Advances in wound care最新文献

{"title":"Patterns of Co-Occurring Pressure Injuries: A Data-Driven Study Using Real-World Clinical Records.","authors":"Veysel Karani Baris, Wenyu Song, Min-Jeoung Kang, Luwei Liu, Graham Lowenthal, Luciana Schleder Goncalves, Tanya Martel, Sandy Cho, Diane L Carroll, Debra Furlong, Wadia Gilles-Fowler, Lisa Herlihy, Beth Melanson, Jacqueline Massaro, Lori D Morrow, Paula Wolski, Patricia C Dykes","doi":"10.1089/wound.2025.0019","DOIUrl":"10.1089/wound.2025.0019","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to investigate patterns and risk factors associated with co-occurring pressure injuries (PrIs) using real-world clinical data.</p><p><strong>Approach: </strong>This retrospective cohort study analyzed electronic health records (EHRs) of adult patients with PrIs from 2015 to 2023 across five hospitals within a large U.S. health care system. An EHR-based phenotype-a set of algorithmic rules using structured clinical data-was developed and validated to identify patients with co-occurring PrIs, enabling classification of all patients in the study cohort into either single-occurring or co-occurring PrI groups. The accuracy of the co-occurring PrI phenotype was assessed through chart review. Univariate analyses and binary logistic regression were employed to identify risk factors associated with co-occurring PrIs. All findings are reported in accordance with the STROBE checklist.</p><p><strong>Results: </strong>Among 18,195 patients with at least one PrI record, 4,415 (24.3%) had co-occurring PrIs. The phenotype demonstrated high accuracy (accuracy = 0.96). Pattern analysis showed a direct association between the number of PrIs and severe-stage injuries. Logistic regression revealed that severe PrIs (odds ratio [OR] 3.47; 95% confidence interval [CI]: 3.23-3.74) were most strongly associated with co-occurring PrIs, followed by Black or African American race (OR: 1.45; 95% CI: 1.14-1.84) and spinal cord injury (OR: 1.32; 95% CI: 1.14-1.52).</p><p><strong>Innovation: </strong>This study introduces a validated EHR-based phenotype for identifying co-occurring PrIs. It reveals a direct link between co-occurring PrIs and injury severity, as well as unique risk factors associated with co-occurring PrIs.</p><p><strong>Conclusions: </strong>Co-occurring PrIs are prevalent and strongly associated with severe PrIs. This study also revealed distinct occurrence patterns, with injury severity increasing as the number of co-occurring PrIs rises. The findings from this study emphasize the need for targeted risk assessment and prevention efforts for co-occurring PrIs.</p>","PeriodicalId":7413,"journal":{"name":"Advances in wound care","volume":" ","pages":"735-746"},"PeriodicalIF":5.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144635964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of Perioperative Real-Time Fluorescence Imaging to Achieve High-Quality Debridement: A Randomized Control Trial.","authors":"Jui-Chen Hsu, Yi-Hung Chu, Yi-Chun Wu, Jung-Hsuan Chang, Ching-Uen Huang, Xin-Yi Lin, Yu-Fen Chiu, Fu-Yu Wang, Ka-Wai Tam, Shun-Cheng Chang","doi":"10.1177/21621918251359558","DOIUrl":"10.1177/21621918251359558","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the effectiveness of real-time fluorescence imaging (RTFI)-assisted debridement in managing chronic wounds compared with standard surgical debridement.</p><p><strong>Approach: </strong>This study was a patient-blinded, randomized clinical trial conducted from February 17, 2021, to July 30, 2021, on patients with chronic wounds. Patients were randomized to an RTFI group (M group) or conventional group (C group). The primary outcomes were as follows: percentage of residual bacterial area (preoperative and postoperative), number of debridements, high-quality debridement ratio, operation duration, and wound healing duration.</p><p><strong>Results: </strong>A total of 100 patients were enrolled in both groups. No significant difference in the percentage of preoperative residual bacterial area or high-quality debridement ratio was seen. The M group underwent debridement an average of 2.6 times and had a significantly longer duration of operation (33.5 ± 12.7 min) than the C group (29.9 ± 10.4 min; <i>p</i> = 0.031). The postoperative residual bacterial area was significantly lower in the M than in the C group (6.83% ± 1.39% vs. 30.0% ± 12.37%, respectively; <i>p</i> < 0.001). The M group required significantly fewer wound healing days (49.2 ± 25.3 vs. 63.0 ± 27.9, <i>p</i> < 0.001). Secondary outcomes also demonstrated statistically significant differences in total hospitalized days (17.5 ± 9.3 vs. 21.5 ± 12.5, <i>p</i> < 0.01), days of antibiotic use (15.5 ± 8.7 vs. 18.7 ± 6.7, <i>p</i> < 0.01), and reinfection rates (4 of 100 vs. 22 of 100, <i>p</i> < 0.001).