Life metabolism最新文献_第8页

Neural innervation in adipose tissue, gut, pancreas, and liver. 脂肪组织、肠道、胰腺和肝脏的神经支配

Life metabolism Pub Date : 2023-06-06 eCollection Date: 2023-08-01 DOI: 10.1093/lifemeta/load022

Mengxue Sun, Yongwen Wan, Mengjie Shi, Zhuo-Xian Meng, Wenwen Zeng

{"title":"Neural innervation in adipose tissue, gut, pancreas, and liver.","authors":"Mengxue Sun, Yongwen Wan, Mengjie Shi, Zhuo-Xian Meng, Wenwen Zeng","doi":"10.1093/lifemeta/load022","DOIUrl":"10.1093/lifemeta/load022","url":null,"abstract":"Efficient communication between the brain and peripheral organs is indispensable for regulating physiological function and maintaining energy homeostasis. The peripheral nervous system (PNS) in vertebrates, consisting of the autonomic and somatic nervous systems, bridges the peripheral organs and the central nervous system (CNS). Metabolic signals are processed by both vagal sensory nerves and somatosensory nerves. The CNS receives sensory inputs via ascending nerves, serves as the coordination and integration center, and subsequently controls internal organs and glands via descending nerves. The autonomic nervous system consists of sympathetic and parasympathetic branches that project peripheral nerves into various anatomical locations to regulate the energy balance. Sympathetic and parasympathetic nerves typically control the reflexive and involuntary functions in organs. In this review article, we outline the innervation of adipose tissue, gut, pancreas, and liver, to illustrate the neurobiological basis of central-peripheral interactions. We emphasize the importance of understanding the functional atlas of neural control of energy metabolism, and more importantly, provide potential avenues for further research in this area.","PeriodicalId":74074,"journal":{"name":"Life metabolism","volume":" ","pages":"load022"},"PeriodicalIF":0.0,"publicationDate":"2023-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11749697/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42796665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chowing down: diet considerations in rodent models of metabolic disease. 大嚼:代谢性疾病啮齿动物模型中的饮食考虑。

Life metabolism Pub Date : 2023-06-01 Epub Date: 2023-04-26 DOI: 10.1093/lifemeta/load013

Kevin C Klatt, Kevin Bass, John R Speakman, Kevin D Hall

引用次数: 0

Flux measurements of the tricarboxylic acid cycle in the tumors of mice. 小鼠肿瘤中TCA通量的测定

Life metabolism Pub Date : 2023-05-24 eCollection Date: 2023-06-01 DOI: 10.1093/lifemeta/load020

Shiyu Liu, Jason W Locasale

引用次数: 0

Mitochondrial cristae: lung cancer metabolism architects. 线粒体嵴：癌症代谢建筑师

Life metabolism Pub Date : 2023-05-12 eCollection Date: 2023-04-01 DOI: 10.1093/lifemeta/load015

Masafumi Noguchi, Luca Scorrano

引用次数: 0

Safety and immunogenicity of a modified COVID-19 mRNA vaccine, SYS6006, as a fourth-dose booster following three doses of inactivated vaccines in healthy adults: an open-labeled Phase 1 trial. 一种改良的COVID-19 mRNA疫苗SYS6006在健康成人中作为三剂灭活疫苗后的第四剂加强剂的安全性和免疫原性:一项开放标记的1期试验

Life metabolism Pub Date : 2023-05-10 eCollection Date: 2023-06-01 DOI: 10.1093/lifemeta/load019

Yuzhou Gui, Ye Cao, Jiajin He, Chunyang Zhao, Wei Zheng, Ling Qian, Jie Cheng, Chengyin Yu, Chen Yu, Kun Lou, Gangyi Liu, Jingying Jia

