American Journal of Men's Health最新文献_第9页

A Study of Sperm DNA Damage Mechanism Based on miRNA Sequencing. 基于 miRNA 测序的精子 DNA 损伤机制研究

IF 2.1 4区医学

American Journal of Men's Health Pub Date : 2024-09-01 DOI: 10.1177/15579883241286672

Feng Liu, Miaomiao Ma, Luyu Li, Yongtao Zhang, Yihan Shang, Quan Yuan, Baojun Ju, Zulong Wang

{"title":"A Study of Sperm DNA Damage Mechanism Based on miRNA Sequencing.","authors":"Feng Liu, Miaomiao Ma, Luyu Li, Yongtao Zhang, Yihan Shang, Quan Yuan, Baojun Ju, Zulong Wang","doi":"10.1177/15579883241286672","DOIUrl":"10.1177/15579883241286672","url":null,"abstract":"To analyze the differential expression profiles of microRNAs (miRNAs) in spermatozoa of patients with sperm DNA damage and to investigate the role of miRNAs in sperm DNA damage. Male infertility patients with sperm DNA damage who attended the First Affiliated Hospital of Henan University of Chinese Medicine from October 2023 to December 2023 were selected and included in this study as a case group. Fertile healthy men who were seen at the health check-up center during the same period and diagnosed by examination were also included as a control group. Sperm miRNA expression was detected in patients with sperm DNA damage (case group, n = 5) and healthy medical check-ups (control group, n = 5) using high-throughput sequencing technology. The differentially expressed miRNAs between the two groups were bioinformatically analyzed to explore the main biological functions of the target genes. We found that 63 miRNAs were significantly changed in the spermatozoa of patients with sperm DNA damage,|log2 (foldchange)| ≥ 1, p < .05. Gene Ontology (GO) enrichment analysis indicated that these differential miRNAs might be involved in developmental process, anatomical structure development, cellular macromolecule metabolic process, multicellular organism development, system development, and so on. Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis showed that that they mainly affect the PI3K-AKT signaling pathway. The present study suggests that the altered expression of miR-1255a, miR-921, and miR-3156-5p may play an important role in the sperm DNA damage process, and the mechanism may involve the phosphatidylinositol-3'-kinase-AKT (PI3K-AKT) signaling pathway.","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"18 5","pages":"15579883241286672"},"PeriodicalIF":2.1,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11528732/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142492823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Creatinine and Cystatin C: A Measure of Renal Function in Men With Testosterone-Induced Muscle Hypertrophy. 肌酐和胱抑素 C睾酮诱发肌肉肥大男性的肾功能测量。

IF 2.1 4区医学

American Journal of Men's Health Pub Date : 2024-09-01 DOI: 10.1177/15579883241286654

Rani Ashouri, Amica Lertkitcharoenpon, Michael Maidaa, Bobby Brunner, Oscar Velazquez, Larry Lipshultz, Kevin Campbell

{"title":"Creatinine and Cystatin C: A Measure of Renal Function in Men With Testosterone-Induced Muscle Hypertrophy.","authors":"Rani Ashouri, Amica Lertkitcharoenpon, Michael Maidaa, Bobby Brunner, Oscar Velazquez, Larry Lipshultz, Kevin Campbell","doi":"10.1177/15579883241286654","DOIUrl":"https://doi.org/10.1177/15579883241286654","url":null,"abstract":"Creatinine (Cr) is often used as a standalone gold standard marker of kidney function. Cystatin C (Cys C) is a less physiologically labile marker of renal function, particularly in certain subgroups. Herein, we analyze trends in cystatin C as compared to creatinine in men on testosterone replacement therapy with varying body mass indices and percent body fat (PBF). This retrospective analysis observes 227 men with testosterone-induced muscle hypertrophy who visited a men's health tertiary care clinic. All participants were characterized as competitive or recreational athletes. In patients with a normal body mass index (BMI), there was no clinically significant correlation between Cr and Cys C. Slight correlation was seen with overweight (R2 = .27) patients (p < .0001) and obese (R2 = .29) patients (p < .0001). Patients with PBF of 0%-10% (n = 22) exhibited minimal (R2 = .23) positive correlation between Cys C and Cr (p = .03). Positive correlation between Cys C and Cr in patients with PBF of 10%-20% was clinically negligible (R2 = .17, n = 87), modest (R2 = .49) in patients with PBF of 20%-30% (n = 42), and evident (R2 = 1.00) in patients >30% (n = 3) (p < .0001, respectively). Cystatin C measurements display less variance compared with creatinine at differing BMI distinctions. At the upper limit of BMI or PBF in our patient population, cystatin C exhibits minimal to moderate variability compared with creatinine.","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"18 5","pages":"15579883241286654"},"PeriodicalIF":2.1,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11483778/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142455782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Behavioral Weight Management Interventions for Hispanic Men in the United States: A Systematic Review. 针对美国西班牙裔男性的行为体重管理干预：系统回顾。

