Nature synthesis最新文献_第2页

Synthesis of chiral allylic amines through regio- and enantioselective homologation of enamines using Ni catalysis 用镍催化通过胺的区域和对映选择性同源合成手性烯丙基胺

Nature synthesis Pub Date : 2026-10-13 DOI: 10.1038/s44160-026-01172-8

Yi-Ming Du,Li-Xu You,Yu-Long Li,Qiong Yu,Wei Shu

引用次数: 0

A general synthesis of tryptophan-crosslinked macrocyclic peptides enabled by a dual-functional directing group 色氨酸交联大环肽的一般合成，由双功能导向基团实现

Nature synthesis Pub Date : 2026-10-13 DOI: 10.1038/s44160-026-01184-4

Jonathan Z. Huang,Vanessa Y. Ying,Shiloh J. Andersson,Philip D. Jeffrey,Sharon Hammes-Schiffer,Mohammad R. Seyedsayamdost

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Modular synthesis of 3,3-diaryloxetanes 3,3-二乙基氧乙烷的模块化合成

Nature synthesis Pub Date : 2026-10-08 DOI: 10.1038/s44160-026-01183-5

Qikai Sun,Junsong Liu,Tobias Ritter

{"title":"Modular synthesis of 3,3-diaryloxetanes","authors":"Qikai Sun,Junsong Liu,Tobias Ritter","doi":"10.1038/s44160-026-01183-5","DOIUrl":"https://doi.org/10.1038/s44160-026-01183-5","url":null,"abstract":"Abstract Oxetanes are strained four-membered oxygen heterocycles that are valuable motifs for modulating lipophilicity, metabolic stability and three-dimensional structure of pharmaceuticals. Diaryloxetanes with 3,3-substitution are recognized as bioisosteres of diaryl ketones that preserve key electronic features while exhibiting distinct reactivity. However, synthesis of this motif largely relies on Lewis acid-promoted Friedel–Crafts reactions, which are restricted to electron-rich arenes and often suffer from low functional-group tolerance and competing side reactions. Here we report a method for the synthesis of 3,3-substituted diaryloxetanes from readily available 3-oxetanone through a cross-coupling reaction with tetrafluoropyridone as leaving group. The difunctionalization through subsequent addition of two aryl groups, one from an aryl halide, the other from an arylboronic ester, provides access to a variety of benzophenone bioisosteres. The nickel-catalysed cross-coupling at a fully substituted carbon centre is enabled through oxetanyl C–O bond oxidative addition and establishes programmable entry to 3,3-diaryloxetane bioisosteres that are synthetically challenging to access via traditional polar bond disconnection strategies. Mechanistic studies support a Ni(0)-mediated oxidative addition of the oxetanyl tetrafluoropyridine ester.","PeriodicalId":74251,"journal":{"name":"Nature synthesis","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149151259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The road to self-driving laboratories in industry 通往工业自动驾驶实验室的道路

IF 22.6

Nature synthesis Pub Date : 2026-10-08 DOI: 10.1038/s44160-026-01194-2

引用次数: 0

Publisher Correction: Electrosynthesis of arylglycines from carbon dioxide, nitrite and aldehydes 出版者更正：用二氧化碳、亚硝酸盐和醛电合成芳基甘氨酸

Nature synthesis Pub Date : 2026-10-06 DOI: 10.1038/s44160-026-01206-1

Qi Sun,Nia J. Harmon,Zhaoyu ‘Charlie’ Cheng,Yuanzuo Gao,Hailiang Wang

引用次数: 0

Photoelectrochemical C(sp3)–C(sp3) cross-coupling using native functional groups 利用天然官能团的光电化学C(sp3) -C （sp3）交叉偶联

Nature synthesis Pub Date : 2026-10-02 DOI: 10.1038/s44160-026-01162-w

Ping-Fu Zhong, Chao Yang, Lin Guo, Wujiong Xia

{"title":"Photoelectrochemical C(sp3)–C(sp3) cross-coupling using native functional groups","authors":"Ping-Fu Zhong, Chao Yang, Lin Guo, Wujiong Xia","doi":"10.1038/s44160-026-01162-w","DOIUrl":"https://doi.org/10.1038/s44160-026-01162-w","url":null,"abstract":"Radical–radical cross-coupling provides an attractive strategy for constructing C(sp3)–C(sp3) bonds directly from simple feedstocks. However, the diffusion-controlled nature of radical recombination and the sensitivity of transition-metal catalysis to the reaction redox environment have limited the generality of such transformations across diverse substrate classes. Here we report a photoelectrochemical method for selective C(sp3)–C(sp3) cross-coupling using native functional groups. By decoupling alkyl radical generation from catalytic redox maintenance, this strategy integrates photoinduced ligand-to-metal charge transfer for mild radical formation with electrochemical regulation of the catalytic redox balance. In combination with Fe–Ni dual catalysis, the system enables diverse double decarboxylative, dehydroxymethylative and deformylative cross-couplings directly from carboxylic acids, alcohols and aldehydes without pre-activation, accommodating primary, secondary and sterically hindered tertiary carbon centres. Mechanistic studies indicate that a sacrificial alkyl bromide prevents over-reduction of nickel, sustaining a Ni(II)/Ni(III) catalytic cycle that mediates selective radical cross-coupling via SH2 radical sorting.","PeriodicalId":74251,"journal":{"name":"Nature synthesis","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149087893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Descriptor-informed multi-component doping enables high-performance Co-free Ni-rich cathodes 描述符通知的多组分掺杂使高性能无钴富镍阴极

