Nature mental health最新文献

{"title":"Duty and distress — military personnel seeking mental health services","authors":"Rebecca Cooney","doi":"10.1038/s44220-025-00452-0","DOIUrl":"10.1038/s44220-025-00452-0","url":null,"abstract":"","PeriodicalId":74247,"journal":{"name":"Nature mental health","volume":"3 6","pages":"589-589"},"PeriodicalIF":8.7,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145123386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mental healthcare reform 2.0: learning from the global south","authors":"Stella Evangelidou, Angel Martínez-Hernáez, Francisco Ortega","doi":"10.1038/s44220-025-00443-1","DOIUrl":"10.1038/s44220-025-00443-1","url":null,"abstract":"The global south has been at the forefront of developing new low-cost, community-based support interventions for those suffering mental ill-health. We argue that these approaches should inform the reform of mental healthcare globally.","PeriodicalId":74247,"journal":{"name":"Nature mental health","volume":"3 7","pages":"753-755"},"PeriodicalIF":8.7,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145123432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A record-linkage study of post-stroke primary care psychological therapy effectiveness in England","authors":"Jae Won Suh, Vaughan Bell, Joshua E. J. Buckman, Céline El Baou, Roopal Desai, Caroline Fearn, Natalie L. Marchant, Marcus Richards, Claudia Cooper, Stephen Pilling, Amber John, Joshua Stott, Rob Saunders","doi":"10.1038/s44220-025-00429-z","DOIUrl":"10.1038/s44220-025-00429-z","url":null,"abstract":"At least one-third of stroke survivors are affected by depression or anxiety, but no large-scale studies of real-world clinical practice have assessed whether psychological therapies are beneficial for these patients. Here we show that psychological treatment is effective for stroke survivors on average, using national healthcare records from National Health Service Talking Therapies services in England, including 7,597 patients with a hospital diagnosis of stroke before attendance. Following psychological treatment, stroke survivors experienced moderate reductions in depression and large reductions in anxiety symptoms. Patients who started attending the services a year or more after a stroke were less likely to reliably recover from symptoms of depression or anxiety than those seen within six months of a stroke, irrespective of differences in baseline characteristics including age, gender, local area deprivation and symptom severity. Compared with a matched sample of patients without a stroke, stroke survivors were less likely to reliably recover and more likely to reliably deteriorate after psychological treatment, although adjusting for level of physical comorbidity attenuated these relationships. It is crucial that clinicians working with stroke survivors screen for symptoms of depression and anxiety and consider referring patients to primary care psychological therapies as early as possible. This study investigates the effectiveness of psychological therapies for depression and anxiety symptoms in 7,597 stroke survivors within England’s primary care system. Results show that 71.3% of stroke survivors experienced reliable improvement and significant reductions in symptom scores, underscoring the importance of intervention for improving recovery.","PeriodicalId":74247,"journal":{"name":"Nature mental health","volume":"3 6","pages":"626-635"},"PeriodicalIF":8.7,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12165844/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144303892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The genetic relationship between cannabis use disorder, cannabis use and psychiatric disorders","authors":"Marco Galimberti, Cassie Overstreet, Priya Gupta, Sarah Beck, Cecilia Dao, Joseph D. Deak, Hang Zhou, Emma C. Johnson, Arpana Agrawal, Murray B. Stein, Daniel F. Levey, Joel Gelernter","doi":"10.1038/s44220-025-00440-4","DOIUrl":"10.1038/s44220-025-00440-4","url":null,"abstract":"Increasing prevalence of cannabis use and cannabis use disorder (CanUD) may increase risk for psychiatric disorders. We evaluated the relationships between these cannabis traits and a range of psychiatric traits, running global and local genetic correlations, genomic structural equation modeling, colocalization analyses and Mendelian randomization analyses for causality. Global genetic analyses identified significantly different correlations between CanUD and cannabis use. A variant in strong linkage disequilibrium to one regulating CHRNA2 was significantly shared by CanUD and schizophrenia in colocalization analysis and included in a significant region in local genetic correlations between these traits. A three-factor model from genomic structural equation modeling showed that CanUD and cannabis use partially map together onto a factor with major depressive disorder and ADHD. In terms of causality, CanUD showed bidirectional causal relationships with most tested psychiatric disorders, differently from cannabis use. Increasing use of cannabis can increase rates of psychiatric disorders over time, especially in individuals who progress from cannabis use to CanUD. This genetic study utilizing the newest available GWAS summary statistics provides evidence on the relationship between cannabis use, cannabis use disorder and a range of psychiatric disorders.","PeriodicalId":74247,"journal":{"name":"Nature mental health","volume":"3 6","pages":"700-708"},"PeriodicalIF":8.7,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s44220-025-00440-4.