Le Mali medicalPub Date : 2025-07-05eCollection Date: 2025-07-01DOI: 10.4314/mml.v40i2.6
Séraphin Ahoui, Mahublo V Vodouhe, H Yattara, Abigel Shalom Onibon, Evariste Eteka, Nicanor S Houeto, Cédric Aikobinou, Renaud Aholou, Fanny Hounkponou Ahouignan, Jacques Vigan
{"title":"[Chronic Kidney Disease Stages 3-5 In Women Of Childbearing Age At Tanguiéta Hospital (Benin)].","authors":"Séraphin Ahoui, Mahublo V Vodouhe, H Yattara, Abigel Shalom Onibon, Evariste Eteka, Nicanor S Houeto, Cédric Aikobinou, Renaud Aholou, Fanny Hounkponou Ahouignan, Jacques Vigan","doi":"10.4314/mml.v40i2.6","DOIUrl":"10.4314/mml.v40i2.6","url":null,"abstract":"<p><strong>Objective: </strong>To study the epidemiological, clinical and evolutionary aspects of chronic kidney disease (CKD) stages 3-5 in women of childbearing age at Saint Jean de Dieu Hospital in Tanguiéta from 2018-2021.</p><p><strong>Methods: </strong>This was a longitudinal study, with data collection from 1 January 2018 to 31 August 2021. All women of childbearing age with a diagnosis of stage 3-5 CKD and who had given their consent were included. The dependent variable was CKD progression. Progression was considered unfavourable after 3 months of follow-up in patients with a GFR <15ml/mn/1.73m2. The significance threshold was p<0.05.</p><p><strong>Results: </strong>Of 7865 women of childbearing age admitted to the hospital, 70 had CKD stages 3-5, representing a hospital frequency of 0.9%. The mean age of the patients was 45±11 years. During the 3 months of follow-up, 26 deaths (37.1%) were recorded. Of the remaining 44 patients, 37 (84.1%) had persistent stage 5 CKD. Self-medication (p=.0232), use of oestroprogestins (p=0.0289) and hypokalaemia (p=0.0043) were significantly associated with an unfavourable outcome.</p><p><strong>Conclusion: </strong>The majority of CKD stages 3-5 in women of childbearing age were unfavourable. Rigorous and early management is needed to improve renal health as much as possible.</p>","PeriodicalId":74061,"journal":{"name":"Le Mali medical","volume":"40 2","pages":"28-34"},"PeriodicalIF":0.0,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12378581/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148868216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Le Mali medicalPub Date : 2025-07-05eCollection Date: 2025-07-01DOI: 10.4314/mml.v40i2.2
Petula Anicette Ngboko Mirotiga, Antoine Doui Doumgba, Eva Elémence Épouse Maka Tapande Yakossa, Nouganga Emmanuel Diberbekoy, Noella Edwige Épouse Gambo Ignaleamoko, Youssouf Oumarou, Serge Auguste Ndakala, Regis Alexandre Ngouyombo
{"title":"[Management Of Rectum Cancers In A Country With Limited Resources].","authors":"Petula Anicette Ngboko Mirotiga, Antoine Doui Doumgba, Eva Elémence Épouse Maka Tapande Yakossa, Nouganga Emmanuel Diberbekoy, Noella Edwige Épouse Gambo Ignaleamoko, Youssouf Oumarou, Serge Auguste Ndakala, Regis Alexandre Ngouyombo","doi":"10.4314/mml.v40i2.2","DOIUrl":"10.4314/mml.v40i2.2","url":null,"abstract":"<p><strong>Objective: </strong>was to report the difficulties of rectal cancer management in a country with limited resources.</p><p><strong>Patients and methods: </strong>This was a retrospective study of the records of patients aged 15 and over, operated on in the general surgery department for histologically proven rectal cancer from January 2018 to December 2022.</p><p><strong>Results: </strong>The incidence of rectal cancer was 29.27%. The mean age of patients was 46.13 +/-12.74 years. The sex ratio was 1.4 in favor of women. The average consultation time was 9 months. The tumor was accessible by digital rectal examination in 75% of cases. Rectoscopy was performed in only 12 patients (50%). Abdominal CT scans were performed in 25% of patients, and revealed metastases in 16.6%. All patients underwent surgery, including abdominoperineal amputation in 50% of cases, bypass colostomy in 37.5% and anterior resection of the rectum in 12.5%. Histological examination of biopsies and operative specimens confirmed a Frekhunian adenocarcinoma of the rectum in 23 patients (95.83%) and transitional cell carcinoma of the lower rectum in one patient. Six patients (25%) had received postoperative chemotherapy. No patient received radiotherapy. Survival at 24 months was 25%.</p><p><strong>Conclusion: </strong>Accessibility to modern means of diagnosis and radiotherapy could improve prognosis.