Life metabolism最新文献_第6页

Intestinal monocarboxylate transporter 1 mediates lactate transport in the gut and regulates metabolic homeostasis of mouse in a sex-dimorphic pattern 肠道单羧酸转运蛋白1介导乳酸在肠道内的转运，并以性别二态模式调节小鼠的代谢稳态

Life metabolism Pub Date : 2023-11-06 DOI: 10.1093/lifemeta/load041

Shuo Wang, Lingling Zhang, Jingyu Zhao, Meijuan Bai, Yijun Lin, Qianqian Chu, Jue Gong, Ju Qiu, Yan Chen

{"title":"Intestinal monocarboxylate transporter 1 mediates lactate transport in the gut and regulates metabolic homeostasis of mouse in a sex-dimorphic pattern","authors":"Shuo Wang, Lingling Zhang, Jingyu Zhao, Meijuan Bai, Yijun Lin, Qianqian Chu, Jue Gong, Ju Qiu, Yan Chen","doi":"10.1093/lifemeta/load041","DOIUrl":"https://doi.org/10.1093/lifemeta/load041","url":null,"abstract":"Abstract The monocarboxylate transporter 1 (MCT1), encoded by gene Slc16a1, is a proton-coupled transporter for lactate and other monocarboxylates. MCT1-mediated lactate transport was recently found to regulate various biological functions. However, how MCT1 and lactate in the intestine modulate the physiology and pathophysiology of the body is unclear. In this study, we generated a mouse model with specific deletion of Slc16a1 in the intestinal epithelium (Slc16a1IKO mice) and investigated the functions of MCT1 in the gut. When fed a high-fat diet, Slc16a1IKO male mice had improvement in glucose tolerance and insulin sensitivity, while Slc16a1IKO female mice only had increased adiposity. Deficiency of intestinal MCT1 in male mice was associated with downregulation of pro-inflammatory pathways, together with decreased circulating levels of inflammatory cytokines including tumor necrosis factor alpha (TNFα) and C-C motif chemokine ligand 2 (CCL2). Lactate had a stimulatory effect on pro-inflammatory macrophages in vitro. The number of intestinal macrophages was reduced in Slc16a1IKO male mice in vivo. Intestinal deletion of Slc16a1 in male mice reduced interstitial lactate level in the intestine. In addition, treatment of male mice with estrogen lowered interstitial lactate level in the intestine and abolished the difference of glucose homeostasis between Slc16a1IKO and wild-type mice. Deficiency of intestinal MCT1 also blocked transport of lactate and short-chain fatty acids from the intestine to the portal vein. The effect of Slc16a1 deletion on glucose homeostasis in male mice was partly mediated by alterations in gut microbiota. In conclusion, our work reveals that intestinal MCT1 regulates glucose homeostasis in a sex-dependent manner.","PeriodicalId":74074,"journal":{"name":"Life metabolism","volume":"72 5","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135685209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Manganese therapy for dyslipidemia and plaque reversal in murine models 锰治疗小鼠血脂异常和斑块逆转

Life metabolism Pub Date : 2023-10-26 DOI: 10.1093/lifemeta/load040

Yawei Wang, Xin Feng, Wenjing Zhou, Runze Huang, Yating Hu, Hui Hui, Jie Tian, Xiao Wang, Xiao-Wei Chen

引用次数: 1

DIESL fuels a DGAT-independent triglyceride synthesis pathway 柴油为不依赖dgat的甘油三酯合成途径提供燃料

Life metabolism Pub Date : 2023-10-05 DOI: 10.1093/lifemeta/load039

Lauren F Uchiyama, Peter Tontonoz

引用次数: 0

Mitochondrial YBX1 promotes cancer cell metastasis by inhibiting pyruvate uptake 线粒体YBX1通过抑制丙酮酸摄取促进癌细胞转移

Life metabolism Pub Date : 2023-09-27 DOI: 10.1093/lifemeta/load038

Huan Chen, Ting Ling, Di Chen, Wenjuan Liu, Huan Qi, Tian Xia, Xiaolong Liu, Wen Wang, Xin Guo, Wuxiyar Otkur, Fangjun Wang, Zhaochao Xu, Jean-Claude Martinou, Hai-long Piao

引用次数: 0

7-Dehydrocholesterol protects against circadian disruption and experimental colitis: potential role of RORα/γ 7-脱氢胆固醇可预防昼夜节律紊乱和实验性结肠炎:rora /γ的潜在作用

Life metabolism Pub Date : 2023-09-19 DOI: 10.1093/lifemeta/load034

Feng Li, Shubin Lin, Zhiyi Tan, Yanqing Pang, Shuai Wang

引用次数: 0

Transcript profile of CLSTN3B gene in human white adipose tissue is associated with obesity and mitochondrial gene program 人白色脂肪组织CLSTN3B基因转录谱与肥胖和线粒体基因程序相关

Life metabolism Pub Date : 2023-09-14 DOI: 10.1093/lifemeta/load037

Ningning Bai, Xuhong Lu, Yansu Wang, Xiaoya Li, Rong Zhang, Haoyong Yu, Cheng Hu, Xiaojing Ma, Yuqian Bao, Ying Yang

