Life metabolism最新文献_第7页

7-Dehydrocholesterol protects against circadian disruption and experimental colitis: potential role of RORα/γ 7-脱氢胆固醇可预防昼夜节律紊乱和实验性结肠炎:rora /γ的潜在作用

Life metabolism Pub Date : 2023-09-19 DOI: 10.1093/lifemeta/load034

Feng Li, Shubin Lin, Zhiyi Tan, Yanqing Pang, Shuai Wang

引用次数: 0

Transcript profile of CLSTN3B gene in human white adipose tissue is associated with obesity and mitochondrial gene program 人白色脂肪组织CLSTN3B基因转录谱与肥胖和线粒体基因程序相关

Life metabolism Pub Date : 2023-09-14 DOI: 10.1093/lifemeta/load037

Ningning Bai, Xuhong Lu, Yansu Wang, Xiaoya Li, Rong Zhang, Haoyong Yu, Cheng Hu, Xiaojing Ma, Yuqian Bao, Ying Yang

引用次数: 0

Blockade of Arf1-mediated lipid metabolism in cancers promotes tumor infiltration of cytotoxic T cells via the LPE-PPARγ-NF-κB-CCL5 pathway 阻断肿瘤中arf1介导的脂质代谢可通过LPE-PPARγ-NF-κB-CCL5途径促进细胞毒性T细胞的肿瘤浸润

Life metabolism Pub Date : 2023-09-06 DOI: 10.1093/lifemeta/load036

Na Wang, Tiange Yao, Chenfei Luo, Ling Sun, Yuetong Wang, Steven X Hou

{"title":"Blockade of Arf1-mediated lipid metabolism in cancers promotes tumor infiltration of cytotoxic T cells via the LPE-PPARγ-NF-κB-CCL5 pathway","authors":"Na Wang, Tiange Yao, Chenfei Luo, Ling Sun, Yuetong Wang, Steven X Hou","doi":"10.1093/lifemeta/load036","DOIUrl":"https://doi.org/10.1093/lifemeta/load036","url":null,"abstract":"Abstract Tumor immunotherapy has achieved breakthroughs in a variety of tumors. However, the systemic absence of T cells in tumors and immunosuppressive tumor microenvironment so far limits the efficacy of immunotherapy to a small population of patients. Therefore, novel agents to increase T-cell tumor infiltration are urgently needed in the clinic. We recently found that inhibition of the ADP-ribosylation factor 1 (Arf1)-mediated lipid metabolism not only kills cancer stem cells (CSCs) but also elicits an anti-tumor immune response. In this study, we revealed a mechanism that targeting Arf1 promotes the infiltration of cytotoxic T lymphocytes (CTLs) into tumors through the C-C chemokine ligand 5 (CCL5)- C-C chemokine receptor type 5 (CCR5) pathway. We found that blockage of Arf1 induces the production of the unsaturated fatty acid (PE 18:1) that binds and sequestrates peroxisome proliferator-activated receptor-γ (PPARγ) from the PPARγ-nuclear factor-κB (NF-κB) cytoplasmic complex. The released NF-κB was then phosphorylated and translocated into the nucleus to regulate the transcription of chemokine CCL5. CCL5 promoted infiltration of CTLs for tumor regression. Furthermore, the combination of the Arf1 inhibitor and programmed cell death protein 1 (PD-1) blockade induced an even stronger anti-tumor immunity. Therefore, targeting Arf1 represents a novel anti-tumor immune approach by provoking T-cell tumor infiltration and may provide a new strategy for tumor immunotherapy.","PeriodicalId":74074,"journal":{"name":"Life metabolism","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135203505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Life Metabolism Travel Prize of 2023 2023年生命代谢旅游奖

Life metabolism Pub Date : 2023-09-05 DOI: 10.1093/lifemeta/load035

Xiaolei Liu

引用次数: 0

Extracellular matrix remodelling in obesity and metabolic disorders. 肥胖和代谢紊乱中的细胞外基质重塑。

Life metabolism Pub Date : 2023-08-01 Epub Date: 2023-05-26 DOI: 10.1093/lifemeta/load021

