Advances in wound care最新文献

{"title":"Electrically Conductive Hydrogels for Wound Healing.","authors":"Lulu Sun, Ruinan Hao, Kelly Van Van, Feng Tian, Jiajia Xue","doi":"10.1177/21621918251374285","DOIUrl":"https://doi.org/10.1177/21621918251374285","url":null,"abstract":"<p><p><b>Significance:</b> Wound healing is a complex, tightly regulated process involving a range of enzymes, growth factors, and cytokines that coordinate cellular activities essential for tissue repair and wound closure. However, in cases of extensive or severe injury, the intrinsic repair mechanisms are often insufficient, underscoring the need for advanced therapeutic strategies to accelerate healing and minimize scar formation. <b>Recent Advances:</b> Electrically conductive hydrogels (ECHs), combining the advantageous properties of hydrogels with the physiological and electrochemical characteristics of conductive materials, present a safer and more convenient alternative to traditional electrode-based electrical stimulation (ES) for treating chronic and nonhealing wounds. This review summarizes the various types of ECHs and their functional roles in facilitating wound healing. <b>Critical Issues:</b> Understanding the mechanisms by which ECHs interact with electrical signals in the skin, along with precise control of the synergy between these signals and other functional properties, is critical for achieving optimal wound healing outcomes. <b>Future Directions:</b> Future development of ECHs should focus on elucidating underlying mechanisms, standardizing ES parameters, validating efficacy in clinically relevant animal models, and integrating multifunctional systems. Additionally, material design must be optimized for biocompatibility, adaptability, and scalability to facilitate clinical translation in chronic and nonhealing wound treatment.</p>","PeriodicalId":7413,"journal":{"name":"Advances in wound care","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145032432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multi-State Modeling of Pressure Injury Staging Transition Trajectories to Inform Next-Generation Clinical Decision Support.","authors":"Wenyu Song, Min-Jeoung Kang, Luwei Liu, Michael Sainlaire, Graham Lowenthal, Veysel Karani Baris, Sandy Cho, Diane L Carroll, Debra Furlong, Wadia Gilles-Fowler, Luciana Goncalves, Stuart Lipsitz, Beth Melanson, Lori Morrow, Jacqueline Massaro, Tanya Martel, Paula Wolski, Linying Zhang, David W Bates, Patricia C Dykes","doi":"10.1177/21621918251372959","DOIUrl":"https://doi.org/10.1177/21621918251372959","url":null,"abstract":"<p><p><b>Objective:</b> This study aimed to evaluate the location-specific and time-sensitive trajectories of pressure injuries (PrIs) stages using real-world electronic health record (EHR) datasets. <b>Approach:</b> Using a dataset of 29,475 patients with records of PrIs documented from 2015 to 2023, we developed four PrI patient sub-cohorts with common PrI locations, including coccyx, buttocks, sacrum and heel. We estimated transition intensities between three PrI states: stage 1, stage 2, and a severe stage in each group. Stages and transition paths were derived from domain knowledge provided by clinical experts and The National PrI Advisory Panel (NPIAP) guidelines. <b>Results:</b> The trajectory analysis suggested that stage 2 serves as a \"gateway state\" in all four locations, meaning that once a PrI reaches stage 2, the likelihood of transiting to severe stages increases significantly. The commonly used Braden Scale and its sub-components are more likely to be associated with transitions from stage 2 to severe stages, suggesting that manual risk assessment tools are suboptimal for predicting early-stage PrI transitions. Further, we observed race-dependent variations across injury location groups. <b>Innovation:</b> To our knowledge, this is the first study to introduce multi-state trajectory analysis in PrI research. Our model can investigate PrI status in a dynamic manner, which fills an important gap in the field. <b>Conclusion:</b> Our findings underscore the lack of time-sensitive information in existing PrI risk assessment tools, revealing a critical gap in their ability to capture the dynamic nature of PrI progression. Clinical decision support using time sensitive data is needed for delivering personalized, timely, and effective PrI prevention.