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145123265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating the association between gender-affirming treatment intentions and choices on mental health among transgender individuals","authors":"Jiaqi Li, Xin Cui, Qiaoqing Zheng, Hui Yu, Zhihao Ma, Yuanyuan Wang","doi":"10.1038/s44220-025-00434-2","DOIUrl":"10.1038/s44220-025-00434-2","url":null,"abstract":"Gender-affirming treatments, including gender-affirming hormone therapy and gender-affirmation surgery, aim to align transgender individuals’ physical appearance with their intrinsic gender identity. However, one-third of 7,576 participants (mean age: 21.61) in the Chinese Transgender Health Survey reported no intention of pursuing these treatments. This study examines the associations between sociodemographic, treatment-related factors and mental health across four groups: no intention for treatment (n = 2,523), intending treatment not started (n = 2,576), gender-affirming hormone therapy (n = 2,369) and gender-affirmation surgery (n = 290). Notably, the surgery group reported the highest gender dysphoria, while the hormone group exhibited the highest levels of anxiety, depression, post-traumatic stress disorder, self-harm and suicide risk. Multivariate regression models revealed that sociodemographic factors, such as education, were differently associated with mental health statuses across groups, showing a complex mosaic effect. Here we show that these differences do not imply treatment effects but rather highlight the need for personalized clinical considerations in gender-affirming care. This study analyzes associations between sociodemographic factors, treatment intentions and mental health among transgender individuals. Utilizing multivariate regression, findings reveal distinct mental health challenges across treatment groups, emphasizing the necessity for personalized approaches in gender-affirming care.","PeriodicalId":74247,"journal":{"name":"Nature mental health","volume":"3 6","pages":"685-699"},"PeriodicalIF":8.7,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145123430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Shared genetics between cannabis traits and psychiatric disorders","authors":"","doi":"10.1038/s44220-025-00448-w","DOIUrl":"10.1038/s44220-025-00448-w","url":null,"abstract":"Genetic variants and regions associated with cannabis use disorder (CanUD) and cannabis use also influence a range of psychiatric traits. We used genetic methods to demonstrate increased risk caused by CanUD of developing several psychiatric disorders, and that psychiatric disorders also increase CanUD risk. There were genetic differences between cannabis use and CanUD.","PeriodicalId":74247,"journal":{"name":"Nature mental health","volume":"3 6","pages":"592-593"},"PeriodicalIF":8.7,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145123429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anxious–depressive symptoms and sleep disturbances across the Alzheimer disease spectrum","authors":"Ya Chai, Ehsan Shokri-Kojori, Andrew J. Saykin, Meichen Yu","doi":"10.1038/s44220-025-00416-4","DOIUrl":"10.1038/s44220-025-00416-4","url":null,"abstract":"Patients with Alzheimer disease (AD) often experience neuropsychiatric symptoms, particularly anxious–depressive symptoms and sleep disturbances. These symptoms are associated with various factors related to AD, including amyloid-β and tau pathology, neurodegeneration, and cognitive decline, at different stages of the disease. However, it remains unclear whether anxious–depressive symptoms and sleep disturbances are merely symptoms or contribute as risk factors in the development and progression of AD. Consequently, there is a pressing need for a timely and informed discussion regarding these disturbances in AD. Here we discuss the most recent developments in understanding the etiology of anxious–depressive symptoms and sleep disturbances in AD, with a focus on how these symptoms interact with AD biomarkers to influence cognitive decline. Furthermore, we propose models of connections between anxious–depressive symptoms and/or sleep disturbances, AD biomarkers and cognition, aiming to inspire potential treatment plans for addressing these symptoms and exploring their impact on AD pathology and cognitive decline. In this Perspective, the authors cover what is known about anxiety and depression symptoms and sleep disturbance in relation to Alzheimer disease pathology and cognitive decline.","PeriodicalId":74247,"journal":{"name":"Nature mental health","volume":"3 6","pages":"594-612"},"PeriodicalIF":8.7,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145082368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A 20-year longitudinal cohort study of post-traumatic stress disorder in World Trade Center responders","authors":"Frank D. Mann, Monika A. Waszczuk, Sean A. P. Clouston, Scott Feltman, Camilo J. Ruggero, Brian P. Marx, Joseph E. Schwartz, Evelyn J. Bromet, Benjamin J. Luft, Roman