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Gut microbiota, immunity, and bile acid metabolism: decoding metabolic disease interactions. 肠道微生物群、免疫和胆汁酸代谢：解码代谢性疾病的相互作用。
Life metabolism Pub Date : 2023-07-23 eCollection Date: 2023-12-01 DOI: 10.1093/lifemeta/load032
Qixiang Zhao, Jiayu Wu, Yong Ding, Yanli Pang, Changtao Jiang
{"title":"Gut microbiota, immunity, and bile acid metabolism: decoding metabolic disease interactions.","authors":"Qixiang Zhao, Jiayu Wu, Yong Ding, Yanli Pang, Changtao Jiang","doi":"10.1093/lifemeta/load032","DOIUrl":"10.1093/lifemeta/load032","url":null,"abstract":"<p><p>In recent decades, the global prevalence of metabolic syndrome has surged, posing a significant public health challenge. Metabolic disorders, encompassing diabetes, obesity, nonalcoholic fatty liver disease, and polycystic ovarian syndrome, have been linked to alterations in the gut microbiota. Nonetheless, the connection between gut microbiota and host metabolic diseases warrants further investigation. In this review, we delve into the associations between various metabolic disorders and the gut microbiota, focusing on immune responses and bile acid (BA) metabolism. Notably, T helper cells, innate lymphoid cells, macrophages, and dendritic cells have been shown to modulate host metabolism through interactions with intestinal microorganisms and the release of cytokines. Furthermore, secondary BA metabolites, derived from the microbiota, are involved in the pathogenesis of metabolic diseases via the farnesoid X receptor and Takeda G protein-coupled receptor 5. By covering both aspects of this immune system-microorganism axis, we present a comprehensive overview of the roles played by the gut microbiota, microbiota-derived BA metabolites, and immune responses in metabolic diseases, as well as the interplay between these systems.</p>","PeriodicalId":74074,"journal":{"name":"Life metabolism","volume":"2 6","pages":"load032"},"PeriodicalIF":0.0,"publicationDate":"2023-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11749371/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143054207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Glucokinase and glucokinase activator. 葡萄糖激酶和葡萄糖激酶激活剂
Life metabolism Pub Date : 2023-07-13 eCollection Date: 2023-10-01 DOI: 10.1093/lifemeta/load031
Changhong Li, Yi Zhang, Li Chen, Xiaoying Li
{"title":"Glucokinase and glucokinase activator.","authors":"Changhong Li, Yi Zhang, Li Chen, Xiaoying Li","doi":"10.1093/lifemeta/load031","DOIUrl":"10.1093/lifemeta/load031","url":null,"abstract":"<p><p>Glucokinase (GK) plays a pivotal role in glucose homeostasis as the glucose sensor in the pancreas and liver. Loss of function of GK results in hyperglycemia, and gain of function causes congenital hyperinsulinemic hypoglycemia. We speculate that the progressive loss of GK at both messenger RNA (mRNA) and protein levels in the islets and liver would be the key mechanism for Type 2 diabetes (T2D) pathogenesis. The development of GK activator (GKA) as an anti-diabetic drug has been endeavored for several decades. The failure of the early development of GKAs is due to the limitation of understanding the mode of GKA action. The success of dorzagliatin in the treatment of T2D has brought new hope for GK in setting a good model for repairing the underlying defects in the pancreatic islets and liver of T2D patients.</p>","PeriodicalId":74074,"journal":{"name":"Life metabolism","volume":" ","pages":"load031"},"PeriodicalIF":0.0,"publicationDate":"2023-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11749227/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47036801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A review collection on immunometabolism. 免疫代谢研究综述
Life metabolism Pub Date : 2023-07-02 eCollection Date: 2023-10-01 DOI: 10.1093/lifemeta/load030
Ping-Chih Ho, Chenqi Xu, Tiffany Horng
{"title":"A review collection on immunometabolism.","authors":"Ping-Chih Ho, Chenqi Xu, Tiffany Horng","doi":"10.1093/lifemeta/load030","DOIUrl":"10.1093/lifemeta/load030","url":null,"abstract":"","PeriodicalId":74074,"journal":{"name":"Life metabolism","volume":" ","pages":"load030"},"PeriodicalIF":0.0,"publicationDate":"2023-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11749129/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42709889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sleep-time eating boosts exercise endurance. 睡眠时间进食可以增强运动耐力
