Advances in wound care最新文献

{"title":"Flexible Pressure Sensors for Optimizing Pressure Garment Therapy in Periarticular Scar Treatment: Preclinical and Clinical Applications.","authors":"Jia Xu, Yaxin Xue, Wei Xu, Xin Li, Weijie Su, Jiajun Fan, Yanhong Ma, Dong Han","doi":"10.1089/wound.2024.0139","DOIUrl":"10.1089/wound.2024.0139","url":null,"abstract":"<p><strong>Objective: </strong>Pressure garment therapy is a common strategy for controlling hypertrophic scars; however, insufficient pressure due to reduced elasticity or joint movement limits its effectiveness around joints. The FlexiForce B201 pressure sensor offers precise pressure measurements, thereby demonstrating a promising solution.</p><p><strong>Approach: </strong>This study used a Bama pig scar model with an untreated group, a pressure garment group, and a pressure monitoring group that was treated with FlexiForce B201 sensors and pressure garments. The therapeutic effects were recorded over 1 month. The clinical research followed the Consolidated Standards of Reporting Trials and was registered as ChiCTR2200064173. Eighty-two patients with peri-joint hypertrophic scars were enrolled. Forty-one patients were randomly assigned to the control group and received conventional pressure garment therapy, whereas the remaining 41 patients were included in the monitoring group. Treatment outcomes were tracked at 3 months and 6 months.</p><p><strong>Results: </strong>The Bama pig scar model demonstrated reduced scar hypertrophy in the monitoring group. In the clinical study, the scar thickness in the monitoring group was 47.76% of the initial thickness after 6 months, thereby representing an additional 11.33% reduction compared to the control group. The Vancouver Scar Scale score of the monitoring group (6.44 ± 1.62) was significantly better than that of the control group (7.33 ± 1.53).</p><p><strong>Innovation: </strong>The FlexiForce B201 pressure sensor is soft and flexible. It provides accurate pressure measurements within the pressure garment and guides physicians in adjusting the pressure distribution.</p><p><strong>Conclusion: </strong>This study revealed that pressure monitoring technology enhances the effectiveness of pressure garments.</p>","PeriodicalId":7413,"journal":{"name":"Advances in wound care","volume":" ","pages":"195-207"},"PeriodicalIF":5.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143603392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic Models for Mortality in Patients with Diabetic Foot Ulcers: A Systematic Review.","authors":"Huiren Zhuang, Yihao Gu, Jingjing Guo, Jinyi Zhu, Xiaojing Li, Weiying Zhang","doi":"10.1177/21621918261429115","DOIUrl":"10.1177/21621918261429115","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to systematically review and summarize existing prognostic models for all-cause mortality in patients with diabetic foot ulcers (DFUs). It further evaluates their characteristics, performance, and methodological quality to inform future model development and clinical application.</p><p><strong>Approach: </strong>We searched eight databases from their inception to February 24, 2025. Extracted data included general study characteristics and model-specific information. The prognostic models were classified using the transparent reporting of a multivariable prediction model for Individual Prognosis Or Diagnosis guidelines and evaluated using the Prediction Model Risk of Bias Assessment Tool (PROBAST) to assess the risk of bias (ROB) and applicability.</p><p><strong>Results: </strong>Of the 1,580 retrieved studies, 19 were included, reporting a total of 22 prognostic models. Reported mortality rates among DFU patients ranged from 4.2% to 48.5%, with follow-up durations varying from 12 weeks to 22 years. All studies exhibited a high ROB due to issues with data sources, small sample sizes, inadequate data handling, and model validation flaws. Across the included prognostic models, the most frequently reported predictors were age, cardiovascular disease, renal disease, ulcer severity, ischemia, and serum albumin.