乳酸作为铁体内平衡的调节剂

Life metabolism Pub Date : 2023-07-27 DOI:10.1093/lifemeta/load033

G. Anderson, D. Frazer

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引用次数: 0

摘要

关键的代谢中间产物乳酸可以增加肝源肽hepcidin的表达，hepcidin是体内铁稳态的中央调节剂。Liu等人的一篇新论文表明，乳酸通过结合并激活可溶性腺苷酸环化酶，从而增加细胞环磷酸腺苷(cAMP)，并通过骨形态发生蛋白(BMP)途径增强信号传导调节hepcidin的表达。

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Lactate as a regulator of iron homeostasis

The key metabolic intermediate lactate can increase expression of the liver-derived peptide hepcidin, the central regulator of body iron homeostasis. A new paper by Liu et al. shows that lactate achieves this by binding to and activating soluble adenylyl cyclase, thereby increasing cellular cyclic adenosine monophosphate (cAMP) (cAMP) and enhancing signaling through the bone morphogenetic protein (BMP) pathway to modulate hepcidin expression.

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来源期刊

Life metabolism

CiteScore

1.10

自引率

0.00%

发文量