</p><p><strong>Innovation: </strong>RTFI can detect signals from normal skin components and bacterial metabolites. Therefore, interpretation of RTFI results should be correlated with the clinical condition. RTFI is associated with high-quality debridement. This technique can also be applied in targeted biopsy and in training young staff to mature debridement procedures.</p><p><strong>Conclusion: </strong>RTFI in debridement is associated with favorable clinical outcomes and may have a positive influence on chronic wound healing.</p>","PeriodicalId":7413,"journal":{"name":"Advances in wound care","volume":" ","pages":"722-734"},"PeriodicalIF":5.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144625270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiological Trends of Pressure Injuries at the Global, Regional, and National Levels: A Trend Analysis Study from 1990 to 2021.","authors":"Hao Yang, Yuxi Zhou, Honglin Wu, Yongfei Chen, Xiaohui Li, Peng Wang, Jiayuan Zhu, Zhicheng Hu, Shuting Li","doi":"10.1089/wound.2025.0003","DOIUrl":"10.1089/wound.2025.0003","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate global, regional, and national trends in the prevalence and disability-adjusted life years (DALYs) of pressure injuries (PIs) from 1990 to 2021 and project future trends to 2035, based on data from the Global Burden of Disease (GBD) study.</p><p><strong>Approach: </strong>This study used GBD 2021 data to analyze PIs prevalence and DALYs by age, sex, and Sociodemographic Index (SDI) region. The Bayesian age-period-cohort model was employed for temporal trend analysis and future projections.</p><p><strong>Results: </strong>From 1990 to 2021, the global prevalence slightly decreased from 8.246 to 7.920 per 100,000 (estimated annual percentage change -0.023%), whereas DALYs decreased by 9.7%. High-SDI regions presented significant DALY reductions (-39.3%), whereas middle- and low-middle-SDI regions presented increased prevalence rates (20.5% and 28.9%, respectively). The prevalence was highest in the ageing population, peaking in the 95+ year age group. Projections estimate that there will be 720,660 global cases by 2035, with the greatest burden expected among older adults in developing regions.</p><p><strong>Innovation: </strong>This study provides a comprehensive longitudinal analysis of PIs, revealing global disparities and emphasizing demographic-specific risks, especially in ageing populations and low-SDI regions. Bayesian modeling offered robust future projections.</p><p><strong>Conclusion: </strong>Despite modest improvements globally, significant disparities in the prevalence of PIs persist, particularly in developing regions and among older adults. Targeted interventions, preventive strategies, and health care policies are critical for addressing these challenges and mitigating future disease burdens.</p>","PeriodicalId":7413,"journal":{"name":"Advances in wound care","volume":" ","pages":"747-760"},"PeriodicalIF":5.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144300956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plasma Medicine in Wound Care.","authors":"Han Wu, Jiunn-Der Liao, Shin-Chen Pan, Pei-Lin Shao, Tak-Wah Wong, Han Lee","doi":"10.1177/21621918251366631","DOIUrl":"10.1177/21621918251366631","url":null,"abstract":"<p><p>Plasma medicine offers an innovative and advanced physical approach to wound care that uniquely combines wound antimicrobial effects (primary goal) and accelerated regeneration of injured tissue (secondary goal). This review explores its transformative potential in modern medicine, demonstrating how this technology can enhance wound healing, reduce microbial load, and improve clinical outcomes. A certified plasma device provides an add-on technology that has the potential to improve current wound care medical procedures by integrating findings from basic research, preclinical models, and clinical applications. This review underscores the significant role of plasma medicine in transforming wound care practices by bridging fundamental research, preclinical validation, regulatory compliance, and clinical application, paving the way for safer, more effective, and minimally invasive treatment strategies.</p>","PeriodicalId":7413,"journal":{"name":"Advances in wound care","volume":" ","pages":"761-786"},"PeriodicalIF":5.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144870849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Wound Healing, Senescence, and Senotherapeutics.","authors":"Louise E Pitcher, Junyu Zhu, Elizabeth L Schmidt, Laura J Niedernhofer, Ming Xu, Paul D Robbins","doi":"10.1177/21621918261490101","DOIUrl":"https://doi.org/10.1177/21621918261490101","url":null,"abstract":"<p><strong>Significance: </strong>Dermal repair is a tightly regulated process that becomes progressively impaired with aging, chronic diseases, and persistent tissue injury. Senescent cells (SnCs) accrue in the skin following damage and with advancing age, contributing to alterations in tissue homeostasis and repair. However, the role of SnCs in normal and impaired wound repair is pleiotropic and context-dependent, particularly in the context of age and chronic disease. Furthermore, the use of senotherapeutics that target SnCs can slow aging, mitigate chronic disease, and promote rejuvenation of aged tissues, implicating their potential efficacy in reverting dysregulated wound repair.