</p><p><strong>Innovation: </strong>Prognostic assessment of mortality risk in patients with DFUs is critical for effective clinical management. This study systematically evaluated 22 published prognostic models using the PROBAST, identifying key methodological limitations and commonly used predictors. The findings provide a scientific basis for the future development of higher quality, clinically applicable prognostic models. In addition, this work offers valuable insights to inform clinical risk stratification and decision-making for DFU patients.</p><p><strong>Conclusions: </strong>All included prognostic models demonstrated a high ROB according to the PROBAST assessment. Future research should focus on using larger sample sizes, rigorous study designs, and multicenter external validation to develop more reliable prognostic models. Given the multifactorial nature of mortality risk in DFU patients, multidisciplinary collaboration is essential to improve clinical outcomes.</p>","PeriodicalId":7413,"journal":{"name":"Advances in wound care","volume":" ","pages":"21621918261429115"},"PeriodicalIF":5.6,"publicationDate":"2026-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147525334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can Electrical Stimulation Prevent Recurrence of Keloid Scars? A Scoping Review.","authors":"Robert E George, Caroline C Bay, Sarah M Thornton, Jessieka T Knazze, Nicole C Kane, Kip A Ludwig, D'Andrea T Donnelly, Samuel O Poore, Aaron M Dingle","doi":"10.1089/wound.2023.0203","DOIUrl":"10.1089/wound.2023.0203","url":null,"abstract":"<p><strong>Objective: </strong>Keloids represent a symptomatic, aberrant healing process that is difficult to treat with high recurrence rates spanning from 55% to 100% if treated <i>via</i> excision without adjuvant therapy. Electrical stimulation (ES) has demonstrated findings that suggest it could reduce the recurrence rate of keloids after resection. Therefore, the aim of this study is to conduct a scoping review to investigate ES as an adjuvant therapy for decreasing keloid recurrence after excision.</p><p><strong>Approach: </strong>A scoping review was performed using PubMed and Web of Science databases. The search strategy encompassed terms linking keloids and various aspects of electrical stimulation.</p><p><strong>Results: </strong>Our search yielded 2,229 articles, of which 115 articles were analyzed as full text and 1 article met inclusion criteria. Despite this, ES has demonstrated other evidence that suggests its utility. ES has been shown to counter keloidic features by reducing mast cell counts, shifting wound composition from M2 to M1 macrophages, promoting angiogenesis, and controlling fibroblast orientation and location. An alternating current will orient fibroblasts perpendicular to the current without unintended migration.</p><p><strong>Innovation: </strong>Our study indicates that, based on a compilation of clinical and preclinical <i>in vitro</i> data, the optimal scenario for ES in the role of keloid treatment is after excision with a biphasic pulsed application and square waveform.</p><p><strong>Conclusions: </strong>ES could serve as a multifaceted, adjuvant treatment after keloid excision, steering the healing process away from keloid-associated characteristics. Its cost-effectiveness means it could be adopted globally, providing a strategy to mitigate the burden of keloids irrespective of other available treatments or economic conditions.</p>","PeriodicalId":7413,"journal":{"name":"Advances in wound care","volume":" ","pages":"157-167"},"PeriodicalIF":5.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141417209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AURKA Activates <i>FOXO3a</i> to Form a Positive Feedback Loop in the Proliferation and Migration of Keloid Fibroblasts.","authors":"Xi Chu, Jiaqi Sun, Siya Dai, Yehua Liang, Xifei Qian, Jinghong Xu, Jufang Zhang","doi":"10.1089/wound.2024.0055","DOIUrl":"10.1089/wound.2024.0055","url":null,"abstract":"<p><strong>Objective: </strong>Keloids are benign fibroproliferative disorders with invasive growth exceeding the wound boundary. Aurora kinase A (AURKA) is a serine/threonine kinase highly expressed in various tumors, facilitating tumor growth and invasion. Currently, the role of AURKA in keloid remains unclear.