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Enantioselective synthesis of chiral 2-azaspiro[3.3]heptanes and their application as piperidine bioisosteres 手性2-氮杂螺[3.3]庚烷的对映选择性合成及其在哌啶类生物异构体中的应用
Nature synthesis Pub Date : 2026-09-10 DOI: 10.1038/s44160-026-01147-9
Yong-Ke Qiu,Yu-Ping Tang,Chao-Gang Zhang,Qingqin Huang,Jingyang Li,Liang Chen,Zhen Wang,Lei Dai
{"title":"Enantioselective synthesis of chiral 2-azaspiro[3.3]heptanes and their application as piperidine bioisosteres","authors":"Yong-Ke Qiu,Yu-Ping Tang,Chao-Gang Zhang,Qingqin Huang,Jingyang Li,Liang Chen,Zhen Wang,Lei Dai","doi":"10.1038/s44160-026-01147-9","DOIUrl":"https://doi.org/10.1038/s44160-026-01147-9","url":null,"abstract":"","PeriodicalId":74251,"journal":{"name":"Nature synthesis","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148933622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Meet the editors 与编辑见面
IF 22.6
Nature synthesis Pub Date : 2026-09-08 DOI: 10.1038/s44160-026-01153-x
{"title":"Meet the editors","authors":"","doi":"10.1038/s44160-026-01153-x","DOIUrl":"10.1038/s44160-026-01153-x","url":null,"abstract":"The six editors of Nature Synthesis outline their key topics of interest within the scope of the journal.","PeriodicalId":74251,"journal":{"name":"Nature synthesis","volume":"5 9","pages":"1305-1305"},"PeriodicalIF":22.6,"publicationDate":"2026-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s44160-026-01153-x.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148904439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A coumarin-linked conjugated covalent organic framework for enhanced photocatalytic hydrogen evolution 用于增强光催化析氢的香豆素连接共轭共价有机框架
Nature synthesis Pub Date : 2026-09-08 DOI: 10.1038/s44160-026-01146-w
Yuxiang Zhao,Juan Li,Junyi Han,Guang-En Fu,Wuxin Zhang,Tao Chen,Li-Zhu Wu,Xu-Bing Li,Tao Zhang
{"title":"A coumarin-linked conjugated covalent organic framework for enhanced photocatalytic hydrogen evolution","authors":"Yuxiang Zhao,Juan Li,Junyi Han,Guang-En Fu,Wuxin Zhang,Tao Chen,Li-Zhu Wu,Xu-Bing Li,Tao Zhang","doi":"10.1038/s44160-026-01146-w","DOIUrl":"https://doi.org/10.1038/s44160-026-01146-w","url":null,"abstract":"","PeriodicalId":74251,"journal":{"name":"Nature synthesis","volume":"40 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148933624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Author Correction: Gram-per-litre-scale production of lutein by engineered Corynebacterium 作者更正：克/升规模的叶黄素生产工程棒状杆菌
IF 22.6
Nature synthesis Pub Date : 2026-09-07 DOI: 10.1038/s44160-026-01166-6
Hyunmin Eun, Cindy Pricilia Surya Prabowo, Sang Yup Lee
{"title":"Author Correction: Gram-per-litre-scale production of lutein by engineered Corynebacterium","authors":"Hyunmin Eun, Cindy Pricilia Surya Prabowo, Sang Yup Lee","doi":"10.1038/s44160-026-01166-6","DOIUrl":"10.1038/s44160-026-01166-6","url":null,"abstract":"","PeriodicalId":74251,"journal":{"name":"Nature synthesis","volume":"5 10","pages":"1659-1659"},"PeriodicalIF":22.6,"publicationDate":"2026-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s44160-026-01166-6.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148933625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Modular assembly of bioisosteric bridged aza-frameworks via ring strain release 通过环应变释放的生物等构桥aza框架的模块化组装
Nature synthesis Pub Date : 2026-09-02 DOI: 10.1038/s44160-026-01149-7
Haotian Jiang,Yuxia Dai,Kai Tang,Bo Pan,Hongming Jin,Xiangyang Chen,Yangyang Yang
{"title":"Modular assembly of bioisosteric bridged aza-frameworks via ring strain release","authors":"Haotian Jiang,Yuxia Dai,Kai Tang,Bo Pan,Hongming Jin,Xiangyang Chen,Yangyang Yang","doi":"10.1038/s44160-026-01149-7","DOIUrl":"https://doi.org/10.1038/s44160-026-01149-7","url":null,"abstract":"","PeriodicalId":74251,"journal":{"name":"Nature synthesis","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148895818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Author Correction: Accelerating synthesis at scale requires a coordinated ecosystem 作者更正：加速大规模合成需要一个协调的生态系统
IF 22.6
Nature synthesis Pub Date : 2026-09-02 DOI: 10.1038/s44160-026-01165-7
Brandon R. Sutherland, Varinia Bernales, Alán Aspuru-Guzik
{"title":"Author Correction: Accelerating synthesis at scale requires a coordinated ecosystem","authors":"Brandon R. Sutherland, Varinia Bernales, Alán Aspuru-Guzik","doi":"10.1038/s44160-026-01165-7","DOIUrl":"10.1038/s44160-026-01165-7","url":null,"abstract":"","PeriodicalId":74251,"journal":{"name":"Nature synthesis","volume":"5 10","pages":"1658-1658"},"PeriodicalIF":22.6,"publicationDate":"2026-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s44160-026-01165-7.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148895819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Designing heterogeneous electrocatalytic sites using reticular chemistry 利用网状化学设计多相电催化位点
