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Hyperoxidized PRDX3 as a specific ferroptosis marker. 过氧化的 PRDX3 是一种特异性铁变态反应标记。
Life metabolism Pub Date : 2023-12-01 Epub Date: 2023-11-18 DOI: 10.1093/lifemeta/load042
Yuelong Yan, Boyi Gan
{"title":"Hyperoxidized PRDX3 as a specific ferroptosis marker.","authors":"Yuelong Yan, Boyi Gan","doi":"10.1093/lifemeta/load042","DOIUrl":"10.1093/lifemeta/load042","url":null,"abstract":"<p><p>The lack of a reliable and specific marker for ferroptosis has hindered the advancement of treatments related to this cell death mechanism toward clinical application. A recent study published in <i>Molecular Cell</i> has identified hyperoxidized peroxiredoxin 3 (PRDX3) as a promising marker for ferroptosis, opening up new avenues for monitoring and targeting ferroptosis in disease treatment.</p>","PeriodicalId":74074,"journal":{"name":"Life metabolism","volume":"2 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10766428/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139099341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Metabolic restraining of epigenetic modifications promotes cardiomyocyte proliferation 代谢抑制表观遗传修饰促进心肌细胞增殖
Life metabolism Pub Date : 2023-12-01 DOI: 10.1093/lifemeta/load047
Xiuxiu Liu, Bin Zhou
{"title":"Metabolic restraining of epigenetic modifications promotes cardiomyocyte proliferation","authors":"Xiuxiu Liu, Bin Zhou","doi":"10.1093/lifemeta/load047","DOIUrl":"https://doi.org/10.1093/lifemeta/load047","url":null,"abstract":"\u0000 The metabolic state of a cell is closely related to its structure and function in adult mammalian cardiomyocytes. These adult cardiomyocytes primarily use fatty acids as an energy substrate to support heart contraction. Recently, Li and his colleagues reported that inhibiting fatty acid oxidation in cardiomyocytes keeps them in an immature state. This influences epigenomic modifications and ultimately increases the proliferation capacity of the cardiomyocytes.","PeriodicalId":74074,"journal":{"name":"Life metabolism","volume":"336 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138625844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A metabolic signaling role for arginine in liver cancer 精氨酸在肝癌中的代谢信号作用
Life metabolism Pub Date : 2023-11-27 DOI: 10.1093/lifemeta/load046
David Sokolov, Lucas B Sullivan
{"title":"A metabolic signaling role for arginine in liver cancer","authors":"David Sokolov, Lucas B Sullivan","doi":"10.1093/lifemeta/load046","DOIUrl":"https://doi.org/10.1093/lifemeta/load046","url":null,"abstract":"In addition to their canonical roles in biosynthetic pathways, metabolites can be active participants in oncogenic signaling, but our understanding of these signaling mechanisms is incomplete. In a recent article published in Cell, Mossmann and colleagues find a novel signaling role for accumulated arginine in hepatocellular carcinoma (HCC), mediated by the RNA splicing factor and transcriptional modifier RNA-binding protein 39 (RBM39).","PeriodicalId":74074,"journal":{"name":"Life metabolism","volume":"77 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139230477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Regulation of hepatic lipid metabolism by intestine epithelium-derived exosomes 肠上皮源性外泌体对肝脏脂质代谢的调控
Life metabolism Pub Date : 2023-11-21 DOI: 10.1093/lifemeta/load044
Tiange Feng, Yuan Liang, Lijun Sun, Lu Feng, Jiajie Min, Michael W Mulholland, Yue Yin, Weizhen Zhang
{"title":"Regulation of hepatic lipid metabolism by intestine epithelium-derived exosomes","authors":"Tiange Feng, Yuan Liang, Lijun Sun, Lu Feng, Jiajie Min, Michael W Mulholland, Yue Yin, Weizhen Zhang","doi":"10.1093/lifemeta/load044","DOIUrl":"https://doi.org/10.1093/lifemeta/load044","url":null,"abstract":"The “gut-liver axis” is critical for the control of hepatic lipid homeostasis, where the intestine affects the liver through multiple pathways such as nutrient uptake, gastrointestinal hormone release, and gut microbiota homeostasis. Whether intestine-originated exosomes mediate the gut’s influence