</p>","PeriodicalId":74061,"journal":{"name":"Le Mali medical","volume":"40 2","pages":"6-10"},"PeriodicalIF":0.0,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12378580/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148868208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Dilemal Diagnosis Of A Rare Association Of Still's Disease And Sc Drepanocytosis: A Case Report From Bouaké University Hospital].","authors":"Renée Paule Botti, Aya Annick Charlène N'Dri, Jack Fabrice Konan Koffi, Romeo Ayemou, Mahi Gnemagnon, Awa Ouattara, Kouassi Gustave Koffi, Bourhaima Ouattara","doi":"10.4314/mml.v40i2.7","DOIUrl":"10.4314/mml.v40i2.7","url":null,"abstract":"<p><p>Still's disease is characterized by relapses simulating a sickle cell crisis. It is even rarer in sickle-cell patients. We report a case of a 25-year-old SC patient in crisis with fever evolving for 1 month despite usual analgesic treatment of a sickle cell crisis. Investigations revealed T 39.1°C, polyarthritis with skin lesions. Hyperleukocytosis at 17.5 G/L, anemia at 9 g/dl, hyperferritinemia at 1000 µg/l and hepatic cytolysis. MSA was considered in view of the presence of 7 Yamaguchi criteria. Progression was favorable with corticosteroid therapy.</p>","PeriodicalId":74061,"journal":{"name":"Le Mali medical","volume":"40 2","pages":"35-36"},"PeriodicalIF":0.0,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12378578/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148868202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Le Mali medicalPub Date : 2025-07-05eCollection Date: 2025-07-01DOI: 10.4314/mml.v40i2.5
Séraphin Ahoui, Cossi Adebayo Alassani, Hamadoun Yattara, Stéphanie Régina Gangbe, Willis Allawenon, Renaud Aholou, Evariste Eteka, Nicanor S Houeto, Albert Comlan Dovonou, Jacques Vigan
{"title":"[Factors In The Poor Prognosis Of Chronic Renal Disease At The District Hospital In Tanguiéta (Benin)].","authors":"Séraphin Ahoui, Cossi Adebayo Alassani, Hamadoun Yattara, Stéphanie Régina Gangbe, Willis Allawenon, Renaud Aholou, Evariste Eteka, Nicanor S Houeto, Albert Comlan Dovonou, Jacques Vigan","doi":"10.4314/mml.v40i2.5","DOIUrl":"10.4314/mml.v40i2.5","url":null,"abstract":"<p><strong>Objective: </strong>To study the poor prognostic factors of renal failure under conservative treatment at Tanguiéta Zone Hospital (Benin) from 2018 to 2021.</p><p><strong>Methods: </strong>This was a longitudinal study with data collection from 1 January 2018 to 30 June 2021 with a minimum follow-up of 12 months. Patients of both sexes admitted to the internal medicine department with structural and functional renal impairment evolving for more than three months and who had given their consent were included. The dependent variable was the prognosis of patients with a GFR <15ml/mn/1.73m2, undergoing conservative treatment at the end of 12 months of follow-up in patients and undergoing conservative treatment. The prognosis was poor in the event of persistent renal failure or death. Sampling was exhaustive. Factors were identified and the significance threshold was set at p<0.05.</p><p><strong>Results: </strong>A total of 55 patients were included. The mean age of the patients was 39 ± 17 years [range 15 years to 86 years]. The proportion of women was 54.7%, with a sex ratio of 0.83. Of the 55 patients, 20.3% had arterial hypertension. The prognosis was poor in 21.8% of cases. Pneumopathy (p= 0.0311), corticosteroid therapy (p=0.0198) and hypernatremia (p= 0.0423) were significantly associated with the poor prognosis of renal failure.</p><p><strong>Conclusion: </strong>There are many factors contributing to the poor prognosis of renal failure. Early detection of CKD is essential in order to institute conservative treatment to avoid complications.</p>","PeriodicalId":74061,"journal":{"name":"Le Mali medical","volume":"40 2","pages":"23-27"},"PeriodicalIF":0.0,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12378576/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148868236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Evaluation Of Monitoring Of Patients In Plaster At The Sanoyah Clinic].","authors":"Issiaga Bangoura, Souleymane Diakité, Oumar Barry, Clarice Kamano, Ibrahima Sory Cissoko","doi":"10.4314/mml.v40i2.4","DOIUrl":"10.4314/mml.v40i2.4","url":null,"abstract":"<p><p>The aim of our study was to evaluate the follow-up of patients in plaster in our facility.