo, Delmar Teixeira Gomes, Andrey Ferreira da Silva, Aurea Christina de Paula Corrêa, Álvaro Francisco Lopes de Sousa, Rosseirys Noelia De La Rosa, Johis Ortega, Álvaro Pereira, Anderson Reis de Sousa
{"title":"15 Years of the National Policy for Comprehensive Men's Health Care in Brazil: Perception of Strengths and Opportunities.","authors":"Nilo Manoel Pereira Vieira Barreto, Jeferson Santos Araújo, Delmar Teixeira Gomes, Andrey Ferreira da Silva, Aurea Christina de Paula Corrêa, Álvaro Francisco Lopes de Sousa, Rosseirys Noelia De La Rosa, Johis Ortega, Álvaro Pereira, Anderson Reis de Sousa","doi":"10.1177/15579883251368315","DOIUrl":"10.1177/15579883251368315","url":null,"abstract":"<p><p>This study aims to evaluate the strengths, opportunities, and facilitators in the implementation of the National Policy for Comprehensive Men's Health Care (PNAISH) in Brazil in response to user demands. A mixed-method approach was applied to residents across Brazil between April and July 2024 through a web survey using a semi-structured questionnaire addressing sociodemographic characteristics, engagement, and critiques of the PNAISH. The qualitative analysis employed the Collective Subject Discourse method. A total of 144 individuals participated, primarily young cisgender men, with 80.5% holding postgraduate degrees and 75.7% engaged in male health initiatives. Progress has been observed in the implementation of the PNAISH, particularly in primary care, yet challenges persist regarding policy dissemination and managerial involvement. Most respondents (77.8%) recognized strengths and facilitators in PNAISH, with 43.8% reporting its implementation at both state and municipal levels. Qualitative narratives revealed that participants perceive PNAISH as a strategic opportunity not only to engage men in preventive care but also to foster reflection on masculinities, self-care, and health promotion. Many highlighted that the policy helps to overcome cultural stigmas that traditionally distance men from health services, especially through educational actions and intersectoral strategies. While the policy has advanced access and male participation in health services, structural barriers and limited visibility still constrain its broader impact and effective engagement.</p>","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"19 6","pages":"15579883251368315"},"PeriodicalIF":2.4,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12696301/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145712930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Window of Opportunity to Address the Critical Issue of U.S. Male Longevity and Disease Burden Gaps: A Call for U.S. Federal Oversight. 解决美国男性寿命和疾病负担差距这一关键问题的机会之窗:呼吁美国联邦监管。
IF 2.4 4区 医学
American Journal of Men's Health Pub Date : 2025-11-01 Epub Date: 2025-12-06 DOI: 10.1177/15579883251400718
Salvatore J Giorgianni, Ronald K Henry
{"title":"A Window of Opportunity to Address the Critical Issue of U.S. Male Longevity and Disease Burden Gaps: A Call for U.S. Federal Oversight.","authors":"Salvatore J Giorgianni, Ronald K Henry","doi":"10.1177/15579883251400718","DOIUrl":"10.1177/15579883251400718","url":null,"abstract":"","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"19 6","pages":"15579883251400718"},"PeriodicalIF":2.4,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12682996/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145686742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Demography of Mortality Disadvantage Among Male U.S. Veterans in Later Life: New Evidence From the Health and Retirement Study. 美国男性退伍军人晚年死亡率劣势的人口统计:来自健康和退休研究的新证据。
IF 2.4 4区 医学
American Journal of Men's Health Pub Date : 2025-11-01 Epub Date: 2025-12-08 DOI: 10.1177/15579883251397903
Sven E Wilson
{"title":"The Demography of Mortality Disadvantage Among Male U.S. Veterans in Later Life: New Evidence From the Health and Retirement Study.","authors":"Sven E Wilson","doi":"10.1177/15579883251397903","DOIUrl":"10.1177/15579883251397903","url":null,"abstract":"<p><p>Using the Health and Retirement Study (HRS), this article explores the association between military service and mortality among American men over age 50 between 1992 and 2020. Cox regressions show veterans who served during wartime have consistently higher mortality than nonveterans across major conflicts of the 20th century. Peacetime service does not increase mortality significantly, but Hispanic peacetime veterans have lower mortality than other Hispanic veterans and nonveterans. Using a much larger set of survey data than has been used previously, the findings here reveal a different age profile than found in some previous research. In particular, the 50s and 60s are particularly sensitive life stages for wartime veterans, especially for the Vietnam-era veterans. Finally, this analysis suggests some potential health benefits from military service-even in wartime-but, on balance, the negative consequences of warmaking are stronger and extend well into later life.