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Metabolic reprogramming in inflammaging and aging in T cells. T细胞炎症和衰老过程中的代谢重编程
Life metabolism Pub Date : 2023-06-28 eCollection Date: 2023-10-01 DOI: 10.1093/lifemeta/load028
Alessio Bevilacqua, Ping-Chih Ho, Fabien Franco
{"title":"Metabolic reprogramming in inflammaging and aging in T cells.","authors":"Alessio Bevilacqua, Ping-Chih Ho, Fabien Franco","doi":"10.1093/lifemeta/load028","DOIUrl":"10.1093/lifemeta/load028","url":null,"abstract":"<p><p>Aging represents an emerging challenge for public health due to the declined immune responses against pathogens, weakened vaccination efficacy, and disturbed tissue homeostasis. Metabolic alterations in cellular and systemic levels are also known to be cardinal features of aging. Moreover, cellular metabolism has emerged to provide regulations to guide immune cell behavior via modulations on signaling cascades and epigenetic landscape, and the aberrant aging process in immune cells can lead to inflammaging, a chronic and low-grade inflammation that facilitates aging by perturbing homeostasis in tissues and organs. Here, we review how the metabolic program in T cells is influenced by the aging process and how aged T cells modulate inflammaging. In addition, we discuss the potential approaches to reverse or ameliorate aging by rewiring the metabolic programming of immune cells.</p>","PeriodicalId":74074,"journal":{"name":"Life metabolism","volume":" ","pages":"load028"},"PeriodicalIF":0.0,"publicationDate":"2023-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11749375/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49423720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
AMPK promotes lysosomal and mitochondrial biogenesis via folliculin:FNIP1. AMPK通过毛囊素促进溶酶体和线粒体的生物发生：FNIP1。
Life metabolism Pub Date : 2023-06-22 eCollection Date: 2023-10-01 DOI: 10.1093/lifemeta/load027
Jordana B Freemantle, D Grahame Hardie
{"title":"AMPK promotes lysosomal and mitochondrial biogenesis via folliculin:FNIP1.","authors":"Jordana B Freemantle, D Grahame Hardie","doi":"10.1093/lifemeta/load027","DOIUrl":"10.1093/lifemeta/load027","url":null,"abstract":"<p><p>The AMP-activated protein kinase (AMPK) is known to maintain the integrity of cellular mitochondrial networks by (i) promoting fission, (ii) inhibiting fusion, (iii) promoting recycling of damaged components via mitophagy, (iv) enhancing lysosomal biogenesis to support mitophagy, and (v) promoting biogenesis of new mitochondrial components. While the AMPK targets underlying the first three of these effects are known, a recent paper suggests that direct phosphorylation of the folliculin-interacting protein 1 (FNIP1) by AMPK may be involved in the remaining two.</p>","PeriodicalId":74074,"journal":{"name":"Life metabolism","volume":"2 5","pages":"load027"},"PeriodicalIF":0.0,"publicationDate":"2023-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10445941/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10127834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A dahlia flower extract has antidiabetic properties by improving insulin function in the brain. 大丽花提取物具有改善大脑胰岛素功能的抗糖尿病特性
Life metabolism Pub Date : 2023-06-18 eCollection Date: 2023-08-01 DOI: 10.1093/lifemeta/load026
Dominik Pretz, Philip M Heyward, Jeremy Krebs, Joel Gruchot, Charles Barter, Pat Silcock, Nerida Downes, Mohammed Zubair Rizwan, Alisa Boucsein, Julia Bender, Elaine J Burgess, Geke Aline Boer, Pramuk Keerthisinghe, Nigel B Perry, Alexander Tups
{"title":"A dahlia flower extract has antidiabetic properties by improving insulin function in the brain.","authors":"Dominik Pretz, Philip M Heyward, Jeremy Krebs, Joel Gruchot, Charles Barter, Pat Silcock, Nerida Downes, Mohammed Zubair Rizwan, Alisa Boucsein, Julia Bender, Elaine J Burgess, Geke Aline Boer, Pramuk Keerthisinghe, Nigel B Perry, Alexander Tups","doi":"10.1093/lifemeta/load026","DOIUrl":"10.1093/lifemeta/load026","url":null,"abstract":"<p><p>Butein, a rare chalcone found in the toxic plant <i>Toxicodendron vernicifluum</i>, has been shown to regulate glucose homeostasis via inhibition of the nuclear factor kappa-B kinase subunit beta (IKKβ)/nuclear factor kappa B (NF-κB) pathway in the brain. Here, we investigated whether the nonpoisonous plant <i>Dahlia pinnata</i> could be a source of butein