[Epidemiology Of Cerebral Malaria At The University Huc Gabriel Toure Before And After The Implementation Of Seasonnal Malaria Chemoprevention In Bamako].

Le Mali medical Pub Date : 2024-01-01

A K Kone, B Maiga, S Konate, M Coulibaly, M S Sissoko, A Dabo, M A Thera

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Abstract

Aims: Malaria remains a health problem. The objective was to study cerebral malaria (CM) epidemiology before and after the implementation of seasonal malaria chemoprevention (SMC).

Materials and methods: This was a retrospective cross-sectional study carried out from January 01, 2014 to December 31, 2018 in children aged 0 to 15 years hospitalized for CM at the paediatrics' department of CHU Gabriel Touré.

Results: We recorded 1336 cases of CM, 803 boys and 533 girls with a sex ratio of 1.5. CM accounted for 92.1% and 83.5% respectively two years before and three years after the SMC implementation (p = 0.013). The overall lethality was 9.2% varying according to the years of follow up (p = 0.001) The SMC led to decrease of CM frequency of 8.6%.

Conclusion: SMC could have an impact on the expression of severe malaria phenotypes, with an increase of frequency of CM and CM associated with pulmonary oedema, a decrease of the frequency of CM associated with severe anaemia. Prospective studies will enable to understand the increasing case lethality rate observed during SMC period.

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[巴马科 Huc Gabriel Toure 大学在实施季节性疟疾化学预防前后的脑疟疾流行病学]。

目的：疟疾仍然是一个健康问题。目的是研究季节性疟疾化学预防（SMC）实施前后的脑疟疾（CM）流行病学：这是一项回顾性横断面研究，研究时间为2014年1月1日至2018年12月31日，研究对象为在加布里埃尔-图雷中央医院（CHU Gabriel Touré）儿科住院治疗的0至15岁儿童：我们记录了1336例CM病例，其中男孩803例，女孩533例，性别比为1.5。在实施 SMC 的两年前和三年后，CM 发病率分别为 92.1%和 83.5%（P = 0.013）。总死亡率为 9.2%，随随访年份的不同而变化（p = 0.001）：SMC对重症疟疾表型的表现有影响，CM和与肺水肿相关的CM发病率增加，与严重贫血相关的CM发病率减少。前瞻性研究将有助于了解在 SMC 期间观察到的病例致死率增加的情况。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Le Mali medical

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0.10

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