Advances in wound care最新文献

{"title":"Comparison of \"Semiocclusive Dressing\" Treatment Using Plastic Wrap or Low-Adherent Absorbent Wound Dressings Versus Occlusive Dressing Treatment for Stage II Pressure Injuries: A Randomized, Controlled, Noninferiority Trial.","authors":"Jun Takahashi, Kayoko Nakae, Osamu Yokota, Rena Nakata, Hayato Hasegawa, Masaharu Miyagawa","doi":"10.1177/21621918251401165","DOIUrl":"10.1177/21621918251401165","url":null,"abstract":"<p><strong>Objective: </strong>To verify the noninferiority of the effectiveness of \"semiocclusive dressing\" (SOD) treatment using plastic wrap or low-adherent absorbent wound dressings compared with occlusive dressing (OD) treatment for National Pressure Injury Advisory Panel stage II pressure injuries.</p><p><strong>Approach: </strong>This 12-week, open-label, randomized, controlled, noninferiority trial was conducted at one hospital and three care facilities. Of the 115 participants, 56 were assigned to SOD treatment and 59 to OD treatment. The study design adhered to the CONSORT 2010 extension statement for noninferiority trials. The primary outcome was a comparison of the healing times for both treatments, with the noninferiority margin set at 7.0 days. Secondary outcomes included treatment costs, Kaplan-Meier curves, and incidence of adverse events.</p><p><strong>Results: </strong>The mean healing times for SOD and OD treatments were 19.7 and 22.5 days, respectively (<i>p</i> = 0.4175). The 95% confidence interval of the difference was -4.0 to 9.6. Since its lower limit was within the noninferiority margin, SOD treatment was confirmed to be not significantly worse than OD treatment. OD treatment had a significantly higher mean cost than SOD treatment (<i>p</i> < 0.0001). Kaplan-Meier curves for both groups were similar (<i>p</i> = 0.249). The incidence of adverse events in both groups was comparable.</p><p><strong>Innovation: </strong>Uniquely, the SOD does not tightly adhere to or completely occlude the wound and can manage abundant exudate. Therefore, SOD treatment maintains an adequately moist environment to facilitate wound healing.</p><p><strong>Conclusion: </strong>SOD treatment was more cost-effective than OD treatment for stage II pressure injuries.</p>","PeriodicalId":7413,"journal":{"name":"Advances in wound care","volume":" ","pages":"459-468"},"PeriodicalIF":5.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145666672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adipose-Based Therapeutics and Transplantation of Hypodermis.","authors":"Shawn Jeffrey Loder, J Peter Rubin","doi":"10.1177/21621918251400625","DOIUrl":"10.1177/21621918251400625","url":null,"abstract":"<p><strong>Significance: </strong>Wound healing is a complex process, and while the epidermis and dermis receive significant attention, the role of the hypodermis is important. The adipose-rich hypodermis or subcutaneous layer supports overall skin function, and loss or injury can impair wound healing, result in adhesions and/or contracture, and restrict soft-tissue mobility. Traditional wound management methods are often insufficient for hypodermal injuries, necessitating innovative approaches.</p><p><strong>Recent advances: </strong>Hypodermal adipose-based solutions, including fat grafting and stem cell therapies, show promise for reconstruction. Fat grafting enhances soft-tissue bulk and contour, enhances mechanical properties, and promotes angiogenesis, offering versatility in addressing a range of wound scenarios, including challenging cases. Adipose-derived stem cells exhibit regenerative potential, modulate inflammation, and facilitate tissue repair, making them valuable for scar revision, skin rejuvenation, and managing chronic wounds. Acellular adipose derivatives, such as exosomes and liquid extracts, contain bioactive molecules that support tissue regeneration and collagen production. Adipose-derived acellular extracellular matrix holds promise in wound healing by enhancing cell behavior and angiogenesis.</p><p><strong>Critical issues: </strong>In this review, we will discuss adipose-centered options for improvement of wound healing and for restoration of the hypodermis together as a cluster of efficient and cost-effective wound management in cases of complex soft-tissue injuries.