</p><p><strong>Materials and methods: </strong>The Sanoyah Clinic (Guinea) served as the setting for this study. It was a 24-month prospective descriptive and analytical study. Patients who had given their consent and who had received cast immobilisation were included. Patients who did not receive cast immobilisation or who were lost to follow-up were not included in the study. Stable lesions were immobilised in the plaster cast room, while unstable and intractable lesions were immobilised in the operating theatre under image intensifier control. Results were assessed according to our own criteria after a mean follow-up of 5.8 months.</p><p><strong>Results: </strong>The study involved 82 patients, 58 of whom were men. Fractures of the leg and forearm were most frequently observed. The cruropedic cast accounted for 51.2%. The average duration of immobilisation was 39 days, and malunion was the most common complication.</p><p><strong>Conclusion: </strong>Monitoring patients in plaster casts is a medical exercise that requires effort on the part of all nursing staff. Patient education and information are necessary in this monitoring.</p>","PeriodicalId":74061,"journal":{"name":"Le Mali medical","volume":"40 2","pages":"17-22"},"PeriodicalIF":0.0,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12378577/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148868239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Le Mali medicalPub Date : 2025-07-05eCollection Date: 2025-07-01DOI: 10.4314/mml.v40i2.3
Etobo Innocent Ahounou, Rita Ahou Aka, Ange Sylvain Allou, Jocelyne Prisca Son Gbolerou, Roméo Yao, Hamdan Sarah Kourouma, Yessonguilana Jean-Marie Yeo-Tenena
{"title":"[Voluntary Skin Depigmentation: Results Of The Rosenberg Global Self-Esteem Scale Applied To 150 Patients At The Dermatology And Venereology Department Of The Treichville University Hospital In Abidjan].","authors":"Etobo Innocent Ahounou, Rita Ahou Aka, Ange Sylvain Allou, Jocelyne Prisca Son Gbolerou, Roméo Yao, Hamdan Sarah Kourouma, Yessonguilana Jean-Marie Yeo-Tenena","doi":"10.4314/mml.v40i2.3","DOIUrl":"10.4314/mml.v40i2.3","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate self-esteem in voluntary depigmented patients.</p><p><strong>Patients and method: </strong>We conducted a descriptive cross-sectional study at the Dermatology and Venereology Department of the Treichville University Hospital Centre (CHU) in Abidjan (Côte d'Ivoire) from July 2017 to January 2018 and it included 150 black African patients. The non-probability purposive sampling method was used. To assess self-esteem, we applied the Rosenberg scale.</p><p><strong>Results: </strong>(98%) of those surveyed were female and aged between 15 and 35 (76.70%). One depigmented person in two was single (53.30%). More than half(58.70%) said they had a tanned complexion before using lightening products and were satisfied with their physical appearance in 76% of cases. The main reasons for using depigmenting products were to improve physical appearance(80%) and to repair a physical defect(28%). The results of the Rosenberg global self-esteem scale showed that more than three quarters of the respondents (79.30%) had average to very high self-esteem.</p><p><strong>Conclusion: </strong>Voluntary skin depigmentation in black sub-Saharan Africans does not necessarily reflect a problem with self-esteem, but could be part of a fashionable aesthetic project.</p>","PeriodicalId":74061,"journal":{"name":"Le Mali medical","volume":"40 2","pages":"11-16"},"PeriodicalIF":0.0,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12378579/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148868183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Variability In Demographic And Clinical Characteristics Of Covid-19 Cases Between The First And Second Waves In Mali].","authors":"Ibrahima Berthé, Ahmadou Boly, Moctar Tounkara, Bourahima Koné, Mady Cissoko, Alou Diaby, Aissata Koné, Souleymane Sékou Diarra, Elhadj Issa Amaguiré Sy, Ousmane Boua Togola, Aminata Tounkara, Oumou Yacouba Coulibaly, AliouBadra Coulibaly, Yacouba Koné, Bouyagui Traoré, Cheick Amadou Tidiane Traoré, Issaka Sagara","doi":"10.4314/mml.v40i1.1","DOIUrl":"10.4314/mml.v40i1.1","url":null,"abstract":"<p><strong>Introduction: </strong>Since the confirmation of the first case of SARS-CoV-2 in China in December 2019, all countries in the world have been affected by this pandemic. After one (1) year of the pandemic in Mali, two outbreaks were observed. The objective of this study was to characterize the demographic and clinical variability of cases between the two episodes.