</p><p><strong>Recent advances: </strong>The implementation of multi-OMIC analysis examining SnCs has improved our understanding of SnC heterogeneity within the skin and identified distinct SnC subsets that differentially influence tissue repair and its dysfunction. These studies have facilitated the development of senotherapeutics that selectively eliminate SnCs or suppress their detrimental phenotype. Preclinical studies demonstrate that treatment with senotherapeutics can improve tissue integrity and restore regenerative capacity.</p><p><strong>Critical issues: </strong>Despite significant progress, the types, functions, and temporal dynamics of SnC populations involved in wound healing remain poorly characterized. Further molecular and functional SnC phenotyping, especially under aged and diseased conditions, will be required to distinguish beneficial reparative senescence from persistent pathogenic senescence. In addition, optimal therapeutic timing, specificity, and delivery strategies remain unresolved.[Figure: see text]Future Directions:Integrating multiomics approaches in preclinical and clinical studies will be required to distinguish beneficial transient senescence from persistent pathogenic senescence for the further development of SnC-targeting therapies.</p>","PeriodicalId":7413,"journal":{"name":"Advances in wound care","volume":" ","pages":"21621918261490101"},"PeriodicalIF":5.7,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149102827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Admission Red Cell Distribution Width-Albumin Ratio and 1-Year Mortality in Chronic-Wound Inpatients: Prediction-Model Development, Internal Validation, and Exploratory Temporal Evaluation.","authors":"Mert Can Rador, Gaye Filinte, Bakhtiyar Mammadzada, Çağla Çiçek","doi":"10.1177/21621918261487905","DOIUrl":"https://doi.org/10.1177/21621918261487905","url":null,"abstract":"<p><strong>Objective: </strong>To identify admission-day factors associated with 1-year mortality in adults hospitalized with a chronic wound of any etiology, and to develop and internally validate a model pairing the red cell distribution width-albumin ratio (RAR) with the age-adjusted Charlson Comorbidity Index (ACCI).</p><p><strong>Approach: </strong>In a single-center retrospective cohort reported per Strengthening the Reporting of Observational Studies in Epidemiology and Transparent Reporting of a multivariable prediction model for Individual Prognosis or Diagnosis + Artificial Intelligence, adults admitted for a chronic wound (2021-2024) were analyzed at first admission (<i>n</i> = 584). Admission markers were compared by area under the curve; a logistic model of RAR and ACCI was internally validated by bootstrapping and applied unchanged to a later same-center cohort (<i>n</i> = 124) for exploratory temporal evaluation. The primary outcome was 1-year all-cause mortality.</p><p><strong>Results: </strong>Fifty-three patients (9.1%) died within 1 year. Pressure ulcers carried the highest mortality; the strongest comorbid markers were prior intensive care, dementia, and cardiopulmonary disease. RAR discriminated best, ahead of its components, albumin and red cell distribution width. The two-variable model showed strong discrimination (optimism-corrected C-statistic 0.855) and good calibration, stratifying patients into low-, intermediate-, and high-risk tiers (observed mortality 1.3%, 9.0%, and 36.8%); a high admission RAR (≥5.2) or low albumin (<3.0 g/dL) likewise flagged high-risk patients. In an exploratory same-center temporal evaluation, discrimination was similar; calibration was imprecise.</p><p><strong>Innovation: </strong>This provides a simple, admission-day, patient-level 1-year mortality model for mixed-etiology chronic-wound inpatients, a group for whom admission-day mortality tools have been lacking.</p><p><strong>Conclusion: </strong>Two routine admission-day variables estimated 1-year mortality in chronic-wound inpatients well enough to separate risk groups on the day of admission.</p>","PeriodicalId":7413,"journal":{"name":"Advances in wound care","volume":" ","pages":"21621918261487905"},"PeriodicalIF":5.7,"publicationDate":"2026-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148966036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Practice Guidelines for the Prevention and Management of Pressure Injury in Critically Ill Patients Undergoing Prone Position Ventilation: A Systematic Review.","authors":"Ya-Bin Zhang, Chun-Yan Han, Dan Ma, Rui Li, Ai-Bing Si, Shui-Yu Wang","doi":"10.1089/wound.2024.0239","DOIUrl":"10.1089/wound.2024.0239","url":null,"abstract":"<p><strong>Significance: </strong>This systematic review was conducted to assess the quality of clinical practice guidelines (CPGs) on prevention and management of pressure injury (PI) in patients undergoing prone position ventilation (PPV) and summarize the recommendations based on the analyses of the CPGs.