</p>","PeriodicalId":7413,"journal":{"name":"Advances in wound care","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144991100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alginate Formulation for Wound Healing Applications.","authors":"Louai Alrata, Dahlia Abdulsattar, Sabrina Madrigal, Sophia R Pyeatte, Mohamed Zaghloul, Wahid Abu-Amer, Batool Arif, Tarek Alhamad, Maria Remedi, Yiing Lin, Mohamed A Zayed","doi":"10.1089/wound.2024.0081","DOIUrl":"10.1089/wound.2024.0081","url":null,"abstract":"<p><p><b>Significance:</b> Alginate, sourced from seaweed, holds significant importance in industrial and biomedical domains due to its versatile properties. Its chemical composition, primarily comprising β-D-mannuronic acid and α-L-guluronic acid, governs its physical and biological attributes. This polysaccharide, extracted from brown algae and bacteria, offers diverse compositions impacting key factors such as molecular weight, flexibility, solubility, and stability. <b>Recent Advances:</b> Commercial extraction methods yield soluble sodium alginate essential for various biomedical applications. Extraction processes involve chemical treatments converting insoluble alginic acid salts into soluble forms. While biosynthesis pathways in bacteria and algae share similarities, differences in enzyme utilization and product characteristics are noted. <b>Critical Issues:</b> Despite its widespread applicability, challenges persist regarding alginate's stability, biodegradability, and bioactivity. Further understanding of its interactions in complex biological environments and the optimization of extraction and synthesis processes are imperative. Additionally, concerns regarding immune responses to alginate-based implants necessitate thorough investigation. <b>Future Directions:</b> Future research endeavors aim to enhance alginate's stability and bioactivity, facilitating its broader utilization in regenerative medicine and therapeutic interventions. Novel approaches focusing on tailored hydrogel formations, advanced drug delivery systems, and optimized cellular encapsulation techniques hold promise. Continued exploration of alginate's potential in tissue engineering and wound healing, alongside efforts to address critical issues, will drive advancements in biomedical applications.</p>","PeriodicalId":7413,"journal":{"name":"Advances in wound care","volume":" ","pages":"467-478"},"PeriodicalIF":5.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142611749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Structured Exercise Therapy Increases Endogenous Antioxidants to Repair Muscle Strength and Health in Porcine Ischemic Myopathy Model of Peripheral Artery Disease.","authors":"Carson Hoffmann, Dennis Foster, Emma Fletcher, Maiko Sasaki, Feifei Li, Dylan McLaughlin, Xiangqin Cui, Panagiotis Koutakis, Jarrod A Call, Luke Brewster","doi":"10.1089/wound.2024.0053","DOIUrl":"10.1089/wound.2024.0053","url":null,"abstract":"<p><p><b>Objective:</b> The mechanisms of structured exercise therapy (SET) in peripheral artery disease (PAD) are not clear. We have developed an SET module for our large animal model of ischemic myopathy. We hypothesized that SET would increase muscle strength and walking distance in this model. The objective was to discover the SET-dependent mechanisms involved in this process. <b>Approach:</b> After induction of unilateral hind limb ischemia, three animals were exposed to standard environmental enrichment (sedentary or SED) and four animals underwent SET thrice weekly for 4 weeks postoperatively. Walking, hind limb pressure indices, and strength testing were performed weekly. Terminal muscle samples were used for skeletal muscle testing. <b>Results:</b> SET animals increased walking distance over time. SET increased muscle strength in both the ischemic and nonischemic limb. When comparing the ischemic SED hind limb muscle with that of ischemic + SET, the SET group has improved respiration and decreased oxidative stress. Markers of cell death and impaired functional regeneration were increased in SED ischemic muscles but returned toward baseline in the SET ischemic muscle. <b>Innovation:</b> This study uses a validated, large animal model of ischemic myopathy similar to that seen in humans with PAD. The effects of exercise on limb function, strength, and skeletal muscle health are reported in this model. <b>Conclusion:</b> SET increases muscle strength and regeneration by increasing endogenous antioxidants and mitochondrial respiration, resulting in favorable muscle health despite ongoing ischemia. This model may assist in preclinical testing of PAD therapies designed to improve muscle health.</p>","PeriodicalId":7413,"journal":{"name":"Advances in wound care","volume":" ","pages":"450-466"},"PeriodicalIF":5.