as a potential treatment for type 2 diabetes (T2D). In mice fed a high-fat diet (HFD) to induce glucose intolerance, an oral <i>D. pinnata</i> petal extract improved glucose tolerance at doses of 3.3 mg/kg body weight and 10 mg/kg body weight. Surprisingly, this effect was not mediated by butein alone but by butein combined with the closely related flavonoids, sulfuretin and/or isoliquiritigenin. Mechanistically, the extract improved systemic insulin tolerance. Inhibition of phosphatidylinositol 3-kinase to block insulin signaling in the brain abrogated the glucoregulatory effect of the orally administered extract. The extract reinstated central insulin signaling and normalized astrogliosis in the hypothalamus of HFD-fed mice. Using NF-κB reporter zebrafish to determine IKKβ/NF-κB activity, a potent anti-inflammatory action of the extract was found. A randomized controlled crossover clinical trial on participants with prediabetes or T2D confirmed the safety and efficacy of the extract in humans. In conclusion, we identified an extract from the flower petals of <i>D. pinnata</i> as a novel treatment option for T2D, potentially targeting the central regulation of glucose homeostasis as a root cause of the disease.</p>","PeriodicalId":74074,"journal":{"name":"Life metabolism","volume":" ","pages":"load026"},"PeriodicalIF":0.0,"publicationDate":"2023-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11749471/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48373127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction to: Intergenerational hyperglycemia through epigenetic alterations of gametes. 更正：通过配子表观遗传学改变的代际高血糖
Life metabolism Pub Date : 2023-06-16 eCollection Date: 2023-08-01 DOI: 10.1093/lifemeta/load023
{"title":"Correction to: Intergenerational hyperglycemia through epigenetic alterations of gametes.","authors":"","doi":"10.1093/lifemeta/load023","DOIUrl":"10.1093/lifemeta/load023","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1093/lifemeta/loac007.].</p>","PeriodicalId":74074,"journal":{"name":"Life metabolism","volume":" ","pages":"load023"},"PeriodicalIF":0.0,"publicationDate":"2023-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11749230/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48490941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A myofiber-derived secreted factor for muscle regeneration. 用于肌肉再生的肌纤维衍生的分泌因子
Life metabolism Pub Date : 2023-06-14 eCollection Date: 2023-08-01 DOI: 10.1093/lifemeta/load025
Fang Xiao, Zheng Sun
{"title":"A myofiber-derived secreted factor for muscle regeneration.","authors":"Fang Xiao, Zheng Sun","doi":"10.1093/lifemeta/load025","DOIUrl":"10.1093/lifemeta/load025","url":null,"abstract":"","PeriodicalId":74074,"journal":{"name":"Life metabolism","volume":" ","pages":"load025"},"PeriodicalIF":0.0,"publicationDate":"2023-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11749707/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42129045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hunger extends lifespan by modulating histone proteins. 饥饿通过调节组蛋白延长寿命
Life metabolism Pub Date : 2023-06-12 eCollection Date: 2023-08-01 DOI: 10.1093/lifemeta/load024
Hailan Liu, Hongjie Li, Yong Xu
{"title":"Hunger extends lifespan by modulating histone proteins.","authors":"Hailan Liu, Hongjie Li, Yong Xu","doi":"10.1093/lifemeta/load024","DOIUrl":"10.1093/lifemeta/load024","url":null,"abstract":"","PeriodicalId":74074,"journal":{"name":"Life metabolism","volume":" ","pages":"load024"},"PeriodicalIF":0.0,"publicationDate":"2023-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11749563/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49286536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neural innervation in adipose tissue, gut, pancreas, and liver. 脂肪组织、肠道、胰腺和肝脏的神经支配
Life metabolism Pub Date : 2023-06-06 eCollection Date: 2023-08-01 DOI: 10.1093/lifemeta/load022
Mengxue Sun, Yongwen Wan, Mengjie Shi, Zhuo-Xian Meng, Wenwen Zeng
