Nature synthesis最新文献

Palladium makes agostic C–H bonds more acidic 钯使有机碳氢键酸性更强

IF 2

Nature synthesis Pub Date : 2025-10-08 DOI: 10.1038/s44160-025-00906-4

Eric J. Piechota

引用次数: 0

Dynamic Al–Cd frameworks 动态Al-Cd框架

IF 2

Nature synthesis Pub Date : 2025-09-30 DOI: 10.1038/s44160-025-00905-5

Joel Cejas-Sánchez

引用次数: 0

Applications of thianthrene chemistry in organic synthesis 噻吩化学在有机合成中的应用

IF 2

Nature synthesis Pub Date : 2025-09-29 DOI: 10.1038/s44160-025-00878-5

Zibo Bai, Tobias Ritter

{"title":"Applications of thianthrene chemistry in organic synthesis","authors":"Zibo Bai, Tobias Ritter","doi":"10.1038/s44160-025-00878-5","DOIUrl":"10.1038/s44160-025-00878-5","url":null,"abstract":"Thianthrene was first reported in 1869 and has been widely used in materials science for redox-flow batteries, polymers, supramolecular chemistry and phosphorescent materials. Despite extensive studies of the thianthrene radical cation and its reactivity since 1957, applications of thianthrene in synthetic chemistry were virtually absent from the literature until 2019. The then-discovered unusually high selectivity for thianthrenation by electrophilic aromatic substitution allowed for the synthesis of single constitutional isomers of structurally complex aryl-thianthrenium salts, which were mostly used as aryl (pseudo)halide analogues for subsequent functionalization. Since then, it has become apparent that the electronic structure of the thianthrenium substituent enables reaction chemistry that in part goes beyond what can be achieved with conventional organo(pseudo)halides. In this Review, we analyse and explain the fundamental aspects of organothianthrene chemistry, highlight the difference in reactivity to conventional organo(pseudo)halides and showcase its diverse applications. Thianthrene, long used in materials science, has recently emerged as a powerful reagent in organic synthesis. Its unique electronic structure enables access to diverse aryl, alkenyl and alkyl thianthrenium salts, which exhibit reactivity beyond conventional (pseudo)halides. This Review highlights the fundamental properties, distinctive reactivity and synthetic applications of these thianthrenium salts.","PeriodicalId":74251,"journal":{"name":"Nature synthesis","volume":"4 10","pages":"1187-1199"},"PeriodicalIF":20.0,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145256853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hydrogenation using ammonia-borane 氨-硼烷加氢

IF 2

Nature synthesis Pub Date : 2025-09-23 DOI: 10.1038/s44160-025-00900-w

Peter W. Seavill

引用次数: 0

Global aromaticity at the macrocyclic size limit 大环尺寸限制下的全局芳构性

IF 2

Nature synthesis Pub Date : 2025-09-23 DOI: 10.1038/s44160-025-00901-9

Jet-Sing M. Lee

引用次数: 0

Sustainable oxime production via the electrosynthesis of hydroxylamine in a free state 在自由状态下通过电合成羟胺实现可持续的肟生产

Nature synthesis Pub Date : 2025-09-16 DOI: 10.1038/s44160-025-00879-4

Jing Li, Xiang Liu, Si-Min Xu, Ming Xu, Yunlong Wang, Yizheng Lyu, An-Zhen Li, Ye Wang, Xi Wang, Tiancong Zhou, Hua Zhou, Yue Peng, Xuning Li, Lirong Zheng, Haohong Duan

{"title":"Sustainable oxime production via the electrosynthesis of hydroxylamine in a free state","authors":"Jing Li, Xiang Liu, Si-Min Xu, Ming Xu, Yunlong Wang, Yizheng Lyu, An-Zhen Li, Ye Wang, Xi Wang, Tiancong Zhou, Hua Zhou, Yue Peng, Xuning Li, Lirong Zheng, Haohong Duan","doi":"10.1038/s44160-025-00879-4","DOIUrl":"https://doi.org/10.1038/s44160-025-00879-4","url":null,"abstract":"Hydroxylamine (NH2OH) is an important feedstock for oxime production. Coreduction of NOx and aldehydes or ketones enables sustainable one-step oximation by utilizing in situ *NH2OH intermediates but suffers from side reactions and reduced current density due to the presence of multiple reactants in one reactor. Here we decouple oximation into two steps, the electrochemical synthesis of free NH2OH via nitrite (NO2−) electroreduction and the aldehyde or ketone oximation chemical step, circumventing the negative effects (such as site blocking, aldehyde or ketone electroreduction, or crossover) encountered in one-step oximation. By using a Ketjen-black-supported iron phthalocyanine as the catalyst, we achieve an exceptionally high partial current density of free NH2OH (jNH2OH) of 262.9 mA cm−2 (corresponding to productivity of 2.452 mmol cm−2 h−1) in neutral conditions at an industrially relevant current density of 500 mA cm−2. By coupling NH2OH electrosynthesis with subsequent oximation in two steps, nearly stoichiometric oximes are produced with high efficiency and broad applicability. This work paves the way toward a sustainable oxime industry.<figure></figure>","PeriodicalId":74251,"journal":{"name":"Nature synthesis","volume":"40 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145073040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Direct access to a neutral alumene via CO reduction by a dialane and further CO homologation 通过二烷还原CO和进一步的CO同源性直接获得中性铝

Nature synthesis Pub Date : 2025-09-16 DOI: 10.1038/s44160-025-00874-9

John A. Kelly, Arseni Kostenko, Shigeyoshi Inoue

引用次数: 0

Regiocontrollable [2 + 2] benzannulation of γ,δ-C(sp3)–H bonds with dihaloarenes using palladium catalysis 钯催化下γ，δ-C(sp3) -H键与二卤芳烃的区域可控[2 + 2]苄环反应

Nature synthesis Pub Date : 2025-09-16 DOI: 10.1038/s44160-025-00883-8

Liang Hu, Jie-Lun Yan, Yu-Kun Lin, Daniel A. Strassfeld, Jin-Quan Yu

引用次数: 0

The synthesis of perovskites 钙钛矿的合成

IF 2

Nature synthesis Pub Date : 2025-09-11 DOI: 10.1038/s44160-025-00893-6