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143187966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Analysis of Animal Models in Wound Healing Research and the Utility for Humanized Mice Models.","authors":"Haley Cirka, Tammy T Nguyen","doi":"10.1089/wound.2024.0082","DOIUrl":"10.1089/wound.2024.0082","url":null,"abstract":"<p><p><b>Significance:</b> The rise of chronic nonhealing lower extremity wounds among aging, diabetic, obese, and cardiovascular patients has surged. Despite a decade of drug testing in preclinical animal models, few federally approved therapies have emerged. This translational gap raises concerns about the efficacy of current wound healing models and the need for improved research development. <b>Recent Advances:</b> To improve commonly used animal models of chronic wounds, researchers have made several animal model modifications to better mimic and understand the microbiota and immune-mediated wound healing processes that occur in humans. <b>Critical Issues:</b> Existing models do not fully account for the differences in skin architecture, healing processes, and immune system responses in wound healing between animal models and humans. Therefore, it is imperative to understand the limitations of a chosen model when designing experiments. As such, findings must be interpreted cautiously and validated in human contexts. <b>Future Directions:</b> Given the complexity of human wound healing, the use of several different animal models tailored to specific biological questions is necessary. Recent advancement in humanized mouse models and microbiota consideration offer a promising approach to study the human immune-mediated response in chronic wound healing.</p>","PeriodicalId":7413,"journal":{"name":"Advances in wound care","volume":" ","pages":"479-512"},"PeriodicalIF":5.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12411096/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144141276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Smoking Status Impacts Mitochondrial Function and Synthetic Function in Mesenchymal Stem Cells Derived from Diabetics with Arterial Insufficiency.","authors":"Dylan McLaughlin, Maiko Sasaki, Carson Hoffmann, Luke Brewster, Katherine E Hekman","doi":"10.1089/wound.2024.0075","DOIUrl":"10.1089/wound.2024.0075","url":null,"abstract":"<p><p><b>Objective:</b> Diabetes and smoking are frequently co-morbid conditions leading to arterial insufficiency, significantly increasing the risk of non-healing wounds and subsequent major amputation. Autologous patient-specific mesenchymal stem cells (MSCs) present a novel tool for regenerative therapy to treat advanced stages of arterial insufficiency. The regenerative performance of cells from diabetics with impaired arterial perfusion is known to be reduced, but the impact of additional patient factors such as smoking remains poorly understood. <b>Approach:</b> MSCs were harvested from amputees under IRB approval. Mitochondria were evaluated for mitophagy and bioenergetic function. MSC growth, reactive oxygen species (ROS), and synthetic function were measured. Exogenous nicotine was used to mimic smoking byproducts. Data were analyzed by one-way analysis of variance with <i>p</i> < 0.05 considered statistically significant. <b>Results:</b> Four MSC patient lines were from smokers and four were from non-smokers. All were male, diabetic, and matched for age. Mitochondrial turnover, ROS production, proliferation, and doubling time were comparable between groups. Smoking status significantly decreased glycolytic capacity, maximal mitochondrial respiration, and the synthetic function of MSCs compared with non-smokers (<i>p</i> < 0.05). Acute nicotine exposure in non-smoker MSCs significantly increased mitochondrial function, an effect that incompletely resolved with nicotine withdrawal (<i>p</i> < 0.001). <b>Innovation:</b> This study implicates mitochondrial dysfunction in smoking-mediated impairment of MSC synthetic function. <b>Conclusion:</b> Smoking alters mitochondrial bioenergetics and synthetic function of MSCs from diabetic patients with arterial insufficiency. Restoring mitochondrial function may improve synthetic function and therapeutic capabilities of smoker MSCs. Targeted rejuvenation strategies may be required based on smoking status for autologous MSC therapies for patients with arterial insufficiency.</p>","PeriodicalId":7413,"journal":{"name":"Advances in wound care","volume":" ","pages":"439-449"},"PeriodicalIF":5.