{"title":"Safety and immunogenicity of a modified COVID-19 mRNA vaccine, SYS6006, as a fourth-dose booster following three doses of inactivated vaccines in healthy adults: an open-labeled Phase 1 trial.","authors":"Yuzhou Gui, Ye Cao, Jiajin He, Chunyang Zhao, Wei Zheng, Ling Qian, Jie Cheng, Chengyin Yu, Chen Yu, Kun Lou, Gangyi Liu, Jingying Jia","doi":"10.1093/lifemeta/load019","DOIUrl":"10.1093/lifemeta/load019","url":null,"abstract":"The continuous emergence of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants led to a rapid decline in protection efficacy and neutralizing titers even after three doses of COVID-19 vaccines. Here, we report an open-labeled Phase I clinical trial of a modified mRNA vaccine (SYS6006) as a fourth-dose booster in healthy adults. Eighteen eligible participants, who had completed three doses of inactivated COVID-19 vaccines, received a fourth boosting dose of SYS6006-20 μg. Eighteen convalescent COVID-19 patients were enrolled for the collection of serum samples as a comparator of immunogenicity. The primary endpoint of this trial was titers of anti-receptor binding domain of spike glycoprotein (RBD) antibodies of the Omicron strain (BA.2 and BA.4/5) in serum; titers of neutralizing antibodies against pseudovirus of the Omicron strain (BA.2 and BA.4/5). The secondary endpoint was the incidence of adverse events within 30 days after the boosting. The exploratory endpoint was the cellular immune responses (interferon gamma, IFN-γ). This trial was registered with the Chinese Clinical Trial Registry website. No serious adverse events were reported within 30 days after vaccination. No Grade 3 fever or serious adverse event was reported in the SYS6006 group. Notably, SYS6006 elicited higher titers and longer increases in anti-RBD antibodies and neutralizing antibodies (>90 days) compared with the convalescent group (P < 0.0001) against Omicron strain (BA.2 and BA.4/5). Besides, higher positive spots of T-cell-secreting IFN-γ were observed in the SYS6006 group than those in the convalescent group (P < 0.05). These data demonstrated that SYS6006 was well tolerated and highly immunogenic, generating a stronger and more durable immune response against different variants of SARS-CoV-2.","PeriodicalId":74074,"journal":{"name":"Life metabolism","volume":" ","pages":"load019"},"PeriodicalIF":0.0,"publicationDate":"2023-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11749786/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45992088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Opioid growth factor receptor promotes adipose tissue thermogenesis via enhancing lipid oxidation. 阿片生长因子受体通过增强脂质氧化促进脂肪组织产热

Life metabolism Pub Date : 2023-05-04 eCollection Date: 2023-06-01 DOI: 10.1093/lifemeta/load018

Shan Zhang, Jianhui Chen, Qingqing Li, Wenwen Zeng

{"title":"Opioid growth factor receptor promotes adipose tissue thermogenesis via enhancing lipid oxidation.","authors":"Shan Zhang, Jianhui Chen, Qingqing Li, Wenwen Zeng","doi":"10.1093/lifemeta/load018","DOIUrl":"10.1093/lifemeta/load018","url":null,"abstract":"The thermogenic brown and beige adipocytes consume fatty acids and generate heat to maintain core body temperature in the face of cold challenges. Since their validated presence in humans, the activation of thermogenic fat has been an attractive target for treating obesity and related metabolic diseases. Here, we reported that the opioid growth factor receptor (Ogfr) was highly expressed in adipocytes and promoted thermogenesis. The mice with genetic deletion of Ogfr in adipocytes displayed an impaired capacity to counter environmental cold challenges. Meanwhile, Ogfr ablation in adipocytes led to reduced fatty acid oxidation, enhanced lipid accumulation, impaired glucose tolerance, and exacerbated tissue inflammation under chronic high-fat diet (HFD)-fed conditions. At the cellular level, OGFr enhanced the production of mitochondrial trifunctional protein subunit α (MTPα) and also interacted with MTPα, thus promoting fatty acid oxidation. Together, our study demonstrated the important role of OGFr in fatty acid metabolism and adipose thermogenesis.","PeriodicalId":74074,"journal":{"name":"Life metabolism","volume":" ","pages":"load018"},"PeriodicalIF":0.0,"publicationDate":"2023-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11749475/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45596018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lactate: an intracellular metabolite regulates cell cycle progression. 乳酸：一种细胞内代谢产物调节细胞周期进程