引用次数: 0

Blockade of Arf1-mediated lipid metabolism in cancers promotes tumor infiltration of cytotoxic T cells via the LPE-PPARγ-NF-κB-CCL5 pathway 阻断肿瘤中arf1介导的脂质代谢可通过LPE-PPARγ-NF-κB-CCL5途径促进细胞毒性T细胞的肿瘤浸润

Life metabolism Pub Date : 2023-09-06 DOI: 10.1093/lifemeta/load036

Na Wang, Tiange Yao, Chenfei Luo, Ling Sun, Yuetong Wang, Steven X Hou

{"title":"Blockade of Arf1-mediated lipid metabolism in cancers promotes tumor infiltration of cytotoxic T cells via the LPE-PPARγ-NF-κB-CCL5 pathway","authors":"Na Wang, Tiange Yao, Chenfei Luo, Ling Sun, Yuetong Wang, Steven X Hou","doi":"10.1093/lifemeta/load036","DOIUrl":"https://doi.org/10.1093/lifemeta/load036","url":null,"abstract":"Abstract Tumor immunotherapy has achieved breakthroughs in a variety of tumors. However, the systemic absence of T cells in tumors and immunosuppressive tumor microenvironment so far limits the efficacy of immunotherapy to a small population of patients. Therefore, novel agents to increase T-cell tumor infiltration are urgently needed in the clinic. We recently found that inhibition of the ADP-ribosylation factor 1 (Arf1)-mediated lipid metabolism not only kills cancer stem cells (CSCs) but also elicits an anti-tumor immune response. In this study, we revealed a mechanism that targeting Arf1 promotes the infiltration of cytotoxic T lymphocytes (CTLs) into tumors through the C-C chemokine ligand 5 (CCL5)- C-C chemokine receptor type 5 (CCR5) pathway. We found that blockage of Arf1 induces the production of the unsaturated fatty acid (PE 18:1) that binds and sequestrates peroxisome proliferator-activated receptor-γ (PPARγ) from the PPARγ-nuclear factor-κB (NF-κB) cytoplasmic complex. The released NF-κB was then phosphorylated and translocated into the nucleus to regulate the transcription of chemokine CCL5. CCL5 promoted infiltration of CTLs for tumor regression. Furthermore, the combination of the Arf1 inhibitor and programmed cell death protein 1 (PD-1) blockade induced an even stronger anti-tumor immunity. Therefore, targeting Arf1 represents a novel anti-tumor immune approach by provoking T-cell tumor infiltration and may provide a new strategy for tumor immunotherapy.","PeriodicalId":74074,"journal":{"name":"Life metabolism","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135203505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Life Metabolism Travel Prize of 2023 2023年生命代谢旅游奖

Life metabolism Pub Date : 2023-09-05 DOI: 10.1093/lifemeta/load035

Xiaolei Liu

引用次数: 0

Extracellular matrix remodelling in obesity and metabolic disorders. 肥胖和代谢紊乱中的细胞外基质重塑。

Life metabolism Pub Date : 2023-08-01 Epub Date: 2023-05-26 DOI: 10.1093/lifemeta/load021

Vishal Musale, David H Wasserman, Li Kang

{"title":"Extracellular matrix remodelling in obesity and metabolic disorders.","authors":"Vishal Musale, David H Wasserman, Li Kang","doi":"10.1093/lifemeta/load021","DOIUrl":"10.1093/lifemeta/load021","url":null,"abstract":"<p><p>Obesity causes extracellular matrix (ECM) remodelling which can develop into serious pathology and fibrosis, having metabolic effects in insulin-sensitive tissues. The ECM components may be increased in response to overnutrition. This review will focus on specific obesity-associated molecular and pathophysiological mechanisms of ECM remodelling and the impact of specific interactions on tissue metabolism. In obesity, complex network of signalling molecules such as cytokines and growth factors have been implicated in fibrosis. Increased ECM deposition contributes to the pathogenesis of insulin resistance at least in part through activation of cell surface integrin receptors and CD44 signalling cascades. These cell surface receptors transmit signals to the cell adhesome which orchestrates an intracellular response that adapts to the extracellular environment. Matrix proteins, glycoproteins, and polysaccharides interact through ligand-specific cell surface receptors that interact with the cytosolic adhesion proteins to elicit specific actions. Cell adhesion proteins may have catalytic activity or serve as scaffolds. The vast number of cell surface receptors and the complexity of the cell adhesome have made study of their roles challenging in health and disease. Further complicating the role of ECM-cell receptor interactions is the variation between cell types. This review will focus on recent insights gained from studies of two highly conserved, ubiquitously axes and how they contribute to insulin resistance and metabolic dysfunction in obesity. These are the collagen-integrin receptor-IPP (ILK-PINCH-Parvin) axis and the hyaluronan-CD44 interaction. We speculate that targeting ECM components or their receptor-mediated cell signalling may provide novel insights into the treatment of obesity-associated cardiometabolic complications.</p>","PeriodicalId":74074,"journal":{"name":"Life metabolism","volume":"2 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10299575/pdf/nihms-1904676.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10275103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lactate as a regulator of iron homeostasis. 乳酸作为铁体内平衡的调节剂

Life metabolism Pub Date : 2023-07-27 eCollection Date: 2023-10-01 DOI: 10.1093/lifemeta/load033

Gregory J Anderson, David M Frazer

引用次数: 0