Life metabolism Pub Date : 2023-06-30 eCollection Date: 2023-10-01 DOI: 10.1093/lifemeta/load029
Jonas T Treebak
{"title":"Sleep-time eating boosts exercise endurance.","authors":"Jonas T Treebak","doi":"10.1093/lifemeta/load029","DOIUrl":"10.1093/lifemeta/load029","url":null,"abstract":"<p><p>Light phase-restricted feeding in mice enhances exercise endurance in sedentary mice through a mechanism involving BMAL1-induced inhibition of <i>Plin5</i> expression (created with BioRender.com).</p>","PeriodicalId":74074,"journal":{"name":"Life metabolism","volume":" ","pages":"load029"},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11749696/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43228743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Metabolic reprogramming in inflammaging and aging in T cells. T细胞炎症和衰老过程中的代谢重编程
Life metabolism Pub Date : 2023-06-28 eCollection Date: 2023-10-01 DOI: 10.1093/lifemeta/load028
Alessio Bevilacqua, Ping-Chih Ho, Fabien Franco
{"title":"Metabolic reprogramming in inflammaging and aging in T cells.","authors":"Alessio Bevilacqua, Ping-Chih Ho, Fabien Franco","doi":"10.1093/lifemeta/load028","DOIUrl":"10.1093/lifemeta/load028","url":null,"abstract":"<p><p>Aging represents an emerging challenge for public health due to the declined immune responses against pathogens, weakened vaccination efficacy, and disturbed tissue homeostasis. Metabolic alterations in cellular and systemic levels are also known to be cardinal features of aging. Moreover, cellular metabolism has emerged to provide regulations to guide immune cell behavior via modulations on signaling cascades and epigenetic landscape, and the aberrant aging process in immune cells can lead to inflammaging, a chronic and low-grade inflammation that facilitates aging by perturbing homeostasis in tissues and organs. Here, we review how the metabolic program in T cells is influenced by the aging process and how aged T cells modulate inflammaging. In addition, we discuss the potential approaches to reverse or ameliorate aging by rewiring the metabolic programming of immune cells.</p>","PeriodicalId":74074,"journal":{"name":"Life metabolism","volume":" ","pages":"load028"},"PeriodicalIF":0.0,"publicationDate":"2023-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11749375/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49423720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
AMPK promotes lysosomal and mitochondrial biogenesis via folliculin:FNIP1. AMPK通过毛囊素促进溶酶体和线粒体的生物发生：FNIP1。
Life metabolism Pub Date : 2023-06-22 eCollection Date: 2023-10-01 DOI: 10.1093/lifemeta/load027
Jordana B Freemantle, D Grahame Hardie
{"title":"AMPK promotes lysosomal and mitochondrial biogenesis via folliculin:FNIP1.","authors":"Jordana B Freemantle, D Grahame Hardie","doi":"10.1093/lifemeta/load027","DOIUrl":"10.1093/lifemeta/load027","url":null,"abstract":"<p><p>The AMP-activated protein kinase (AMPK) is known to maintain the integrity of cellular mitochondrial networks by (i) promoting fission, (ii) inhibiting fusion, (iii) promoting recycling of damaged components via mitophagy, (iv) enhancing lysosomal biogenesis to support mitophagy, and (v) promoting biogenesis of new mitochondrial components. While the AMPK targets underlying the first three of these effects are known, a recent paper suggests that direct phosphorylation of the folliculin-interacting protein 1 (FNIP1) by AMPK may be involved in the remaining two.</p>","PeriodicalId":74074,"journal":{"name":"Life metabolism","volume":"2 5","pages":"load027"},"PeriodicalIF":0.0,"publicationDate":"2023-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10445941/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10127834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A dahlia flower extract has antidiabetic properties by improving insulin function in the brain. 大丽花提取物具有改善大脑胰岛素功能的抗糖尿病特性
Life metabolism Pub Date : 2023-06-18 eCollection Date: 2023-08-01 DOI: 10.1093/lifemeta/load026
Dominik Pretz, Philip M Heyward, Jeremy Krebs, Joel Gruchot, Charles Barter, Pat Silcock, Nerida Downes, Mohammed Zubair Rizwan, Alisa Boucsein, Julia Bender, Elaine J Burgess, Geke Aline Boer, Pramuk Keerthisinghe, Nigel B Perry, Alexander Tups