</p><p><strong>Approach: </strong>Fibroblasts were isolated from keloid and normal skin samples. AURKA was evaluated by qPCR, Western blot, and immunohistochemistry. Transcriptome sequencing and dual-luciferase reporter assays were applied to figure out targets of AURKA. Following expression alteration and MLN8237 (an AURKA kinase inhibitor, AKI) treatment, phenotypical experiments were conducted to clarify biological functions of AURKA along with its target, and to probe into the clinical potential of AURKA inhibition.</p><p><strong>Results: </strong>AURKA was upregulated in keloid tissues and fibroblasts. Forkhead box O 3a (FOXO3a) was verified as a downstream of AURKA. Further experiments demonstrated that AURKA transactivated <i>FOXO3a</i> by binding to FOXO3a, while FOXO3a directly transactivated <i>AURKA</i>. Functionally, AURKA and FOXO3a cooperated in enhancing the proliferation and migration of keloid fibroblasts <i>via</i> protein kinase B (AKT) phosphorylation. Although MLN8237 weakened the proliferation and migration in keloid fibroblasts, the transactivation of AURKA on <i>FOXO3a</i> was independent of kinase activity.</p><p><strong>Innovation: </strong>This study reveals that AURKA and FOXO3a compose a transactivation loop in enhancing the proliferative and migrative properties of keloid fibroblasts, and proposes AURKA as a promising target.</p><p><strong>Conclusion: </strong>AURKA/FOXO3a loop promotes the proliferation and migration of keloid fibroblasts <i>via</i> AKT signaling. Despite the anti-keloid effects of AKIs, AURKA acts as a transcription factor independently of kinase activity, deepening our understanding on AKI insensitivity.</p>","PeriodicalId":7413,"journal":{"name":"Advances in wound care","volume":" ","pages":"168-180"},"PeriodicalIF":5.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141791651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalent Types of Peristomal Skin Damage During Chemoradiotherapy and Their Risk Factors.","authors":"Yi Chen, Yan Lu, LiJuan Zhang, LaiJuan Li","doi":"10.1089/wound.2023.0215","DOIUrl":"10.1089/wound.2023.0215","url":null,"abstract":"<p><strong>Significance: </strong>Colorectal cancer is currently ranked third in terms of the global cancer incidence. Enterostomy, a common surgical procedure for colorectal cancer treatment, creates a temporary or permanent stoma in the abdominal wall for waste excretion. Cancer itself and the associated treatments, such as chemotherapy and radiation therapy, increase the likelihood of various types of peristomal skin damage.</p><p><strong>Recent advances: </strong>Recent research has focused on developing more targeted treatment approaches for peristomal moisture-associated skin damage (P-MASD). In addition, studies are investigating the potential of novel wound care products and therapies to enhance healing and reduce the risk of complications. There is also growing interest in understanding the different types except P-MASD during chemoradiotherapy. Different types match the varied treatments. Thus, we aimed to comprehensively review the most prevalent types of peristomal skin damage during chemoradiotherapy and their associated risk factors.</p><p><strong>Critical issues: </strong>The five prevalent types of peristomal skin damage that occur during chemoradiotherapy are peristomal radiodermatitis, P-MASD, peristomal acneiform rash, peristomal pyoderma gangrenosum, and peristomal abscess/infection/fistula. The risk factors vary depending on the type; however, they include the radiation dose, ileostomy surgery, chemoradiotherapy-associated diarrhea, use of epidermal growth factor receptor inhibitors, inflammatory bowel disease, and unclear factors.</p><p><strong>Future directions: </strong>This review guides the clinical identification of peristomal skin damage during chemoradiotherapy, laying a solid foundation for developing effective strategies to prevent this condition.</p>","PeriodicalId":7413,"journal":{"name":"Advances in wound care","volume":" ","pages":"181-190"},"PeriodicalIF":5.