IF 2.1 4区医学

American Journal of Men's Health Pub Date : 2024-09-01 DOI: 10.1177/15579883241290344

Hana R Flaxman, Noelia G Hernandez, Brian Critelli, Brittney K Chong, Karolina Sadowska, Kevin Pain, Christopher J Gonzalez

{"title":"Behavioral Weight Management Interventions for Hispanic Men in the United States: A Systematic Review.","authors":"Hana R Flaxman, Noelia G Hernandez, Brian Critelli, Brittney K Chong, Karolina Sadowska, Kevin Pain, Christopher J Gonzalez","doi":"10.1177/15579883241290344","DOIUrl":"10.1177/15579883241290344","url":null,"abstract":"Hispanic men have the highest prevalence of obesity relative to other racial and ethnic subgroups; however, this population is consistently underrepresented in weight management interventions. This systematic review aims to provide an overview of behavioral weight management interventions adapted for Hispanic men and describe their tailoring strategies and efficacy. Six online databases were selected for their abundant collection of high-quality, peer-reviewed literature and searched for studies which evaluated and reported weight outcomes for a cohort of adult (>18 years) Hispanic men. Of 6,508 unique publications screened, 12 interventions met inclusion criteria, the majority of which were published in the past 10 years. Only one study regarding an intervention tailored for Hispanic men was a randomized controlled trial adequately powered to assess a weight-based outcome; the remaining assessed feasibility or utilized quasi-experimental methods. Intervention characteristics and tailoring strategies varied considerably, but content was most frequently based on the Diabetes Prevention Program. Tailoring strategies commonly focused on improving linguistic access and incorporating social or family support. Follow-up varied from 1 month to 30 months and mean change in weight, the most common outcome, ranged from 0.6 to -6.3 kg. Our findings reveal a need for more fully powered randomized controlled trials evaluating the efficacy of interventions systematically tailored specifically for Hispanic men. Although the majority were not fully powered, these interventions showed some efficacy among their small cohorts for short-term weight loss. Future directions include exploring how to tailor goals, concepts, and metaphors included in interventions and comparing individual to group delivery settings.","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"18 5","pages":"15579883241290344"},"PeriodicalIF":2.1,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11528914/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142492824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Health Care Engagement in Disease Prevention and Management: Factors Influencing Chronic Disease Program Referral Adherence Among Non-Hispanic Black and Hispanic Men With Chronic Conditions. 医疗保健参与疾病预防和管理：影响非西班牙裔黑人和西班牙裔男性慢性病患者坚持慢性病计划的因素。

IF 2.1 4区医学

American Journal of Men's Health Pub Date : 2024-09-01 DOI: 10.1177/15579883241288978

Caroline D Bergeron, Cynthia L Cisneros Franco, Ledric D Sherman, Kristin Pullyblank, Wendy Brunner, Arica A Brandford, Chung Lin Kew, Matthew Lee Smith