</p><p><strong>Materials and methods: </strong>This was a secondary analysis of data from patients with COVID-19 in Mali during the first and the second outbreaks. The anonymous list of all COVID-19 cases confirmed by RT-PCR was used. Pearson's and Student's Chi-square tests were performed with a significance level of 5%.</p><p><strong>Results: </strong>During the study period, 2567 and 4610 people were confirmed positive for SARS-CoV-2 respectively for the first and second epidemics with a similar average age (40.4 years ±17.6 for the first against 39.9 years ± 17.2 for the second). The male sex had a higher proportion in the two outbreaks but different between the waves (69% for the first outbreak and 60% for the second, p < 0.001). The proportion of symptomatic patients was significantly different between the two waves (6.2% for the first wave versus 13.1% for the second wave, p < 0.001). The proportions of cases by age group were significantly similar between the two waves (0-20 years: 10.1% vs 11.3%; 21-40 years: 46.3% vs 45.7%; 41-60 years: 28.2% vs 29.4%; Over 60: 15.4% vs 13.5%; p = 0.063). Death rate was higher in the first episode compared to the second (5.8% versus 4.3%; p = 0.003).</p><p><strong>Conclusion: </strong>SARS-CoV-2 infection in Mali had a significant variation in symptomatology between the two waves, more highlighted in the second. The proportions of age groups of patients with COVID-19 did not vary between the two outbreaks. Death rate was higher in the first wave.</p>","PeriodicalId":74061,"journal":{"name":"Le Mali medical","volume":"40 1","pages":"2-8"},"PeriodicalIF":0.0,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12378592/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148868110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Le Mali medicalPub Date : 2025-05-13eCollection Date: 2025-05-01DOI: 10.4314/mml.v40i1.5
Relwendé Louis Arnaud Ouédraogo, Nongodo Firmin Kaboré, Dénahou Mathias Kpadonou, Julien Raymond Dango, Cheick Ahmed Ouattara, Tiandiogo Isidore Traoré, Ziemlé Clément Méda, Léon Gueswende Blaise Savadogo
{"title":"[Prenatal Malaria Care And Immediate Neonatal Outcome In The Do Health District, Burkina Faso, 2022].","authors":"Relwendé Louis Arnaud Ouédraogo, Nongodo Firmin Kaboré, Dénahou Mathias Kpadonou, Julien Raymond Dango, Cheick Ahmed Ouattara, Tiandiogo Isidore Traoré, Ziemlé Clément Méda, Léon Gueswende Blaise Savadogo","doi":"10.4314/mml.v40i1.5","DOIUrl":"10.4314/mml.v40i1.5","url":null,"abstract":"<p><strong>Introduction: </strong>Malaria in pregnancy (MIP) is a major public health problem, with considerable risks for the mother, fetus and newborn. This study assessed the effectiveness of preventive measures against malaria and the effect of malaria on immediate neonatal outcome (INO) in parturient in the Do health district.</p><p><strong>Methods: </strong>This was a descriptive and analytical cross-sectional study from November to December 2022. Clinical data on women and newborns were collected. Factors associated with the occurrence of malaria and INO were investigated using logistic regression.</p><p><strong>Results: </strong>We enrolled 250 parturient with a median age of 25 years. The use of long-lasting insecticidal nets (LLINs) reduced the risk of gestational malaria (OR = 0.25 [0.06-0.99], p=0.049). The INO was favorable in 85.20% of cases and hospitalization for malaria compromised the INO (OR = 11.23 [2.49-50.56] p=0.002).</p><p><strong>Conclusion: </strong>The emphasis must be on prevention through the use of LLINs and the introduction of effective, early treatment in the event of malaria.</p>","PeriodicalId":74061,"journal":{"name":"Le Mali medical","volume":"40 1","pages":"31-40"},"PeriodicalIF":0.0,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12378587/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148868067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Le Mali medicalPub Date : 2025-05-13eCollection Date: 2025-05-01DOI: 10.4314/mml.v40i1.3