</p><p><strong>Future directions: </strong>These innovative therapies, while requiring further research, hold significant potential to simplify procedures, reduce costs, and improve the quality of life for patients facing challenging wounds.</p>","PeriodicalId":7413,"journal":{"name":"Advances in wound care","volume":" ","pages":"520-533"},"PeriodicalIF":5.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145666597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Partnering with Communities to Improve Diabetic Foot Ulcer Care in High-Risk Populations.","authors":"Nancy Gauvin, Breana Wayne, Shomita S Mathew-Steiner, Teresa L Z Jones, Rodica Pop-Busui, Cathie Spino, Fleur Maturo, Brian M Schmidt, Crystal Holmes, Chandan K Sen, Wagahta Semere","doi":"10.1177/21621918261440435","DOIUrl":"10.1177/21621918261440435","url":null,"abstract":"<p><strong>Background: </strong>Diabetic foot ulcers (DFUs) remain one of the most devastating complications of diabetes, accounting for over 80% of nontraumatic amputations and contributing to a 5-year mortality rate exceeding 30%. Despite significant clinical advances, profound disparities persist. Racial and ethnic minoritized populations, rural communities, and people with low socioeconomic resources experience disproportionate rates of severe ulceration, infection, delayed healing, and amputation.</p><p><strong>Problem: </strong>Traditional research approaches, often developed in academic settings without community input, have insufficiently addressed the contextual, cultural, and structural factors shaping DFU risk and outcomes.</p><p><strong>Approach: </strong>Community-engaged research (CEnR) offers a promising pathway to address these inequities; yet, DFU-specific evidence remains limited and heterogeneous. In response, the Diabetic Foot Consortium (DFC), a national research network funded by the National Institute of Diabetes and Digestive and Kidney Diseases, has initiated multisite efforts to embed community advisory boards, faith-based partnerships, mobile outreach, and culturally aligned engagement into DFU research.</p><p><strong>Model: </strong>We propose the DFC-CEnR Model, a conceptual framework for integrating community-engaged approaches to DFU prevention, early detection, treatment, and research participation. The model distinguishes CEnR from related approaches (community-based participatory research, patient and public involvement, cultural humility, and equity-focused system interventions), outlining hypothesized mechanisms and evaluation domains. Illustrative consortium examples demonstrate how engagement domains may be operationalized and inform future testing of validated outcome measures.</p><p><strong>Implications: </strong>This article positions community engagement as a hypothesis-generating strategy that requires rigorous empirical testing to determine its impact on DFU outcomes and disparities.</p>","PeriodicalId":7413,"journal":{"name":"Advances in wound care","volume":" ","pages":"481-486"},"PeriodicalIF":5.7,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13535595/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147687505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Diabetic Foot Consortium Biomarker Platform Study: A New Approach to Advance Diabetic Foot Ulcer Healing.","authors":"Brian M Schmidt, Cathie Spino, Teresa L Z Jones, Michael Conte, Gayle Gordillo, Geoffrey Gurtner, Crystal Holmes, Cathy Martin, Fleur Maturo, Kourtney Noll, Steven Thelen-Perry, Nazila Mirzadjahromi, Chandan K Sen, Rodica Pop-Busui","doi":"10.1177/21621918251405881","DOIUrl":"10.1177/21621918251405881","url":null,"abstract":"<p><strong>Objective: </strong>Platform studies are an innovative clinical trial design to evaluate multiple potential therapies simultaneously using a master protocol framework for more rapid discovery of critical new disease-modifying therapies. Initially pioneered in cancer clinical trials, platform studies have more recently been adopted for new vaccine trials and other disease states. This approach has not been used for biomarker(s) validation.</p><p><strong>Approach: </strong>We present the development and successful implementation of a master protocol for a platform study in the National Institute of Diabetes and Digestive and Kidney Diseases Diabetic Foot Consortium (DFC) that concomitantly tests multiple biomarkers that could be used to predict diabetic foot ulcer (DFU) healing outcomes in people with DFUs.