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142870972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Human Wound and Its Burden: Updated 2025 Compendium of Estimates.","authors":"Chandan K Sen","doi":"10.1177/21621918251359554","DOIUrl":"10.1177/21621918251359554","url":null,"abstract":"<p><p>Chronic wounds are a silent epidemic in the United States, affecting one in six Medicare beneficiaries-about 10.5 million people-and costing Medicare an estimated $22.5 billion annually. While outpatient wound care costs dropped from $10.5 billion in 2014 to $2.5 billion in 2019, physician office costs rose to $4.1 billion, reflecting a shift in care delivery. Globally, wound care expenditure reached a staggering $148.65 billion in 2022. Despite this burden, federal research funding remains disproportionately low. Chronic wounds often recur due to incomplete healing. Many wounds close by resurfacing without discharge but fail to restore the skin's barrier function-measured by transepidermal water loss at the site of closure-making them prone to reopening. Outcomes of recent patient-based studies advocate redefining wound closure endpoint to include full barrier restoration. The 2023 Wound Balance Framework promotes holistic, patient-centered care, while cutting-edge technologies are reshaping the field. Bioengineered skin therapies can reduce healing time. Machine learning tools, such as scanning electron microscopy-based trainable Weka (Waikato Environment for Knowledge Analysis) intelligent segmentation technology, detect biofilms, while other tools predict healing outcomes and amputation risks. Multiomics technologies identify biomarkers such as Fos-related antigen 1 (FOSL1), enabling precision therapies tailored to wound phase and patient biology. Telehealth is proving to be transformative for wound care. A 2023 meta-analysis of 2,397 patients showed it significantly reduced healing time, pain, and amputation rates. Policy is catching up: Centers for Medicare & Medicaid Services doubled allowable skin substitute applications (from four to eight) and extended treatment windows to 16 weeks. The Better Wound Care at Home Act established national payment for disposable negative pressure wound therapy, and the Lymphedema Treatment Act mandated Medicare coverage for compression garments, projected to save $1.3-$1.5 billion over 10 years. Together, these advances signal a shift toward proactive, personalized, and equitable wound care-driven by science, guided by ethics, supported by policy, and centered on patients.</p>","PeriodicalId":7413,"journal":{"name":"Advances in wound care","volume":" ","pages":"429-438"},"PeriodicalIF":5.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144635963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of Diabetic Wounds: Expert Panel Consensus Statement.","authors":"Henry C Hsia, Elof Eriksson, Geoffrey C Gurtner, Aristidis Veves, Osama Hamdy, David J Margolis, David G Armstrong, Lawrence A Lavery, Elisabeth A Grice, Greg Schultz, Michael S Conte, Robert S Kirsner, Christopher E Attinger, John S Steinberg, Karen K Evans, Dot Weir, Paul J Kim, Dennis P Orgill, Kenneth W Liechty, J Peter Rubin","doi":"10.1177/21621918251366586","DOIUrl":"https://doi.org/10.1177/21621918251366586","url":null,"abstract":"<p><p><b>Significance:</b> The Wound Healing Foundation recognized the need for consensus-based unbiased recommendations for the treatment of wounds. Consensus statements on the treatment of chronic wounds and acute wounds have been developed and published previously. The current publication on diabetic wounds represents the next step in this process. Diabetic wounds constitute a major problem. Population-based and meta-analytic studies indicate that the presence of foot wounds in patients with diabetes increases their mortality risk by more than twofold. The management of diabetic wounds requires consistent and evidence-driven intervention to achieve optimal clinical outcomes. This consensus statement provides the clinician with the necessary foundational approaches to the causes, diagnosis, and therapeutic management of diabetic wounds. Presented in a structured format, this is a useful guide for clinicians and learners in all patient care settings. <b>Recent Advances:</b> Continuous glucose monitoring and other new tools have facilitated better diabetes management and the management of associated wounds. Diabetic limb salvage should focus on achieving and optimizing function for the patient with diabetes rather than preserving limb tissue at all costs. <b>Critical Issues:</b> Successful management of diabetic wounds requires a multidisciplinary approach encompassing comprehensive assessment, timely intervention, and collaborative care by the wound clinician with providers who can address critical aspects to achieve healing, including careful management of blood glucose levels, optimization of off-loading and physical therapy, assessment and treatment of limb ischemia, control and prevention of wound infection, and optimal pain management. <b>Future Directions:</b> Emerging treatments offer hope and promise, but the heterogenicity of diabetic wounds poses a challenge to performing good studies, which will be necessary to advance new treatments for diabetic wounds.