{"title":"Health Care Engagement in Disease Prevention and Management: Factors Influencing Chronic Disease Program Referral Adherence Among Non-Hispanic Black and Hispanic Men With Chronic Conditions.","authors":"Caroline D Bergeron, Cynthia L Cisneros Franco, Ledric D Sherman, Kristin Pullyblank, Wendy Brunner, Arica A Brandford, Chung Lin Kew, Matthew Lee Smith","doi":"10.1177/15579883241288978","DOIUrl":"10.1177/15579883241288978","url":null,"abstract":"This study aimed to identify factors associated with being referred to an evidence-based disease prevention and management program by a health care provider and adherence to such referrals by non-Hispanic Black and Hispanic men. Utilizing a cross-sectional design, data were collected via an internet-based questionnaire from a national sample of 1,679 non-Hispanic Black and Hispanic men ages 40 years and older with one or more chronic diseases. A 105-item survey assessed program referral and attendance, chronic conditions and medications, disease symptoms, support, communication during physician visit, health care frustrations, disease self-management efficacy, barriers to self-care, helpfulness of learning from others for self-care, and sociodemographics. Binary logistic regression models were fitted to assess factors associated with referrals to a disease prevention and management program and attendance. Results indicated that approximately 23% of participants were referred to a program, and 19.2% reported attendance. Factors associated with being referred to and attending a program included being younger, having more chronic conditions, taking more medications daily, having higher pain scores, reporting more health care frustrations, and reporting better communication with physicians during visits. Men referred to attend a chronic disease program by a health care provider were 16.86 times more likely to attend a chronic disease program (p < .001). These findings suggest the importance of health care engagement for non-clinical disease prevention and management programs, particularly among non-Hispanic Black and Hispanic men with complex disease profiles.","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"18 5","pages":"15579883241288978"},"PeriodicalIF":2.1,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11526160/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142492826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Screening of the Combined Risk of Genetics and Epidemiology on Infertility Among Indian Men: Synergistic Effect of AZFc Partial Deletions and Habits of Smokeless Chewing Tobacco. 印度男性不育症遗传学和流行病学综合风险筛查：AZFc 部分缺失与无烟咀嚼烟草习惯的协同效应。

IF 2.1 4区医学

American Journal of Men's Health Pub Date : 2024-09-01 DOI: 10.1177/15579883241279195

Saurav Dutta, Pranab Paladhi, Samudra Pal, Souvik Srimani, Gunja Bose, Papiya Ghosh, Ratna Chattopadhyay, Sujay Ghosh

{"title":"Screening of the Combined Risk of Genetics and Epidemiology on Infertility Among Indian Men: Synergistic Effect of AZFc Partial Deletions and Habits of Smokeless Chewing Tobacco.","authors":"Saurav Dutta, Pranab Paladhi, Samudra Pal, Souvik Srimani, Gunja Bose, Papiya Ghosh, Ratna Chattopadhyay, Sujay Ghosh","doi":"10.1177/15579883241279195","DOIUrl":"10.1177/15579883241279195","url":null,"abstract":"The AZFc partial deletions of Y chromosome and lifestyle/epidemiological factors such as the use of smokeless chewing tobacco (SCT) exhibit intriguing variations in their association with male infertility across the population, ethnicity, and genetic background. Here, a pioneering attempt has been made to elucidate the interactions of such deletions with the habits of SCT consumption among the participating individuals, using their large epidemiological data. This screening program was conducted among Bengali-speaking men in West Bengal, India. We screened the prevalence and association of distinct partial deletions (gr/gr, b1/b3, and b2/b3) of the AZFc region using locus-specific sequence-tagged site (STS) markers among 728 case subjects and compared them with 264 ethnicity- and age-matched proven-fertile control men. The recorded epidemiological data of the study group and the outcome of partial deletion analysis were compiled to frame the plausible Gene × Epidemiological factor (G × E) interactions. The gr/gr deletion was reported to be significantly associated with azoospermic (p = .0015, odds ratio [OR] = 3.413) and oligozoospermic (p = .0382, OR = 3.012) case subgroups, and b1/b3 deletions were also detected among the infertile persons only. The G × E model revealed that men who carried microdeletions as well as were SCT users had an elevated risk of infertility (p = .002, OR = 6.38). The study highlights the fact that AZFc partial deletions and SCT, when co-occurred, synergistically increase the risk of infertility among men. This work helps to get more insight into the etiology of male infertility in the light of gene-environmental interaction.","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"18 5","pages":"15579883241279195"},"PeriodicalIF":2.1,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11437552/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142278929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Improved Health Care Utilization Among Men With Depression Undergoing Inflatable Penile Prosthesis in a U.S. Commercial Population. 在美国商业人群中，接受充气阴茎假体手术的抑郁症男性使用医疗服务的情况有所改善。