</p>","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"19 6","pages":"15579883251397903"},"PeriodicalIF":2.4,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12686381/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145699613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploration of the Prognostic Value of PANoptosis-Related Genes in Bladder Cancer. 膀胱癌panoptosis相关基因的预后价值探讨。
IF 2.4 4区 医学
American Journal of Men's Health Pub Date : 2025-11-01 Epub Date: 2025-12-26 DOI: 10.1177/15579883251404985
Jichao Tan, Yanjue Wang, Jian Huang, Bo Dong, Tao Liu, Yang Shi, Yuncheng Wu, Lihe Wang
{"title":"Exploration of the Prognostic Value of PANoptosis-Related Genes in Bladder Cancer.","authors":"Jichao Tan, Yanjue Wang, Jian Huang, Bo Dong, Tao Liu, Yang Shi, Yuncheng Wu, Lihe Wang","doi":"10.1177/15579883251404985","DOIUrl":"10.1177/15579883251404985","url":null,"abstract":"<p><p>This study systematically investigates the prognostic value and clinical significance of PANoptosis-related genes in bladder cancer (BC). By integrating the TCGA and GEO databases, two PANoptosis molecular subtypes with significant survival differences were identified, with the C2 subtype demonstrating a more favorable prognosis. A prognostic model comprising nine key genes was constructed, demonstrating robust risk stratification capabilities in both training and validation sets. Further analysis revealed that high-risk patients exhibited distinct immunosuppressive microenvironment characteristics, including enrichment of Treg cells and M2 macrophages. Single-cell sequencing analysis elucidated the cell-type-specific expression patterns of these genes within the tumor microenvironment. Experimental validation confirmed the significant overexpression of KCNJ15, FASN, and ADAMTS12 in BC tissues. The prognostic model established in this study provides a novel tool for risk stratification of BC patients while simultaneously establishing the foundation for in-depth exploration of PANoptosis mechanisms in BC.</p>","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"19 6","pages":"15579883251404985"},"PeriodicalIF":2.4,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12745600/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145832194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prostate Cancer Screening Practices Among High-Risk Patients: A Retrospective Analysis. 高危患者前列腺癌筛查实践:回顾性分析
IF 2.4 4区 医学
American Journal of Men's Health Pub Date : 2025-11-01 Epub Date: 2025-11-20 DOI: 10.1177/15579883251392440
Aditya K Ghosh, Barath P Sivasubramanian, Rana H Asif, Steven Barker, Sudha Dirisanala, Shane S Robinson, Ania Izabela Rynarzewska, Andrew Johnson
{"title":"Prostate Cancer Screening Practices Among High-Risk Patients: A Retrospective Analysis.","authors":"Aditya K Ghosh, Barath P Sivasubramanian, Rana H Asif, Steven Barker, Sudha Dirisanala, Shane S Robinson, Ania Izabela Rynarzewska, Andrew Johnson","doi":"10.1177/15579883251392440","DOIUrl":"10.1177/15579883251392440","url":null,"abstract":"<p><p>Prostate cancer is the second most common cancer in U.S. men, with higher incidence and mortality among African Americans and those with genetic or familial risk. Despite guidelines promoting early detection, prostate-specific antigen (PSA) screening in primary care remains inconsistent. We assessed PSA screening patterns and the association between risk factors and testing.A retrospective analysis was conducted on men aged ≥40 seen at primary care clinics from 2020 to 2022. Risk scores were created based on the number of prostate cancer risk factors. Univariate and multivariate analyses assessed associations between the risk scores, PSA screening, and cancer diagnosis. Of 176,326 patients, 31.4% underwent PSA testing, rising to 78.1% with a risk score of 4. The predictive model was significant (χ<sup>2</sup> = 19,527.021, <i>df</i> = 11, <i>p</i> < .001). PSA testing odds were higher