</p><p><strong>Results: </strong>This flexible master protocol, allowing the study of multiple biomarkers in a perpetual manner, designed to be inclusive of a broad spectrum of people with DFUs operating under the mantra \"No DFU Goes Unstudied\" successfully collects participant data and biospecimens for biomarker development and validation in a standardized manner across multiple DFC sites.</p><p><strong>Innovation: </strong>Integrating multiple biomarkers with a rich database of participants' clinical characteristics, patient-reported outcomes, and standard of care practices at various sites collected longitudinally over 52 weeks following a pragmatic approach and thus relevant to people with DFU as seen in today's daily practice, enable their subsequent implementation at the point of care to guide timely personalized DFU management decisions.</p><p><strong>Conclusion: </strong>Leveraging this robust platform will help to identify new therapeutic targets and design and conduct effective interventional clinical trials for DFU wound healing, which could inform the standards of care.</p>","PeriodicalId":7413,"journal":{"name":"Advances in wound care","volume":"15 7","pages":"469-480"},"PeriodicalIF":5.7,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13535658/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147947486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of Diabetic Wounds: Expert Panel Consensus Statement.","authors":"Henry C Hsia, Elof Eriksson, Geoffrey C Gurtner, Aristidis Veves, Osama Hamdy, David J Margolis, David G Armstrong, Lawrence A Lavery, Elisabeth A Grice, Greg Schultz, Michael S Conte, Robert S Kirsner, Christopher E Attinger, John S Steinberg, Karen K Evans, Dot Weir, Paul J Kim, Dennis P Orgill, Kenneth W Liechty, J Peter Rubin","doi":"10.1177/21621918251366586","DOIUrl":"10.1177/21621918251366586","url":null,"abstract":"<p><strong>Significance: </strong>The Wound Healing Foundation recognized the need for consensus-based unbiased recommendations for the treatment of wounds. Consensus statements on the treatment of chronic wounds and acute wounds have been developed and published previously. The current publication on diabetic wounds represents the next step in this process. Diabetic wounds constitute a major problem. Population-based and meta-analytic studies indicate that the presence of foot wounds in patients with diabetes increases their mortality risk by more than twofold. The management of diabetic wounds requires consistent and evidence-driven intervention to achieve optimal clinical outcomes. This consensus statement provides the clinician with the necessary foundational approaches to the causes, diagnosis, and therapeutic management of diabetic wounds. Presented in a structured format, this is a useful guide for clinicians and learners in all patient care settings.</p><p><strong>Recent advances: </strong>Continuous glucose monitoring and other new tools have facilitated better diabetes management and the management of associated wounds. Diabetic limb salvage should focus on achieving and optimizing function for the patient with diabetes rather than preserving limb tissue at all costs.</p><p><strong>Critical issues: </strong>Successful management of diabetic wounds requires a multidisciplinary approach encompassing comprehensive assessment, timely intervention, and collaborative care by the wound clinician with providers who can address critical aspects to achieve healing, including careful management of blood glucose levels, optimization of off-loading and physical therapy, assessment and treatment of limb ischemia, control and prevention of wound infection, and optimal pain management.</p><p><strong>Future directions: </strong>Emerging treatments offer hope and promise, but the heterogenicity of diabetic wounds poses a challenge to performing good studies, which will be necessary to advance new treatments for diabetic wounds.</p>","PeriodicalId":7413,"journal":{"name":"Advances in wound care","volume":" ","pages":"487-519"},"PeriodicalIF":5.