IF 2.1 4区医学

American Journal of Men's Health Pub Date : 2024-09-01 DOI: 10.1177/15579883241290714

Roei Golan, Alysha M McGovern, Young Eun Shin, Sirikan Rojanasarot, Taylor Kohn, Sirpi Nackeeran, Francis Petrella, Ranjith Ramasamy

{"title":"Improved Health Care Utilization Among Men With Depression Undergoing Inflatable Penile Prosthesis in a U.S. Commercial Population.","authors":"Roei Golan, Alysha M McGovern, Young Eun Shin, Sirikan Rojanasarot, Taylor Kohn, Sirpi Nackeeran, Francis Petrella, Ranjith Ramasamy","doi":"10.1177/15579883241290714","DOIUrl":"10.1177/15579883241290714","url":null,"abstract":"We evaluated depression-related health care resource utilization and antidepressant prescription medication utilization among commercially insured men in the United States who underwent inflatable penile prosthesis (IPP) implantation between January 1, 2007 and December 31, 2020, and who received a depression diagnosis in the year preceding the IPP procedure. A total of 11,177 patients received an IPP during the index period, 808 of whom were diagnosed with depression. A statistically significant reduction in overall depression-related health care visits occurred from pre- to post-IPP, decreasing from 4.9 to 3.8, p < .001. In addition, there was a significant reduction in depression-related inpatient visits (0.07 vs. 0.03, p = .02) and office visits (4.25 vs. 3.29, p < .001) from pre- to post-IPP. Of the 678 men who received an antidepressant medication within 1 year prior to their IPP date, 15% stopped antidepressant medication use entirely post-IPP. Among patients with continued antidepressant medication use post-IPP (n = 574), there was a significant decrease in the number of prescriptions (7.55 vs. 8.09, p < .0001) and refills (7.52 vs. 8.11, p = .0015), with a higher likelihood of discontinuation (17.6% vs. 10.5%, p < .0001) and a lower proportion of days covered (0.79 vs. 0.83, p = .0004) post-IPP compared with pre-IPP. In conclusion, IPP was associated with reduced depression-related health care utilization and antidepressant medication use among recipients. This suggests potential mental health benefits for IPP recipients beyond restoration of erectile function. Comprehensive insurance coverage for IPP, especially for men with depression, may be beneficial to both patients and insurers.","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"18 5","pages":"15579883241290714"},"PeriodicalIF":2.1,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11503714/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142455783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bridging the Gap: A Community Advisory Board Promoting Community Engagement in Cancer Research for Ethnically Diverse Populations. 缩小差距：社区咨询委员会促进社区参与针对不同种族人群的癌症研究。

IF 2.1 4区医学

American Journal of Men's Health Pub Date : 2024-09-01 DOI: 10.1177/15579883241280826

Motolani E Ogunsanya, Ernest Kaninjing, Daniel J Morton, Kathleen Dwyer, Mary Ellen Young, Folakemi T Odedina