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143254520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of Skin Multicellular Reprogramming Factors as Potential Treatment for Nonhealing Diabetic Foot Ulcers.","authors":"Ahmed S Abouhashem, Sherine K Saber, Sara Abouzekry, Mohammed Elkholy, Ahmed Moustafa, Ahmed Abdellatif, Hassan M E Azzazy, Ahmed A Elbaz, Kanhaiya Singh, Chandan K Sen, Hossam Sharara","doi":"10.1177/21621918251376348","DOIUrl":"10.1177/21621918251376348","url":null,"abstract":"<p><strong>Objective: </strong>In a complex environment such as that in a diabetic foot ulcer (DFU), multiple factors, including cross talk between distinct cell types of the affected tissue, play a significant role. We identified a transcription factor (TF) cocktail that induces a transition from nonhealing to healing states across multiple cell types.</p><p><strong>Approach: </strong>Thirty-three skin and wound single-cell RNA-sequencing samples (85,928 cells) from patients with diabetes with healing or nonhealing DFU were analyzed (GSE165816). The relative activity of cell type-specific TF in healing versus nonhealing DFU was compared, and the cumulative additive effect of different TF cocktails was assessed.</p><p><strong>Results: </strong>We used a cumulative additive-effect approach to identify five transcription factors, FOS Like 2, AP-1 Transcription Factor Subunit (<i>FOSL2)</i>, CAMP Responsive Element Binding Protein 3 Like 1, RELB Proto-Oncogene, NF-KB Subunit, ETS Proto-Oncogene 1 (<i>ETS1</i>), and X-Box Binding Protein 1, whose targets include 66.5% of pro-healing genes and only 12.5% of anti-healing genes across all cell types. In vascular endothelial cells, this TF panel accounted for 95% of vasculature-development genes; in myeloid cells, it regulated 85% of antimicrobial-response genes. <i>In silico</i> knockout of <i>ETS1</i> or <i>FOSL2</i> shifted cells toward nonhealing states, whereas Nuclear Receptor Subfamily 3 Group C Member 1 knockout shifted endothelial cells, fibroblasts, and myeloid cells toward healing-associated state.</p><p><strong>Innovation: </strong>This work recognizes a TF panel that is likely to have therapeutic value in promoting healing in nonhealing DFU.</p><p><strong>Conclusion: </strong>In this work, we identified a set of candidate TFs with the potential to induce a cell state transition favoring a switch from nonhealing to healing outcomes in patients with nonhealing DFU. Overall, our gene regulatory network-driven TF cocktail provides a rational blueprint for reprogramming DFU cell states and paves the way toward targeted regenerative therapies.</p>","PeriodicalId":7413,"journal":{"name":"Advances in wound care","volume":" ","pages":"139-156"},"PeriodicalIF":5.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145197872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fisetin-Mediated Topical Modulation of Senescent Cells in Skin Improves Wound Healing Dynamics in Diabetic Mice.","authors":"Asfia Numani, Margarita Carrasco-Jeldres, Barbara Hernandez-Rovira, K-Raman Purushothaman, Matthew M Melin, James L Kirkland, Saranya Wyles","doi":"10.1177/21621918261426580","DOIUrl":"10.1177/21621918261426580","url":null,"abstract":"<p><strong>Objective: </strong>Diabetes mellitus affects over 25% of adults aged 65+ in the United States and is associated with a heightened risk of developing diabetic foot ulcers. Accumulation of senescent cells within the wound microenvironment can impair cutaneous repair, and senolytic therapies offer a promising approach to accelerate wound healing.</p><p><strong>Approach: </strong>In this study, topical fisetin, a flavonoid that promotes apoptosis of senescent cells, was evaluated for its impact on diabetic wound repair. Full-thickness excisional wounds were created on the dorsal skin of diabetic (db/db) mice. Animals were randomized to receive either topical vehicle (<i>n</i> = 12) or fisetin (<i>n</i> = 12) for three consecutive days per week, and wound healing outcomes were longitudinally assessed.