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144938809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adult Burn Survivors Face Elevated Long-Term Risk of Major Adverse Cardiovascular Events, Venous Thromboembolism, and Mortality: A Real-World Analysis.","authors":"Yu-Hsiang Lin, Yu-Ching Wang, Tai-Li Chen, Ling-Chuan Juan, Chih-Chiang Chen, Cian-Hao Ye, Sheng-Hsiang Ma","doi":"10.1177/21621918261462931","DOIUrl":"10.1177/21621918261462931","url":null,"abstract":"<p><strong>Objective: </strong>Burn injuries affect millions globally, with increasing survival rates due to advances in acute care. However, long-term cardiovascular outcomes including major adverse cardiovascular events (MACE), venous thromboembolism (VTE), and mortality in burn survivors remain under-investigated.</p><p><strong>Approach: </strong>We conducted a retrospective propensity score-matched cohort study using the TriNetX US Collaborative Network. Individuals aged 18 years or older who had an emergency department visit or hospitalization with a diagnosis of burn injuries occurring between January 1, 2014, and January 1, 2019, were identified and matched 1:1 to nonburn controls who were selected based on similar demographics, comorbidities, and medications. The primary outcomes were the hazard ratios (HRs) and absolute risk differences (ARDs) of MACE, VTE, and mortality occurring between 3 months and 5 years after the index date. Secondary cardiovascular and thromboembolic endpoints included the HRs and ARDs of coronary artery disease (CAD), cerebrovascular disease (CVD), pulmonary embolism (PE), and deep vein thrombosis (DVT).</p><p><strong>Results: </strong>A total of 71,426 propensity score-matched pairs of burn survivors and nonburn controls were included. Burn survivors had significantly elevated risks of MACE (HR 1.95, 95% confidence intervals [CI] 1.84-2.07; ARD 0.9%), VTE (HR 1.99, 95% CI 1.80-2.19; ARD 0.4%), and all-cause mortality (HR 2.29, 95% CI 2.10-2.49; ARD 0.7%) compared with controls. Increased risks were also observed for CAD (HR 1.85, 95% CI 1.72-1.98; ARD 0.5%), CVD (HR 2.05, 95% CI 1.88-2.24; ARD 0.5%), PE (HR 2.09, 95% CI 1.77-2.47; ARD 0.1%), and DVT (HR 1.96, 95% CI 1.69-2.27; ARD 0.1%).</p><p><strong>Innovation: </strong>We demonstrate that burn injury is associated with sustained long-term cardiovascular and thromboembolic risks up to 5 years after injury.</p><p><strong>Conclusions: </strong>These findings establish burn injury as a chronic condition, requiring routine cardiovascular screening and targeted prevention in long-term care.</p>","PeriodicalId":7413,"journal":{"name":"Advances in wound care","volume":" ","pages":"21621918261462931"},"PeriodicalIF":5.7,"publicationDate":"2026-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148300687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of Infected Wounds: A Wound Healing Foundation Consensus Statement.","authors":"Nicolás Cortés-Penfield, Benjamin A Lipsky, Elof Eriksson, Meghan B Brennan, Martin Clauss, Catherine Dunyach-Remy, Sue Gardner, Roman Hayda, Lindsay Kalan, Paul Kim, Klaus Kirketerp-Møller, Paul Liu, Samuel Mandell, Oscar Murillo, Gojiro Nakagami, Laura K S Parnell, Edgar J G Peters, Parham Sendi, Gary Sibbald, Terry Swanson, Rica Tanaka, Tze-Woei Tan, Ilker Uçkay, Dot Weir","doi":"10.1177/21621918261459794","DOIUrl":"https://doi.org/10.1177/21621918261459794","url":null,"abstract":"<p><p>The Wound Healing Foundation (WHF) previously organized consensus panels on the management of chronic wounds (2022), acute wounds (2024), and diabetic wounds (2025). This WHF consensus statement, authored by a global interdisciplinary panel of clinicians and researchers, focuses on the management of infected wounds. The panel members reviewed the literature and reached consensus on elements of an evidence-based approach to infected wounds. Using a structured format, this statement progresses from discussing how wound infections develop, how to diagnose them, how to provide the most appropriate antimicrobial and surgical treatment, how to assess response to treatment, and how to further investigate instances of unsuccessful treatment.