{"title":"Neural innervation in adipose tissue, gut, pancreas, and liver.","authors":"Mengxue Sun, Yongwen Wan, Mengjie Shi, Zhuo-Xian Meng, Wenwen Zeng","doi":"10.1093/lifemeta/load022","DOIUrl":"10.1093/lifemeta/load022","url":null,"abstract":"<p><p>Efficient communication between the brain and peripheral organs is indispensable for regulating physiological function and maintaining energy homeostasis. The peripheral nervous system (PNS) in vertebrates, consisting of the autonomic and somatic nervous systems, bridges the peripheral organs and the central nervous system (CNS). Metabolic signals are processed by both vagal sensory nerves and somatosensory nerves. The CNS receives sensory inputs via ascending nerves, serves as the coordination and integration center, and subsequently controls internal organs and glands via descending nerves. The autonomic nervous system consists of sympathetic and parasympathetic branches that project peripheral nerves into various anatomical locations to regulate the energy balance. Sympathetic and parasympathetic nerves typically control the reflexive and involuntary functions in organs. In this review article, we outline the innervation of adipose tissue, gut, pancreas, and liver, to illustrate the neurobiological basis of central-peripheral interactions. We emphasize the importance of understanding the functional atlas of neural control of energy metabolism, and more importantly, provide potential avenues for further research in this area.</p>","PeriodicalId":74074,"journal":{"name":"Life metabolism","volume":" ","pages":"load022"},"PeriodicalIF":0.0,"publicationDate":"2023-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11749697/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42796665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chowing down: diet considerations in rodent models of metabolic disease. 大嚼：代谢性疾病啮齿动物模型中的饮食考虑。
Life metabolism Pub Date : 2023-06-01 Epub Date: 2023-04-26 DOI: 10.1093/lifemeta/load013
Kevin C Klatt, Kevin Bass, John R Speakman, Kevin D Hall
{"title":"Chowing down: diet considerations in rodent models of metabolic disease.","authors":"Kevin C Klatt, Kevin Bass, John R Speakman, Kevin D Hall","doi":"10.1093/lifemeta/load013","DOIUrl":"10.1093/lifemeta/load013","url":null,"abstract":"<p><p>Diet plays a substantial role in the etiology, progression, and treatment of chronic disease and is best considered as a multifaceted set of modifiable input variables with pleiotropic effects on a variety of biological pathways spanning multiple organ systems. This brief review discusses key issues related to the design and conduct of diet interventions in rodent models of metabolic disease and their implications for interpreting experiments. We also make specific recommendations to improve rodent diet studies to help better understand the role of diet on metabolic physiology and thereby improve our understanding of metabolic disease.</p>","PeriodicalId":74074,"journal":{"name":"Life metabolism","volume":"2 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10361708/pdf/nihms-1901420.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9867642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Flux measurements of the tricarboxylic acid cycle in the tumors of mice. 小鼠肿瘤中TCA通量的测定
Life metabolism Pub Date : 2023-05-24 eCollection Date: 2023-06-01 DOI: 10.1093/lifemeta/load020
Shiyu Liu, Jason W Locasale
{"title":"Flux measurements of the tricarboxylic acid cycle in the tumors of mice.","authors":"Shiyu Liu, Jason W Locasale","doi":"10.1093/lifemeta/load020","DOIUrl":"10.1093/lifemeta/load020","url":null,"abstract":"","PeriodicalId":74074,"journal":{"name":"Life metabolism","volume":" ","pages":"load020"},"PeriodicalIF":0.0,"publicationDate":"2023-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11749565/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46030334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mitochondrial cristae: lung cancer metabolism architects. 线粒体嵴：癌症代谢建筑师
Life metabolism Pub Date : 2023-05-12 eCollection Date: 2023-04-01 DOI: 10.1093/lifemeta/load015
Masafumi Noguchi, Luca Scorrano
{"title":"Mitochondrial cristae: lung cancer metabolism architects.","authors":"Masafumi Noguchi, Luca Scorrano","doi":"10.1093/lifemeta/load015","DOIUrl":"10.1093/lifemeta/load015","url":null,"abstract":"","PeriodicalId":74074,"journal":{"name":"Life metabolism","volume":" ","pages":"load015"},"PeriodicalIF":0.0,"publicationDate":"2023-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11749634/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48866660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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