Vishal Musale, David H Wasserman, Li Kang

{"title":"Extracellular matrix remodelling in obesity and metabolic disorders.","authors":"Vishal Musale, David H Wasserman, Li Kang","doi":"10.1093/lifemeta/load021","DOIUrl":"10.1093/lifemeta/load021","url":null,"abstract":"Obesity causes extracellular matrix (ECM) remodelling which can develop into serious pathology and fibrosis, having metabolic effects in insulin-sensitive tissues. The ECM components may be increased in response to overnutrition. This review will focus on specific obesity-associated molecular and pathophysiological mechanisms of ECM remodelling and the impact of specific interactions on tissue metabolism. In obesity, complex network of signalling molecules such as cytokines and growth factors have been implicated in fibrosis. Increased ECM deposition contributes to the pathogenesis of insulin resistance at least in part through activation of cell surface integrin receptors and CD44 signalling cascades. These cell surface receptors transmit signals to the cell adhesome which orchestrates an intracellular response that adapts to the extracellular environment. Matrix proteins, glycoproteins, and polysaccharides interact through ligand-specific cell surface receptors that interact with the cytosolic adhesion proteins to elicit specific actions. Cell adhesion proteins may have catalytic activity or serve as scaffolds. The vast number of cell surface receptors and the complexity of the cell adhesome have made study of their roles challenging in health and disease. Further complicating the role of ECM-cell receptor interactions is the variation between cell types. This review will focus on recent insights gained from studies of two highly conserved, ubiquitously axes and how they contribute to insulin resistance and metabolic dysfunction in obesity. These are the collagen-integrin receptor-IPP (ILK-PINCH-Parvin) axis and the hyaluronan-CD44 interaction. We speculate that targeting ECM components or their receptor-mediated cell signalling may provide novel insights into the treatment of obesity-associated cardiometabolic complications.","PeriodicalId":74074,"journal":{"name":"Life metabolism","volume":"2 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10299575/pdf/nihms-1904676.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10275103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lactate as a regulator of iron homeostasis. 乳酸作为铁体内平衡的调节剂

Life metabolism Pub Date : 2023-07-27 eCollection Date: 2023-10-01 DOI: 10.1093/lifemeta/load033

Gregory J Anderson, David M Frazer

引用次数: 0

Gut microbiota, immunity, and bile acid metabolism: decoding metabolic disease interactions. 肠道微生物群、免疫和胆汁酸代谢：解码代谢性疾病的相互作用。

Life metabolism Pub Date : 2023-07-23 eCollection Date: 2023-12-01 DOI: 10.1093/lifemeta/load032

Qixiang Zhao, Jiayu Wu, Yong Ding, Yanli Pang, Changtao Jiang

{"title":"Gut microbiota, immunity, and bile acid metabolism: decoding metabolic disease interactions.","authors":"Qixiang Zhao, Jiayu Wu, Yong Ding, Yanli Pang, Changtao Jiang","doi":"10.1093/lifemeta/load032","DOIUrl":"10.1093/lifemeta/load032","url":null,"abstract":"In recent decades, the global prevalence of metabolic syndrome has surged, posing a significant public health challenge. Metabolic disorders, encompassing diabetes, obesity, nonalcoholic fatty liver disease, and polycystic ovarian syndrome, have been linked to alterations in the gut microbiota. Nonetheless, the connection between gut microbiota and host metabolic diseases warrants further investigation. In this review, we delve into the associations between various metabolic disorders and the gut microbiota, focusing on immune responses and bile acid (BA) metabolism. Notably, T helper cells, innate lymphoid cells, macrophages, and dendritic cells have been shown to modulate host metabolism through interactions with intestinal microorganisms and the release of cytokines. Furthermore, secondary BA metabolites, derived from the microbiota, are involved in the pathogenesis of metabolic diseases via the farnesoid X receptor and Takeda G protein-coupled receptor 5. By covering both aspects of this immune system-microorganism axis, we present a comprehensive overview of the roles played by the gut microbiota, microbiota-derived BA metabolites, and immune responses in metabolic diseases, as well as the interplay between these systems.","PeriodicalId":74074,"journal":{"name":"Life metabolism","volume":"2 6","pages":"load032"},"PeriodicalIF":0.0,"publicationDate":"2023-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11749371/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143054207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Glucokinase and glucokinase activator. 葡萄糖激酶和葡萄糖激酶激活剂

Life metabolism Pub Date : 2023-07-13 eCollection Date: 2023-10-01 DOI: 10.1093/lifemeta/load031

Changhong Li, Yi Zhang, Li Chen, Xiaoying Li

引用次数: 0

A review collection on immunometabolism. 免疫代谢研究综述

Life metabolism Pub Date : 2023-07-02 eCollection Date: 2023-10-01 DOI: 10.1093/lifemeta/load030

Ping-Chih Ho, Chenqi Xu, Tiffany Horng

引用次数: 0

Sleep-time eating boosts exercise endurance. 睡眠时间进食可以增强运动耐力

Life metabolism Pub Date : 2023-06-30 eCollection Date: 2023-10-01 DOI: 10.1093/lifemeta/load029

Jonas T Treebak

引用次数: 0