{"title":"Bridging the Gap: A Community Advisory Board Promoting Community Engagement in Cancer Research for Ethnically Diverse Populations.","authors":"Motolani E Ogunsanya, Ernest Kaninjing, Daniel J Morton, Kathleen Dwyer, Mary Ellen Young, Folakemi T Odedina","doi":"10.1177/15579883241280826","DOIUrl":"10.1177/15579883241280826","url":null,"abstract":"Prostate cancer disproportionately affects Black men in the United States, leading to higher mortality rates and health disparities. In addition, based on historical mistreatment and discrimination and the resulting distrust of the medical system, Black populations are consistently underrepresented in health care-related research. Addressing these challenges requires community-driven approaches integrating diverse perspectives and fostering equitable health outcomes. This article describes the formation and impact of The Multidisciplinary Health Outcomes Research and Economics (MORE) Lab Community Advisory Board (CAB) at The University of Oklahoma Health Sciences. We purposefully recruited Black men with CaP and Black health care professionals to serve on a CAB and advise on ongoing research to address quality of life (QoL) issues in ethnically diverse Black CaP survivors. The CAB seeks to mitigate CaP disparities and improve health equity by empowering Black voices and promoting collaborative research practices. The MORE Lab CAB has successfully provided a venue for community members to contribute to designing a culturally relevant research program to improve the QoL in ethnically diverse Black men with CaP. The CAB has been instrumental in developing research goals and tools, implementing a series of town hall meetings to educate and support Black CaP survivors, and disseminating research findings. In conclusion, CABs are potentially critical in guiding research, enhancing community engagement, and advocating for culturally responsive health interventions.","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"18 5","pages":"15579883241280826"},"PeriodicalIF":2.1,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11440528/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142339113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of the VEGF 2578C>A Polymorphism With Metabolic Syndrome and Erectile Dysfunction. 血管内皮生长因子 2578C>A 多态性与代谢综合征和勃起功能障碍的关系

IF 2.1 4区医学

American Journal of Men's Health Pub Date : 2024-09-01 DOI: 10.1177/15579883241282385

Chih-I Liu, Chia-Chu Liu, Shu-Pin Huang, Jiun-Hung Geng, Yung-Chin Lee

{"title":"Association of the VEGF 2578C>A Polymorphism With Metabolic Syndrome and Erectile Dysfunction.","authors":"Chih-I Liu, Chia-Chu Liu, Shu-Pin Huang, Jiun-Hung Geng, Yung-Chin Lee","doi":"10.1177/15579883241282385","DOIUrl":"https://doi.org/10.1177/15579883241282385","url":null,"abstract":"Accumulating evidence suggests a link between vascular endothelial growth factor (VEGF), erectile dysfunction (ED), and metabolic syndrome (Mets), possibly because VEGF can alter the physiological pathways involved in the regulation of endothelial cell proliferation. This study aimed to investigate the genetic susceptibility of VEGF 2578C>A polymorphism to the development of ED and Mets. Collected data included five-item International Index of Erectile Function (IIEF-5), components of Mets, and VEGF 2578C>A polymorphism. A total of 596 subjects from Kaohsiung with a mean age of 55.5 years were enrolled, data collection was done at our hospital. Individuals carrying the VEGF 2578 A allele (CA+AA genotypes) demonstrated a higher prevalence of ED compared to those with the CC genotype, with an adjusted odds ratio (OR) of 1.582 (95% confidence interval [95% CI] = 1.123-2.227, p value = 0.009) in multivariate binary regression analysis. Similarly, individuals carrying the VEGF 2578 A allele showed a higher prevalence of Mets compared to those with the CC genotype, with an adjusted OR of 2.461 (95% CI = 1.491-4.064, p value < 0.001). Furthermore, A allele carriers had significantly lower IIEF-5 scores and a higher number of Mets components compared to those with the C allele (P value < 0.001, respectively). In conclusion, VEGF 2578 A allele carriers are at a greater risk of both Mets and ED, suggesting that the VEGF 2578C>A polymorphism may serve as a common genetic susceptibility factor in the development of both disorders. Further research is warranted to evaluate the mechanisms underlying this association.","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"18 5","pages":"15579883241282385"},"PeriodicalIF":2.1,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11475241/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142455779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From Lawn to Health: Understanding the Prostate Cancer Risk in Light DIY Activities. 从草坪到健康：了解轻度 DIY 活动中的前列腺癌风险。

IF 2.1 4区医学

American Journal of Men's Health Pub Date : 2024-09-01 DOI: 10.1177/15579883241287386