</p>","PeriodicalId":7413,"journal":{"name":"Advances in wound care","volume":" ","pages":"21621918261459794"},"PeriodicalIF":5.7,"publicationDate":"2026-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148262801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predicting Harm: A Systematic Review of Pediatric Pressure Injury Models and Their Clinical Shortcomings.","authors":"Xiaojie Zhang, Zhichao Yang, Xiuping Li, Jianan Wang, Rui Pang, Haofen Li, Kanfei Yao, Hongying Pan, Yihong Xu","doi":"10.1177/21621918261455528","DOIUrl":"https://doi.org/10.1177/21621918261455528","url":null,"abstract":"<p><strong>Significance: </strong>Pediatric pressure injuries (PIs) are a distinct and preventable clinical challenge, yet risk prediction models tailored to children remain underdeveloped. This systematic review critically evaluates existing pediatric PI prediction models to assess their methodological rigor, predictive performance, and clinical applicability.</p><p><strong>Recent advances: </strong>Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses 2020 guidelines, nine databases were searched to identify studies developing or validating PI risk prediction models for hospitalized patients younger than 18 years. Twelve models from nine studies were included. Risk of bias and applicability were assessed using the Prediction Model Risk Of Bias Assessment Tool (PROBAST) and PROBAST + AI tool.</p><p><strong>Critical issues: </strong>All models demonstrated acceptable discrimination (area under the curve [AUC] range: 0.612-0.978), with seven exceeding an AUC of 0.75. However, calibration was inconsistently reported, and only two models evaluated clinical utility-just one showed net benefit across a realistic threshold range. All models were rated as high risk of bias, and 10 had major concerns regarding applicability. Common methodological flaws included low events per variable <10, inappropriate categorization of continuous variables, poor handling of missing data, and lack of external validation. Most models were developed in single-center studies from China, limiting generalizability. Compared with adult PI models, pediatric models lacked age stratification, standardized outcome definitions, and robust validation. The first application of PROBAST + AI for evaluating machine learning prediction models highlighted algorithmic fairness and ethical risks within these models, but it showed insufficient interpretability regarding aspects such as the optimization process and the transparency of \"black box\" data leakage.</p><p><strong>Future directions: </strong>To improve predictive accuracy and clinical relevance, future models should adopt the Transparent Reporting of a Multivariable Prediction Model for Individual Prognosis or Diagnosis, PROBAST, and PROBAST + AI standards, use multicenter data, stratify by age and clinical setting, and focus on early-stage PIs. Incorporating objective measures and evaluating clinical utility will enhance model integration into practice. PROBAST + AI, in alignment with the advancements in information technology, requires widespread attention for its practical utility and ease of use to be further validated and optimized.[Figure: see text][Figure: see text]Conclusion:Current pediatric PI prediction models show promise but fall short in methodological rigor and clinical applicability. Addressing these gaps is essential to support early identification and targeted prevention in pediatric care.</p>","PeriodicalId":7413,"journal":{"name":"Advances in wound care","volume":" ","pages":"21621918261455528"},"PeriodicalIF":5.6,"publicationDate":"2026-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148209846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diabetic Wound Vasculopathy and Neuropathy: Spotlight on Wound Lipid Signaling.","authors":"Theja Bhamidipati, John P Hajj, Nehal I Ghoneim, Arhat M Pradhan, Sanjay Mishra, Bharat Gummalla, Ahmed Safwat Abouhashem, Avanish Singh Parmar, Savita Khanna, Sashwati Roy, Chandan K Sen, Kanhaiya Singh","doi":"10.1177/21621918251366681","DOIUrl":"10.1177/21621918251366681","url":null,"abstract":"<p><strong>Significance: </strong>Skin lipids are essential for various skin functions including maintaining barrier integrity, regulating hydration, and providing protection against microbes and inflammatory irritants. Along with skin health, the role of lipids in the etiology of macroangiopathic diseases, such as atherosclerosis of arteries, is well recognized.