on liver steatosis remains unknown. Here we aimed to determine whether intestinal epithelium-derived exosomes (intExos) contribute to the regulation of hepatic lipid metabolism. We found that mouse intExos could be taken up by hepatic cells. Mice fed high-fat diet (HFD) received intExos showed strong resistance to liver steatosis. MicroRNA sequencing of intExos indicated the correlation between miR-21a-5p/miR-145a-5p and hepatic lipid metabolism. Both liver overexpression of miR-21a-5p and intExos containing miR-21a-5p alleviated hepatic steatosis in mice fed with HFD. Mechanistically, miR-21a-5p suppressed the expression of Ccl1 (C-C motif chemokine ligand 1) in macrophages, as well as lipid transport genes Cd36 (cluster of differentiation 36) and Fabp7 (fatty acid binding protein 7) in hepatocytes. Liver-specific inhibition of miR-145a-5p significantly reduced hepatic lipid accumulation in mice fed with HFD through negatively regulating the expression of Btg1 (BTG anti-proliferation factor 1), leading to an increase of stearoyl-CoA desaturase-1 and lipogenesis.Our study demonstrates that intExos regulate hepatic lipid metabolism and NAFLD (non-alcoholic fatty liver disease) progression via miR-21a-5p and miR-145a-5p pathways, providing novel mediators for the gut-liver crosstalk and potential targets for regulating hepatic lipid metabolism.","PeriodicalId":74074,"journal":{"name":"Life metabolism","volume":"63 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139250806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Single-nucleus RNA sequencing reveals heterogeneity among multiple white adipose tissue depots 单核 RNA 测序揭示了多种白色脂肪组织贮备的异质性
Life metabolism Pub Date : 2023-11-21 DOI: 10.1093/lifemeta/load045
Limin Xie, Wanyu Hu, Haowei Zhang, Yujin Ding, Qin Zeng, Xiyan Liao, Dandan Wang, Wanqin Xie, Xiaoyan Hui, Tuo Deng
{"title":"Single-nucleus RNA sequencing reveals heterogeneity among multiple white adipose tissue depots","authors":"Limin Xie, Wanyu Hu, Haowei Zhang, Yujin Ding, Qin Zeng, Xiyan Liao, Dandan Wang, Wanqin Xie, Xiaoyan Hui, Tuo Deng","doi":"10.1093/lifemeta/load045","DOIUrl":"https://doi.org/10.1093/lifemeta/load045","url":null,"abstract":"Regardless of its anatomical site, adipose tissue shares a common energy-storage role but exhibits distinctive properties. Exploring the cellular and molecular heterogeneity of white adipose tissue (WAT) is crucial for comprehending its function and properties. However, existing single-nucleus RNA sequencing (snRNA-seq) studies of adipose tissue heterogeneity have examined only one or two depots. In this study, we employed snRNA-seq to test five representative depots including inguinal, epididymal, mesenteric, perirenal, and pericardial adipose tissues in mice under physiological conditions. By analyzing the contents of main cell categories and gene profiles of various depots, we identified their distinctive physiological properties. Immune cells and fibro-adipogenic progenitor cells (FAPs) showed dramatic differences among WAT depots, while adipocytes seemed to be conserved. The heightened presence of regulatory macrophages and B cells in pericardial adipose tissues implied their potential contribution to the preservation of coronary vascular function. Moreover, the selective aggregation of pericytes within mesenteric adipose tissue was likely associated with the maintenance of intestinal barrier homeostasis. Using a combination of RNA sequencing and snRNA-seq analysis, the major subpopulations of FAPs derived from these depots determined the site characteristics of FAPs to a certain extent. Our work establishes a systematic and reliable foundation for investigating the heterogeneity of WAT depots and elucidating the unique roles these depots play in coordinating the function of adjacent organs.","PeriodicalId":74074,"journal":{"name":"Life metabolism","volume":"242 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139252397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exercise training improves long-term memory in obese mice 运动训练可改善肥胖小鼠的长期记忆力