</p><p><strong>Recent advances: </strong>We searched the PubMed, Cochrane library, Embase databases, guideline websites, professional association, quality standards, and Wound-Related Research Journals from January 1, 2010 to August 31, 2024. Included guidelines were those with recommendations for prevention and management of PI in patients undergoing PPV published in English. Four researchers independently assessed the eligible studies and extracted the data. Appraisal of Guidelines Research & Evaluation (AGREE II) instrument and the Reporting Items for Practice Guidelines in Healthcare checklist were used to assess the quality of the CPGs.</p><p><strong>Critical issues: </strong>A total of 13 CPGs were included in this review. AGREE II demonstrated that the highest mean score was based on the scope and purpose and was 73.65 ± 10.91, whereas the lowest mean score was based on the editorial independence and was 49.79 ± 19.49. The scores of inter-rater agreements for AGREE-II quality appraisal ranged from 0.86 to 0.96. Recommendations for prevention and management of PI in patients undergoing PPV were inconsistent.</p><p><strong>Future directions: </strong>The included CPGs were limited due to methodological issues and exhibited discrepancies in the coverage of important topics. Therefore, existing evidence should be used to propose identifiable recommendations and strengthen the rigor and standardization of guideline development in future research.[Figure: see text].</p>","PeriodicalId":7413,"journal":{"name":"Advances in wound care","volume":" ","pages":"693-706"},"PeriodicalIF":5.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144232933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Noninferiority of Copper Dressings Than Negative Pressure Wound Therapy in Healing Diabetic Wounds: A Randomized Clinical Trial.","authors":"Eyal Melamed, Jihad Dabbah, Talia Israel, Ilana Kan, Michael S Pinzur, Tohar Roth, Gadi Borkow","doi":"10.1089/wound.2024.0273","DOIUrl":"10.1089/wound.2024.0273","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate if treatment of diabetic wounds by copper oxide impregnated dressings (COD) is noninferior to negative pressure wound therapy (NPWT).</p><p><strong>Approach: </strong>Following the CONSORT guidelines, patients with diabetes mellitus (type 1 or type 2) and noninfected wounds eligible for treatment with NPWT were randomized into two groups. One group received NPWT followed by standard wound care dressings, whereas the other was treated exclusively with COD. The primary outcome was wound size reduction, measured blindly using a 3D wound-imaging system. Secondary outcomes included patient and caregiver convenience (assessed <i>via</i> visual analog scores), cost, and additional wound parameters.</p><p><strong>Results: </strong>COD showed statistically significant noninferiority to NPWT in wound size reduction throughout the study (<i>p</i> < 0.01). The percentage of wounds that closed was 47.83% (11/23) and 34.78% (8/23) in the COD and NPWT arms, respectively (<i>p</i> > 0.05). The average time to wound closure, adjusted to potential confounders, such as gender, age, body mass index, diabetes, and smokers, was similar in both arms (<i>p</i> > 0.05). COD were found to be more convenient than NPWT for both patients (<i>p</i> < 0.001) and caregivers (<i>p</i> = 0.003), with a significantly shorter application time (<i>p</i> < 0.001). The COD cost was 14% of NPWT cost ($470 compared with $3,360).</p><p><strong>Innovation: </strong>COD may be considered as the first line of treatment for diabetic foot wounds when NPWT seems indicated.</p><p><strong>Conclusions: </strong>Using copper dressings as a first line of treatment of diabetic wounds, when NPWT is indicated, is expected to reduce health costs, improve convenience, and increase compliance without compromising the final outcome.</p>","PeriodicalId":7413,"journal":{"name":"Advances in wound care","volume":" ","pages":"659-670"},"PeriodicalIF":5.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143963906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and Validation of a Novel Risk Prediction Model for Incident Diabetic Foot Complications: A Large, Longitudinal, Population-Based Machine Learning Study.","authors":"Ziyun Li, Aomingyang Wang, Ruilin Wang, Yang Cao, Zaijin Tao, Zehou Sun, Zhiqi Lin, Xu Cao, Jin-Tai Yu, Xiaoqi Zheng, Xin Ma, Jia Jiang","doi":"10.1177/21621918261455459","DOIUrl":"10.1177/21621918261455459","url":null,"abstract":"<p><strong>Objective: </strong>Diabetic foot complications (DFCs) are common diabetes complications. Existing tools for predicting incident DFCs remain insufficient. This study aimed to develop and validate a novel machine learning-based model for incident DFC prediction.