</p><p><strong>Recent advances: </strong>In diabetes, lipid dysregulation is evident and may contribute to the diverse complications of the disease. Diabetic vasculopathy primarily reflects the dysfunction and deterioration of existing blood vessels, as their preservation is key in preventing the progression of vascular disease and reducing the need for compensatory angiogenesis. In the peripheral diabetic skin of the limbs, diabetic vasculopathy runs alongside peripheral neuropathy. Although a causative link between the two is plausible, direct evidence in support of such claim is scanty.</p><p><strong>Critical issues: </strong>Diabetic skin is known to be compromised in many ways, including weakened barrier functionality and diabetes-induced alterations in the extracellular matrix, likely stemming from chronic inflammation, which may directly affect vascular integrity and nerve health. Both, in the compromised skin and within wounds, microbial pathogens and their enzymes may metabolize host lipids, driving inflammatory reactions and exacerbating the pathogenesis of diabetic vasculopathy and related neuropathy.</p><p><strong>Future directions: </strong>This review focuses on lipid mediators such as sphingolipids, resolvins, oxidized low-density lipoproteins and their specific downstream signaling pathways to obtain a comprehensive understanding of diabetic complications relevant to wound healing. Through lipid-based strategies, this review hopes to inspire the development and utilization of individualized, precision-based approaches to manage diabetic vasculopathy and neuropathy.</p>","PeriodicalId":7413,"journal":{"name":"Advances in wound care","volume":" ","pages":"426-453"},"PeriodicalIF":5.7,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12442785/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144844061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancing Therapeutic Solutions for Burn Wounds: Potential Use of Noninvasive Ultrasound-Driven Splenic Stimulation.","authors":"Ahmed Sami Raihane, David G Armstrong, T Justin Gillenwater, Robert D Galiano","doi":"10.1089/wound.2024.0181","DOIUrl":"10.1089/wound.2024.0181","url":null,"abstract":"<p><strong>Significance: </strong>Burn wound injuries are a global health challenge, affecting millions annually and resulting in significant morbidity, mortality, and economic burden. The urgent need for accessible and cost-effective therapeutic alternatives, especially for underserved populations, has driven interest in novel approaches such as noninvasive splenic stimulation using pulsed-focused ultrasound (pFUS). This technique targets systemic inflammation, a key factor in delayed wound healing, offering a potential shift in burn care management.</p><p><strong>Recent advances: </strong>Preclinical studies have shown that pFUS applied to the spleen can accelerate wound healing by activating the cholinergic anti-inflammatory pathway, promoting pro-angiogenic and anti-inflammatory responses. While current treatments-including biologics, antioxidants, and growth factors-have limitations, pFUS presents a noninvasive alternative. One interventional study and ongoing clinical trials are now investigating its application in burn wound care, marking an important step toward clinical translation.</p><p><strong>Critical issues: </strong>Despite encouraging results, research on splenic stimulation for wound healing remains limited. The small number of studies highlights the need for further investigation into the underlying mechanisms, optimal treatment parameters, and potential risks. Additionally, the scalability and cost-effectiveness of pFUS in diverse clinical settings require thorough evaluation.</p><p><strong>Future directions: </strong>Ongoing clinical trials will provide critical data on the efficacy and safety of splenic pFUS in burn patients. Future research should focus on expanding clinical studies, refining stimulation protocols, and exploring its broader application in tissue repair. If validated, this approach could offer a cost-effective, noninvasive treatment, particularly valuable in socioeconomically challenged regions.</p>","PeriodicalId":7413,"journal":{"name":"Advances in wound care","volume":" ","pages":"414-425"},"PeriodicalIF":5.6,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143727388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}