Life metabolism Pub Date : 2023-04-24 eCollection Date: 2023-08-01 DOI: 10.1093/lifemeta/load017

Jinke Cheng, Edward T H Yeh

引用次数: 0

Three 700$ awards available from Life Metabolism to support conference attendance. Life Metabolism提供三个700美元的奖励，以支持会议出席

Life metabolism Pub Date : 2023-04-19 eCollection Date: 2023-06-01 DOI: 10.1093/lifemeta/load016

John R Speakman

引用次数: 0

Weight loss increases skeletal muscle mitochondrial energy efficiency in obese mice. 减肥可提高肥胖小鼠骨骼肌线粒体的能量效率。

Life metabolism Pub Date : 2023-04-01 Epub Date: 2023-04-04 DOI: 10.1093/lifemeta/load014

Patrick J Ferrara, Marisa J Lang, Jordan M Johnson, Shinya Watanabe, Kelsey L McLaughlin, J Alan Maschek, Anthony R P Verkerke, Piyarat Siripoksup, Amandine Chaix, James E Cox, Kelsey H Fisher-Wellman, Katsuhiko Funai

{"title":"Weight loss increases skeletal muscle mitochondrial energy efficiency in obese mice.","authors":"Patrick J Ferrara, Marisa J Lang, Jordan M Johnson, Shinya Watanabe, Kelsey L McLaughlin, J Alan Maschek, Anthony R P Verkerke, Piyarat Siripoksup, Amandine Chaix, James E Cox, Kelsey H Fisher-Wellman, Katsuhiko Funai","doi":"10.1093/lifemeta/load014","DOIUrl":"10.1093/lifemeta/load014","url":null,"abstract":"Weight loss from an overweight state is associated with a disproportionate decrease in whole-body energy expenditure that may contribute to the heightened risk for weight regain. Evidence suggests that this energetic mismatch originates from lean tissue. Although this phenomenon is well documented, the mechanisms have remained elusive. We hypothesized that increased mitochondrial energy efficiency in skeletal muscle is associated with reduced expenditure under weight loss. Wildtype (WT) male C57BL6/N mice were fed with high fat diet for 10 weeks, followed by a subset of mice that were maintained on the obesogenic diet (OB) or switched to standard chow to promote weight loss (WL) for additional 6 weeks. Mitochondrial energy efficiency was evaluated using high-resolution respirometry and fluorometry. Mass spectrometric analyses were employed to describe the mitochondrial proteome and lipidome. Weight loss promoted ~50% increase in the efficiency of oxidative phosphorylation (ATP produced per O2 consumed, or P/O) in skeletal muscle. However, weight loss did not appear to induce significant changes in mitochondrial proteome, nor any changes in respiratory supercomplex formation. Instead, it accelerated the remodeling of mitochondrial cardiolipin (CL) acyl-chains to increase tetralinoleoyl CL (TLCL) content, a species of lipids thought to be functionally critical for the respiratory enzymes. We further show that lowering TLCL by deleting the CL transacylase tafazzin was sufficient to reduce skeletal muscle P/O and protect mice from diet-induced weight gain. These findings implicate skeletal muscle mitochondrial efficiency as a novel mechanism by which weight loss reduces energy expenditure in obesity.","PeriodicalId":74074,"journal":{"name":"Life metabolism","volume":"2 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10195096/pdf/nihms-1890467.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9770381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Glutathione restoration: a sword to combat skeletal muscle stem cell aging. 谷胱甘肽修复：对抗骨骼肌干细胞衰老的利剑

Life metabolism Pub Date : 2023-03-31 eCollection Date: 2023-06-01 DOI: 10.1093/lifemeta/load012

Zeming Wu, Jie Ren, Guang-Hui Liu

引用次数: 0