Life metabolism Pub Date : 2023-11-15 DOI: 10.1093/lifemeta/load043
O. K. Fuller, Casey L. Egan, Tina L Robinson, Nimna Perera, Heidy K Latchman, Lauren V Terry, Emma D. McLennan, Carolina Chavez, Emma L. Burrows, John W Scott, Robyn M Murphy, H. van Praag, M. Whitham, M. Febbraio
{"title":"Exercise training improves long-term memory in obese mice","authors":"O. K. Fuller, Casey L. Egan, Tina L Robinson, Nimna Perera, Heidy K Latchman, Lauren V Terry, Emma D. McLennan, Carolina Chavez, Emma L. Burrows, John W Scott, Robyn M Murphy, H. van Praag, M. Whitham, M. Febbraio","doi":"10.1093/lifemeta/load043","DOIUrl":"https://doi.org/10.1093/lifemeta/load043","url":null,"abstract":"Obesity has been linked to a range of pathologies, including dementia. In contrast, regular physical activity is associated with the prevention or reduced progression of neurodegeneration. Specifically, physical activity can improve memory and spatial cognition, reduce age-related cognitive decline, and preserve brain volume, but the mechanisms are not fully understood. Accordingly, we investigated whether any detrimental effects of high-fat diet (HFD)-induced obesity on cognition, motor behavior, adult hippocampal neurogenesis, and brain-derived neurotrophic factor (BDNF) could be mitigated by voluntary exercise training in male C57Bl/6 mice. HFD-induced impairment of motor function was not reversed by exercise. Importantly, voluntary wheel running improved long-term memory and increased hippocampal neurogenesis, suggesting that regular physical activity may prevent cognitive decline in obesity.","PeriodicalId":74074,"journal":{"name":"Life metabolism","volume":"182 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139273321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Intestinal monocarboxylate transporter 1 mediates lactate transport in the gut and regulates metabolic homeostasis of mouse in a sex-dimorphic pattern 肠道单羧酸转运蛋白1介导乳酸在肠道内的转运，并以性别二态模式调节小鼠的代谢稳态
Life metabolism Pub Date : 2023-11-06 DOI: 10.1093/lifemeta/load041
Shuo Wang, Lingling Zhang, Jingyu Zhao, Meijuan Bai, Yijun Lin, Qianqian Chu, Jue Gong, Ju Qiu, Yan Chen
{"title":"Intestinal monocarboxylate transporter 1 mediates lactate transport in the gut and regulates metabolic homeostasis of mouse in a sex-dimorphic pattern","authors":"Shuo Wang, Lingling Zhang, Jingyu Zhao, Meijuan Bai, Yijun Lin, Qianqian Chu, Jue Gong, Ju Qiu, Yan Chen","doi":"10.1093/lifemeta/load041","DOIUrl":"https://doi.org/10.1093/lifemeta/load041","url":null,"abstract":"Abstract The monocarboxylate transporter 1 (MCT1), encoded by gene Slc16a1, is a proton-coupled transporter for lactate and other monocarboxylates. MCT1-mediated lactate transport was recently found to regulate various biological functions. However, how MCT1 and lactate in the intestine modulate the physiology and pathophysiology of the body is unclear. In this study, we generated a mouse model with specific deletion of Slc16a1 in the intestinal epithelium (Slc16a1IKO mice) and investigated the functions of MCT1 in the gut. When fed a high-fat diet, Slc16a1IKO male mice had improvement in glucose tolerance and insulin sensitivity, while Slc16a1IKO female mice only had increased adiposity. Deficiency of intestinal MCT1 in male mice was associated with downregulation of pro-inflammatory pathways, together with decreased circulating levels of inflammatory cytokines including tumor necrosis factor alpha (TNFα) and C-C motif chemokine ligand 2 (CCL2). Lactate had a stimulatory effect on pro-inflammatory macrophages in vitro. The number of intestinal macrophages was reduced in Slc16a1IKO male mice in vivo. Intestinal deletion of Slc16a1 in male mice reduced interstitial lactate level in the intestine. In addition, treatment of male mice with estrogen lowered interstitial lactate level in the intestine and abolished the difference of glucose homeostasis between Slc16a1IKO and wild-type mice. Deficiency of intestinal MCT1 also blocked transport of lactate and short-chain fatty acids from the intestine to the portal vein. The effect of Slc16a1 deletion on glucose homeostasis in male mice was partly mediated by alterations in gut microbiota. In conclusion, our work reveals that intestinal MCT1 regulates glucose homeostasis in a sex-dependent manner.","PeriodicalId":74074,"journal":{"name":"Life metabolism","volume":"72 5","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135685209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Manganese therapy for dyslipidemia and plaque reversal in murine models 锰治疗小鼠血脂异常和斑块逆转