Kotov","doi":"10.1038/s44220-025-00419-1","DOIUrl":"10.1038/s44220-025-00419-1","url":null,"abstract":"Post-traumatic stress disorder (PTSD) is a debilitating condition with serious implications for mental and physical health. Although previous studies have documented PTSD prevalence and short-term trajectories, detailed examination of long-term symptom patterns remains limited, especially in large cohorts. This study investigates 20-year PTSD symptom trajectories in World Trade Center responders, constituting one of the largest and longest studies of PTSD to date. We aimed to answer the following questions. How stable are symptoms? What is the average trajectory? What are atypical trajectories? How quickly do symptoms improve and worsen? Does symptom course differ across demographics or predict functional impairments or mental health care utilization? Data include 81,298 observations from 12,822 responders. Symptoms were stable in the short term but changed significantly over two decades, peaking over a decade after exposure and declining modestly thereafter. Demographic differences in average trajectories were small. The median time before symptoms improved was 8–10 years for PTSD cases (median = 8.88; 95% confidence interval, 8.01–9.79). Most experienced improvement after a decade but approximately 10% reported elevated symptoms two decades after trauma. Changes in symptoms predicted higher functional impairments and mental health care utilization. Our findings highlight the enduring impact of PTSD among World Trade Center responders, with substantial variability in individual trajectories. Despite overall modest declines, a subset remained highly symptomatic, underscoring the need for continued treatment. These results emphasize the importance of long-term monitoring and highlight the need for tailored treatment strategies for trauma-exposed populations. This study investigates long-term trajectories of post-traumatic-stress-disorder symptoms of World Trade Center responders (n = 12,822), revealing highly variable symptom trajectories and 10% of responders experiencing persistence or worsening of symptoms after 20 years.","PeriodicalId":74247,"journal":{"name":"Nature mental health","volume":"3 7","pages":"789-802"},"PeriodicalIF":8.7,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145123436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"International solutions for the US youth mental health crisis","authors":"Jennifer Debenham, Katherine M. Keyes, Nicola C. Newton, Maree Teesson","doi":"10.1038/s44220-025-00435-1","DOIUrl":"10.1038/s44220-025-00435-1","url":null,"abstract":"Mental disorders among young people are rising in incidence and severity, yet access to effective treatment is limited. This Comment presents leading international mental health policies that could be adapted and applied in the USA through an integrated, three-tiered prevention approach.","PeriodicalId":74247,"journal":{"name":"Nature mental health","volume":"3 6","pages":"585-587"},"PeriodicalIF":8.7,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145123268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations among bipolar II depression white matter subgroups, inflammation, symptoms and childhood maltreatment","authors":"Yuan Cao, Paulo Lizano, Meng Li, Lejla Colic, Tara Chand, Nooshin Javaheripour, Huan Sun, Gaoju Deng, Xiaoqin Zhou, Xipeng Long, Qiyong Gong, Changjian Qiu, Martin Walter, Zhiyun Jia","doi":"10.1038/s44220-025-00432-4","DOIUrl":"10.1038/s44220-025-00432-4","url":null,"abstract":"Childhood maltreatment has long-term effects on brain structure, inflammation and psychiatric symptoms, yet its impact on white matter (WM) integrity in bipolar disorder type II depression (BDII-D) remains understudied. Here, we investigate WM alterations in BDII-D and their associations with childhood maltreatment, inflammation and psychiatric symptoms. Using TractSeg, we analyzed WM integrity in 146 patients with BDII-D and 151 healthy controls, identifying significantly lower fractional anisotropy (FA) in the corpus callosum, left inferior longitudinal fasciculus and right striato-fronto-orbital tract, alongside higher FA in sensory-motor regions. WM alterations were correlated with inflammatory markers and psychiatric symptoms. Non-negative matrix factorization and clustering analysis revealed two BDII-D subgroups, with one subgroup showing lower corpus callosum FA, higher inflammatory markers, greater childhood emotional maltreatment and psychiatric symptoms. These findings suggest deficits in WM integrity in thalamo-subcortical-cortical and somatosensory areas in BDII-D. Childhood emotional maltreatment may contribute to long-term effects on inflammation and psychiatric symptoms in adulthood BDII-D. The authors analyze white matter alterations in bipolar II depression, revealing significant correlations with inflammation and psychiatric symptoms. These findings suggest that childhood emotional maltreatment may exacerbate these effects and offer insights into potential therapeutic targets.","PeriodicalId":74247,"journal":{"name":"Nature mental health","volume":"3 6","pages":"724-734"},"PeriodicalIF":8.7,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145123627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}