with Medicaid or commercial insurance (vs. Medicare) and lower for self-pay patients. Former and never smokers were more likely to be tested than current smokers. Age, African American race, and family history increased the odds of receiving PSA testing. Prostate cancer diagnosis reached 25% at a risk score of 5, with significant predictors including older age, African American race, family history, and mention of \"prostate\" in clinical notes. PSA screening remains underused in primary care, even among high-risk patients. More risk factors were linked to higher testing rates, but African American and low-income groups were under-tested. Provider education and decision-support tools may improve guideline adherence and equity.</p>","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"19 6","pages":"15579883251392440"},"PeriodicalIF":2.4,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12638686/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145556081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Public Perceptions of Vasectomy in China: A Social Media Content Analysis of User-Generated Narratives on Rednote. 中国公众对输精管结扎术的认知:Rednote上用户生成叙事的社交媒体内容分析。
IF 2.4 4区 医学
American Journal of Men's Health Pub Date : 2025-11-01 Epub Date: 2025-12-26 DOI: 10.1177/15579883251400714
Hui-Quan Shu, Zheng-Mu Wu, Chao Feng
{"title":"Public Perceptions of Vasectomy in China: A Social Media Content Analysis of User-Generated Narratives on Rednote.","authors":"Hui-Quan Shu, Zheng-Mu Wu, Chao Feng","doi":"10.1177/15579883251400714","DOIUrl":"10.1177/15579883251400714","url":null,"abstract":"<p><p>This study examines public perceptions of vasectomy in China through a content analysis of user-generated posts on Rednote, one of the country's most influential social media platforms. A total of 106 posts published up to August 2025 were analyzed, focusing on individual experiences, decision-making processes, postoperative outcomes, and emotional tone. The results show that vasectomy is predominantly portrayed in a positive light (92.5%), with most decisions made by men themselves (57.5%). The majority of patients were married with children, but a notable proportion consisted of Dual Income No Kids (DINK) individuals, reflecting shifting fertility intentions in China. Reported complications were rare, with only a few cases of persistent pain, contraceptive failure, or repeat surgery. Engagement metrics revealed highly skewed interaction patterns, where a small number of posts drove significant discussion and visibility. Geographically, most posts originated from economically developed coastal provinces. The findings suggest that social media narratives are reshaping public discourse around vasectomy, positioning it as a legitimate, responsible contraceptive option aligned with evolving cultural norms, gender equality, and modern lifestyle choices in urban China. Nevertheless, limitations include reliance on self-reported content and the platform's demographic skew toward younger, urban populations.</p>","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"19 6","pages":"15579883251400714"},"PeriodicalIF":2.4,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12745603/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145832105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Preconception Health Behavioral Patterns and Predictors in Chinese Reproductive-Aged Men: A Latent Profile Analysis. 中国育龄男性孕前健康行为模式及其预测因素:潜在剖面分析。
IF 2.4 4区 医学
American Journal of Men's Health Pub Date : 2025-11-01 Epub Date: 2025-12-26 DOI: 10.1177/15579883251400712
Ruyu Sun, Rui Fan, Hanqian Wang, Xin Xu, Lu Li
{"title":"Preconception Health Behavioral Patterns and Predictors in Chinese Reproductive-Aged Men: A Latent Profile Analysis.","authors":"Ruyu Sun, Rui Fan, Hanqian Wang, Xin Xu, Lu Li","doi":"10.1177/15579883251400712","DOIUrl":"10.1177/15579883251400712","url":null,"abstract":"<p><p>Preconception health behaviors significantly influence pregnancy outcomes, yet patterns of these behaviors and their determinants have received limited attention, particularly among men. Understanding behavioral profiles is essential for developing targeted interventions to improve paternal reproductive health. We conducted a cross-sectional study examining over 20 guideline-recommended preconception health behaviors among 952 Chinese men. Latent profile analysis was utilized to identify different behavioral profiles. Multinomial logistic regressions