</p><p><strong>Results: </strong>Topical fisetin significantly increased the ratio of healthy dermis to granulation by day 7 (<i>p</i> = 0.04) and reduced dermal fibrosis by day 21 (<i>p</i> = 0.03). Fisetin decreased p16+ cells (<i>p</i> = 0.01) but increased p21+ cells (<i>p</i> = 0.02) at day 7 in the dermis, indicating varied effects on senescent cells. M1 macrophages (CD80+) were decreased in the fisetin-treated group (<i>p</i> = 0.05) at day 21, accompanied by a decrease in pro-inflammatory senescence-associated secretory phenotype cytokines, tumor necrosis factor alpha (<i>p</i> = 0.03), and interleukin-1beta (<i>p</i> = 0.01) at day 7.</p><p><strong>Innovation: </strong>Fisetin is the first topical seno-modulatory agent shown to enhance wound repair when administered after injury onset. Its favorable safety and efficacy in both modulating senescence and inflammation highlight its potential as a novel therapy for diabetic wounds.</p><p><strong>Conclusion: </strong>Topical fisetin enhances diabetic wound healing by reducing fibrosis and promoting healthy dermal regeneration through senescence and inflammation modulation. [Figure: see text].</p>","PeriodicalId":7413,"journal":{"name":"Advances in wound care","volume":" ","pages":"21621918261426580"},"PeriodicalIF":5.6,"publicationDate":"2026-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13078590/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147275398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Efficacy of Negative Pressure Wound Therapy Combined with Topical Oxygen Therapy in Treating Chronic Refractory Wounds: A Systematic Review and Meta-Analysis.","authors":"Junwei Su, Dong Zhang, Jincheng Du, Ruozu Xiao, Zhe Liu, Yuqian Li, Haowei Zhou, Jing Li","doi":"10.1177/21621918251366606","DOIUrl":"10.1177/21621918251366606","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the clinical efficacy of negative pressure wound therapy (NPWT) combined with topical oxygen therapy (TOT) for chronic refractory wounds (CRWs), addressing potential hypoxia limitation of NPWT through oxygen supplementation, thereby offering an innovative therapeutic approach for CRWs.</p><p><strong>Approach: </strong>The study was performed according to the 2015 Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols statement. A comprehensive search was conducted in PubMed, Cochrane, Embase, Web of Science, CNKI, VIP, and Wanfang databases for randomized controlled trials (RCTs) on the treatment of CRWs with NPWT combined with TOT (inception to October 2024). Studies were screened based on predefined criteria, and data were extracted and assessed using RevMan 5.4. Meta-analysis, sensitivity analysis, and publication bias assessment were performed using Stata 15.0.</p><p><strong>Results: </strong>Eleven RCTs (844 patients) were included. Compared with NPWT, the combination therapy was associated with the following outcomes: increased healing rate (risk ratio [RR] = 1.51, 95% confidence interval [CI]: 1.36-1.69, <i>I</i>² = 18.1%), reduced time from debridement to skin grafting (mean difference [MD] = -2.82 days, 95% CI: -3.15 to -2.50, <i>I</i>² = 4%), shortened healing time (MD = -9.09 days, 95% CI: -11.98 to -6.20, <i>I</i>² = 91.2%), enhanced granulation coverage (MD = 7.56%, 95% CI: 6.09-9.03, <i>I</i>² = 0.0%), and decreased bacterial positivity (RR = 0.27, 95% CI: 0.18-0.41, <i>I</i>² = 0.0%).</p><p><strong>Innovation: </strong>This study provides evidence-based medical research supporting NPWT plus TOT as a synergistic strategy for CRWs.</p><p><strong>Conclusion: </strong>Combined therapy may offer benefits over NPWT alone in CRW treatment, suggesting a promising approach to improve healing outcomes.</p>","PeriodicalId":7413,"journal":{"name":"Advances in wound care","volume":" ","pages":"21621918251366606"},"PeriodicalIF":5.6,"publicationDate":"2026-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144833616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic Nutritional Index as a Predictor of Mortality in Intensive Care Unit Patients with Pressure Injuries: Insights from a Large Cohort Study.","authors":"Wen Gao, Jia-Tong Zhou, Ke Shi, Jian-da Zhou","doi":"10.1177/21621918251387643","DOIUrl":"10.1177/21621918251387643","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the association between the Prognostic Nutritional Index (PNI) and mortality risk in intensive care unit (ICU) patients with pressure injuries (PIs) to provide a basis for early risk stratification and clinical decision-making.