Fanta Diallo, Zakaria Keita, Souleymane S Diarra, Mamadou Berthé, Maminata Diamounténé, Daly Siby, Issa Cissé, Nouhoum Telly, Doumbo Safiatou Niaré
{"title":"[Diagnostic Audit Of Mali's Central Laboratories Involved In The Confirmation Of Diseases With Epidemic Potential In 2023].","authors":"Fanta Diallo, Zakaria Keita, Souleymane S Diarra, Mamadou Berthé, Maminata Diamounténé, Daly Siby, Issa Cissé, Nouhoum Telly, Doumbo Safiatou Niaré","doi":"10.4314/mml.v40i1.3","DOIUrl":"10.4314/mml.v40i1.3","url":null,"abstract":"<p><p>Biological diagnosis is a key step in the detection and confirmation of epidemics.</p><p><strong>Objectives: </strong>Determine the performance score of the laboratories of research institutions (IR) and University Hospital Centers (CHU) of Bamako in terms of Quality Management System (QMS).</p><p><strong>Materials and methods: </strong>This is a cross-sectional, evaluative study of a comparative nature carried out from March to October 2023, in eight human health analysis laboratories (four IR and four University Hospitals) in Bamako, involved in the confirmation of diseases with epidemic potential. Six areas of the critical QMS QMS for monitoring were used from the SLIPTA (Gradual Process for Laboratory Assessment towards Accreditation) checklist.</p><p><strong>Results: </strong>the eight laboratories had a performance varying from 0 to 4 stars. Out of an expected total of 165 points, the total score obtained was respectively 64, 73, 96, 143 for IRs versus 43, 47, 75, 97 for CHUs. There is no statistically significant difference (p=0.0829) between the average score of IRs and that of CHUs.</p>","PeriodicalId":74061,"journal":{"name":"Le Mali medical","volume":"40 1","pages":"15-20"},"PeriodicalIF":0.0,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12378590/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148868112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Clinical And Therapeutic Characteristics Of Gestational Trophoblastic Tumors In The Point G's University Hospital].","authors":"Fatoumata Matokoma Sidibé, Salia Kéita, Mountaga Diallo, Mamadou Sima, Aicha Sidibé, Moussa Bathily, Cheick Oumar Samaké, Zakari Saye, Abdramane A Koné, Hamidou D Doumbia, Habib Diallo, Siaka Sidibé","doi":"10.4314/mml.v40i1.6","DOIUrl":"10.4314/mml.v40i1.6","url":null,"abstract":"<p><strong>Introduction: </strong>Gestational trophoblastic tumors (GTT) are heterogeneous tumors characterized by trophoblast involvement with an abnormal increase in human chorionic gonadotropin (HCG). The aim of this study was to describe in our context, the clinical, diagnostic, therapeutic characteristics and poor prognostic factors influencing the survival of these tumors.</p><p><strong>Patients and methods: </strong>This was a descriptive study of 90 patients followed for GTT at the Point G University Hospital between August 2007 and May 2020. Clinical, paraclinical and therapeutic data were collected retrospectively from the medical records of these patients and analyzed by SPSS version 21 software.</p><p><strong>Results: </strong>The mean age of the patients was 31 years ± 10.08 (15-54 years) with a peak frequency between 20-40 years. The clinical picture was frequently dominated by the following symptoms: metrorrhagia (97.8%), anemia (86.7%) and poor Performans Status (PPS) (42.2%). The mean βHCG level was 589,394.15 U/l and choriocarcinoma was the most common histological type -64.9%-. The disease was metastatic in 46.7% with a FIGO 2000 (Fédération Internationale de Gynécologie-Obstétrique) prognostic score of high risk in 57.8%. Regardless of this score, 92.7% underwent polychemotherapy. Only 41.1% of patients were alive at the end of the study. Poor prognostic factors associated with decreased overall survival were WHO PS 2-4, grade 2-4 anemia, high-risk prognostic score, and resistance to chemotherapy, all of which indicate delayed management.</p><p><strong>Conclusion: </strong>Despite their chemosensitivity, GTT may have a poor prognosis if their diagnosis is late and their management is not adapted.</p>","PeriodicalId":74061,"journal":{"name":"Le Mali medical","volume":"40 1","pages":"41-51"},"PeriodicalIF":0.0,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12378589/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148868083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}