Rui Yang, Xiguang Zhang, Chen Chen, Ya Li, Jun Yin

{"title":"From Lawn to Health: Understanding the Prostate Cancer Risk in Light DIY Activities.","authors":"Rui Yang, Xiguang Zhang, Chen Chen, Ya Li, Jun Yin","doi":"10.1177/15579883241287386","DOIUrl":"10.1177/15579883241287386","url":null,"abstract":"This study employs two-sample Mendelian Randomization (MR) analysis to investigate the causal relationship between light DIY activities and prostate cancer. We used single nucleotide polymorphisms (SNPs) associated with light DIY activities obtained from published genome-wide association studies (GWASs) and summary-level genetic data related to prostate cancer from published GWAS. The primary analysis was conducted using the inverse-variance weighted (IVW) method for two-sample MR analysis. Cochran's Q statistic was used to assess heterogeneity, MR-Egger was employed to detect horizontal pleiotropy, and \"leave-one-out\" analysis was performed for sensitivity analysis. Given the presence of heterogeneity, the random-effects IVW method was used for the primary analysis. The random-effects IVW results indicated a positive causal relationship between participation in light DIY activities and the risk of prostate cancer (odds ratio [OR] = 1.024, 95% confidence interval [CI]: 1.001-1.048; p = .039). The weighted median (WM) method results supported this finding (OR = 1.025, 95% CI: 1.003-1.048; p = .024). Participation in light DIY activities may slightly increase the risk of prostate cancer. This finding emphasizes the need to carefully consider the types and intensities of physical activities when making public health recommendations and personal lifestyle choices.","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"18 5","pages":"15579883241287386"},"PeriodicalIF":2.1,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11526161/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142485626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Does Sperm DNA Fragmentation Index Continuously Decrease Over Time After Varicocelectomy in Varicocele-Induced Infertility? A Systematic Review and Meta-Analysis. 精索静脉曲张导致的不育症患者在接受精索静脉曲张切除术后，精子 DNA 碎片指数是否会随时间推移持续下降？系统回顾与元分析》。

IF 2.1 4区医学

American Journal of Men's Health Pub Date : 2024-09-01 DOI: 10.1177/15579883241285670

Lihong Wang, Lei Zheng, Hui Jiang, Tao Jiang

{"title":"Does Sperm DNA Fragmentation Index Continuously Decrease Over Time After Varicocelectomy in Varicocele-Induced Infertility? A Systematic Review and Meta-Analysis.","authors":"Lihong Wang, Lei Zheng, Hui Jiang, Tao Jiang","doi":"10.1177/15579883241285670","DOIUrl":"10.1177/15579883241285670","url":null,"abstract":"Varicocele (VC) is the most frequent and reversible cause of male infertility. One of the preferred management strategies to alleviate this problem is varicocelectomy. However, there are no researchers who have explored the relationship between better timing and postoperative sperm DNA fragmentation index (DFI) improvement in patients. We conducted this meta-analysis by enrolling published studies to find out the best waiting time after varicocelectomy to wait for better improvement of sperm DFI. A literature search was conducted using PubMed, Embase, Scopus, Web of Science, and Cochrane Library databases. The data from the pooled analysis were presented as mean difference (MD) along with a 95% confidence interval (CI). Heterogeneity was evaluated using I2. Four studies were included after screening relevant literature. Statistical analysis revealed that after varicocelectomy, follow-up results within 3 months showed a significant improvement in sperm DFI compared with the preoperative period (MD: -3.66, 95% CI = [-5.17, -2.14], p < .00001), and follow-up results with 6 months showed a significant improvement in sperm DFI compared with the postoperative 3 months as well (MD: -1.51, 95% CI = [-2.73, -0.29], p = .02). Notably, no further improvement in sperm DFI was observed when the follow-up period reached 12 months (MD: -1.59, 95% CI = [-3.22, 0.05], p = .06). Six months after varicocelectomy may be the optimal time for sperm DFI compared with 12 months or even longer, which means it is also the preferable time for conception. However, more well-designed prospective studies are needed in the future to validate our conclusion.","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"18 5","pages":"15579883241285670"},"PeriodicalIF":2.1,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11459657/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142387235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0