assessed associations of profile membership with sociodemographic and medical history characteristics. Four distinct preconception health behavioral profiles were identified: a \"Moderate\" profile (44.0%) with scores near or slightly above the overall mean on most behaviors; a \"Vulnerable\" profile (4.5%) showing markedly negative scores across multiple behaviors; and two intermediate profiles \"Unmotivated\" (33.2%) and \"At-Risk\" (18.3%) with scores closer to average on some behaviors but notably lower on others (e.g., planning, avoidance of environmental hazards and domestic violence, treating existing diseases). Several behaviors received low scores across all profiles, including preconception check-ups, genetic screening, receiving professional preconception education, physical activity, and immunization. Lower education and unplanned pregnancy were consistently associated with at-risk behavioral profiles. Interventions must combine universal campaigns to elevate systematically neglected behaviors with targeted strategies addressing profile-specific needs. Pregnancy planning emerges as a keystone intervention opportunity. National programs require rebranding to emphasize paternal participation, while all strategies must address underlying social determinants rather than focusing solely on individual behavior change.</p>","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"19 6","pages":"15579883251400712"},"PeriodicalIF":2.4,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12745564/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145832165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluating Semen Parameters for Predictive Correlations Between Fresh and Delayed Analysis Using an At-Home Semen Collection Kit. 使用家庭精液采集试剂盒评估新鲜和延迟分析的精液参数预测相关性。
IF 2.4 4区 医学
American Journal of Men's Health Pub Date : 2025-11-01 Epub Date: 2025-12-24 DOI: 10.1177/15579883251401308
Unika Alexander, Denny Sakkas, Francisco Arredondo, Khaled Kteily, Ramy Abou Ghayda
{"title":"Evaluating Semen Parameters for Predictive Correlations Between Fresh and Delayed Analysis Using an At-Home Semen Collection Kit.","authors":"Unika Alexander, Denny Sakkas, Francisco Arredondo, Khaled Kteily, Ramy Abou Ghayda","doi":"10.1177/15579883251401308","DOIUrl":"10.1177/15579883251401308","url":null,"abstract":"<p><p>Male factor infertility contributes to nearly half of all infertility cases, yet timely semen analysis is often hindered by logistical and psychosocial barriers. The standard recommendation for in-clinic analysis within 1 hr post-ejaculation limits access, prompting interest in at-home semen collection and mail-in testing solutions. This prospective study evaluates the Give Legacy At-Home Semen Collection Kit for its ability to preserve semen quality over time and assesses whether delayed analyses (up to 48 hr post-ejaculation) can reliably predict baseline semen parameters. Thirty participants provided 60 semen samples analyzed across five timepoints (T0: 30 min, T1: 1 hr, T2: 6 hr, T3: 24 hr, T4: 30 hr). Total and progressive motility declined over time, with the greatest reductions after 6 hr. At baseline, high total motile sperm count (TOMO) individuals exhibited significantly greater motility than those in the low TOMO group and retained relatively higher motility across time points. Predictive models using delayed data (T1-T4) accurately estimated baseline motility values, with strong performance metrics (e.g., progressive motility model: mean absolute error [MAE] = 7.31, root mean squared error [RMSE] = 11.15, <i>r</i> = .86, intraclass correlation coefficient [ICC] = .74). These findings suggest that semen degradation during transit is predictable and that baseline motility can be reconstructed with clinically acceptable accuracy. This study supports the clinical utility of at-home semen collection and mail-in analysis for male fertility assessment. Predictive modeling enables diagnostic insights even when testing is delayed, expanding access while maintaining diagnostic integrity. Future research should explore broader populations and integrate additional fertility biomarkers.</p>","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"19 6","pages":"15579883251401308"},"PeriodicalIF":2.4,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12744095/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145815085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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