Nature synthesis Pub Date : 2026-10-01 DOI: 10.1038/s44160-026-01152-y

Siqi Guan, Tong Yu, Pei Tang, Huize Wu, Qian Wei, Nan Piao, Lixiang Li, Jianqiu Zhu, Linjuan Zhang, Baigang An, Yutao Niu, Guangjian Hu, Zhenhua Sun, Chunyang Wang, Hui-Ming Cheng, Feng Li

{"title":"Descriptor-informed multi-component doping enables high-performance Co-free Ni-rich cathodes","authors":"Siqi Guan, Tong Yu, Pei Tang, Huize Wu, Qian Wei, Nan Piao, Lixiang Li, Jianqiu Zhu, Linjuan Zhang, Baigang An, Yutao Niu, Guangjian Hu, Zhenhua Sun, Chunyang Wang, Hui-Ming Cheng, Feng Li","doi":"10.1038/s44160-026-01152-y","DOIUrl":"https://doi.org/10.1038/s44160-026-01152-y","url":null,"abstract":"Co-free Ni-rich layered oxide cathodes hold great promise for cost-effective, high-energy lithium-ion batteries, but their practical application remains limited by sluggish Li+ kinetics and rapid capacity fading. Although doping has been widely used to mitigate these issues, conventional trial-and-error dopant selection remains inefficient for guiding rational materials development. Here we move beyond empirical dopant screening by developing a descriptor-informed multi-component dopant selection strategy based on dopant charge density and metal–oxygen bond strength. Low-charge-density dopants reduce electrostatic barriers to Li+ migration, while high-bond-energy dopants reinforce the oxygen sublattice and stabilize the metal–oxygen framework. This doping strategy simultaneously accelerates Li+ kinetics, suppresses cycling-induced phase transitions and mitigates chemomechanical fatigue, thereby delivering exceptional electrochemical performance in Co-free Ni-rich cathodes. The enhanced apparent Li+ transport and structural stability enable an ultrahigh-rate capability of 130.9 mAh g−1 at 25 C and at 25 °C, excellent cycling retention of 82.4% after 350 cycles at 10 C and robust low-temperature operation delivering 112.2 mAh g−1 at 1 C under −20 °C. These findings, transitioning the design principle from empirical or trial-based selection to a targeted selection regime, present a promising route for developing high-performance cathode materials for lithium-ion batteries.","PeriodicalId":74251,"journal":{"name":"Nature synthesis","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149087897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Programming membranes with ice 用冰编程膜

Nature synthesis Pub Date : 2026-10-01 DOI: 10.1038/s44160-026-01148-8

Moon Jeong Park

引用次数: 0

Ice-mediated interfacial membrane synthesis of cargo-independent microcapsules 冰介导的界面膜合成与货物无关的微胶囊

Nature synthesis Pub Date : 2026-10-01 DOI: 10.1038/s44160-026-01164-8

Hongzhong Du, Jiahui Wu, Kai Yang, Chuanbiao Zhang, Dan Wang, Xiaoting Chen, Siyuan Wang, Yuchen Wu, Shuo Jin, Xiaofei Chen, Zhiyuan He

{"title":"Ice-mediated interfacial membrane synthesis of cargo-independent microcapsules","authors":"Hongzhong Du, Jiahui Wu, Kai Yang, Chuanbiao Zhang, Dan Wang, Xiaoting Chen, Siyuan Wang, Yuchen Wu, Shuo Jin, Xiaofei Chen, Zhiyuan He","doi":"10.1038/s44160-026-01164-8","DOIUrl":"https://doi.org/10.1038/s44160-026-01164-8","url":null,"abstract":"Membrane-defined compartmentalization enables selective transport and protects biomacromolecules in living systems, yet synthetic microcapsules remain difficult to fabricate because existing methods are often harsh, multistep or cargo-specific. Here we report an ice-mediated interfacial reaction platform that programmes membrane growth on ice-sphere templates to generate closed microcapsules with cargo-independent encapsulation. During ice recrystallization, monomers preloaded within the ice matrix are enriched into the quasi-liquid layer, where they undergo confined interfacial amidation with a complementary organic-phase monomer to form a conformal polyamide membrane. Melting the ice releases intact microcapsules with encapsulated cargo retained. The resulting microcapsules exhibit tunable membrane thicknesses (7–260 nm) and diameters (30–500 μm), and function as confined microreactors for multienzyme redox cascades, achieving up to an 80-fold enhancement in visible-light-driven CO2-to-methanol conversion. This strategy provides a mild and potentially scalable route to programmable semipermeable microcompartments.","PeriodicalId":74251,"journal":{"name":"Nature synthesis","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149087895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Propionic acid synthesis via room-temperature coupling of ethane and CO 乙烷与一氧化碳室温偶联合成丙酸

Nature synthesis Pub Date : 2026-10-01 DOI: 10.1038/s44160-026-01168-4

Jiajie Hou, Wenxuan Liu, Kuan-hua Wang, Minghan Li, Shao-chun Wen, Mu-jeng Cheng, Bingjun Xu, Qi Lu

引用次数: 0