Life metabolism Pub Date : 2023-10-26 DOI: 10.1093/lifemeta/load040
Yawei Wang, Xin Feng, Wenjing Zhou, Runze Huang, Yating Hu, Hui Hui, Jie Tian, Xiao Wang, Xiao-Wei Chen
{"title":"Manganese therapy for dyslipidemia and plaque reversal in murine models","authors":"Yawei Wang, Xin Feng, Wenjing Zhou, Runze Huang, Yating Hu, Hui Hui, Jie Tian, Xiao Wang, Xiao-Wei Chen","doi":"10.1093/lifemeta/load040","DOIUrl":"https://doi.org/10.1093/lifemeta/load040","url":null,"abstract":"","PeriodicalId":74074,"journal":{"name":"Life metabolism","volume":"8 3","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134908080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
DIESL fuels a DGAT-independent triglyceride synthesis pathway 柴油为不依赖dgat的甘油三酯合成途径提供燃料
Life metabolism Pub Date : 2023-10-05 DOI: 10.1093/lifemeta/load039
Lauren F Uchiyama, Peter Tontonoz
{"title":"DIESL fuels a DGAT-independent triglyceride synthesis pathway","authors":"Lauren F Uchiyama, Peter Tontonoz","doi":"10.1093/lifemeta/load039","DOIUrl":"https://doi.org/10.1093/lifemeta/load039","url":null,"abstract":"Alternative triglyceride (TG) synthesis pathways have yet to be identified in mammalian cells. In a recent article published in Nature, Brummelkamp and colleagues reported the acyltransferase TMEM68/DIESL synthesizes TG in the absence of the canonical enzymes diacylglycerol acyltransferase 1 (DGAT1) and DGAT2.","PeriodicalId":74074,"journal":{"name":"Life metabolism","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135483097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mitochondrial YBX1 promotes cancer cell metastasis by inhibiting pyruvate uptake 线粒体YBX1通过抑制丙酮酸摄取促进癌细胞转移
Life metabolism Pub Date : 2023-09-27 DOI: 10.1093/lifemeta/load038
Huan Chen, Ting Ling, Di Chen, Wenjuan Liu, Huan Qi, Tian Xia, Xiaolong Liu, Wen Wang, Xin Guo, Wuxiyar Otkur, Fangjun Wang, Zhaochao Xu, Jean-Claude Martinou, Hai-long Piao
{"title":"Mitochondrial YBX1 promotes cancer cell metastasis by inhibiting pyruvate uptake","authors":"Huan Chen, Ting Ling, Di Chen, Wenjuan Liu, Huan Qi, Tian Xia, Xiaolong Liu, Wen Wang, Xin Guo, Wuxiyar Otkur, Fangjun Wang, Zhaochao Xu, Jean-Claude Martinou, Hai-long Piao","doi":"10.1093/lifemeta/load038","DOIUrl":"https://doi.org/10.1093/lifemeta/load038","url":null,"abstract":"Abstract Pyruvate is an essential fuel for maintaining the tricarboxylic acid (TCA) cycle in the mitochondria. However, the precise molecular mechanism of pyruvate uptake by mitochondrial pyruvate carrier (MPC) is largely unknown. Here, we report that the DNA/RNA-binding protein Y-box binding protein 1 (YBX1) is localized to the mitochondrial inter-membrane space (IMS) by its C-terminal domain (CTD) in cancer cells. In mitochondria, YBX1 inhibits pyruvate uptake by associating with MPC1/2, thereby suppressing pyruvate-dependent TCA cycle flux. This association, in turn, promotes MPC-mediated glutaminolysis and histone lactylation. Our findings reveal that the YBX1-MPC axis exhibits a positive correlation with metastatic potential, while does not affect cell proliferation in both cultured cells and tumor xenografts. Therefore, the restricted pyruvate uptake into mitochondria potentially represents a hallmark of metastatic capacity, suggesting that the YBX1-MPC axis is a therapeutic target for combating cancer metastasis.","PeriodicalId":74074,"journal":{"name":"Life metabolism","volume":"101 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135579139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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