</p>","PeriodicalId":7413,"journal":{"name":"Advances in wound care","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144938809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plasma Medicine in Wound Care.","authors":"Han Wu, Jiunn-Der Liao, Shin-Chen Pan, Pei-Lin Shao, Tak-Wah Wong, Han Lee","doi":"10.1177/21621918251366631","DOIUrl":"10.1177/21621918251366631","url":null,"abstract":"<p><p>Plasma medicine offers an innovative and advanced physical approach to wound care that uniquely combines wound antimicrobial effects (primary goal) and accelerated regeneration of injured tissue (secondary goal). This review explores its transformative potential in modern medicine, demonstrating how this technology can enhance wound healing, reduce microbial load, and improve clinical outcomes. A certified plasma device provides an add-on technology that has the potential to improve current wound care medical procedures by integrating findings from basic research, preclinical models, and clinical applications. This review underscores the significant role of plasma medicine in transforming wound care practices by bridging fundamental research, preclinical validation, regulatory compliance, and clinical application, paving the way for safer, more effective, and minimally invasive treatment strategies.</p>","PeriodicalId":7413,"journal":{"name":"Advances in wound care","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144870849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diabetic Wound Vasculopathy and Neuropathy: Spotlight on Wound Lipid Signaling.","authors":"Theja Bhamidipati, John P Hajj, Nehal I Ghoneim, Arhat M Pradhan, Sanjay Mishra, Bharat Gummalla, Ahmed Safwat Abouhashem, Avanish Singh Parmar, Savita Khanna, Sashwati Roy, Chandan K Sen, Kanhaiya Singh","doi":"10.1177/21621918251366681","DOIUrl":"10.1177/21621918251366681","url":null,"abstract":"<p><p><b>Significance:</b> Skin lipids are essential for various skin functions including maintaining barrier integrity, regulating hydration, and providing protection against microbes and inflammatory irritants. Along with skin health, the role of lipids in the etiology of macroangiopathic diseases, such as atherosclerosis of arteries, is well recognized. <b>Recent Advances:</b> In diabetes, lipid dysregulation is evident and may contribute to the diverse complications of the disease. Diabetic vasculopathy primarily reflects the dysfunction and deterioration of existing blood vessels, as their preservation is key in preventing the progression of vascular disease and reducing the need for compensatory angiogenesis. In the peripheral diabetic skin of the limbs, diabetic vasculopathy runs alongside peripheral neuropathy. Although a causative link between the two is plausible, direct evidence in support of such claim is scanty. <b>Critical Issues:</b> Diabetic skin is known to be compromised in many ways, including weakened barrier functionality and diabetes-induced alterations in the extracellular matrix, likely stemming from chronic inflammation, which may directly affect vascular integrity and nerve health. Both, in the compromised skin and within wounds, microbial pathogens and their enzymes may metabolize host lipids, driving inflammatory reactions and exacerbating the pathogenesis of diabetic vasculopathy and related neuropathy. <b>Future Directions:</b> This review focuses on lipid mediators such as sphingolipids, resolvins, oxidized low-density lipoproteins and their specific downstream signaling pathways to obtain a comprehensive understanding of diabetic complications relevant to wound healing. Through lipid-based strategies, this review hopes to inspire the development and utilization of individualized, precision-based approaches to manage diabetic vasculopathy and neuropathy.</p>","PeriodicalId":7413,"journal":{"name":"Advances in wound care","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12442785/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144844061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}