Age-Dependent Effects of Homocysteine on Erectile Dysfunction Risk Among U.S. Males: A NHANES Analysis.

IF 2.1 4区 医学 Q3 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
Xuewen Diao, Chenming Zhang, Zulong Wang
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Abstract

Erectile dysfunction (ED) is a common problem that seriously impacts men's quality of life and mental health. Earlier studies have indicated that homocysteine (HCY) levels might be linked to the risk of ED, although these studies are limited by small sample sizes and insufficient correction for confounding factors. This study uses data from the 2001-2004 National Health and Nutrition Examination Survey (NHANES) to evaluate the relationship between HCY levels and ED risk in U.S. adult males. The analysis involved using a weighted generalized linear model to assess main effects and restricted cubic splines (RCS) to explore nonlinear relationships. Results showed that the association between HCY and ED was not statistically significant after adjusting for covariates. However, interaction analyses between age and the HCY-ED relationship showed that as age increases, the impact of HCY on ED strengthens. Based on this, subgroup analysis by age was carried out, revealing that in people aged 50 and above, HCY levels were significantly positively correlated with ED, especially when HCY levels exceeded 9.22 μmol/L, significantly increasing the risk of ED. Sensitivity analysis further confirmed the robustness of these findings. This study indicates that controlling HCY levels, especially in middle-aged and older men, might help prevent and treat ED, providing a foundation for future preventive strategies.

同型半胱氨酸对美国男性勃起功能障碍风险的年龄依赖性影响:NHANES 分析。
勃起功能障碍(ED)是一种严重影响男性生活质量和心理健康的常见问题。早期的研究表明,同型半胱氨酸(HCY)水平可能与勃起功能障碍的风险有关,但这些研究由于样本量较小和对混杂因素的校正不足而受到限制。本研究利用 2001-2004 年美国国家健康与营养调查(NHANES)的数据来评估美国成年男性的 HCY 水平与 ED 风险之间的关系。分析中使用加权广义线性模型评估主效应,并使用受限立方样条(RCS)探讨非线性关系。结果表明,在对协变量进行调整后,HCY 与 ED 之间的关系在统计学上并不显著。然而,年龄与 HCY-ED 关系之间的交互分析表明,随着年龄的增长,HCY 对 ED 的影响会增强。在此基础上,我们按年龄进行了亚组分析,结果显示,在50岁及以上人群中,HCY水平与ED呈显著正相关,尤其是当HCY水平超过9.22 μmol/L时,ED风险显著增加。敏感性分析进一步证实了这些结果的稳健性。这项研究表明,控制HCY水平,尤其是中老年男性的HCY水平,可能有助于预防和治疗ED,为未来的预防策略奠定了基础。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
American Journal of Men's Health
American Journal of Men's Health PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-
CiteScore
3.70
自引率
4.30%
发文量
107
审稿时长
15 weeks
期刊介绍: American Journal of Men"s Health will be a core resource for cutting-edge information regarding men"s health and illness. The Journal will publish papers from all health, behavioral and social disciplines, including but not limited to medicine, nursing, allied health, public health, health psychology/behavioral medicine, and medical sociology and anthropology.
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