</p><p><strong>Approach: </strong>Using UK Biobank data, we built a longitudinal incident DFC cohort, with DFCs identified using International Classification of Diseases codes. Clinical features were screened by Cox models, and a machine learning model (DFC-Clin) was developed using fivefold cross-validation and leave-one-center-out validation. Performance was compared with diabetic foot risk stratification tools using the DeLong test. A web-based tool and risk stratification system were also developed.</p><p><strong>Results: </strong>Among 502,175 participants, 29,766 individuals formed the incident cohort, with 1,252 incident DFC events. Demographics, blood markers, lifestyle factors, and comorbidities were selected to construct DFC-Clin, with glycated hemoglobin and body mass index emerging as the most predictive features. The model showed improved discrimination compared with existing risk stratification tools, achieving area under the receiver operating characteristic curves of 0.782 ± 0.042, 0.766 ± 0.042, and 0.747 ± 0.021 for 5-year, 10-year, and overall incident DFC prediction, respectively.</p><p><strong>Innovation: </strong>DFC-Clin is a machine learning model for incident DFC prediction that uses accessible clinical features from a large population-based cohort and is coupled with a web-based application and risk stratification system.</p><p><strong>Conclusion: </strong>DFC-Clin estimates the risk of incident DFC across multiple time horizons and demonstrates improved discrimination compared with existing approaches. The web-based application and stratification framework are intended to support risk identification and preventive decision-making. Further studies are required for clinical deployment and evaluation on more clinical outcomes, including amputations, recurrence, and health care costs.[Figure: see text][Figure: see text][Figure: see text].</p>","PeriodicalId":7413,"journal":{"name":"Advances in wound care","volume":" ","pages":"643-658"},"PeriodicalIF":5.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148196897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pressure Injury Incidence and Quality of Care Index (1990-2021): An Analysis of Trends and Health Inequalities Based on the Study of Global Burden of Disease 2021.","authors":"Zhi-Qin Xie, Xue-Mei Tao, Ze-Quan Wang, Yun-Yu Du, Lin-Xia Yi, Chao Xie, Han-Xiao Yi, Min Zhang, Wan-Yin Xiong, Shi-Han Chen, Chao-Zhu He, Rui Liu, Li Zhou, Zhen Yang","doi":"10.1089/wound.2024.0241","DOIUrl":"10.1089/wound.2024.0241","url":null,"abstract":"<p><strong>Objectives: </strong>To elucidate the global disease burden and care quality associated with pressure injury (PI).</p><p><strong>Approach: </strong>This study examined temporal trends in PI incidence over the past 32 years. Decomposition analysis attributed these trends to demographic and epidemiological shifts, and cross-national health inequities were quantified. The Quality of Care Index (QCI) was constructed using principal component analysis to assess spatiotemporal variations in global PI care quality. A log-linear age-period-cohort model was employed to forecast trends over the next 15 years.</p><p><strong>Results: </strong>In 2021, there were nearly 2.47 million PI cases globally, a 115.92% increase from 1.14 million in 1990. Decomposition analysis revealed that population aging and demographic growth were the primary drivers of increasing PI incidence. Lower QCI was concentrated in African countries and those with low sociodemographic index (SDI). Incidence rates increased gradually with improving SDI. Significant health inequalities existed among 204 countries and regions, with minimal changes in inequality slope indices over time. Projections indicate a gradual increase to 3.5 million PI cases globally by 2035.</p><p><strong>Innovation: </strong>This study developed a novel comprehensive indicator, the QCI, and for the first time, shed light on health inequalities in PI across 204 countries and territories.</p><p><strong>Conclusion: </strong>Over the past 32 years, the global disease burden of PI has been significant, accompanied by health inequalities across countries and regions. For nations with low SDI, there remains considerable room for improvement in the quality of care for PI, necessitating more effective strategies to address health care disparities.</p>","PeriodicalId":7413,"journal":{"name":"Advances in wound care","volume":" ","pages":"681-692"},"PeriodicalIF":5.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144245727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}