</p><p><strong>Approach: </strong>This retrospective cohort study used data from the Medical Information Mart for Intensive Care IV database, which included 972 ICU patients diagnosed with PI. Patients were stratified by median PNI levels, and Kaplan-Meier survival analysis, Cox regression, logistic regression, restricted cubic splines, and propensity score matching (PSM) were performed to assess the relationship between PNI and 28-day, 90-day, and ICU mortality.</p><p><strong>Results: </strong>A higher PNI was significantly associated with lower 28-day (hazard ratio [HR] = 0.702, 95% confidence interval [CI] 0.551-0.895), 90-day (HR = 0.722, 95% CI: 0.576-0.905), and ICU mortality (odds ratio [OR] = 0.644, 95% CI: 0.474-0.872). An L-shaped relationship between the PNI and all-cause mortality was observed. This association remained robust after multivariate adjustment, subgroup analysis, and PSM.</p><p><strong>Innovation: </strong>This study is the first to evaluate the prognostic significance of the PNI in ICU patients with PIs, addressing the gap in current research by identifying a simple and accessible marker associated with mortality risk in this vulnerable population.</p><p><strong>Conclusion: </strong>PNI can be calculated from routine laboratory results and may guide early nutritional or wound care interventions in ICU patients with PI. A PNI value below 19.02 is associated with an increased risk of mortality (<i>i.e.</i>, PNI <19.02 = high risk) and serves as a critical threshold for identifying patients at elevated risk.</p>","PeriodicalId":7413,"journal":{"name":"Advances in wound care","volume":" ","pages":"21621918251387643"},"PeriodicalIF":5.6,"publicationDate":"2026-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145290625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Selective Autophagy: A Potential Player in Cutaneous Wound Healing.","authors":"Weixue Jin, Danyang Ren, Meirong Yu, Yi Li, Wei Zhang, Songxue Guo","doi":"10.1177/21621918251372954","DOIUrl":"10.1177/21621918251372954","url":null,"abstract":"<p><strong>Significance: </strong>Refractory wounds are complicated multistep biological processes that can lead to severe complications in patients. Selective autophagy plays a crucial role in precisely controlling the quality of intracellular components and regulating biological behavior. This review explores the features and underlying mechanisms of various types of selective autophagy and highlights their implications in burn injury and wound healing.</p><p><strong>Recent advances: </strong>In-depth studies have underscored the critical role of selective autophagy, including mitophagy, endoplasmic reticulum (ER)-phagy, pexophagy, xenophagy, lysophagy, ferritinophagy, and lipophagy, in effectively controlling the quality of intracellular components and regulating biological behavior, which may enhance wound-healing process.</p><p><strong>Critical issues: </strong>Autophagy is a housekeeping and self-renewal process that utilizes lysosomal machinery to degrade and recycle cellular components, thereby enhancing cellular adaptability to stressful conditions. In addition to nonselective bulk degradation, autophagy selectively recycles specific cell constituents, including mitochondria, ER, peroxisomes, pathogens, lysosomes, lipid droplets, and ferritin. The effective management of the quality of cellular components during wound healing remains a challenge in clinical practice.</p><p><strong>Future directions: </strong>Understanding the basic mechanisms and intricate crosstalk underlying selective autophagy may facilitate the development of comprehensive strategies and therapeutic targets for wound healing.</p>","PeriodicalId":7413,"journal":{"name":"Advances in wound care","volume":" ","pages":"21621918251372954"},"PeriodicalIF":5.6,"publicationDate":"2026-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145068810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}