{"title":"A dahlia flower extract has antidiabetic properties by improving insulin function in the brain.","authors":"Dominik Pretz, Philip M Heyward, Jeremy Krebs, Joel Gruchot, Charles Barter, Pat Silcock, Nerida Downes, Mohammed Zubair Rizwan, Alisa Boucsein, Julia Bender, Elaine J Burgess, Geke Aline Boer, Pramuk Keerthisinghe, Nigel B Perry, Alexander Tups","doi":"10.1093/lifemeta/load026","DOIUrl":"10.1093/lifemeta/load026","url":null,"abstract":"<p><p>Butein, a rare chalcone found in the toxic plant <i>Toxicodendron vernicifluum</i>, has been shown to regulate glucose homeostasis via inhibition of the nuclear factor kappa-B kinase subunit beta (IKKβ)/nuclear factor kappa B (NF-κB) pathway in the brain. Here, we investigated whether the nonpoisonous plant <i>Dahlia pinnata</i> could be a source of butein as a potential treatment for type 2 diabetes (T2D). In mice fed a high-fat diet (HFD) to induce glucose intolerance, an oral <i>D. pinnata</i> petal extract improved glucose tolerance at doses of 3.3 mg/kg body weight and 10 mg/kg body weight. Surprisingly, this effect was not mediated by butein alone but by butein combined with the closely related flavonoids, sulfuretin and/or isoliquiritigenin. Mechanistically, the extract improved systemic insulin tolerance. Inhibition of phosphatidylinositol 3-kinase to block insulin signaling in the brain abrogated the glucoregulatory effect of the orally administered extract. The extract reinstated central insulin signaling and normalized astrogliosis in the hypothalamus of HFD-fed mice. Using NF-κB reporter zebrafish to determine IKKβ/NF-κB activity, a potent anti-inflammatory action of the extract was found. A randomized controlled crossover clinical trial on participants with prediabetes or T2D confirmed the safety and efficacy of the extract in humans. In conclusion, we identified an extract from the flower petals of <i>D. pinnata</i> as a novel treatment option for T2D, potentially targeting the central regulation of glucose homeostasis as a root cause of the disease.</p>","PeriodicalId":74074,"journal":{"name":"Life metabolism","volume":" ","pages":"load026"},"PeriodicalIF":0.0,"publicationDate":"2023-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11749471/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48373127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction to: Intergenerational hyperglycemia through epigenetic alterations of gametes. 更正：通过配子表观遗传学改变的代际高血糖
Life metabolism Pub Date : 2023-06-16 eCollection Date: 2023-08-01 DOI: 10.1093/lifemeta/load023
{"title":"Correction to: Intergenerational hyperglycemia through epigenetic alterations of gametes.","authors":"","doi":"10.1093/lifemeta/load023","DOIUrl":"10.1093/lifemeta/load023","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1093/lifemeta/loac007.].</p>","PeriodicalId":74074,"journal":{"name":"Life metabolism","volume":" ","pages":"load023"},"PeriodicalIF":0.0,"publicationDate":"2023-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11749230/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48490941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A myofiber-derived secreted factor for muscle regeneration. 用于肌肉再生的肌纤维衍生的分泌因子
Life metabolism Pub Date : 2023-06-14 eCollection Date: 2023-08-01 DOI: 10.1093/lifemeta/load025
Fang Xiao, Zheng Sun
{"title":"A myofiber-derived secreted factor for muscle regeneration.","authors":"Fang Xiao, Zheng Sun","doi":"10.1093/lifemeta/load025","DOIUrl":"10.1093/lifemeta/load025","url":null,"abstract":"","PeriodicalId":74074,"journal":{"name":"Life metabolism","volume":" ","pages":"load025"},"PeriodicalIF":0.0,"publicationDate":"2023-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11749707/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42129045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hunger extends lifespan by modulating histone proteins. 饥饿通过调节组蛋白延长寿命
Life metabolism Pub Date : 2023-06-12 eCollection Date: 2023-08-01 DOI: 10.1093/lifemeta/load024
Hailan Liu, Hongjie Li, Yong Xu
{"title":"Hunger extends lifespan by modulating histone proteins.","authors":"Hailan Liu, Hongjie Li, Yong Xu","doi":"10.1093/lifemeta/load024","DOIUrl":"10.1093/lifemeta/load024","url":null,"abstract":"","PeriodicalId":74074,"journal":{"name":"Life metabolism","volume":" ","pages":"load024"},"PeriodicalIF":0.0,"publicationDate":"2023-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11749563/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49286536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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