IF 22.6
Nature synthesis Pub Date : 2026-08-28 DOI: 10.1038/s44160-026-01130-4
Arnab Ghatak, G. Shiva Shanker, Ran Shimoni, Idan Hod
{"title":"Designing heterogeneous electrocatalytic sites using reticular chemistry","authors":"Arnab Ghatak, G. Shiva Shanker, Ran Shimoni, Idan Hod","doi":"10.1038/s44160-026-01130-4","DOIUrl":"10.1038/s44160-026-01130-4","url":null,"abstract":"Catalytic activation of small molecules offers opportunities for sustainable energy conversion and storage, addressing the demand for carbon-neutral energy sources. This need has prompted the development of advanced heterogeneous electrocatalytic systems that are capable of efficiently driving these molecular transformations. Consequently, substantial progress has been made in explaining the structural and functional characteristics of catalytically active sites and their influence on electrochemical performance. However, the molecular-level understanding and manipulation of the immediate microenvironment surrounding heterogeneous catalytic centres, and its role in governing electrocatalysis, remain limited. To address this knowledge gap this Review discusses recent developments, showing how reticular chemistry can regulate the proximal chemical environment of active sites, thereby influencing electrocatalytic activity and selectivity. Moreover, as the field progresses towards more complex multi-electron and proton-coupled reactions, emerging challenges and reticular chemistry-based approaches for overcoming them are outlined. This Review explores how reticular chemistry regulates the proximal chemical environment of heterogeneous electrocatalytic sites to enhance the activity and selectivity of small-molecule activation reactions. The authors discuss recent advances in microenvironment control, outline emerging challenges for multi-electron and proton-coupled reactions, and present reticular chemistry-based strategies for overcoming such issues.","PeriodicalId":74251,"journal":{"name":"Nature synthesis","volume":"5 9","pages":"1316-1326"},"PeriodicalIF":22.6,"publicationDate":"2026-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148904457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nanoconfined electrocatalytic CO2 reduction 纳米限电催化CO2还原
IF 22.6
Nature synthesis Pub Date : 2026-08-27 DOI: 10.1038/s44160-026-01156-8
Alexandra R. Groves
{"title":"Nanoconfined electrocatalytic CO2 reduction","authors":"Alexandra R. Groves","doi":"10.1038/s44160-026-01156-8","DOIUrl":"10.1038/s44160-026-01156-8","url":null,"abstract":"","PeriodicalId":74251,"journal":{"name":"Nature synthesis","volume":"5 9","pages":"1307-1307"},"PeriodicalIF":22.6,"publicationDate":"2026-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148904440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Combining CO2 and bicycloalkanes for polyester production 结合二氧化碳和双环烷烃生产聚酯
IF 22.6
Nature synthesis Pub Date : 2026-08-27 DOI: 10.1038/s44160-026-01154-w
Thomas West
{"title":"Combining CO2 and bicycloalkanes for polyester production","authors":"Thomas West","doi":"10.1038/s44160-026-01154-w","DOIUrl":"10.1038/s44160-026-01154-w","url":null,"abstract":"","PeriodicalId":74251,"journal":{"name":"Nature synthesis","volume":"5 9","pages":"1306-1306"},"PeriodicalIF":22.6,"publicationDate":"2026-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148904497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Accelerating synthesis at scale requires a coordinated ecosystem 加速大规模合成需要一个协调的生态系统
IF 22.6
Nature synthesis Pub Date : 2026-08-26 DOI: 10.1038/s44160-026-01133-1
Brandon R. Sutherland, Varinia Bernales, Alán Aspuru-Guzik
{"title":"Accelerating synthesis at scale requires a coordinated ecosystem","authors":"Brandon R. Sutherland, Varinia Bernales, Alán Aspuru-Guzik","doi":"10.1038/s44160-026-01133-1","DOIUrl":"10.1038/s44160-026-01133-1","url":null,"abstract":"The pace of materials discovery is increasingly determined by how quickly candidate materials can be made, characterized, and validated at scales relevant to real applications. Sustaining progress will require not only technical advances but also a coordinated ecosystem of standards, shared data, and translational infrastructure across sectors.","PeriodicalId":74251,"journal":{"name":"Nature synthesis","volume":"5 10","pages":"1472-1474"},"PeriodicalIF":22.6,"publicationDate":"2026-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149126000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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